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Antenatal phenobarbital for the prevention of neonatal intracerebral hemorrhage
Citations from
Ultrasound evaluation of amniotic fluid: Outcome of pregnancies with severe oligohydramnios Bastide A; Manning F; Harman C; et al.
Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Manitoba, Winnipeg, Man., Canada AM. J. OBSTET. GYNECOL.; 154/4 (895900) 1986 Severe oligohydramnios, defined as a condition in which the largest pocket of amniotic fluid measures less than 1 cm in its vertical axis as determined by an ultrasound method, was observed in 113 patients in a population of 15,431 referred high-risk patients (0.7%). In all cases, intervention took place unless there was a recognized structural anomaly or extreme prematurity. Overall gross perinatal mortality was 132.7/ 1000, and the incidence of major anomaly was 13.3%. With intervention the corrected perinatal mortality rate was 17.7/l 000, a rate not significantly different from that observed in the entire population. All end points of perinatal mortality were significantly increased in patients with severe oligohydramnios, in comparison with randomly selected control subjects with normal amniotic fluid. These findings are interpreted to indicate thatsevereoligohydramnios indicate that severe oligohydramnios in a structurally normal fetus is an indication for delivery. Antenatal phenobarbital for the prevention of neonatal in tracerebral hemorrhage Shankaran S; Cepeda EE; Ilagan N; et al.
Department of Pediatrics, Wayne State University School of Medicine, Hutzel Hospital, Detroit, MI, USA. AM. J. OBSTET. GYNECOL.; 154/l (53-57) 1986 Forty-six pregnant women less than 35 weeks of gestation were enrolled in a prospective randomized controlled study evaluating the effects of antenatal phenobarbital on neonatal intracerebral hemorrhage. The women were randomly assigned to control
the Literature
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(n = 22) or treatment (n = 24) groups; the received 500 mg of treatment group The time intravenously . phenobarbital interval between the dose of phenobarbital and delivery was 5.5 + 4.8 hours (mean f SD). The infants in the controlgroup (n = 23) and those in the phenobarbital-treated group (n = 25) were comparable regarding birth weight, gestational age, and other obstetric and neonatal risk factors associated with intracerebral hemorrhage. The incidence of intracerebral hemorrhage was 56.5% (13 of 23 infants) in the control group and 32% (eight of 25 infants) in the phenobarbitaltreated group (P = 0.08). Moderate or severe hemorrhage was diagnosed in six of 13 control infants and in none of the phenobarbital-treated infants (P < 0.01). The mortality rate was significantly lower in the phenobarbital-treated group (two of 25 infants) than in the control group (eight of 23 infants; P < 0.05). Our study suggests that antenatal phenobarbital administration results in a decrease in mortality and in the severity of intracerebral hemorrhage in the preterm neonate. Amniotomy and the use of oxytocin in nulliparous women Seitchik J; Holden AEC; Castillo M
in labor
Department of Obstetrics and Gq~necolog?~, University of Texas Health Science Center, San Antonio, TX 78284, USA AM. J. OBSTET. GYNECOL.; 153/8 (848854) 1985 A group of 242 nulliparous women in spontaneous, term, first-stage, true labor, with cephalic presentations and intact membranes, underwent amniotomy in the first stage. Sixty-nine of 242 (29%) received oxytocin prior to complete dilatation. The group that received oxytocin was characterized by fewer women less than 20 years of age, more patients with an additional diagnosis such as preeclampsia, longer labors, and slower mean rates of dilatation before and after amniotomy. There was no correlation between the last dilatation rate before and the first after
Ultrasound evaluation of amniotic fluid: Outcome of pregnancies with severe oligohydramnios Bastide A; Manning F; Harman C; et al.
Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Manitoba, Winnipeg, Man., Canada AM. J. OBSTET. GYNECOL.; 154/4 (895900) 1986 Severe oligohydramnios, defined as a condition in which the largest pocket of amniotic fluid measures less than 1 cm in its vertical axis as determined by an ultrasound method, was observed in 113 patients in a population of 15,431 referred high-risk patients (0.7%). In all cases, intervention took place unless there was a recognized structural anomaly or extreme prematurity. Overall gross perinatal mortality was 132.7/ 1000, and the incidence of major anomaly was 13.3%. With intervention the corrected perinatal mortality rate was 17.7/l 000, a rate not significantly different from that observed in the entire population. All end points of perinatal mortality were significantly increased in patients with severe oligohydramnios, in comparison with randomly selected control subjects with normal amniotic fluid. These findings are interpreted to indicate thatsevereoligohydramnios indicate that severe oligohydramnios in a structurally normal fetus is an indication for delivery. Antenatal phenobarbital for the prevention of neonatal in tracerebral hemorrhage Shankaran S; Cepeda EE; Ilagan N; et al.
Department of Pediatrics, Wayne State University School of Medicine, Hutzel Hospital, Detroit, MI, USA. AM. J. OBSTET. GYNECOL.; 154/l (53-57) 1986 Forty-six pregnant women less than 35 weeks of gestation were enrolled in a prospective randomized controlled study evaluating the effects of antenatal phenobarbital on neonatal intracerebral hemorrhage. The women were randomly assigned to control
the Literature
395
(n = 22) or treatment (n = 24) groups; the received 500 mg of treatment group The time intravenously . phenobarbital interval between the dose of phenobarbital and delivery was 5.5 + 4.8 hours (mean f SD). The infants in the controlgroup (n = 23) and those in the phenobarbital-treated group (n = 25) were comparable regarding birth weight, gestational age, and other obstetric and neonatal risk factors associated with intracerebral hemorrhage. The incidence of intracerebral hemorrhage was 56.5% (13 of 23 infants) in the control group and 32% (eight of 25 infants) in the phenobarbitaltreated group (P = 0.08). Moderate or severe hemorrhage was diagnosed in six of 13 control infants and in none of the phenobarbital-treated infants (P < 0.01). The mortality rate was significantly lower in the phenobarbital-treated group (two of 25 infants) than in the control group (eight of 23 infants; P < 0.05). Our study suggests that antenatal phenobarbital administration results in a decrease in mortality and in the severity of intracerebral hemorrhage in the preterm neonate. Amniotomy and the use of oxytocin in nulliparous women Seitchik J; Holden AEC; Castillo M
in labor
Department of Obstetrics and Gq~necolog?~, University of Texas Health Science Center, San Antonio, TX 78284, USA AM. J. OBSTET. GYNECOL.; 153/8 (848854) 1985 A group of 242 nulliparous women in spontaneous, term, first-stage, true labor, with cephalic presentations and intact membranes, underwent amniotomy in the first stage. Sixty-nine of 242 (29%) received oxytocin prior to complete dilatation. The group that received oxytocin was characterized by fewer women less than 20 years of age, more patients with an additional diagnosis such as preeclampsia, longer labors, and slower mean rates of dilatation before and after amniotomy. There was no correlation between the last dilatation rate before and the first after