Age-Related Extensive Fragmentation of Mitochondrial DNA into Minicircles

Age-Related Extensive Fragmentation of Mitochondrial DNA into Minicircles

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 232, 832 (1997) ERRATUM Volume 226, Number 2 (1996), in the article ‘‘Age-Related Extensive Frag...

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

232, 832 (1997)

ERRATUM Volume 226, Number 2 (1996), in the article ‘‘Age-Related Extensive Fragmentation of Mitochondrial DNA into Minicircles,’’ by Mika Hayakawa, Kazumi Katsumata, Makoto Yoneda, Masashi Tanaka, Satoru Sugiyama, and Takayuki Ozawa, pages 369–377: On page 371, Table I, the head for column 11 should read ‘‘8-OH-dG per 104 dG’’ instead of ‘‘8-OH-dG per 105 dG.’’ For the reader’s convenience, the correct Table I is printed here. This erratum is Article No. RC976332.

TABLE 1

Types of mtDNA among Subjects Sub-Type of DmtDNA Subject

Sex

Age

Disease

DmtDNA Type (n)

OriL//H/

OriL0

OriH0

OriL0/H0

vmtDNA (%)

8-OH-dG per 104 dG

A.K. S.T. N.N. Y.I. Y.T. Y.Y. K.A. H.M.

F M F F M F M F

3 24 28 48 60 76 85 97

VSD Accident Pul. Emb. Thymoma Gastric ca. SAH Colon ca. Gastric ca.

5 49 67 43 49 218 230 358

4 16 23 13 13 66 61 78

1 15 14 8 23 68 64 88

0 8 8 4 1 37 33 63

0 10 22 18 12 47 72 129

ú99 85 71 73 71 47 58 11

õ1 õ1 õ1 5.9 17.5 18.6 15.3 148

M.K. H.A. T.K. r/ r/

F F M

7 17 19

DCM mtCM mtCM normoxia 95% O2

212 n.d. 235 49 187

37 n.d. 48 14 35

58 n.d. 59 15 55

38 n.d. 31 5 28

79 n.d. 97 15 69

n.d. n.d. 16 n.d. n.d.

n.d. 21.5 20.1 n.d. n.d.

Abbreviations: DmtDNA, mtDNA with deletions; vmtDNA, wild type mtDNA; Ori, replication origin; F, female; M, male; VSD, ventricular septal defect; Pul. Emb., pulmonary embolism; ca., cancer; SAH, subarachnoidal hemorrhage; DCM, dilated cardiomyopathy (12); mtCM, mitochondrial cardiomyopathy (30); r/, a cultured human cell line, 701.2.8c (31); n.d., could not be determined due to the storage of specimen.

832 Copyright q 1997 by Academic Press All rights of reproduction in any form reserved.

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