Analytical biochemistry Volume 200: Where we were; where we stand

ANALYTICAL

BIOCHEMISTRY

200,1-5

(19%')

EDITORIAL Analytical Biochemistry Volume 200: Where We Were; Where We Stand Alvin Nason recognized that the biochemical community would benefit from a forum specializing in analytical techniques, and for almost two decades served as the editor of the journal he founded, Analytical Biochemistry. Upon his death in 1977, Nathan Kaplan and William McElroy jointly headed the journal and pointed it to an even larger base: Analytical Biochemistry became a source for general methods in the biochemical sciences. In keeping with this broader mandate, executive editors who had specialized knowledge in the diverse fields that make up the modern aspects of our science were appointed. When the editorship changed again in 1987, this structure was retained and our interest was expanded to methods as they apply to the service of biology. With the appearance of Volume 200 of Analytical Biochemistry after 32 years of publication, we can look back on a revolution in approaches, techniques, and instruments that has been recognized and recorded in these pages. The sources are global; slightly more than half of the submitted manuscripts are from outside the United States. The journal has created a role for itself and has experienced the flattery of serving as an example for new publications with similar specialization. As has been true since the first issue, Volume 200 is intended to serve science by providing critically evaluated articles and reviews on methods. Such changes as have occurred over time have not altered the standards of excellence. The number of papers submitted each year and the number accepted have remained stable over the past decade despite turnover of the Editorial Board. It will be evident from the following list of editors who have served over the years that this journal has had the benefit of sound and critical evaluation. We work hard at being fair. We obviously try to make judicious choices during the review process but know that we are dealing in value judgments and expect that mistakes will be made: a few good papers are declined and some less so are printed. The entire enterprise depends on the quality of the work that is presented for review-the quality of the material you offer us. For the future we, the editors and the publisher, continue to extend our invitation, to you and to the next generation of investigators, for manuscripts that record your innovative work on the methods applicable to the biological sciences. WILLIAM

Copyright All rights

0 1992 by Academic Press, of reproduction in any form

Inc. reserved.

B. JAKOBY

Editorial John N. Abelson*

William

California

Harvard

Institute

of Technology

Board

Members

Braell

Arnold

University

Dunn

University

of Southern

Gary K. Ackers

Ludwig Brand*

Mary P. Edmonds

Johns

Johns

University

Hopkins

University

Hopkins

University

John J. Albers

Alexander

University

of Washington

William

S. Allison*

Institute of Molecular Moscow

University

of California,

Matthew Mayo

San Diego

M. Ames

Medical

and Graduate

Schools

E. Braunstein

of Lund

Harry

P. Broquist

Virginia

Phyllis

R. Brown

G. Anderson

Eraldo

Antonini

University

of Rome

University University

Ettore Appella National

of Health

Michael

Appleman

University

of Southern

Philippe

Arnaud

Institutes

P. Butler, University

of Health

of Southern Beecham,

Raymond

F. Chen

Everse

Texas Tech University Sciences Center

Mississippi

Robert C. Fahey

King

Henry M. Fales

University of

Institutes

Princeton

of Health

of Health

University

Andreas Chrambach

University

National

Duke

University

of California,

of Health

University

Frank Chytil

Theodore

Vanderbilt

Medical

University

of California,

Sidney Colowick

Othmar

Gabriel*

Louisiana

Vanderbilt

Georgetown Center

University

University

Robert G. Bartsch University

University

H. Edward Conrad

of Arizona

Glycomed,

James A. Bassham University

University

of California,

Berkeley

Johns

Oschner Medical Orleans

National

Rodney Croteau

Institutes

of Health

Samuel P. Bessman University

of Southern

Melvin

Washington California

Institutes

Jonathan

University

Michael

A. Cusanovich

Tel Aviv

of Arizona

Hiram

Deininger*

Baylor

of Health

Louisiana Center

State

University

Hopkins

University

Boston Biomedical Institute

University

Simon Black National

New

Prescott

State

Medical

M. Gershoni

F. Gilbert College

of Medicine,

Purdue

University

Gordon N. Gill

Wybren

of Nevada

Robert

M. Bock

Marion Merrell Dow Research Institute, Strasbourg

Victor Ginsburg

Marlene

DeLuca*

National

University

of California,

of Wisconsin

American Pearl

Cyanamid River

de Jong*

University

J. Bowie

Jack E. Dixon*

Evanston

Hospital

University

Robert

L. Bowman of Health es Executive

Editor.

