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AGE AND GENDER AFFECT LEFT VENTRICULAR RELAXATION IN PATIENTS WITH MYOCARDIAL INFARCTION: A TISSUE DOPPLER ECHOCARDIOGRAPHY STUDY
E664 JACC April 5, 2011 Volume 57, Issue 14
IMAGING AND DIAGNOSTIC TESTING AGE AND GENDER AFFECT LEFT VENTRICULAR RELAXATION IN PATIENTS WITH MYOCARDIAL INFARCTION: A TISSUE DOPPLER ECHOCARDIOGRAPHY STUDY ACC Poster Contributions Ernest N. Morial Convention Center, Hall F Sunday, April 03, 2011, 10:00 a.m.-11:15 a.m.
Session Title: Tisue Doppler, Speckle Tracking and Diastolic Function Abstract Category: 31. General Echocardiography: TTE Session-Poster Board Number: 1024-221 Authors: Hiroyuki Okura, Ryugo Yamakawa, Noriko Toyoshima, Shogo Sakamoto, Yoko Morishita, Nobuya Mastushita, Kenji Shimeno, Takeshi Ozaki, Hiroyuki Yamagishi, Iku Toda, Kiyoshi Yoshida, Kawasaki Medical School, Kurashiki, Japan, Bell Land General Hospital, Sakai, Japan Background: Previous reports have suggested that female gender may have worse prognosis among patients with myocardial infarction (MI). The aim of this study was to investigate whether left ventricular relaxation is affected by age and gender in patients with MI. Methods: A total of 729 consecutive patients (527 males and 202 females, mean age 69 years) who had prior (> 14 days) history of MI were enrolled and analyzed. Echocardiographic examinations including tissue Doppler imaging were performed. Early mitral annular velocity (e’) was measured as an index of left ventricular relaxation. Based on the e’ value, patients were grouped into quartiles. Results: Univariable predictors of the lowest quartile (e’ < 3.8 cm/sec) were age, female gender, left ventricular (LV) end-diastolic volume, LV endsystolic volume, LV ejection fraction and LV mass. By multivariable logistic regression analysis, age (OR 1.05, 95%CI:1.04-1.08, p<0.0001), female gender (OR 2.28, 95%CI:1.46-3.56, p=0.0003) and LV ejection fraction (OR 0.95, 95%CI:0.90-0.99, p=0.01) were independent predictors of the lowest quartile of e’. Patients with the lowest quartile of e’ had significantly higher mortality rate than the others (Figure, P=0.003). Conclusions: Age and gender affect LV relaxation independent of LV systolic function in MI patients. These results may explain excessive mortality among female gender in patients with MI.
IMAGING AND DIAGNOSTIC TESTING AGE AND GENDER AFFECT LEFT VENTRICULAR RELAXATION IN PATIENTS WITH MYOCARDIAL INFARCTION: A TISSUE DOPPLER ECHOCARDIOGRAPHY STUDY ACC Poster Contributions Ernest N. Morial Convention Center, Hall F Sunday, April 03, 2011, 10:00 a.m.-11:15 a.m.
Session Title: Tisue Doppler, Speckle Tracking and Diastolic Function Abstract Category: 31. General Echocardiography: TTE Session-Poster Board Number: 1024-221 Authors: Hiroyuki Okura, Ryugo Yamakawa, Noriko Toyoshima, Shogo Sakamoto, Yoko Morishita, Nobuya Mastushita, Kenji Shimeno, Takeshi Ozaki, Hiroyuki Yamagishi, Iku Toda, Kiyoshi Yoshida, Kawasaki Medical School, Kurashiki, Japan, Bell Land General Hospital, Sakai, Japan Background: Previous reports have suggested that female gender may have worse prognosis among patients with myocardial infarction (MI). The aim of this study was to investigate whether left ventricular relaxation is affected by age and gender in patients with MI. Methods: A total of 729 consecutive patients (527 males and 202 females, mean age 69 years) who had prior (> 14 days) history of MI were enrolled and analyzed. Echocardiographic examinations including tissue Doppler imaging were performed. Early mitral annular velocity (e’) was measured as an index of left ventricular relaxation. Based on the e’ value, patients were grouped into quartiles. Results: Univariable predictors of the lowest quartile (e’ < 3.8 cm/sec) were age, female gender, left ventricular (LV) end-diastolic volume, LV endsystolic volume, LV ejection fraction and LV mass. By multivariable logistic regression analysis, age (OR 1.05, 95%CI:1.04-1.08, p<0.0001), female gender (OR 2.28, 95%CI:1.46-3.56, p=0.0003) and LV ejection fraction (OR 0.95, 95%CI:0.90-0.99, p=0.01) were independent predictors of the lowest quartile of e’. Patients with the lowest quartile of e’ had significantly higher mortality rate than the others (Figure, P=0.003). Conclusions: Age and gender affect LV relaxation independent of LV systolic function in MI patients. These results may explain excessive mortality among female gender in patients with MI.