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Antimicrobial Chemotherapy (3rd edn)
0
0
K
Predicting
s
experts in each area. After the lntre duction, chapters by Jurs and colleagues and by Kier present alterrelationships native ways to describe a molecule to the computer. The next four chapters Chemomehic Methods in (Au&l, Sjijstromand Eriksson, Hall, and van de Waterbeemd and colMoleculacDesign leagues, respectively) discuss applyedited by H. um dc Waterbtmrd, ing the principles of experimental VCH, 1995. DM188.00 design either to designing the set (xix + 359 pages) of molecules to be studied or to MN 3 527 3CKM4 9 analysing the resulting structureactivity relationships. Following this In the 1960s Hansch and Fujita are nine chapters on statistical invented quantitative structure- methodologies that are useful in activity relationships @AR), the QSAR; these are written by Franke quantitative analysis of the relation- and Gruska, Devillers and Chess& Dunn and Wold, Wold, Lewi, ships between the physical and bie logical properhes of mokcuies. They Devillers, Ford and tilt, van de built on the viewpoint of physical Waterbeemd, and McFarland and organic chemists such as Hammett Cans. The book concludes with chap and Taft who showed that the rela- ters by Wold and E&son and by tive effects of different substituents Clementi and Wold on the validation of QSAR results. ona newsystemareoftensktistically The positive aspect of chapters correlated with the effeck of these substituenk on a standard reactionor written by experts is that the exposiequilibrium. They added the experi- tions are complete and up to date. ence of biologists such as Meyer, The negative aspect is that such Overtou, Fquson, and Brodie who authors may be unable to see the de showed that the lipid solubility of ficiencies of their own method or the advantages of other methods. In par molecules is an important detem+ nant of their biological potency. tic&r, Clementi and Wold proclaim Hansch and Fujita showed that that the SAMPLE algorithm of Bush statistics can help one distinguish and Nachbar is worthless. Such comwhether electronic, steric, and ments clearlydo not n&cl the excitehydrophobic effects of substituents ment of a three-dimensional @AR are conelated with changes in practitioner who sees an analysis blok@cal potency. At least four complete in a minute instead of conunecGa1 pesticides and drugs several hours with exactly the same have resulted from such Q5AR statistical results. Erratic copysditing mars the analyses. Once the QSAR paradigm was book: most distracting is that some established, many workers proposed chapters are sprinkled with commas alternative mathematical methods to in irrelevant places. Distinctions analyse the relationships, alternative between which and that, and prinmolecular descriptors, and exten- cipal and principle are also incursionsoftheconcepkinordertoplan rectly made. Such errors often make series of molecules to synthesize. it drily difficult to follow the QSAR ptactirioners share many otherwise interesting expositions by methodologies with analytical chem- the authors. ists who seek to optimize the way In summary, this is a very inleresting book. It will be of interest prithattheyplanandanalysetheirdata. The latterfield has become known as marily to those who practice one of the many aspecis of computerThis book provides a view of novel assisted design of biological molmolecular descriptors and methods ecules, both newcDmersand experts. for analysis of s~ological However,readers who just wish to data, with chapters written by get a flavour of various approaches to 2 8
TiPS -January 1996 (Vol. 17)
traditional @AR will also find it worthwhile to read. YvonneC Martim
ComputerAssistedMolscular Design (O-475 APlO), Pharmaceutical Pmdu& Division,AbbottLaboratories.100Abbott Park Road,AbbottPark, It 80084_35fM, USA.
New edition Antimicrobial Chemotherapy (3rd edn) cd&-d6~D&d ckmmd, Oxford University Prew, 1995. f25.00 (xiv + 428 pages) ISBN 0 19 854944 X
This edition is thoroughly revised and updated and is targeted at those wishing to undersknd the principles that uncle&e antimicrobial chemotherapy, namely students, trainee
doctors, pharmacists and other healthcare professionals. Topics covered include: the general proper ties of all typesof antimicrobialagent (antibacterial, antifungal, antiviral, and antiparasitic);laboratoryaspeck of antimicrobialchemotherapy;problems of resistance;general principles of treatment (including phannacokinetic aspects and the special problems of children and the elderly), side-effects, and chemoprophylaxis; and treatment of specific groups of infectious diseases. There is also a postscript on the development of new antimicrobial agents.
Book Reviews If you are interested in reviewing a recently published book, please write with details tiontoz
of the publica-
TiPS Book Reviaus, Elsevier Trends Journals, 68 Hills Road, Cambridge, UK CB2 1LA.
