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Anthropometric Measures and Lung Function Test in Asthmatic Pacients, Asthmatic Obese, Obese without Asthma and Healthy Pacients
S296 Abstracts
Association between IgA and IgG1 Serum Level and Atopy in Children P. Majak, J. Jerzynska, I. Stelmach; Dep. Allergy and Pediatrics, M Curie Hospital, Zgierz, POLAND. RATIONALE: Atopy may be an error in immunoglobulin isotype class switching during a normal process of antigen recognition and generation of a humoral antibody response. We hypothesized that atopy in children may by associated with low serum level of immunoglobulin (Ig)G and IgA. METHODS: This study was the part of Asthma Prevention Program sponsored by Lodz Regional Health Insurance Fund in 2000-03. In the programme participated 127 primary and 12 specialized care centres. In 550 children below 19 years old serum level of IgA, IgG1, IgG2, IgG3, IgG4 and IgM were measured. Atopy was established by positive skinprick tests and by the presence of specific IgE to one or more allergen. RESULTS: Atopy was identified in 320 (58%) children. Multivariate logistic regression analysis showed that low level of IgG1 (OR:7.8; 95%CI: 3.3-10.5 ) and low level of IgA (OR: 3.8; 95%CI: 1.3-5.4 ) was associated with atopy in young children. CONCLUSIONS: Low level of IgA and IgG1 increase risk of atopy in children.
1141
1142
Asthma Prevalence in Public Housing Communities
J. Poyser, T. Richards, D. Collins, T. Green, R. Morgan, E. Horowitz, A. Togias; Johns Hopkins University, Baltimore, MD. RATIONALE: Last year, we reported that, in two Baltimore City public housing communities, the prevalence of “probable asthma”, based on a door-to-door population survey of 600 individuals, was 21%. An additional 17% reported symptoms indicative of “possible asthma”. We are now reporting on the process of confirming the above diagnoses and obtaining a more reliable estimate of asthma prevalence. METHODS: We tested 80 individuals from the above population, older than 6 years, by conducting either a methacholine bronchoprovocation or a reversibility test with inhaled albuterol. RESULTS: Of 43 subjects with survey diagnosis of “no asthma”, 34 had negative objective tests, while 9 reacted to methacholine (PC20 12%. Of 18 subjects with survey diagnosis of “possible asthma”, 12 were confirmed as asthmatics on the basis of the above tests. Of 19 subjects with “probable asthma” on survey, 9 were confirmed. Extrapolation of these data to the entire population yields an asthma prevalence of 21.9%. CONCLUSIONS: In Baltimore public housing residents, the prevalence of asthma, confirmed with objective testing of airways hyperresponsiveness or reversible airway obstruction, is three times higher than that of the US population. Funding: NIAID Association of Mycoplasma Pneumoniae with Initial Wheezer for 3 Years Follow-Up H. Yoon1, W. Kim2; 1Hallym University, Seoul, REPUBLIC OF KOREA, 2Pediatrics, Inje University, Seoul, REPUBLIC OF KOREA.
