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Allergic conjunctivitis due to fungi
431
ABSl’RACTS
In the first patient there was bleeding from both sides of the novarsenobenzol. nasal septum. On the posterior wall of the pharynx there was a large purple bulla There was also bleeding from the tonsillar fossae. By with bleeding edges. endoseopic examination lesions were noted in the esophagus. A few purpuric spots Recovery followed discontinuation of the were also noted on the extremities. drug treatment. The faucial surface
second patient showed violet-black staining of the mueosa of the anterior pillars, the gum margins adjacent to the teeth in both jaws, and the inner of both cheeks opposite the molars. There were no cutaneous lesions in The patient recovered after discontinuation of the injection of novarcase.
this senobenzol.
The third patient had purpuric lesions of the also had some purpuric skin lesions of the chin case followed the ingestion of “aspro” tablets. extensive. The patient completely recovered.
Recurrent Report
nose, mouth, and pharynx. She and neck. The purpura in this The faucial lesions were very
Paralysis of the Larynx Following Injection of Tetanus of a Case. Neffson, A.: Arch. Otolaryng. 27: 201, 1938.
Antitoxin.
A very interesting case of recurrent paralysis of the larynx following the injection of tetanus antitoxin was reported by Neffson. The patient was a male, aged 19 years, who, after the injection of 1,500 units of tetanus antitoxin developed first an urticaria, later generalized muscular and articular pains, and then Examination of the larynx showed a complete paralysis suddenly a hoarseness. of the left vocal cord and diminution of sensation on the left side of the larynx. The left pupil was slightly larger than the right. There was also an equivocal Babinski sign on the left, and questionable paresis of the right side of the face The laryngeal paralysis improved gradually and disappeared of central origin. completely three months after the onset.
Lysozyme of Nasal Mucus: Method Its Effect on Growth and Virulence Daly,
S.:
Arch.
Otolaryng.
27:
of Preparation and Preliminary Report on of Common Pathogens of Paranasal Sinuses.
189, 1938.
Daly has shown that lysozyme is present in normal nasal mucus. He described a method of obtaining sterile preparations from nasal mucus. His experiments showed that nasal lysozyme in sufficient concentrations caused Staphylococcus az1ceas, Streptococcus hemolyticus, and pneumococcus III to grow in a granular manner. In one experiment pneumococcus III suffered some loss of virulence as a result of contact with nasal lysozyme. Although the results of these experiments on pneumococeus III were considered inconclusive, they seem worthy of note since they are in agreement with the findings of others.
Allergic
Conjunctivitis
Due to Fungi.
Simon,
F.:
J. A.
M.
A.
110:
440,
1928.
In a study of a case of conjunctivitis the following evidence indicated that the chief etiologic factor was an allergic reaction to the spores of air-borne fungi. Seasonal variations in the patient’s symptoms coincided with seasonal variations in the atmospheric concentration of fungus spores. Changes in the patient’s geographical location were accompanied by changes in his symptoms. Skin tests with fungus extracts were definitely positive. The clinical symptoms of conjunctivitis were reproduced by the application of fungus extract to the The control test in a non-sensitive subject was negative. The conjunctiva.
432
THE
patient was in his home. symptoms.
JOIJRNJAL
exposed to fungus Hyposensitization
spores with
OF
ALI,l+:IiGY
in that fungus
these extracts
were cultured was followed
in by
abundance relief of
Miscellaneous Hypersensitiveness
to Digitalis.
Brandt,
R.:
Wien.
klin.
Wchnschr.
50:
1525,
1937. A patient, a woman aged forty-six years, developed an eczematous lesion of the skin on several occasions. It was finally discovered that each time the skin manifestations were preceded by the oral ingestion of digitalis, taken for myocardial weakness. The drug was taken in the form of powdered digitalis leaves. On testing the patient at a later time with a different digitalis preparation, namely, Digilanid, in doses sufficient to produce a pharmacologic effect, no evidence of hypersensitization occurred. The extreme rarity of sensitivity to digitalis in this sense, rather to its pharmacologic effect, is pointed out.
