SELECTED
393
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Effect of Constriction of the Renal Arteries in Dill, L. V., and Erickson, C. C.: Pregnancy and in Certain Endocrine States of Rabbits. Arch. Path. 31: 68, 1941. Severe renal ischemia convulsions, and death. occur.
in the rabbit Focal necroses
produces hypertension, albuminuria, uremia, of the myocardium and necroses of the liver
The pregnant rabbit differs from the nonpregnant one in showing increased susceptibility to the effects of renal ischemia or renal injury. The pregnant rabbit demonstrates extensive focal necroses of t,he liver in a significantly high percentage of experiments. Renal insufficiency alone or pregnancy alone does not account for the variation nf response by the pregnant animal. Other endocrine states do not demonstrate the reaction of the pregnant animal. Hypertension, renal ischemia, or renal injury in association with pregnancy seems to complete the essential combination of factors. These experimental observations support the thesis suggested in our report of preliminary observations that renal ischemia or renal injury in the pregnant animal produces a syndrome with involvement of physiologic factors similar to, and production of pathologic lesions analogous to, those in at least some of the human toxemias of pregnancy. AUTHORS.
Nesbit, Reed M., and Ratliff, Rigdon K.: lateral Renal Disease. J. A. M. A. 116: Experimental evidence and clinical may result from pathologic conditions unilateral. Three different with hypertension: arteries including chronic inflammatory
Hypertension Associated With Uni194, 1041.
observations have shown that hypertension of the kidney which may be bilateral
or
types of unilateral renal lesions are most commonly associated (1) those produced by gross vascular occlusion of the renal trauma to the kidney, (2) the obstructive uropathies, and (3) lesions.
Since chronic infection appears to be the most important etiologic factor, it would appear that the best treatment of this type is prophylactic. In this regard the value of modern chemotherapeutic methods for the prevention of chronic infections of the urinary tract cannot be overemphasized. Hypertensive of the routine urinary findings
patients should be submitted to complete urologic study as a part examination, even in the absence of a history of renal disorijers or suggesting disease of the urinary tract.
The rational treatment of the hypertensive patient with unilateral nephropathy is removal of the diseased kidney, provided the function of the opposite kidney is not significantly reduced. With this restriction, a reasonable expectancy of improvement or cure can be hoped for in the majority of cases. NAIDE.
Howard, T. L., Forbes, R. P., and Lipscomb, W. R.: Aneurysm of the Left Renal Artery in a Child 5 Years Old With Persistent Hypertension. J. Urol. 44: 808,
1940.
A case of persistent hyperten,sion left renal artery in a 5-year-old child nephrectomy.
as a result is reported.
of a multilocular The hypertension
aneurysm of the was relieved by NAIDE.