1143
J ALLERGY CLIN IMMUNOL FEBRUARY 2006
RATIONALE: Several studies have suggested that respiratory infection by Mycoplasma pneumoniae is associated with reactive asthma. The purpose of this study was placed to investigate the ECP level that suggested allergic inflammation during an episode of acute lower respiratory tract infection caused by Mycoplasma pneumoniae and follow-up the patients for 3 years later. METHODS: We studied 120 children with pneumonia who were hospitalizes from September 2002 to December 2002. We measured the serum concentrations of ECP produced by eosinophils in 90 children with M. Peumoniae infected group, 30 children with non-infected group. And also we measured eosinophil count, total specific IgE. Ten month late we follow-up prevalence rate of asthma in this patients by telephone interview and then three years later we follow-up the patients by methacholine test. RESULTS: There was no sex and age difference between two group. Total eosinophil count in infected group (252.7±220.3/mm3) was significantly higher than that of non-infected group (142.2±198.8/mm3). It showed significant change statistically. (p<0.01) Between infected group and non-infected group positive ECP level were 35% vs 3,3%. Our data show that only total IgE (r=0.39, p<0.01) and serum ECP level (r=0.58, p<0.01) were correlated. Positive rates of specific IgE in each group were no significantly different. CONCLUSIONS: This study suggests that the proportion of eosinophils and the level of ECP may as a factor cause damage to the respiratory system similar to asthma in children with M. pneumoniae. Anthropometric Measures and Lung Function Test in Asthmatic Pacients, Asthmatic Obese, Obese without Asthma and Healthy Pacients J. E. Guillen Escalon, J. J. L. Sienra, G. Toussaint, M. A. Rosas, B. E. Del Rio; Pediatric Allergy and Immunology, Hospital Infantil de Mexico, Mexico DF, MEXICO. RATIONALE: Our objective was to determine and to compare the anthropometric measures and the lung function in obese and not obese children with and without asthma. METHODS: Observational, comparative, descriptive and cross sectional study in children (7-17 years), classified based on clinical diagnostic (healthy, obese, and asthmatic) and body mass index according to Coles charts: overweight (percentile 85-95), normal: (percentile 50-85), obese (percentile >95). For the asthma diagnosis we used the classification of GINA. RESULTS: In our results we find that FVC was diminished in the asthma with obesity and obese groups in comparison with those of the asthma without obesity and healthy groups, but no stadistical significance. The same behavior was for the FEV1 and FEF. With Tiffaneau index, there was significant tendency when comparing the healthy one against the group of obese (P= 0.000) and the group of obese asthmatic. The best correlation was for the percentage of fat mass reserve with the FEV1, a greater percentage of fat reserve a smaller value of FEV1. CONCLUSIONS: In mild intermittent asthma the lung volumes doesn’t change with obesity. The obese patients with mild intermittent asthma have alterations of the Tiffaneau index in comparison with the healthy ones. A greater percentage of fat mass reserve a smaller FEV1.
1144
TUESDAY
Association between IgA and IgG1 Serum Level and Atopy in Children P. Majak, J. Jerzynska, I. Stelmach; Dep. Allergy and Pediatrics, M Curie Hospital, Zgierz, POLAND. RATIONALE: Atopy may be an error in immunoglobulin isotype class switching during a normal process of antigen recognition and generation of a humoral antibody response. We hypothesized that atopy in children may by associated with low serum level of immunoglobulin (Ig)G and IgA. METHODS: This study was the part of Asthma Prevention Program sponsored by Lodz Regional Health Insurance Fund in 2000-03. In the programme participated 127 primary and 12 specialized care centres. In 550 children below 19 years old serum level of IgA, IgG1, IgG2, IgG3, IgG4 and IgM were measured. Atopy was established by positive skinprick tests and by the presence of specific IgE to one or more allergen. RESULTS: Atopy was identified in 320 (58%) children. Multivariate logistic regression analysis showed that low level of IgG1 (OR:7.8; 95%CI: 3.3-10.5 ) and low level of IgA (OR: 3.8; 95%CI: 1.3-5.4 ) was associated with atopy in young children. CONCLUSIONS: Low level of IgA and IgG1 increase risk of atopy in children.
