- Email: [email protected]
Airway function in sarcoidosis
Membranous nephropathy
Diffuse proliterative nephritis
Focal sclerosis
Uric acid
Renal handling
Ascorbic acid clearance increases when plasma ascorbic acid is increased by intravenous injection of ascorbic acid. Net tubular secretkx? of ascorbic acid is not shown with plasma levels up to 12 mg/lOO ml in man and 28 mg/lOO ml in dog. With decreased glomerular filtration rate (GFR), however, Casdic ac&%R approaches unity. In man, Casmbic ..d:GFR rises from 0.081 f 0.020 to 0.116 f 0.026 after the intravenous administration of ascorbic acid. No convincing change is seen in dog. lhe uricosuric effect of ascorbic acid in man may be due to competition for tubular transport between uric acid and ascorbic acid.
Berger L, Gerson CD, Yii T-F: The effect of ascorbic acid on uric acid excretion with a commentary on the renal handling of ascorbic acid. Am J Med 82: 71-76, 1977.
Ascorbic acid
Cell-associated
immunity Varicella-Zoster
Hodgkin’s disease virus
Thirty-two patients with Hodgkin’s disease and 12 normal donors were studied for in vitro lymphocyte responsiveness to a membrane-associated varicella-zoster (VZ) antigen. When compared to normal donors, patients with Hodgkin’s disease in whom radiotherapy was recently completed and those with active recurrent disease, had markedly impaired cell-associated immunity to VZ antigen; patients in long-term remission (radiotherapy and chemotherapy) had an impaired response; newly diagnosed, untreated patients dii not differ significantly from ncxrnal persons as a group, but two of six were unresponsive to the VZ antigen whereas all normal subjects were responsive. Herpes zoster developed in two patients with absent in vitro lymphocyte reactivity to the VZ antigen. These data suggest that the use of in vitro lymphocyte responsiveness may enable us to predict the susceptibility of patients with Hodgkin’s disease to this viral infection.
Ruckdeschel JC, Schimpff SC, Smyth AC, Mardiney MR Jr: Herpes zoster and impaired cell-associated immunity to the varicella-zoster virus in patients with Hodgkin’s disease. Am J h&d 62: 77-85, 1977.
Lymphocyte responsiveness
Herpes zoster
Eighty-one adult patients with the idiopathic nephrotic syndrome were treated with prednisane, 60 to 120 mg, on alternate days. Treatment was continued with diminishing drug doses for up to 10 years. Biopsy specimens were categorized as showing lipoid nephrosis, focal sclerosis, diffuse proliferative and membranous nephropathy. Patients with systemic causes of the nephrotic syndrome were excluded. Death or dialysis occurred in 12 per cent of the patients, and complications coincident with treatment occurred once every 12 patient years. Compared to other series of patients with the idiopathic nephrotic syndrome, therapy of our patients with prolonged alternate day steroids resulted in (1) decreased protein excretion, (2) maintenance of good renal function and (3) decreased number of complications of therapy.
Lipoid nephrosis
Idiopathic nephrotic syndrome
Airway function was studied in 16 patients with sarcoidosis, aged 18 to 49 years. Eleven of the patients were smokers. All patients had the characteristic functional changes of restrictive lung disease: decreased lung volumes and single breath diffusing capacity, and increased static transpulmonary pressures. Abnormal airway function was demonstrated in every patient by at least one test, and nearly always by multiple tests. Specific airway conductance was abnormally low in two patients. The ratio of the 1 second forced expiratory volume to the forced vital capacity was decreased in six patients. Frequency dependence of dynamic compliance was demonstrated in eight patients. The ratio of closing volume to vital capacity was increased above age-corrected predictions in all but two patients. Upstream airway resistance was abnormally increased in 16 of the patients. These results suggest that airway dysfunction is not uncommon in sarcoidosis.
Pulmonary sarcoidosis
Lung disease
Bolton WK. Atuk NO, Sturgill BC, Westervelt FB Jr: Therapy of the idiopathic nephrotic syndrome with alternate day steroids. Am J Med 62: 60-70, 1977.
Dynamic compliance
FEV,:FVC ratios
Levinson RS, Metzger LF, Stanley NN, K&en SG, Altose MD, Cherniack NS, Brady JS: Airway function in sarcoidosis. Am J Med 62: 51-59, 1977.
