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Angiogenesis in health and disease
1344
Book Reviews
Nucleic Acid Targeted Drug D&-Edited by C. L. PROFIT PERUN. 619 pp. 1992. Marcel Dekker, New York.
A. T. SUMNERand A. WARLEY.337 pp. 1993. Cambridge University Press, Cambridge. f50.
X-ray crystallography, NMR, molecular modelling and computer soft ware/graphics have provided a better understanding of DNA and RNA structure and drug-DNA binding. This book deals with the design of drugs that interact with nucleic acids; X-ray crystallographic and NMR studies of drug-DNA interactions; sequence specificity; QSAR of ligand-DNA. netropsin and lexitropsins, minor groove binding ligands; pyrrolo( 1,4) benzodiazepines, Tomaymycin-DFNA ligands; quinolon*DNA binding, DNA gyrase inhibition; neocarzinostatin and other bicyclic enediyne antibiotics; intercalative DNA-drug interactions; catalytic antisense RNAs; oligonucleotide based therapeutics.
Electron probe X-ray analysis determines the elemental composition of specimens on a microscopic scale. It has been in use for about 30yr and the machines have been improving all the time with better solid state silicon and germanium detectors and electronics, improved specimen preparation, reduction in radiation damage and artifacts. This book deals with the detection and quantification of X-rays; improved specimen preparation (rapid freezing, low temperature machines, histochemistry, sprayed microdroplets, renal physiology); applications (P, S, Cl, K and Ca in plant pathogenic bacteria, K, Na, Cl, ion localization in cells, diffusible ions, Zn, Mn, Mg, Cd pollution studies, biomaterial research, biomedicine, mammalian cells in culture).
and T. J. $165.
StablIlty of ProteinWarmaeeuticaIs-Edited by T. J. &iERN and M. C. MANNING.Part A. Chemical and Physical Pathways of Protein LIegradation. 434 pp. 1992. Plenum Press, New York. S79.50. Part B. In OrnoPathways of Degradation pod Strategies for Protein Stabilization. 337 pp. 1992. Plenum Press, New York. $65. Recombinant DNA technology has made it possible to produce designer proteins on a large enough scale to make their use as drugs economically feasible. Such proteins would have to be stable and steps have to be taken to reduce their premature denaturation. These two volumes deal with this problem. In Part A, the topics are; lability of asparagine and aspartic acid residues, spontaneous deamidation; disulphide bonds; proteolytically sensitive peptides; protein solubility; aggregation-precipitation; conformational stability; adsorption at interfaces; effect of temperature; protein water interactions; water sorption; compaction; effect of radiation. Part B deals with; improper glycosylation; protein aggregation; intracellular protein degradation; aging of proteins; increase in stability of subtilisin; increased stability of yeast cytochrome c; formulation of protein pharmaceuticals; PEG-modified proteins; solvent additives; heat shock proteins as pharmaceuticals. Specificity of Proteolysis-B.
KEIL. 336 pp. 1992. Springer
Verlag, Berlin. DM 249. The specificity of proteinases is determined by the sequence of amino acids at the cleavage site of the substrate. This book provides data on 295 endopeptidases, 1082 protein substrates, and 6300 degradation cases. The chapters deal with nomenclature and conventions; data treatment; standard polypeptide substrates; essential substrate residues for action of endopeptidases; frequently used proteinases and restriction proteinases; microbial proteinases; index of enzymes; index of proteins. The author has also prepared two discs that provide the proteolysis data base (280 endopeptidases; cleavage sites in 1000 peptides and proteins) for use on a PC. This is available separately (it is called Lysis and is published by Springer, priced DM 398 to Academic users). The discs and this book are complimentary; the book is available for those who prefer to browse through printed pages rather than consult a screen. X-Ray Mic~anaiysia in Biology; bperime-nti Tedmiques and ApplIcatIowEdited by D. C. &GEE, A. J. MORGAN,
Role of Free Radicals in Biological SystesEdited by J. FEHER,A. BLAZOVICS, B. MATKOVICS and M. MEZES.258 pp. 1993. Akademiai Kiado, Budapest. $52.