Institutes

San Diego

of Health

Howard Goldfine* Patrick

of Michigan of California,

of California,

of Pennsylvania

W. Gray

ZCOS Corporation, Washington

Russell F. Doolittle University

University

University

of Minnesota

Lemuel

National Institutes * Denotes service

San Diego

Mary E. Dempsey

Company,

Houston

Peter T. Gilham

University University

Research

University

Gary J. Blomquist

Peter Biihlen

Medical

John Gergely

University

L. Billingsley

Pennsylvania

Foundation,

State

San Diego

Betty J. Gaffney

Inc., Alameda

Julia Cook

Shelby L. Berger*

Center

Friedmann*

Mary D. Barkley State

Berkeley

Institutes

San Diego

Jacques R. Fresco Irwin Fridovich

H. A. Barker

Health

of California,

John K. Baker of Mississippi

West

Research

Berkeley

National

Institutes

Inc.,

San Diego

Johannes

Smith Kline Prussia National

La Jolla Cancer Foundation Salk Institute,

Cannon

University

Diagnostics,

Fred S. Esch

Jr.

of California,

Gordon California

Madison

Calvin

University

of South

National

of Wisconsin,

Columbia

San

Eva Engvall

Island

Irwin M. Chaiken

Medical University Carolina

Ashwell

Molecular Haven

Vincent Melvin

Institutes

Gilbert

of Rho&

Institute,

James J. Elting

Robert H. Burris

Corporation,

Jr. of Health

Scripps Research Diego

University

University

Large Scale Biological Argonne

Institutes

John H. Elder

Vanderbilt

Norman

National

Peter Brodelius*

Bruce M. Anderson Tech

of Pittsburgh

Frank Eisenberg,

Biology,

California

Bothell,

Owen W. Griffith* San Diego

Cornell

University

Medical

College

3

EDITORIAL

Ueli Gubler Hoffman-La

Michael Roche,

Nutley

Applied

I. C. Gunsalus of Illinois,

William

H. Habig

Sen-itiroh

Urbana

Memorial Center

Hakomori 0. Halvorson

Marine Biological Woods Hole

Laboratory,

John A. Hanover* Joe B. Harford Institutes

of Health

Elvin Harper of California,

William

F. Harrington*

Hopkins

San Diego

University

William

Z. Hassid

University

of California,

Nicolas

Berkeley

Hospital,

Biosciences

John E. Hearst* of California,

Berkeley

Edward C. Heath University

Hopkins

University

University Sciences

of Colorado Center

of Massachusetts

of California,

San Diego

Baylor

College

Martin New

York

of Medicine,

Houston

I. Horowitz Medical

Rollin

of New

York,

D. Kamen*

Albert Light

University

of California,

San Diego

Andrew A. Kandutsch Laboratory,

Bar Harbor

Nathan

0. Kaplan*

University

of California,

Walter

L. Hughes National

San

Laboratory

Tony E. Hugli* Institute,

San

Purdue

Pennsylvania

University

Olov Lindberg Wenner-Grens

Institute,

Nicholas San Diego

Whittier

Stockholm

C. Ling Institute

Robert Linhardt

University

University

of Iowa

Ephraim

Katchalski-Katzir

Alfred Linker

Weizmann Rehovot

Institute

of Science,

Veteran’s Administration Salt Lake City

Center,

National

Institutes

Walter

M. Lovenberg*

Los

of Health

Christopher

Kawasaki

University

University of Texas Health San Antonio

Science

D. Klausner*

Boston

for

University

National

University

Kozulic

Institutes

of Health

Vincent

Massey

University

of Michigan

Franz M. Matschinsky

Zurich

University

of Pennsylvania

David A. Matthews of

Agouron

Institute

Dwight E. Matthews

John J. Langone

Cornell

Food and Drug Rockville

Manfred

Administration,

of

Munich

Carol J. Marcus-Sekura

University

Hospital of the University Pennsylvania

School

Edward F. MacNichol,

of Health

Klotz

Ltd.,

University

Max-Planck-Institute Biochemistry,

of Health

