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Alzheimer's neuropathology in brains of Schizophrenic patients
44A
BIOt PSYCHIATRY 1990;27:41A-179A
Biology of Depression I
ALZHEIMER'S NEUROPATHOLOGY IN BRAINS OF SCHIZOPHRENIC PATIENTS Isak Prohovnik, Ph.D. (by invitation), Mavis Kaufman, M.D. (by invitation), Sukdeb l~ukherjee, M.D. New York State Psychiatric Institute, New Fork, NY 10032. We reviewed the neuropathological findings in the brains of 1,046 patients who died at various New York State psychiatric centers between 1978 and 1987. The findings were compared with antemortem ch,a ~ ! diagnoses, as recorded in autopsy reports. The prevalence of neuropathological diagnoses of Alzheimer's disease (AD) as a function of age at death differed significantly between patients with a diagnosis of primary degenerative dementia and those diagnosed to have schizophrenic disorder. A neuropathological diagnosis of AD was noted in about 60% of the primary, dementia patients and was age-invariant. By contrast, in schizophrenic patients, the rate of a neuropathol,-~gical diagnosis of AD increased from about 2% at the age of 60 years to about 50% in those older than 90 years of age. The distribution was remarkably similar to the curve proposed by Breitner et al. for first-degree relatives of AD patients. The data will be presented in detail, and the possible relationship between AD and schizophrenia will be discussed.
BIOLOGY OF DEPRESSION I Thursday, M a y 10, 1 : 0 0 - 4 : 0 0 PM
Royal Ballroom B
THE RELATIONSHIP BETWEEN CSF PEPTIDES, NEUROTRANSMITTERS, AND VBR IN DEPRESSED PATIENTS AND NORMAL CONTROLS S. Craig Risch, M.D., Richard J. Lewine, Ph.D., Rita D. Jewart, Ph.D., William E. Pollard, Ph.D., Jane Caudle, Ph.D., Ned H. Kalin, M.D., Mark Stipetie, M.S., Mary Eecard, M.S.N., Emile D. Risby, M.D., Marijyn Brummer, M.S. Emory University School of Medicine, Department of Psychiatry, Atlanta, GA 30322. Abnormalities in CSF neurochemistiy, neuropeptides, and in VBR have been reported in depressed patients. We preliminarily report the relations between CSF neurochemistry and neuropeptides and MRl-determined VBR in depressed patients (n -- 20) and controls (n = 84). As reported by Nemeroff et al., depressed subjects have significantly higher CSF CRF (79.9 _+ 7.6) than normal controls (61.2 -+ 3.8), p < 0.03. To date, we have observed no nosological differences in mean CSF MHPG, 5-HIAA, HVA, ACTH, or VBR and no significant correlations between CSF 5-HIAA, MHPG, HVA, ACTH, or CRF and VBR in either the depressed patients or in the normal controls.
BIOt PSYCHIATRY 1990;27:41A-179A
Biology of Depression I
ALZHEIMER'S NEUROPATHOLOGY IN BRAINS OF SCHIZOPHRENIC PATIENTS Isak Prohovnik, Ph.D. (by invitation), Mavis Kaufman, M.D. (by invitation), Sukdeb l~ukherjee, M.D. New York State Psychiatric Institute, New Fork, NY 10032. We reviewed the neuropathological findings in the brains of 1,046 patients who died at various New York State psychiatric centers between 1978 and 1987. The findings were compared with antemortem ch,a ~ ! diagnoses, as recorded in autopsy reports. The prevalence of neuropathological diagnoses of Alzheimer's disease (AD) as a function of age at death differed significantly between patients with a diagnosis of primary degenerative dementia and those diagnosed to have schizophrenic disorder. A neuropathological diagnosis of AD was noted in about 60% of the primary, dementia patients and was age-invariant. By contrast, in schizophrenic patients, the rate of a neuropathol,-~gical diagnosis of AD increased from about 2% at the age of 60 years to about 50% in those older than 90 years of age. The distribution was remarkably similar to the curve proposed by Breitner et al. for first-degree relatives of AD patients. The data will be presented in detail, and the possible relationship between AD and schizophrenia will be discussed.
BIOLOGY OF DEPRESSION I Thursday, M a y 10, 1 : 0 0 - 4 : 0 0 PM
Royal Ballroom B
THE RELATIONSHIP BETWEEN CSF PEPTIDES, NEUROTRANSMITTERS, AND VBR IN DEPRESSED PATIENTS AND NORMAL CONTROLS S. Craig Risch, M.D., Richard J. Lewine, Ph.D., Rita D. Jewart, Ph.D., William E. Pollard, Ph.D., Jane Caudle, Ph.D., Ned H. Kalin, M.D., Mark Stipetie, M.S., Mary Eecard, M.S.N., Emile D. Risby, M.D., Marijyn Brummer, M.S. Emory University School of Medicine, Department of Psychiatry, Atlanta, GA 30322. Abnormalities in CSF neurochemistiy, neuropeptides, and in VBR have been reported in depressed patients. We preliminarily report the relations between CSF neurochemistry and neuropeptides and MRl-determined VBR in depressed patients (n -- 20) and controls (n = 84). As reported by Nemeroff et al., depressed subjects have significantly higher CSF CRF (79.9 _+ 7.6) than normal controls (61.2 -+ 3.8), p < 0.03. To date, we have observed no nosological differences in mean CSF MHPG, 5-HIAA, HVA, ACTH, or VBR and no significant correlations between CSF 5-HIAA, MHPG, HVA, ACTH, or CRF and VBR in either the depressed patients or in the normal controls.