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Antiaging efficacy of a combined oral & topical regimen: 4-week clinical investigation
P221
P223
Comparative clinical assessment of two skin lightening products in female subjects with dyschromia Christian Oresajo, PhD, L’Oreal Recherche, Clark, NJ, United States; Margarita Yatskayer, MS, L’Oreal Recherche, Clark, NJ, United States; Hani Fares, PhD, L’Oreal Recherche, Clark, NJ, United States; Isabelle Hansenne, PhD, L’Oreal Recherche, Clark, NJ, United States Dyschromia is the irregular or patchy discoloration of skin caused by variations in pigment density, vascular changes, hormonal factors, and chronic sun exposure. In many cases, the dyschromic condition can be improved by the use of bleach or skin lightening products. This controlled single center, randomized, double-blind, parallel group trial was undertaken to compare the efficacy and tolerability of two skin lightening products on 58 female volunteers, 18 years of age or older, having Fitzpatrick skin types II-IV with mild to moderate dyschromia on the face and the back of hands. The volunteers applied daily either product A or product B to their face and back of hands for 16 weeks. Product A contained 2% hydroquinone (monographed active ingredient) while product B contained embilica extract. Embilica extract or Indian gooseberry essentially contains antioxidants and chelating agents. At the baseline visit, the clinician graded the severity of mottled pigmentation and melasma on the face and back of hands using a 10 point visual analog scale from 0 = none to 9 = severe. Subjects with melasma were rated with the Melasma & Severity Index. Objective and subjective skin irritation was graded using a 4 point scale from 0 = none to 3 = severe. Triplicate chromameter measurements were taken on the same selected hyperpigmented lesions of the face and hands at each visit. Subjects’ hands were photographed with a digital camera while subjects’ faces were photographed using VISIA imaging system. Subjects returned at 6, 12, and 16 weeks for repeat grading, chromameter measurements, and photography. Results show that both products A and B were effective in treating dyschromia. Erythema was significantly lower with product B.
Antiaging efficacy of a combined oral & topical regimen: 4-week clinical investigation Nalini Kaul, PhD, Hill Top Research, Winnipeg, Manitoba, Canada; Alessandra Pagnoni, MD, Hill Top Research, Winnipeg, Manitoba, Canada; Wendy Lazer, Hill Top Research, Winnipeg, Manitoba, Canada; Steve Mirabella, MS, N.V. Perricone MD. Ltd., Meriden, CT, United States Facial skin, because of constant exposure, can receive a high cumulative dose of solar radiation, resulting in photoaging. Characteristics of photoaging include wrinkles, dryness, roughness, loss in skin tone, and mottled hyperpigmentation. Free radicals created during UV exposure cause damage to cell structures. Prevention and treatment of damage can be reinforced by antioxidants. AO counteract free radicals and can be supplied orally as well as topically. A peptide blend rich in lignans, vitamins, minerals, omega fatty acids, polysaccharides and dietary fibers from natural food sources was used for oral supplementation in combination with novel neuropeptides in topical facial formulations. Our primary objective was evaluation of facial photoaging parameters involving 33 females (3559 years) in a 4-week clinical study with daily use of a natural regimen involving oral supplementation and topical applications. Secondary objective was to evaluate skin irritation under normal use with the combined regimen. The trial involved a full-face monadic design, with three study visits at baseline, week 2, and 4. Evaluations included clinical efficacy, safety evaluations, silicon replicas, digital photographs, and self assessments. Significant improvement in photodamage, skin roughness, infraorbital wrinkles, facial wrinkles, and skin attributes was evident after 4 weeks. Our study suggests a combination of systemic and topical natural antioxidants may help improve appearance of photoaging and also provide added benefits. Research completed by Hill-Top Research, 100% sponsored by NV. Perricone MD Ltd.
100% is sponsored by L’Oreal.
