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Androgens and behavior in men and women
Y6
Abstracrs
/ Maturitas
smokers as well as in heavy smokers compared to patients who did not smoke (P < 0.05). Conclusion: Tobacco per se can determine a worse climateric syndrome in patients who do not receive HRT and not achieve all the benefits related to it when it is received. However, considering the higher cardiovascular or osteoporosis risk in these women, HRT is specially prescribed. 97118813
Androgens
and behavior in men and women
Bagatell C.J.; Bremner W.J. VA Puget Sound Health Care System, 1660 South Coiumbian Way, Seattle, WA 98108 ENDOCRINOLOGIST 1997 7/2 (97- 102) A growing body of medical evidence substantiates the popular notion that androgens regulate several aspects of behavior in men; in addition, recent studies suggest that androgens modulate certain behaviors in women as well. In hypogonadal men, androgen replacement leads to improved libido and other behaviors, but erectile responses to erotic stimuli do not seem to be affected. Similarly, in normal men, suppression of endogenous androgens to very low levels leads to decreases in a variety of sexual behaviors. Sexual function, however, may be maintained with lower androgen levels than are required for other target tissues. Although higher androgen levels lead to increased aggressive behaviors in animals, this relationship is probably not valid in men. In women, correlations between levels of circulating androgens and sexual behaviors are variable. In some naturally menopausal women with decreased libido, androgen replacement may be effective when estrogen replacement has failed, but few studies have examined this question. In contrast, several studies suggest that in some surgically menopausal women, replacement of estrogen and androgens may lead to better psychological and sexual functioning than replacement of estrogen alone. However, more data are needed before this approach can be recommended to every surgically menopausal woman. 97129284
28 (1997)
89-97
Successful
pregnancy in a 63-year-old
woman
Paulson R.J.; Thornton M.H.; Francis M.M.; Salvador H.S. Department of Obstetrics/Gynecology, Women’s and Children’s Hospital, 1240 North Mission Road, Los Angeles, CA 90033 FERTIL. STERIL. 1997 6715 (949-951) Objective: To report the occurrence of an unusual. case of successful pregnancy achieved by oocyte donation in a woman > 60 years of age. Design: Case report. Setting: University-based assisted reproductive technology program. Patient(s): Sixty-three-year old nulligravida, married for 16 years to her 60-year-old husband. Throughout her infertility treatment, the patient was believed to be 10 years younger, as she claimed. She revealed her true age of 63 only upon being referred for obstetric care at 13 weeks of gestational age. Intervention(s): Oocyte donation, IVF, embryo cryopreservation and ET. Main Outcome Measure(s): Attainment of pregnancy and subsequent delivery. Result(s): The patient underwent two cycles of oocyte donation. During the second attempt, the fresh transfer resulted in a clinical miscarriage at 8 8 weeks of gestational age. A subsequent transfer of three frozen-thawed embryos resulted in an ongoing singleton gestation. The pregnancy was complicated by gestational diabetes (controlled by diet) and mild pregnancy-induced hypertension. Delivery by cesarean section at 38 weeks of gestational age resulted in the birth of a healthy female infant weighing 2844 g with Apgar scores of 9 and 9. Conclusion(s): This case demonstrates that the uterus is capable of supporting nidation and subsequent gestation for many years beyond natural menopause. It shows that other aspects of human physiology are capable of adapting to the stresses and changes of pregnancy sufficiently well to achieve a normal birth at the age of 63 years. This case also exemplifies the difficulty in attempting to regulate the age of recipients in oocyte donation. As in other aspects of human life, when age limits are applied to the provision of certain services, human beings whose age falls outside of these lim-
Abstracrs
/ Maturitas
smokers as well as in heavy smokers compared to patients who did not smoke (P < 0.05). Conclusion: Tobacco per se can determine a worse climateric syndrome in patients who do not receive HRT and not achieve all the benefits related to it when it is received. However, considering the higher cardiovascular or osteoporosis risk in these women, HRT is specially prescribed. 97118813
Androgens
and behavior in men and women
Bagatell C.J.; Bremner W.J. VA Puget Sound Health Care System, 1660 South Coiumbian Way, Seattle, WA 98108 ENDOCRINOLOGIST 1997 7/2 (97- 102) A growing body of medical evidence substantiates the popular notion that androgens regulate several aspects of behavior in men; in addition, recent studies suggest that androgens modulate certain behaviors in women as well. In hypogonadal men, androgen replacement leads to improved libido and other behaviors, but erectile responses to erotic stimuli do not seem to be affected. Similarly, in normal men, suppression of endogenous androgens to very low levels leads to decreases in a variety of sexual behaviors. Sexual function, however, may be maintained with lower androgen levels than are required for other target tissues. Although higher androgen levels lead to increased aggressive behaviors in animals, this relationship is probably not valid in men. In women, correlations between levels of circulating androgens and sexual behaviors are variable. In some naturally menopausal women with decreased libido, androgen replacement may be effective when estrogen replacement has failed, but few studies have examined this question. In contrast, several studies suggest that in some surgically menopausal women, replacement of estrogen and androgens may lead to better psychological and sexual functioning than replacement of estrogen alone. However, more data are needed before this approach can be recommended to every surgically menopausal woman. 97129284
28 (1997)
89-97
Successful
pregnancy in a 63-year-old
woman
Paulson R.J.; Thornton M.H.; Francis M.M.; Salvador H.S. Department of Obstetrics/Gynecology, Women’s and Children’s Hospital, 1240 North Mission Road, Los Angeles, CA 90033 FERTIL. STERIL. 1997 6715 (949-951) Objective: To report the occurrence of an unusual. case of successful pregnancy achieved by oocyte donation in a woman > 60 years of age. Design: Case report. Setting: University-based assisted reproductive technology program. Patient(s): Sixty-three-year old nulligravida, married for 16 years to her 60-year-old husband. Throughout her infertility treatment, the patient was believed to be 10 years younger, as she claimed. She revealed her true age of 63 only upon being referred for obstetric care at 13 weeks of gestational age. Intervention(s): Oocyte donation, IVF, embryo cryopreservation and ET. Main Outcome Measure(s): Attainment of pregnancy and subsequent delivery. Result(s): The patient underwent two cycles of oocyte donation. During the second attempt, the fresh transfer resulted in a clinical miscarriage at 8 8 weeks of gestational age. A subsequent transfer of three frozen-thawed embryos resulted in an ongoing singleton gestation. The pregnancy was complicated by gestational diabetes (controlled by diet) and mild pregnancy-induced hypertension. Delivery by cesarean section at 38 weeks of gestational age resulted in the birth of a healthy female infant weighing 2844 g with Apgar scores of 9 and 9. Conclusion(s): This case demonstrates that the uterus is capable of supporting nidation and subsequent gestation for many years beyond natural menopause. It shows that other aspects of human physiology are capable of adapting to the stresses and changes of pregnancy sufficiently well to achieve a normal birth at the age of 63 years. This case also exemplifies the difficulty in attempting to regulate the age of recipients in oocyte donation. As in other aspects of human life, when age limits are applied to the provision of certain services, human beings whose age falls outside of these lim-