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An evaluation of the P.S.P. (Speck) test for tubal patency
Vol llllle Number
66 1
SELECTED
227
ABSTRACTS
general body habitus were present. Estrogen therapy was successful in producing normal menses in 5 of these women, Thirty-five patients with amenorrhea of primary type had some evidence of genital or systemic infantilism; estrogen therapy and calf hypophysis implantation produced normal menses in only 6 patients in this group. Of the total of 11 patients in the primary amenorrhea group who seemed to benefit from therapy, 3 subsequently became pregnant (7 per cent of patients in this series). One hundred ninety-two patients between the ages of 16 and 42 fell into the category of secondary amenorrhea. In 87 of these women (45 per cent), hormonal treatment resulted in establishment of normal menstrual function. The author’s experience confirms the generally held view that the prognosis in patients with secondary amenorrhea of functional type depends far more on the duration of the condition than it does on the age of the patient. Of 53 patients treated with parenteral preparations of crystalline chorionic gonadotropin, 38 per cent experienced re-establishment of normal menses. A history of delayed menarche did not appear to be a significant predisposing factor in any of the patients in this series. Therapeutic results were uniformly unsatisfactory in all patients in whom the excretion of gonadotropic hormone in the urine was found to be higher than normal. The conclusion to be drawn from the entire series is that endocrine therapy is sometimes of value in functional amenorrhea, provided the reproductive organs are normally developed, and the ovarian lesion is not too severe. DOUGLAS
Salvatore, Carlos 1952.
A. :
Capillary
The author studied capillary increase in fragility in the early fcremes shown by the investigator
Fragility
and
Menstruation,
Burg.,
M.
Gynec.
HAYNES
& Obst.
95:
fragility in 50 women of varying ages. He indicates days of menstruation. Whether or not the slight are statistically significant is not stated. LOUIS M. HELI,MAN
13,
an dif-
Vespasiano Ramoa, A., and Peano, Marcel: Report on Eighteen Cases of Functional Amenorrhea, An. bras& de ginec., January, 1952. The authors report 18 cases of functional amenorrhea, 5 primary and 13 secondary. After a detailed description of the laboratory and clinical picture, the authors present a therapeutic plan which has been very successful in their hands. They employed stilbestrol, 80 mg. a month for the primary types, together with 30 mg. of progesterone during the same time. For the secondary type the authors use a combination of estrone sulphate in varying doses in conjunction with indicated doses of progesterone, stilbestrol and ethinyl-estradiol. They also use estradiol monobenzoate in 1 mg. doses as an intrauterine infiltration. The authors found that stilbestrol was beneficial in most of the secondary types of amenorrhea. There is no bibliography. RICARDO
L.
GORBEA
Tubal Insufllation Davis,
E., Ward, M. E., and King, A. G.: An Evaluation Tubal Patency, Fertil. & Steril. 3: 217, 1952. M.
of the P.S.P. (Speck)
Test for
The authors have evaluated this test of tubal patency which utilizes the detection of phenolsulfonphthalein in the urine following its injection into the uterus as the criterion of peritoneal absorption. This test was compared with the standard ones of insufflation and utersalpingography in a series of 110 patients with an error for the P.S.P. (Speck) test of 15 per cent noted. These investigators discuss the possibility of P.S.P. absorption from traumatized or diseased mucous membranes in uterus and tubes, and conclude that this test offers no advantages over the standard procedures in the study of female sterility by the gynecologist. It is, however, an ingenious and simple test and may find some field of usefulness. 8. B.
GUSBERG
66 1
SELECTED
227
ABSTRACTS
general body habitus were present. Estrogen therapy was successful in producing normal menses in 5 of these women, Thirty-five patients with amenorrhea of primary type had some evidence of genital or systemic infantilism; estrogen therapy and calf hypophysis implantation produced normal menses in only 6 patients in this group. Of the total of 11 patients in the primary amenorrhea group who seemed to benefit from therapy, 3 subsequently became pregnant (7 per cent of patients in this series). One hundred ninety-two patients between the ages of 16 and 42 fell into the category of secondary amenorrhea. In 87 of these women (45 per cent), hormonal treatment resulted in establishment of normal menstrual function. The author’s experience confirms the generally held view that the prognosis in patients with secondary amenorrhea of functional type depends far more on the duration of the condition than it does on the age of the patient. Of 53 patients treated with parenteral preparations of crystalline chorionic gonadotropin, 38 per cent experienced re-establishment of normal menses. A history of delayed menarche did not appear to be a significant predisposing factor in any of the patients in this series. Therapeutic results were uniformly unsatisfactory in all patients in whom the excretion of gonadotropic hormone in the urine was found to be higher than normal. The conclusion to be drawn from the entire series is that endocrine therapy is sometimes of value in functional amenorrhea, provided the reproductive organs are normally developed, and the ovarian lesion is not too severe. DOUGLAS
Salvatore, Carlos 1952.
A. :
Capillary
The author studied capillary increase in fragility in the early fcremes shown by the investigator
Fragility
and
Menstruation,
Burg.,
M.
Gynec.
HAYNES
& Obst.
95:
fragility in 50 women of varying ages. He indicates days of menstruation. Whether or not the slight are statistically significant is not stated. LOUIS M. HELI,MAN
13,
an dif-
Vespasiano Ramoa, A., and Peano, Marcel: Report on Eighteen Cases of Functional Amenorrhea, An. bras& de ginec., January, 1952. The authors report 18 cases of functional amenorrhea, 5 primary and 13 secondary. After a detailed description of the laboratory and clinical picture, the authors present a therapeutic plan which has been very successful in their hands. They employed stilbestrol, 80 mg. a month for the primary types, together with 30 mg. of progesterone during the same time. For the secondary type the authors use a combination of estrone sulphate in varying doses in conjunction with indicated doses of progesterone, stilbestrol and ethinyl-estradiol. They also use estradiol monobenzoate in 1 mg. doses as an intrauterine infiltration. The authors found that stilbestrol was beneficial in most of the secondary types of amenorrhea. There is no bibliography. RICARDO
L.
GORBEA
Tubal Insufllation Davis,
E., Ward, M. E., and King, A. G.: An Evaluation Tubal Patency, Fertil. & Steril. 3: 217, 1952. M.
of the P.S.P. (Speck)
Test for
The authors have evaluated this test of tubal patency which utilizes the detection of phenolsulfonphthalein in the urine following its injection into the uterus as the criterion of peritoneal absorption. This test was compared with the standard ones of insufflation and utersalpingography in a series of 110 patients with an error for the P.S.P. (Speck) test of 15 per cent noted. These investigators discuss the possibility of P.S.P. absorption from traumatized or diseased mucous membranes in uterus and tubes, and conclude that this test offers no advantages over the standard procedures in the study of female sterility by the gynecologist. It is, however, an ingenious and simple test and may find some field of usefulness. 8. B.
GUSBERG