P224 Skin topometry changes demonstrate anti-aging efficacy of a topically applied cosmetic product via in vivo testing Angela Long, PhD, Procter & Gamble, Egham, United Kingdom; Jonathan Crowther, PhD, Procter & Gamble, Egham, United Kingdom; Kim Beach, Procter & Gamble, Egham, United Kingdom; Jones Neil, Procter & Gamble, Egham, United Kingdom
P222 Clinical improvement in the appearance of photoaging with a serum containing retinol Warren Wallo, MS, Johnson & Johnson Consumer and Personal Products Worldwide, Skillman, NJ, United States; Christiane Bertin, Johnson & Johnson Consumer France; Issy les Moulineaux, France; Thierry Oddos, PhD, Johnson & Johnson Consumer France; Val de Reuil, France; Florence Costes, Johnson & Johnson Consumer and Personal Products Worldwide, Skillman, NJ, United States Vitamin A has been proven to be an important ingredient for improving the appearance of photoaged skin. Products containing retinol are available in various forms, such as creams, gels, and lotions, which are applied to the face as part of the daily skin care regimen. Serums represent a new patient-preferred form with better aesthetics and an enhanced delivery profile, capable of providing retinol anti-aging benefits. Studies of retinol delivery to the skin using standardized Franz cell methodology demonstrated the value of serum formulations when compared with more traditional topical vehicles. A new method of measuring permeation, with a membrane system to simulate the skin barrier, provided similar results. A 12-week randomized, placebo-controlled clinical study was performed to evaluate the overall effectiveness of a daily treatment with a retinol-containing serum. Thirty-seven healthy female subjects, ages 35 to 55, exhibiting moderate photodamage of the face with moderate fine lines and wrinkling were enrolled. Dermatologist evaluations at weeks 4, 8, and 12 demonstrated significant improvements versus both placebo and baseline in the appearance of fine lines and wrinkles, skin radiance, as well as the overall appearance of photoaging. This improved topical delivery form, supported with scientific testing and clinical assessments, delivers improvements in cutaneous skin parameters that address the needs of patients with photodamage. 100% is sponsored by Johnson & Johnson Consumer and Personal Products Worldwide.
AB30
J AM ACAD DERMATOL
Background: Facial aging manifests itself in many forms that are both consumer observable and technically measurable. It is well known that the visual appearance of lines and wrinkles and the feel and look of the skin surface reflect both the underlying condition of the skin (skin barrier health) and effects of aging caused by both intrinsic and extrinsic factors. Cosmetic products with anti-aging properties can be demonstrated to positively impact key measures via the use of different technical methods. The non-invasive technique of FOITS (Fast Optical in vivo Topometry of human Skin) is a touch-free fringe projection technique which allows three-dimensional information to be gathered from the surface of the skin. Importantly for anti-aging measures this technique can be used in the periorbital eye area which is known as a wrinkle prone area and, as such, is highly consumer relevant. Objective: The study was conducted to (i) further establish the utility of using FOITS methodology to measure changes in skin surface topometry and (ii) to determine whether a product rich in niacinamide, glycerin, hyaluronic acid, and Pal-KTTKS (peptide) can produce measurable changes in skin topography. Method: Thirty women aged 401 were enrolled in an incomplete block design split face study where each woman, over a period of 4 weeks applied product daily to one side of her face and no product to the other side. Key anti-aging measures were recorded at 24 hours, 2 weeks, and 4 weeks. At each time point, the FOITS measures of Rz and Ra (surface roughness measures) were obtained at a specific site in the periorbital region of each eye and were complemented by the established skin barrier measures of TEWL and corneometer. Results: The FOITS methodology provided an accurate measure of wrinkle depth and length in the periorbital region of the eye and further established itself as a highly relevant tool for evaluating the efficacy of anti-aging cosmetic products. A topically applied anti-aging product rich in niacinamide, glycerin, hyaluronic acid, and Pal-KTTKS (peptide) was shown to provide skin benefits at 24 hours, 2 weeks, and 4 weeks for all 3 key measures studied, demonstrating a positive effect on the surface topometry of aged skin at both acute and chronic time points as well as providing increased hydration and skin barrier improvement. Procter & Gamble Co fully sponsor and support this abstract.
