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Allergen Sensitivity in Adults with Atopic Dermatitis
AB242 Abstracts
758
Insufficient physical activity is a risk factor of atopic dermatitis in Korean adolescents
Yeong-Ho Rha, MD, PhD1, Kyung Suk Lee, MD2, and Sun Hee Choi, MD PhD3; 1Kyung Hee University Hospital, Seoul, Korea, 2Department of Pediatrics, CHA University Bundang Medical Center, Seongnam, South Korea, 3Kyung Hee University Hospital at Gangdong, Seoul, Korea. RATIONALE: Regular physical activity (PA) has been known as beneficial that it reduces the risk of chronic diseases including allergic diseases. However, little has known regarding the relationship between PA and allergic diseases in Korean adolescents. We analyzed the national data whether PA is related to the prevalence of allergic diseases in the population of Korean adolescents. METHODS: Data from sixth Korean National Health and Nutrition Examination Survey (2013 to 2014) that included 1,272 adolescents from 12 to 18 years old was analyzed. We defined regular PA according to Physical Activity Guidelines for Americans. Multivariate regression analysis was performed to find whether insufficient PA could be a risk factor for allergic diseases. RESULTS: The prevalence of asthma, allergic rhinitis (AR) and atopic dermatitis (AD) were 1.3%, 9.3% and 5.2% in Korean adolescents, respectively. After adjusting for factors, PA was not associated with asthma and AR, but was significantly related to AD in Korean adolescents (adjusted odd ratio 3.254, 1.202-8.810, p50.021) CONCLUSIONS: This study suggests insufficient PA is a risk factor of atopic dermatitis in Korean adolescents. These findings may be helpful for management and improving the quality of life in AD of Korean adolescents.
759
Allergen Sensitivity in Adults with Atopic Dermatitis
MONDAY
Roderick McPhee, MD, PhD1, Jingya Wang, PhD1, Yeriel Estrada2, Lydia Greenlees1, Emma Guttman-Yassky, MD, PhD2, and Michael D. Howell, PhD1; 1MedImmune, Gaithersburg, MD, 2Icahn Medical School at the Mount Sinai Medical Center, New York, NY. RATIONALE: Atopic dermatitis (AD) is a chronic inflammatory disease characterized by significant barrier disruption and increased allergen sensitivity. Approximately 80% of patients with AD have evidence of sensitivity to one or more environmental or food allergens. We hypothesized that the frequency and distribution of allergen sensitivity would identify potential subsets of AD patients. METHODS: Serum was collected from 39 healthy controls with no history of skin disease and 76 subjects with AD and analyzed for allergen sensitivity to a panel of 119 environmental and food allergens using the ImmunoCAP Solid-Phase Allergen Chip (ISAC) test. Extrinsic AD (EAD) _ 150 kU/L. was defined as a total IgE level > RESULTS: Total IgE levels were significantly greater (p<0.001) in subjects with AD (1372.52 kU/L) compared to healthy controls (13.68 kU/ L). Additionally, the number of positive allergens was statistically greater for patients with EAD compared to both intrinsic AD (IAD, p<0.001) and healthy controls (p value <0.0001). Interestingly, the number of positive allergens correlated with total serum IgE levels for EAD (r50.7832, p<0.01) and all AD (r50.7042, p<0.0001). Overall, there were significantly more positive results to both environmental and food allergens in the EAD group compared to IAD and healthy control groups. A greater prevalence was observed for dust mite, cat, and horse allergens in all AD subjects (p<0.05). CONCLUSIONS: These findings support the hypothesis that determination of allergen sensitivity in patients with AD may allow identification of patient subsets which may have implications for future therapeutic approaches.
J ALLERGY CLIN IMMUNOL FEBRUARY 2017
760
Patch Testing for Evaluation of Allergic Contact Dermatitis in a Single Academic Allergy Practice
Britta Sundquist, MD, and Muhammad A. Pasha, MD, FAAAAI; Albany Medical College, Albany, NY. RATIONALE: Allergic contact dermatitis (ACD) is frequently encountered by allergists. Patch testing is the ‘‘gold standard’’ to identify culprit allergens causing ACD, but there are limited studies on patch testing in allergy practices. Our objective was to report on patch testing findings in an outpatient allergy practice. METHODS: A retrospective chart review of patients referred for patch testing from July 2013-May 2016 was performed. Data collected included a history of atopy, location of dermatitis, if referred from a dermatologist, and positive patch test results. RESULTS: Of the 387 patients (mean age 49.2, 73% female) who were patch tested over a 34 month period, 241 (62.3%) had a positive reaction. Of those who tested positive, 59.4% reported an atopic history and 55.3% were referred from a dermatologist. The extremities were the most common involved site (53.7%), followed by the head/neck (47.2%) then trunk (29.7%). The five most common positive allergens were gold sodium thiosulfate, nickel sulfate, methylchloroisothiazolinone, thimersol and bacitracin. One hundred twenty five patients (51.8%) were positive to at least 1 Thin-Layer Rapid-Use Epicutaneous (T.R.U.E) test allergens, 49 (20%) were positive on both T.R.U.E. test and additional allergens from the North American Contact Dermatitis (NACDG) panel, 17 (7%) were positive to the additional NACDG allergens alone and 8 (3.3%) were positive only to supplemental allergens provided. CONCLUSIONS: Patch testing is a valuable diagnostic tool for the practicing allergist. Performing a more extended series such as the NACDG and/or supplemental allergens is higher yield when compared to limited standard series in evaluating ACD.