Free radicals are formed in many biological systems such as arachidonic acid metabolism, microsomal enzyme metabolism of drugs, electron transport, and the oxygen dependent killing of bacteria by phagocytes. Free radicals probably are important in the pathology of inflammation, ischaemia-reperfusion damage, hyperlipidemia, liver cirrhosis, streptozotocin induced diabetes, atherosclerosis, and in the ageing process. Naturally occuring antioxidants, ascorbic acid, alpha tocopherol, glutathione, the P450 system, melanins, and specific enzymes protect against reactive oxygen intermediates and lipid peroxides. This volume deals with the role of free radicals in a range of systems with special relevance to enzyme and tissue damage and the extent to which it can be prevented. An&genesis in Health and Disease-Edited by M. E. MARAGOUDAKIS, P. GULLINOand P. I. LELKES402 pp. 1992. Plenum Press, New York. $110. NATO ASI Series A; Life Sciences Vol 227. Angiogenesis (A) the formation of new blood vessels is usually a slow process in adults. It is accelerated in wound healing and ovulation and also in specific diseases such as diabetic retinopathy, arthritis, chronic inflammation, hemangiomas, tumor growth and metastasis. This symposium deals with; the development of the vascular system; biology of endothelial cells and A (endothelial cell heterogeneity, basic fibroblast growth factor, integrins, plasminogen activators, fibronectin and thrombospondin, role of ischaemia); A in disease states (neoplastic transformation, tumor vascular system, PDGF, ischaemic heart, angiogenic factors, calcification linked A and bone growth); promoters and inhibitors of A (low molecular mass A factor ESAF, Hyaluronic acid, brain tumor A, membrane biosynthesis); therapeutic potential of promoters and inhibitors of A; methodology. Anhrtal Models in Toxicology-Edited by S. C. GAD and C. P. CHENGELIS. 884 pp. 1992. Dekker, New York. $225 (on order of 5 or more copies for classroom use only; $65 per COPY). The scientific study of toxicology has to use animals models before the drugs can be tested on humans. It is necessary to
Book Reviews
Nucleic Acid Targeted Drug D&-Edited by C. L. PROFIT PERUN. 619 pp. 1992. Marcel Dekker, New York.
A. T. SUMNERand A. WARLEY.337 pp. 1993. Cambridge University Press, Cambridge. f50.
X-ray crystallography, NMR, molecular modelling and computer soft ware/graphics have provided a better understanding of DNA and RNA structure and drug-DNA binding. This book deals with the design of drugs that interact with nucleic acids; X-ray crystallographic and NMR studies of drug-DNA interactions; sequence specificity; QSAR of ligand-DNA. netropsin and lexitropsins, minor groove binding ligands; pyrrolo( 1,4) benzodiazepines, Tomaymycin-DFNA ligands; quinolon*DNA binding, DNA gyrase inhibition; neocarzinostatin and other bicyclic enediyne antibiotics; intercalative DNA-drug interactions; catalytic antisense RNAs; oligonucleotide based therapeutics.
Electron probe X-ray analysis determines the elemental composition of specimens on a microscopic scale. It has been in use for about 30yr and the machines have been improving all the time with better solid state silicon and germanium detectors and electronics, improved specimen preparation, reduction in radiation damage and artifacts. This book deals with the detection and quantification of X-rays; improved specimen preparation (rapid freezing, low temperature machines, histochemistry, sprayed microdroplets, renal physiology); applications (P, S, Cl, K and Ca in plant pathogenic bacteria, K, Na, Cl, ion localization in cells, diffusible ions, Zn, Mn, Mg, Cd pollution studies, biomaterial research, biomedicine, mammalian cells in culture).
and T. J. $165.