Allergy
to
Liver
Extract.
Criep,
L. H.:
J. A. M.
A. 110:
506,
1938.
Only six previous instances of allergy to the injection of liver extract have been reported. The ease here cited is that of a man forty-one years old with a history of hay fever. He received liver extract intravenously for pernicious anemia at intervals of ten days for a period of one year. Treatment was discontinued in April, 1936, and resumed the following month. Shortly after the third reinjection severe asthma and generalized urticaria developed. The same episodes followed the next injection. Autolyzed liver concentrate was sub stituted without untoward reaction. Six months later the hlvpersensitiveness to the original extract had disappeared. A carefully controlled series of following conclusions arrived at: analogous to that to insulin and to tivity, moreover, is one to an organ tests and reagins are present for at action. Loss of clinical sensitivity reagins. Precipitins were demonstrable anaphylactic bodies were demonstrable. he produced experimentally.
immunologic tests were performed and the the sensitivity is an acquired allergy and solution of posterior pituitary. The sensiand not to a biologic source. Positive skin least three months following the initial rewas coincident with the disappearance of at the same time as reagins, but no This type of acquired allergy could not
Sensitization by Vitamin B, of Isolated Intestinal Strips of Rats and the Circulatory System of Cats to the Action of Acetylcholine. Agid, R., Beau Vallet, M.,
and
Minz,
B.:
Compt.
rend.
Sot.
d. biol.
An intestinal strip from a rat suspended Locke solution was tested with given amounts recorded. On adding vitamin B, in dilution choline, a marked prolongation of contraction
127:
982,
1937.
in a bath of oxygenated Ringerof acetylcholine and its contraction of l:lO-6 and retesting with acetylwas observed.
The choline
carotid caused
blood pressure a characteristic
of a cat was taken. The administration fall, which was greatly enhanced with
The identical
question with
arises whether anaphylactic and allergic disturbances, aeetylcholine effects, may he increased by vitamin R,.
of acetylvitamin B,. which
are
ABSl’RACTS
In the first patient there was bleeding from both sides of the novarsenobenzol. nasal septum. On the posterior wall of the pharynx there was a large purple bulla There was also bleeding from the tonsillar fossae. By with bleeding edges. endoseopic examination lesions were noted in the esophagus. A few purpuric spots Recovery followed discontinuation of the were also noted on the extremities. drug treatment. The faucial surface
second patient showed violet-black staining of the mueosa of the anterior pillars, the gum margins adjacent to the teeth in both jaws, and the inner of both cheeks opposite the molars. There were no cutaneous lesions in The patient recovered after discontinuation of the injection of novarcase.
this senobenzol.
The third patient had purpuric lesions of the also had some purpuric skin lesions of the chin case followed the ingestion of “aspro” tablets. extensive. The patient completely recovered.
Recurrent Report
nose, mouth, and pharynx. She and neck. The purpura in this The faucial lesions were very
Paralysis of the Larynx Following Injection of Tetanus of a Case. Neffson, A.: Arch. Otolaryng. 27: 201, 1938.
Antitoxin.
A very interesting case of recurrent paralysis of the larynx following the injection of tetanus antitoxin was reported by Neffson. The patient was a male, aged 19 years, who, after the injection of 1,500 units of tetanus antitoxin developed first an urticaria, later generalized muscular and articular pains, and then Examination of the larynx showed a complete paralysis suddenly a hoarseness. of the left vocal cord and diminution of sensation on the left side of the larynx. The left pupil was slightly larger than the right. There was also an equivocal Babinski sign on the left, and questionable paresis of the right side of the face The laryngeal paralysis improved gradually and disappeared of central origin. completely three months after the onset.
Lysozyme of Nasal Mucus: Method Its Effect on Growth and Virulence Daly,
S.:
Arch.
Otolaryng.
27:
of Preparation and Preliminary Report on of Common Pathogens of Paranasal Sinuses.
189, 1938.