758
Insufficient physical activity is a risk factor of atopic dermatitis in Korean adolescents
Yeong-Ho Rha, MD, PhD1, Kyung Suk Lee, MD2, and Sun Hee Choi, MD PhD3; 1Kyung Hee University Hospital, Seoul, Korea, 2Department of Pediatrics, CHA University Bundang Medical Center, Seongnam, South Korea, 3Kyung Hee University Hospital at Gangdong, Seoul, Korea. RATIONALE: Regular physical activity (PA) has been known as beneficial that it reduces the risk of chronic diseases including allergic diseases. However, little has known regarding the relationship between PA and allergic diseases in Korean adolescents. We analyzed the national data whether PA is related to the prevalence of allergic diseases in the population of Korean adolescents. METHODS: Data from sixth Korean National Health and Nutrition Examination Survey (2013 to 2014) that included 1,272 adolescents from 12 to 18 years old was analyzed. We defined regular PA according to Physical Activity Guidelines for Americans. Multivariate regression analysis was performed to find whether insufficient PA could be a risk factor for allergic diseases. RESULTS: The prevalence of asthma, allergic rhinitis (AR) and atopic dermatitis (AD) were 1.3%, 9.3% and 5.2% in Korean adolescents, respectively. After adjusting for factors, PA was not associated with asthma and AR, but was significantly related to AD in Korean adolescents (adjusted odd ratio 3.254, 1.202-8.810, p50.021) CONCLUSIONS: This study suggests insufficient PA is a risk factor of atopic dermatitis in Korean adolescents. These findings may be helpful for management and improving the quality of life in AD of Korean adolescents.
759
Allergen Sensitivity in Adults with Atopic Dermatitis
MONDAY
Roderick McPhee, MD, PhD1, Jingya Wang, PhD1, Yeriel Estrada2, Lydia Greenlees1, Emma Guttman-Yassky, MD, PhD2, and Michael D. Howell, PhD1; 1MedImmune, Gaithersburg, MD, 2Icahn Medical School at the Mount Sinai Medical Center, New York, NY. RATIONALE: Atopic dermatitis (AD) is a chronic inflammatory disease characterized by significant barrier disruption and increased allergen sensitivity. Approximately 80% of patients with AD have evidence of sensitivity to one or more environmental or food allergens. We hypothesized that the frequency and distribution of allergen sensitivity would identify potential subsets of AD patients. METHODS: Serum was collected from 39 healthy controls with no history of skin disease and 76 subjects with AD and analyzed for allergen sensitivity to a panel of 119 environmental and food allergens using the ImmunoCAP Solid-Phase Allergen Chip (ISAC) test. Extrinsic AD (EAD) _ 150 kU/L. was defined as a total IgE level > RESULTS: Total IgE levels were significantly greater (p<0.001) in subjects with AD (1372.52 kU/L) compared to healthy controls (13.68 kU/ L). Additionally, the number of positive allergens was statistically greater for patients with EAD compared to both intrinsic AD (IAD, p<0.001) and healthy controls (p value <0.0001). Interestingly, the number of positive allergens correlated with total serum IgE levels for EAD (r50.7832, p<0.01) and all AD (r50.7042, p<0.0001). Overall, there were significantly more positive results to both environmental and food allergens in the EAD group compared to IAD and healthy control groups. A greater prevalence was observed for dust mite, cat, and horse allergens in all AD subjects (p<0.05). CONCLUSIONS: These findings support the hypothesis that determination of allergen sensitivity in patients with AD may allow identification of patient subsets which may have implications for future therapeutic approaches.
J ALLERGY CLIN IMMUNOL FEBRUARY 2017
760
Patch Testing for Evaluation of Allergic Contact Dermatitis in a Single Academic Allergy Practice
Britta Sundquist, MD, and Muhammad A. Pasha, MD, FAAAAI; Albany Medical College, Albany, NY. RATIONALE: Allergic contact dermatitis (ACD) is frequently encountered by allergists. Patch testing is the ‘‘gold standard’’ to identify culprit allergens causing ACD, but there are limited studies on patch testing in allergy practices. Our objective was to report on patch testing findings in an outpatient allergy practice. METHODS: A retrospective chart review of patients referred for patch testing from July 2013-May 2016 was performed. Data collected included a history of atopy, location of dermatitis, if referred from a dermatologist, and positive patch test results. RESULTS: Of the 387 patients (mean age 49.2, 73% female) who were patch tested over a 34 month period, 241 (62.3%) had a positive reaction. Of those who tested positive, 59.4% reported an atopic history and 55.3% were referred from a dermatologist. The extremities were the most common involved site (53.7%), followed by the head/neck (47.2%) then trunk (29.7%). The five most common positive allergens were gold sodium thiosulfate, nickel sulfate, methylchloroisothiazolinone, thimersol and bacitracin. One hundred twenty five patients (51.8%) were positive to at least 1 Thin-Layer Rapid-Use Epicutaneous (T.R.U.E) test allergens, 49 (20%) were positive on both T.R.U.E. test and additional allergens from the North American Contact Dermatitis (NACDG) panel, 17 (7%) were positive to the additional NACDG allergens alone and 8 (3.3%) were positive only to supplemental allergens provided. CONCLUSIONS: Patch testing is a valuable diagnostic tool for the practicing allergist. Performing a more extended series such as the NACDG and/or supplemental allergens is higher yield when compared to limited standard series in evaluating ACD.