Aileen F. Knowles Branko

Washington Medicine

Feodor Lynen

Alan Kimmel Institutes

R. Lowe

of Cambridge

Oliver H. Lowry

T. Kent Keeton

Institutes

of Health

Marion Merrell Dow Research Institute, Cincinnati

T. Kaufmann Institutes

Richard

Hospital,

T.-Y. Liu

Medical

Larry J. Kricka

Institute,

Brookhaven

Scripps Research Diego

Martin

Elchrom,

Frank Huennekens Scripps Research Diego

Immunicon Corporation, Huntingdon Valley,

Northeastern

D. Hotchkiss

State University Albany

Paul A. Liberti

University

Northwestern

of Technology

Li University

Columbia

Irving

College

Institute

of Health

Elvin A. Kabat

National

Suzanne J. Horvath California

Tulane

National

Evan C. Horning

University

B. Jakoby*

University Center,

Alan F. Hofmann University

Su-Chen Li

William

Kyoto Medical

of Wyoming

Tulane

Institutes

V. Lewis

University

Yu-Teh

Takashi

Carlos B. Hirschberg* University Center

Medical

of Georgia

National

Health

University

University

Bernard

C. H. W. Hirs

University

Randolph

Ivarie

Cedar Sinai Angeles

Leslie Hellerman Johns

Brandeis

Joseph Katz

of Iowa

Hopkins

Lawrence Levine* of Health

of Hope National Center, Duarte

Northeastern

Institute

Johns

Instituto de Investigacidnes Bioquimicas Fundacihz Campomar

of

Barry L. Karger

Osamu Hayaishi University

Itakura

Jackson

Hastie

Western General Edinburgh Osaka

Keiichi

National

University Johns

Institute

Institutes

Robert

of Health

of Arizona

Luis F. Leloir

National City

Institutes

Cancer

John K. Inman

Harlyn

University

Y. C. Lee*

Sloan-Kettering

Massachusetts Technology

of Washington

National

City

Vernon M. Ingram

Administration,

University

National

John H. Law*

Inc., Foster

Jerard Hurwitz

University

Food and Drug Bethesda

W. Hunkapiller Biosystems,

Johns

University

M. Mayer

Hopkins

University

Per-Olof

Larsson

Brian J. McCarthy

University

of Lund

Frostbug

State

University

Jr.

EDITORIAL

James A. McCloskey

Beverly Peterkofsky

University

National

of Utah

James Shen University

of California,

Donald McCormick

Gary L. Peterson

Michael

Silverman

Emory

Oregon

Agouron

University

Hugh J. McDonald Loyola University William D. McElroy* University

of California,

Dupont Merck Pharmaceutical Company, Wilmington College

University

B. Merrifield

Rockefeller

Institutes Institutes

of Health

University

of California,

Klaus Mosbach* University

Deane F. Mosher University

of Wisconsin

Abbott

Laboratories,

Abbott

Park

Alvin Nason* Johns

Hopkins

Marshall

University

National

Institutes

Robert

W. Noble of New

York,

Institute

of

National University

Research

of Molecular

Institute,

Biology

of Edinburgh

Columbia

University

Purdue

Rutgers

University

Rich of

University University

of Health

Lennart

Roden

University

of Alabama,

Enrique

of Iowa

Birmingham

Ross

Medical

Brigham and Boston University

School

Rozengurt* Fund,

State

Michigan

State

Institutes

of Health

Children’s

Hospital,

Washington

National

State

University

Sargent Institutes

Institutes

of Health

Children’s

Hospital,

Howard K. Schachman

William

L. Taylor

Vanderbilt

University

University

of California,

Gerhard

Schmidt

Berkeley

of Californiu,

Sela

National

Weizmann Rehovot

Institute

State

University

Richard

N. Perham*

University

of Cambridge

Foundation,

San Diego

University

University

J. Turco of Kentucky

Sidney Udenfriend of Science,

Roche Institute

of Molecular

Bert L. Vallee*

Schmuel

Shaltiel

Weizmann Rehovot

Institute

Jr.