Sarcotdosls
Airway function
Diffuse proliterative nephritis
Focal sclerosis
Uric acid
Renal handling
Ascorbic acid clearance increases when plasma ascorbic acid is increased by intravenous injection of ascorbic acid. Net tubular secretkx? of ascorbic acid is not shown with plasma levels up to 12 mg/lOO ml in man and 28 mg/lOO ml in dog. With decreased glomerular filtration rate (GFR), however, Casdic ac&%R approaches unity. In man, Casmbic ..d:GFR rises from 0.081 f 0.020 to 0.116 f 0.026 after the intravenous administration of ascorbic acid. No convincing change is seen in dog. lhe uricosuric effect of ascorbic acid in man may be due to competition for tubular transport between uric acid and ascorbic acid.
Berger L, Gerson CD, Yii T-F: The effect of ascorbic acid on uric acid excretion with a commentary on the renal handling of ascorbic acid. Am J Med 82: 71-76, 1977.
Ascorbic acid
Cell-associated
immunity Varicella-Zoster
Hodgkin’s disease virus
Thirty-two patients with Hodgkin’s disease and 12 normal donors were studied for in vitro lymphocyte responsiveness to a membrane-associated varicella-zoster (VZ) antigen. When compared to normal donors, patients with Hodgkin’s disease in whom radiotherapy was recently completed and those with active recurrent disease, had markedly impaired cell-associated immunity to VZ antigen; patients in long-term remission (radiotherapy and chemotherapy) had an impaired response; newly diagnosed, untreated patients dii not differ significantly from ncxrnal persons as a group, but two of six were unresponsive to the VZ antigen whereas all normal subjects were responsive. Herpes zoster developed in two patients with absent in vitro lymphocyte reactivity to the VZ antigen. These data suggest that the use of in vitro lymphocyte responsiveness may enable us to predict the susceptibility of patients with Hodgkin’s disease to this viral infection.
Ruckdeschel JC, Schimpff SC, Smyth AC, Mardiney MR Jr: Herpes zoster and impaired cell-associated immunity to the varicella-zoster virus in patients with Hodgkin’s disease. Am J h&d 62: 77-85, 1977.
Lymphocyte responsiveness
Herpes zoster
Eighty-one adult patients with the idiopathic nephrotic syndrome were treated with prednisane, 60 to 120 mg, on alternate days. Treatment was continued with diminishing drug doses for up to 10 years. Biopsy specimens were categorized as showing lipoid nephrosis, focal sclerosis, diffuse proliferative and membranous nephropathy. Patients with systemic causes of the nephrotic syndrome were excluded. Death or dialysis occurred in 12 per cent of the patients, and complications coincident with treatment occurred once every 12 patient years. Compared to other series of patients with the idiopathic nephrotic syndrome, therapy of our patients with prolonged alternate day steroids resulted in (1) decreased protein excretion, (2) maintenance of good renal function and (3) decreased number of complications of therapy.
Lipoid nephrosis
Idiopathic nephrotic syndrome
Airway function was studied in 16 patients with sarcoidosis, aged 18 to 49 years. Eleven of the patients were smokers. All patients had the characteristic functional changes of restrictive lung disease: decreased lung volumes and single breath diffusing capacity, and increased static transpulmonary pressures. Abnormal airway function was demonstrated in every patient by at least one test, and nearly always by multiple tests. Specific airway conductance was abnormally low in two patients. The ratio of the 1 second forced expiratory volume to the forced vital capacity was decreased in six patients. Frequency dependence of dynamic compliance was demonstrated in eight patients. The ratio of closing volume to vital capacity was increased above age-corrected predictions in all but two patients. Upstream airway resistance was abnormally increased in 16 of the patients. These results suggest that airway dysfunction is not uncommon in sarcoidosis.
Pulmonary sarcoidosis
Lung disease
Bolton WK. Atuk NO, Sturgill BC, Westervelt FB Jr: Therapy of the idiopathic nephrotic syndrome with alternate day steroids. Am J Med 62: 60-70, 1977.
Dynamic compliance
FEV,:FVC ratios
Levinson RS, Metzger LF, Stanley NN, K&en SG, Altose MD, Cherniack NS, Brady JS: Airway function in sarcoidosis. Am J Med 62: 51-59, 1977.
Sarcotdosls
Airway function