FEBRUARY 2007
P223
Comparative clinical assessment of two skin lightening products in female subjects with dyschromia Christian Oresajo, PhD, L’Oreal Recherche, Clark, NJ, United States; Margarita Yatskayer, MS, L’Oreal Recherche, Clark, NJ, United States; Hani Fares, PhD, L’Oreal Recherche, Clark, NJ, United States; Isabelle Hansenne, PhD, L’Oreal Recherche, Clark, NJ, United States Dyschromia is the irregular or patchy discoloration of skin caused by variations in pigment density, vascular changes, hormonal factors, and chronic sun exposure. In many cases, the dyschromic condition can be improved by the use of bleach or skin lightening products. This controlled single center, randomized, double-blind, parallel group trial was undertaken to compare the efficacy and tolerability of two skin lightening products on 58 female volunteers, 18 years of age or older, having Fitzpatrick skin types II-IV with mild to moderate dyschromia on the face and the back of hands. The volunteers applied daily either product A or product B to their face and back of hands for 16 weeks. Product A contained 2% hydroquinone (monographed active ingredient) while product B contained embilica extract. Embilica extract or Indian gooseberry essentially contains antioxidants and chelating agents. At the baseline visit, the clinician graded the severity of mottled pigmentation and melasma on the face and back of hands using a 10 point visual analog scale from 0 = none to 9 = severe. Subjects with melasma were rated with the Melasma & Severity Index. Objective and subjective skin irritation was graded using a 4 point scale from 0 = none to 3 = severe. Triplicate chromameter measurements were taken on the same selected hyperpigmented lesions of the face and hands at each visit. Subjects’ hands were photographed with a digital camera while subjects’ faces were photographed using VISIA imaging system. Subjects returned at 6, 12, and 16 weeks for repeat grading, chromameter measurements, and photography. Results show that both products A and B were effective in treating dyschromia. Erythema was significantly lower with product B.
Antiaging efficacy of a combined oral & topical regimen: 4-week clinical investigation Nalini Kaul, PhD, Hill Top Research, Winnipeg, Manitoba, Canada; Alessandra Pagnoni, MD, Hill Top Research, Winnipeg, Manitoba, Canada; Wendy Lazer, Hill Top Research, Winnipeg, Manitoba, Canada; Steve Mirabella, MS, N.V. Perricone MD. Ltd., Meriden, CT, United States Facial skin, because of constant exposure, can receive a high cumulative dose of solar radiation, resulting in photoaging. Characteristics of photoaging include wrinkles, dryness, roughness, loss in skin tone, and mottled hyperpigmentation. Free radicals created during UV exposure cause damage to cell structures. Prevention and treatment of damage can be reinforced by antioxidants. AO counteract free radicals and can be supplied orally as well as topically. A peptide blend rich in lignans, vitamins, minerals, omega fatty acids, polysaccharides and dietary fibers from natural food sources was used for oral supplementation in combination with novel neuropeptides in topical facial formulations. Our primary objective was evaluation of facial photoaging parameters involving 33 females (3559 years) in a 4-week clinical study with daily use of a natural regimen involving oral supplementation and topical applications. Secondary objective was to evaluate skin irritation under normal use with the combined regimen. The trial involved a full-face monadic design, with three study visits at baseline, week 2, and 4. Evaluations included clinical efficacy, safety evaluations, silicon replicas, digital photographs, and self assessments. Significant improvement in photodamage, skin roughness, infraorbital wrinkles, facial wrinkles, and skin attributes was evident after 4 weeks. Our study suggests a combination of systemic and topical natural antioxidants may help improve appearance of photoaging and also provide added benefits. Research completed by Hill-Top Research, 100% sponsored by NV. Perricone MD Ltd.
100% is sponsored by L’Oreal.