San Diego

Tsou

Hopkins

Salvatore

J. Edwin Seegmiller* University

Pennsylvania

Helicon

of Nevada

Michael

Boston

Charles A. Thomas,

University

Janet V. Passonneau of Health

of Health

George Tarr

Chen-Lu

Institutes

Los Angeles

Celia White Tabor

Johns

John H. Pazur

University

Clarence A. Ryan

University

San

University

Lawrence Sweetman

David A. Schooley

J. Oppenheimer

Davis

Charles C. Sweeley

Osaka

University of California, Francisco

Hospital,

of California,

Michigan

Research

Women’s

Clarence H. Suelter*

Tufts

Norman

Science

Paul K. Stumpf

Kazuo Okunuki University

Health

Daniel J. Strydom

Institutes

Sinai

San Diego

B. David Stellar* Tufts University Campus

School

David Rodbard

Mount

of California,

Nancy C. Stellwagon

of Technology

Medical

Stein University

D. Steinberg*

Institute

Institute

Harvard

of Health

Sol Spiegelman Stanley

National

San

Institutes

Austin

Edwin M. Southern

Fred E. Regnier

Thomas

James Ofengand Institute

A. Sober

National

H. O’Farrell

University of California, Francisco Roche

Herbert

Angelo Russo

of Health

State University Buffalo

Patrick

E. Snell

Imperial Cancer London

Nirenberg

Washington,

of Texas,

J. B. Alexander

Ferid Murad

University,

University

National

of Lund

Georgetown D.C.

Esmond

James F. Riordan*

Los Angeles

E. Smulson

S. Radin*

California

Sherie L. Morrison*

University

Mark

of Michigan

John H. Richards

Allen P. Minton National

Park

Purdue

University

Massachusetts Technology

of Health

of Health

Norman

Alexander

University

Carl R. Merrill National

Triangle

Sarah Ratner

John P. Merlie

Institutes

David L. Smith

Preston

Public Health New York

University

Znstitute

National

of Health

Research

Massachusetts Technology

of

Alton Meister

Robert

Office,

U. L. RajBhandary

Alan H. Mehler

Washington

Institutes

C.Z.Z.T.,

James L. Meek

Science D.C.

Davis

Dinah Singer

J. J. Pisano* R. Julian

of Health

Howard University Medicine

University

White House Washington, San Diego

of Health

D. Phillips*

National

Institutes

Cornell

State

William

Peter McPhie National

Institutes

Harvard of Science,

Medical

School

Jane M. Vanderkooi University

of Pennsylvania

Biology

5

EDITORIAL

Donald D. Van Slyke

Arthur

Rockefeller

Roche

Institute

Helen Van Vunakis* Brandeis

Inder M. Verma of California,

San Diego

R. Bruce Wallace City

of Hope Duarte

Research

Institute,

Harry Walter Veterans Affairs Long Beach

Medical

Center,

T. P. Wang Academia

Sinica,

Shanghai

Howard H. Weetall C&a-Corning Walpole

Diagnostics,

George Wolf Biology

East

University

of California,

of Chicago

Albert

Theodor

Wieland

Willis

Einstein

Salk Institute Industrial

Meir Wilchek

Lemuel

Weizmann Rehovot

Institute

Randall

C. Willis

De Novo Beach

Pharmaceuticals,

Herbert National

Cornell

of Medicine

Biotechnology1 Associates, San Diego

D. Wright University

David A. Yphantis University Solana

J. Wilson

Biosystems,

Inc., San Jose

G. Windmueller Institutes

of Health

of Connecticut

Bennie Zak Wayne

Kenneth

University

of Science,

College

A. Wood

Max-Planck-Znstitute for Medical Research, Heidelberg

Applied

Berkeley

Allan W. Wolkoff

University

Samuel B. Weiss of Chicago

of Molecular

John L. Westley

University

University

Weissbach*

Institute

State

University

Daniel M. Ziegler University

of Texas

Gerald Zon Applied

Biosystems,

Inc., Foster

City