1141
1142
Asthma Prevalence in Public Housing Communities
J. Poyser, T. Richards, D. Collins, T. Green, R. Morgan, E. Horowitz, A. Togias; Johns Hopkins University, Baltimore, MD. RATIONALE: Last year, we reported that, in two Baltimore City public housing communities, the prevalence of “probable asthma”, based on a door-to-door population survey of 600 individuals, was 21%. An additional 17% reported symptoms indicative of “possible asthma”. We are now reporting on the process of confirming the above diagnoses and obtaining a more reliable estimate of asthma prevalence. METHODS: We tested 80 individuals from the above population, older than 6 years, by conducting either a methacholine bronchoprovocation or a reversibility test with inhaled albuterol. RESULTS: Of 43 subjects with survey diagnosis of “no asthma”, 34 had negative objective tests, while 9 reacted to methacholine (PC20 12%. Of 18 subjects with survey diagnosis of “possible asthma”, 12 were confirmed as asthmatics on the basis of the above tests. Of 19 subjects with “probable asthma” on survey, 9 were confirmed. Extrapolation of these data to the entire population yields an asthma prevalence of 21.9%. CONCLUSIONS: In Baltimore public housing residents, the prevalence of asthma, confirmed with objective testing of airways hyperresponsiveness or reversible airway obstruction, is three times higher than that of the US population. Funding: NIAID Association of Mycoplasma Pneumoniae with Initial Wheezer for 3 Years Follow-Up H. Yoon1, W. Kim2; 1Hallym University, Seoul, REPUBLIC OF KOREA, 2Pediatrics, Inje University, Seoul, REPUBLIC OF KOREA.
1143
J ALLERGY CLIN IMMUNOL FEBRUARY 2006
RATIONALE: Several studies have suggested that respiratory infection by Mycoplasma pneumoniae is associated with reactive asthma. The purpose of this study was placed to investigate the ECP level that suggested allergic inflammation during an episode of acute lower respiratory tract infection caused by Mycoplasma pneumoniae and follow-up the patients for 3 years later. METHODS: We studied 120 children with pneumonia who were hospitalizes from September 2002 to December 2002. We measured the serum concentrations of ECP produced by eosinophils in 90 children with M. Peumoniae infected group, 30 children with non-infected group. And also we measured eosinophil count, total specific IgE. Ten month late we follow-up prevalence rate of asthma in this patients by telephone interview and then three years later we follow-up the patients by methacholine test. RESULTS: There was no sex and age difference between two group. Total eosinophil count in infected group (252.7±220.3/mm3) was significantly higher than that of non-infected group (142.2±198.8/mm3). It showed significant change statistically. (p<0.01) Between infected group and non-infected group positive ECP level were 35% vs 3,3%. Our data show that only total IgE (r=0.39, p<0.01) and serum ECP level (r=0.58, p<0.01) were correlated. Positive rates of specific IgE in each group were no significantly different. CONCLUSIONS: This study suggests that the proportion of eosinophils and the level of ECP may as a factor cause damage to the respiratory system similar to asthma in children with M. pneumoniae. Anthropometric Measures and Lung Function Test in Asthmatic Pacients, Asthmatic Obese, Obese without Asthma and Healthy Pacients J. E. Guillen Escalon, J. J. L. Sienra, G. Toussaint, M. A. Rosas, B. E. Del Rio; Pediatric Allergy and Immunology, Hospital Infantil de Mexico, Mexico DF, MEXICO. RATIONALE: Our objective was to determine and to compare the anthropometric measures and the lung function in obese and not obese children with and without asthma. METHODS: Observational, comparative, descriptive and cross sectional study in children (7-17 years), classified based on clinical diagnostic (healthy, obese, and asthmatic) and body mass index according to Coles charts: overweight (percentile 85-95), normal: (percentile 50-85), obese (percentile >95). For the asthma diagnosis we used the classification of GINA. RESULTS: In our results we find that FVC was diminished in the asthma with obesity and obese groups in comparison with those of the asthma without obesity and healthy groups, but no stadistical significance. The same behavior was for the FEV1 and FEF. With Tiffaneau index, there was significant tendency when comparing the healthy one against the group of obese (P= 0.000) and the group of obese asthmatic. The best correlation was for the percentage of fat mass reserve with the FEV1, a greater percentage of fat reserve a smaller value of FEV1. CONCLUSIONS: In mild intermittent asthma the lung volumes doesn’t change with obesity. The obese patients with mild intermittent asthma have alterations of the Tiffaneau index in comparison with the healthy ones. A greater percentage of fat mass reserve a smaller FEV1.
1144
TUESDAY