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Allergy to liver extract
432
THE
patient was in his home. symptoms.
JOIJRNJAL
exposed to fungus Hyposensitization
spores with
OF
ALI,l+:IiGY
in that fungus
these extracts
were cultured was followed
in by
abundance relief of
Miscellaneous Hypersensitiveness
to Digitalis.
Brandt,
R.:
Wien.
klin.
Wchnschr.
50:
1525,
1937. A patient, a woman aged forty-six years, developed an eczematous lesion of the skin on several occasions. It was finally discovered that each time the skin manifestations were preceded by the oral ingestion of digitalis, taken for myocardial weakness. The drug was taken in the form of powdered digitalis leaves. On testing the patient at a later time with a different digitalis preparation, namely, Digilanid, in doses sufficient to produce a pharmacologic effect, no evidence of hypersensitization occurred. The extreme rarity of sensitivity to digitalis in this sense, rather to its pharmacologic effect, is pointed out.
Allergy
to
Liver
Extract.
Criep,
L. H.:
J. A. M.
A. 110:
506,
1938.
Only six previous instances of allergy to the injection of liver extract have been reported. The ease here cited is that of a man forty-one years old with a history of hay fever. He received liver extract intravenously for pernicious anemia at intervals of ten days for a period of one year. Treatment was discontinued in April, 1936, and resumed the following month. Shortly after the third reinjection severe asthma and generalized urticaria developed. The same episodes followed the next injection. Autolyzed liver concentrate was sub stituted without untoward reaction. Six months later the hlvpersensitiveness to the original extract had disappeared. A carefully controlled series of following conclusions arrived at: analogous to that to insulin and to tivity, moreover, is one to an organ tests and reagins are present for at action. Loss of clinical sensitivity reagins. Precipitins were demonstrable anaphylactic bodies were demonstrable. he produced experimentally.
immunologic tests were performed and the the sensitivity is an acquired allergy and solution of posterior pituitary. The sensiand not to a biologic source. Positive skin least three months following the initial rewas coincident with the disappearance of at the same time as reagins, but no This type of acquired allergy could not
Sensitization by Vitamin B, of Isolated Intestinal Strips of Rats and the Circulatory System of Cats to the Action of Acetylcholine. Agid, R., Beau Vallet, M.,
and
Minz,
B.:
Compt.
rend.
Sot.
d. biol.
An intestinal strip from a rat suspended Locke solution was tested with given amounts recorded. On adding vitamin B, in dilution choline, a marked prolongation of contraction
127:
982,
1937.
in a bath of oxygenated Ringerof acetylcholine and its contraction of l:lO-6 and retesting with acetylwas observed.
The choline
carotid caused
blood pressure a characteristic
of a cat was taken. The administration fall, which was greatly enhanced with
The identical
question with
arises whether anaphylactic and allergic disturbances, aeetylcholine effects, may he increased by vitamin R,.
of acetylvitamin B,. which
are
THE
patient was in his home. symptoms.
JOIJRNJAL
exposed to fungus Hyposensitization
spores with
OF
ALI,l+:IiGY
in that fungus
these extracts
were cultured was followed
in by
abundance relief of
Miscellaneous Hypersensitiveness
to Digitalis.
Brandt,
R.:
Wien.
klin.
Wchnschr.
50:
1525,
1937. A patient, a woman aged forty-six years, developed an eczematous lesion of the skin on several occasions. It was finally discovered that each time the skin manifestations were preceded by the oral ingestion of digitalis, taken for myocardial weakness. The drug was taken in the form of powdered digitalis leaves. On testing the patient at a later time with a different digitalis preparation, namely, Digilanid, in doses sufficient to produce a pharmacologic effect, no evidence of hypersensitization occurred. The extreme rarity of sensitivity to digitalis in this sense, rather to its pharmacologic effect, is pointed out.
Allergy
to
Liver
Extract.
Criep,
L. H.:
J. A. M.
A. 110:
506,
1938.
Only six previous instances of allergy to the injection of liver extract have been reported. The ease here cited is that of a man forty-one years old with a history of hay fever. He received liver extract intravenously for pernicious anemia at intervals of ten days for a period of one year. Treatment was discontinued in April, 1936, and resumed the following month. Shortly after the third reinjection severe asthma and generalized urticaria developed. The same episodes followed the next injection. Autolyzed liver concentrate was sub stituted without untoward reaction. Six months later the hlvpersensitiveness to the original extract had disappeared. A carefully controlled series of following conclusions arrived at: analogous to that to insulin and to tivity, moreover, is one to an organ tests and reagins are present for at action. Loss of clinical sensitivity reagins. Precipitins were demonstrable anaphylactic bodies were demonstrable. he produced experimentally.
immunologic tests were performed and the the sensitivity is an acquired allergy and solution of posterior pituitary. The sensiand not to a biologic source. Positive skin least three months following the initial rewas coincident with the disappearance of at the same time as reagins, but no This type of acquired allergy could not
Sensitization by Vitamin B, of Isolated Intestinal Strips of Rats and the Circulatory System of Cats to the Action of Acetylcholine. Agid, R., Beau Vallet, M.,
and
Minz,
B.:
Compt.
rend.
Sot.
d. biol.
An intestinal strip from a rat suspended Locke solution was tested with given amounts recorded. On adding vitamin B, in dilution choline, a marked prolongation of contraction
127:
982,
1937.
in a bath of oxygenated Ringerof acetylcholine and its contraction of l:lO-6 and retesting with acetylwas observed.
The choline
carotid caused
blood pressure a characteristic
of a cat was taken. The administration fall, which was greatly enhanced with
The identical
question with
arises whether anaphylactic and allergic disturbances, aeetylcholine effects, may he increased by vitamin R,.
of acetylvitamin B,. which
are