0
K
Predicting
s
experts in each area. After the lntre duction, chapters by Jurs and colleagues and by Kier present alterrelationships native ways to describe a molecule to the computer. The next four chapters Chemomehic Methods in (Au&l, Sjijstromand Eriksson, Hall, and van de Waterbeemd and colMoleculacDesign leagues, respectively) discuss applyedited by H. um dc Waterbtmrd, ing the principles of experimental VCH, 1995. DM188.00 design either to designing the set (xix + 359 pages) of molecules to be studied or to MN 3 527 3CKM4 9 analysing the resulting structureactivity relationships. Following this In the 1960s Hansch and Fujita are nine chapters on statistical invented quantitative structure- methodologies that are useful in activity relationships @AR), the QSAR; these are written by Franke quantitative analysis of the relation- and Gruska, Devillers and Chess& Dunn and Wold, Wold, Lewi, ships between the physical and bie logical properhes of mokcuies. They Devillers, Ford and tilt, van de built on the viewpoint of physical Waterbeemd, and McFarland and organic chemists such as Hammett Cans. The book concludes with chap and Taft who showed that the rela- ters by Wold and E&son and by tive effects of different substituents Clementi and Wold on the validation of QSAR results. ona newsystemareoftensktistically The positive aspect of chapters correlated with the effeck of these substituenk on a standard reactionor written by experts is that the exposiequilibrium. They added the experi- tions are complete and up to date. ence of biologists such as Meyer, The negative aspect is that such Overtou, Fquson, and Brodie who authors may be unable to see the de showed that the lipid solubility of ficiencies of their own method or the advantages of other methods. In par molecules is an important detem+ nant of their biological potency. tic&r, Clementi and Wold proclaim Hansch and Fujita showed that that the SAMPLE algorithm of Bush statistics can help one distinguish and Nachbar is worthless. Such comwhether electronic, steric, and ments clearlydo not n&cl the excitehydrophobic effects of substituents ment of a three-dimensional @AR are conelated with changes in practitioner who sees an analysis blok@cal potency. At least four complete in a minute instead of conunecGa1 pesticides and drugs several hours with exactly the same have resulted from such Q5AR statistical results. Erratic copysditing mars the analyses. Once the QSAR paradigm was book: most distracting is that some established, many workers proposed chapters are sprinkled with commas alternative mathematical methods to in irrelevant places. Distinctions analyse the relationships, alternative between which and that, and prinmolecular descriptors, and exten- cipal and principle are also incursionsoftheconcepkinordertoplan rectly made. Such errors often make series of molecules to synthesize. it drily difficult to follow the QSAR ptactirioners share many otherwise interesting expositions by methodologies with analytical chem- the authors. ists who seek to optimize the way In summary, this is a very inleresting book. It will be of interest prithattheyplanandanalysetheirdata. The latterfield has become known as marily to those who practice one of the many aspecis of computerThis book provides a view of novel assisted design of biological molmolecular descriptors and methods ecules, both newcDmersand experts. for analysis of s~ological However,readers who just wish to data, with chapters written by get a flavour of various approaches to 2 8
TiPS -January 1996 (Vol. 17)
traditional @AR will also find it worthwhile to read. YvonneC Martim
ComputerAssistedMolscular Design (O-475 APlO), Pharmaceutical Pmdu& Division,AbbottLaboratories.100Abbott Park Road,AbbottPark, It 80084_35fM, USA.
New edition Antimicrobial Chemotherapy (3rd edn) cd&-d6~D&d ckmmd, Oxford University Prew, 1995. f25.00 (xiv + 428 pages) ISBN 0 19 854944 X
This edition is thoroughly revised and updated and is targeted at those wishing to undersknd the principles that uncle&e antimicrobial chemotherapy, namely students, trainee
doctors, pharmacists and other healthcare professionals. Topics covered include: the general proper ties of all typesof antimicrobialagent (antibacterial, antifungal, antiviral, and antiparasitic);laboratoryaspeck of antimicrobialchemotherapy;problems of resistance;general principles of treatment (including phannacokinetic aspects and the special problems of children and the elderly), side-effects, and chemoprophylaxis; and treatment of specific groups of infectious diseases. There is also a postscript on the development of new antimicrobial agents.
Book Reviews If you are interested in reviewing a recently published book, please write with details tiontoz
of the publica-
TiPS Book Reviaus, Elsevier Trends Journals, 68 Hills Road, Cambridge, UK CB2 1LA.