P224 Skin topometry changes demonstrate anti-aging efficacy of a topically applied cosmetic product via in vivo testing Angela Long, PhD, Procter & Gamble, Egham, United Kingdom; Jonathan Crowther, PhD, Procter & Gamble, Egham, United Kingdom; Kim Beach, Procter & Gamble, Egham, United Kingdom; Jones Neil, Procter & Gamble, Egham, United Kingdom
P222 Clinical improvement in the appearance of photoaging with a serum containing retinol Warren Wallo, MS, Johnson & Johnson Consumer and Personal Products Worldwide, Skillman, NJ, United States; Christiane Bertin, Johnson & Johnson Consumer France; Issy les Moulineaux, France; Thierry Oddos, PhD, Johnson & Johnson Consumer France; Val de Reuil, France; Florence Costes, Johnson & Johnson Consumer and Personal Products Worldwide, Skillman, NJ, United States Vitamin A has been proven to be an important ingredient for improving the appearance of photoaged skin. Products containing retinol are available in various forms, such as creams, gels, and lotions, which are applied to the face as part of the daily skin care regimen. Serums represent a new patient-preferred form with better aesthetics and an enhanced delivery profile, capable of providing retinol anti-aging benefits. Studies of retinol delivery to the skin using standardized Franz cell methodology demonstrated the value of serum formulations when compared with more traditional topical vehicles. A new method of measuring permeation, with a membrane system to simulate the skin barrier, provided similar results. A 12-week randomized, placebo-controlled clinical study was performed to evaluate the overall effectiveness of a daily treatment with a retinol-containing serum. Thirty-seven healthy female subjects, ages 35 to 55, exhibiting moderate photodamage of the face with moderate fine lines and wrinkling were enrolled. Dermatologist evaluations at weeks 4, 8, and 12 demonstrated significant improvements versus both placebo and baseline in the appearance of fine lines and wrinkles, skin radiance, as well as the overall appearance of photoaging. This improved topical delivery form, supported with scientific testing and clinical assessments, delivers improvements in cutaneous skin parameters that address the needs of patients with photodamage. 100% is sponsored by Johnson & Johnson Consumer and Personal Products Worldwide.
AB30
J AM ACAD DERMATOL
Background: Facial aging manifests itself in many forms that are both consumer observable and technically measurable. It is well known that the visual appearance of lines and wrinkles and the feel and look of the skin surface reflect both the underlying condition of the skin (skin barrier health) and effects of aging caused by both intrinsic and extrinsic factors. Cosmetic products with anti-aging properties can be demonstrated to positively impact key measures via the use of different technical methods. The non-invasive technique of FOITS (Fast Optical in vivo Topometry of human Skin) is a touch-free fringe projection technique which allows three-dimensional information to be gathered from the surface of the skin. Importantly for anti-aging measures this technique can be used in the periorbital eye area which is known as a wrinkle prone area and, as such, is highly consumer relevant. Objective: The study was conducted to (i) further establish the utility of using FOITS methodology to measure changes in skin surface topometry and (ii) to determine whether a product rich in niacinamide, glycerin, hyaluronic acid, and Pal-KTTKS (peptide) can produce measurable changes in skin topography. Method: Thirty women aged 401 were enrolled in an incomplete block design split face study where each woman, over a period of 4 weeks applied product daily to one side of her face and no product to the other side. Key anti-aging measures were recorded at 24 hours, 2 weeks, and 4 weeks. At each time point, the FOITS measures of Rz and Ra (surface roughness measures) were obtained at a specific site in the periorbital region of each eye and were complemented by the established skin barrier measures of TEWL and corneometer. Results: The FOITS methodology provided an accurate measure of wrinkle depth and length in the periorbital region of the eye and further established itself as a highly relevant tool for evaluating the efficacy of anti-aging cosmetic products. A topically applied anti-aging product rich in niacinamide, glycerin, hyaluronic acid, and Pal-KTTKS (peptide) was shown to provide skin benefits at 24 hours, 2 weeks, and 4 weeks for all 3 key measures studied, demonstrating a positive effect on the surface topometry of aged skin at both acute and chronic time points as well as providing increased hydration and skin barrier improvement. Procter & Gamble Co fully sponsor and support this abstract.
FEBRUARY 2007