StablIlty of ProteinWarmaeeuticaIs-Edited by T. J. &iERN and M. C. MANNING.Part A. Chemical and Physical Pathways of Protein LIegradation. 434 pp. 1992. Plenum Press, New York. S79.50. Part B. In OrnoPathways of Degradation pod Strategies for Protein Stabilization. 337 pp. 1992. Plenum Press, New York. $65. Recombinant DNA technology has made it possible to produce designer proteins on a large enough scale to make their use as drugs economically feasible. Such proteins would have to be stable and steps have to be taken to reduce their premature denaturation. These two volumes deal with this problem. In Part A, the topics are; lability of asparagine and aspartic acid residues, spontaneous deamidation; disulphide bonds; proteolytically sensitive peptides; protein solubility; aggregation-precipitation; conformational stability; adsorption at interfaces; effect of temperature; protein water interactions; water sorption; compaction; effect of radiation. Part B deals with; improper glycosylation; protein aggregation; intracellular protein degradation; aging of proteins; increase in stability of subtilisin; increased stability of yeast cytochrome c; formulation of protein pharmaceuticals; PEG-modified proteins; solvent additives; heat shock proteins as pharmaceuticals. Specificity of Proteolysis-B.
KEIL. 336 pp. 1992. Springer
Verlag, Berlin. DM 249. The specificity of proteinases is determined by the sequence of amino acids at the cleavage site of the substrate. This book provides data on 295 endopeptidases, 1082 protein substrates, and 6300 degradation cases. The chapters deal with nomenclature and conventions; data treatment; standard polypeptide substrates; essential substrate residues for action of endopeptidases; frequently used proteinases and restriction proteinases; microbial proteinases; index of enzymes; index of proteins. The author has also prepared two discs that provide the proteolysis data base (280 endopeptidases; cleavage sites in 1000 peptides and proteins) for use on a PC. This is available separately (it is called Lysis and is published by Springer, priced DM 398 to Academic users). The discs and this book are complimentary; the book is available for those who prefer to browse through printed pages rather than consult a screen. X-Ray Mic~anaiysia in Biology; bperime-nti Tedmiques and ApplIcatIowEdited by D. C. &GEE, A. J. MORGAN,
Role of Free Radicals in Biological SystesEdited by J. FEHER,A. BLAZOVICS, B. MATKOVICS and M. MEZES.258 pp. 1993. Akademiai Kiado, Budapest. $52.
Free radicals are formed in many biological systems such as arachidonic acid metabolism, microsomal enzyme metabolism of drugs, electron transport, and the oxygen dependent killing of bacteria by phagocytes. Free radicals probably are important in the pathology of inflammation, ischaemia-reperfusion damage, hyperlipidemia, liver cirrhosis, streptozotocin induced diabetes, atherosclerosis, and in the ageing process. Naturally occuring antioxidants, ascorbic acid, alpha tocopherol, glutathione, the P450 system, melanins, and specific enzymes protect against reactive oxygen intermediates and lipid peroxides. This volume deals with the role of free radicals in a range of systems with special relevance to enzyme and tissue damage and the extent to which it can be prevented. An&genesis in Health and Disease-Edited by M. E. MARAGOUDAKIS, P. GULLINOand P. I. LELKES402 pp. 1992. Plenum Press, New York. $110. NATO ASI Series A; Life Sciences Vol 227. Angiogenesis (A) the formation of new blood vessels is usually a slow process in adults. It is accelerated in wound healing and ovulation and also in specific diseases such as diabetic retinopathy, arthritis, chronic inflammation, hemangiomas, tumor growth and metastasis. This symposium deals with; the development of the vascular system; biology of endothelial cells and A (endothelial cell heterogeneity, basic fibroblast growth factor, integrins, plasminogen activators, fibronectin and thrombospondin, role of ischaemia); A in disease states (neoplastic transformation, tumor vascular system, PDGF, ischaemic heart, angiogenic factors, calcification linked A and bone growth); promoters and inhibitors of A (low molecular mass A factor ESAF, Hyaluronic acid, brain tumor A, membrane biosynthesis); therapeutic potential of promoters and inhibitors of A; methodology. Anhrtal Models in Toxicology-Edited by S. C. GAD and C. P. CHENGELIS. 884 pp. 1992. Dekker, New York. $225 (on order of 5 or more copies for classroom use only; $65 per COPY). The scientific study of toxicology has to use animals models before the drugs can be tested on humans. It is necessary to