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Animal homologue section of HLDA8
Veterinary Immunology and Immunopathology 119 (2007) 1 www.elsevier.com/locate/vetimm
Preface
Animal homologue section of HLDA8
The development of reagents against leukocyte differentiation antigens in veterinary species is delayed compared to mouse and men and therefore also the number of existing reagents for the characterisation of leukocytes derived from species with importance in veterinary medicine is restricted. Even with the relatively limited resources available in veterinary immunology, we face broader requirements for development of specific reagents in multiple species. ‘‘Cross-reactivity’’ studies with monoclonal antibodies generated against human molecules therefore represent an excellent alternate approach for the detection of new reagents for these less well-characterised species. This special issue of ‘‘Veterinary Immunology and Immunopathology’’ describes the activities of scientists in frame of the animal homologue section of ‘‘Human Leukocyte Differentiation Antigen 8-workshop’’ (HLDA8) with its final meeting, held in December 2004 in Adelaide, Australia. The aim of the ‘‘HLDA8— Animal homologue section’’ was to define ‘‘crossreacting’’ monoclonal antibodies in order to increase the antibody-repertoire in as many animal species as possible. Therefore, 376 monoclonal antibodies from various companies, mainly directed against human leukocytes had been tested for their reactivity with 17 different animal species. This special issue presents besides an overview about the reactivity of positively identified antibodies more detailed investigations on the antibodies and their
0165-2427/$ – see front matter # 2007 Elsevier B.V. All rights reserved. doi:10.1016/j.vetimm.2007.06.008
respective antigens. These results will contribute essentially to the discussion of the significance of ‘‘crossreactivity’’ data and give some of the results a solid molecular base. The authors thank all participants for their efforts and the companies for providing the antibodies. Furthermore, thanks go to the Veterinary Immunology Committee of IUIS and the chair of HLDA8, Heddy Zola, Adelaide, for their continuous support. Armin Saalmu¨ller* Clinical Immunology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria Bent Aasted1 Immunological Laboratory, Department of Veterinary Pathobiology, Faculty of Life Sciences, University of Copenhagen, Stigbojlen 7, 1870 Frederiksberg C, Denmark *Corresponding author. Tel.: +43 1 25077 2750; fax: +43 1 25077 2791 E-mail addresses: [email protected] (A. Saalmu¨ller) [email protected] (B. Aasted) 1 Tel.: +45 3528 2727; fax: +45 3528 2742.
Preface
Animal homologue section of HLDA8
The development of reagents against leukocyte differentiation antigens in veterinary species is delayed compared to mouse and men and therefore also the number of existing reagents for the characterisation of leukocytes derived from species with importance in veterinary medicine is restricted. Even with the relatively limited resources available in veterinary immunology, we face broader requirements for development of specific reagents in multiple species. ‘‘Cross-reactivity’’ studies with monoclonal antibodies generated against human molecules therefore represent an excellent alternate approach for the detection of new reagents for these less well-characterised species. This special issue of ‘‘Veterinary Immunology and Immunopathology’’ describes the activities of scientists in frame of the animal homologue section of ‘‘Human Leukocyte Differentiation Antigen 8-workshop’’ (HLDA8) with its final meeting, held in December 2004 in Adelaide, Australia. The aim of the ‘‘HLDA8— Animal homologue section’’ was to define ‘‘crossreacting’’ monoclonal antibodies in order to increase the antibody-repertoire in as many animal species as possible. Therefore, 376 monoclonal antibodies from various companies, mainly directed against human leukocytes had been tested for their reactivity with 17 different animal species. This special issue presents besides an overview about the reactivity of positively identified antibodies more detailed investigations on the antibodies and their
0165-2427/$ – see front matter # 2007 Elsevier B.V. All rights reserved. doi:10.1016/j.vetimm.2007.06.008
respective antigens. These results will contribute essentially to the discussion of the significance of ‘‘crossreactivity’’ data and give some of the results a solid molecular base. The authors thank all participants for their efforts and the companies for providing the antibodies. Furthermore, thanks go to the Veterinary Immunology Committee of IUIS and the chair of HLDA8, Heddy Zola, Adelaide, for their continuous support. Armin Saalmu¨ller* Clinical Immunology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria Bent Aasted1 Immunological Laboratory, Department of Veterinary Pathobiology, Faculty of Life Sciences, University of Copenhagen, Stigbojlen 7, 1870 Frederiksberg C, Denmark *Corresponding author. Tel.: +43 1 25077 2750; fax: +43 1 25077 2791 E-mail addresses: [email protected] (A. Saalmu¨ller) [email protected] (B. Aasted) 1 Tel.: +45 3528 2727; fax: +45 3528 2742.