Daly has shown that lysozyme is present in normal nasal mucus. He described a method of obtaining sterile preparations from nasal mucus. His experiments showed that nasal lysozyme in sufficient concentrations caused Staphylococcus az1ceas, Streptococcus hemolyticus, and pneumococcus III to grow in a granular manner. In one experiment pneumococcus III suffered some loss of virulence as a result of contact with nasal lysozyme. Although the results of these experiments on pneumococeus III were considered inconclusive, they seem worthy of note since they are in agreement with the findings of others.
Allergic
Conjunctivitis
Due to Fungi.
Simon,
F.:
J. A.
M.
A.
110:
440,
1928.
In a study of a case of conjunctivitis the following evidence indicated that the chief etiologic factor was an allergic reaction to the spores of air-borne fungi. Seasonal variations in the patient’s symptoms coincided with seasonal variations in the atmospheric concentration of fungus spores. Changes in the patient’s geographical location were accompanied by changes in his symptoms. Skin tests with fungus extracts were definitely positive. The clinical symptoms of conjunctivitis were reproduced by the application of fungus extract to the The control test in a non-sensitive subject was negative. The conjunctiva.
432
THE
patient was in his home. symptoms.
JOIJRNJAL
exposed to fungus Hyposensitization
spores with
OF
ALI,l+:IiGY
in that fungus
these extracts
were cultured was followed
in by
abundance relief of
Miscellaneous Hypersensitiveness
to Digitalis.
Brandt,
R.:
Wien.
klin.
Wchnschr.
50:
1525,
1937. A patient, a woman aged forty-six years, developed an eczematous lesion of the skin on several occasions. It was finally discovered that each time the skin manifestations were preceded by the oral ingestion of digitalis, taken for myocardial weakness. The drug was taken in the form of powdered digitalis leaves. On testing the patient at a later time with a different digitalis preparation, namely, Digilanid, in doses sufficient to produce a pharmacologic effect, no evidence of hypersensitization occurred. The extreme rarity of sensitivity to digitalis in this sense, rather to its pharmacologic effect, is pointed out.
Allergy
to
Liver
Extract.
Criep,
L. H.:
J. A. M.
A. 110:
506,
1938.
Only six previous instances of allergy to the injection of liver extract have been reported. The ease here cited is that of a man forty-one years old with a history of hay fever. He received liver extract intravenously for pernicious anemia at intervals of ten days for a period of one year. Treatment was discontinued in April, 1936, and resumed the following month. Shortly after the third reinjection severe asthma and generalized urticaria developed. The same episodes followed the next injection. Autolyzed liver concentrate was sub stituted without untoward reaction. Six months later the hlvpersensitiveness to the original extract had disappeared. A carefully controlled series of following conclusions arrived at: analogous to that to insulin and to tivity, moreover, is one to an organ tests and reagins are present for at action. Loss of clinical sensitivity reagins. Precipitins were demonstrable anaphylactic bodies were demonstrable. he produced experimentally.
immunologic tests were performed and the the sensitivity is an acquired allergy and solution of posterior pituitary. The sensiand not to a biologic source. Positive skin least three months following the initial rewas coincident with the disappearance of at the same time as reagins, but no This type of acquired allergy could not
Sensitization by Vitamin B, of Isolated Intestinal Strips of Rats and the Circulatory System of Cats to the Action of Acetylcholine. Agid, R., Beau Vallet, M.,
and
Minz,
B.:
Compt.
rend.
Sot.
d. biol.
An intestinal strip from a rat suspended Locke solution was tested with given amounts recorded. On adding vitamin B, in dilution choline, a marked prolongation of contraction
127:
982,
1937.
in a bath of oxygenated Ringerof acetylcholine and its contraction of l:lO-6 and retesting with acetylwas observed.
The choline
carotid caused
blood pressure a characteristic
of a cat was taken. The administration fall, which was greatly enhanced with
The identical
question with
arises whether anaphylactic and allergic disturbances, aeetylcholine effects, may he increased by vitamin R,.
of acetylvitamin B,. which
are