Free Radical Biology & Medicine, Vol. 12, pp. 97-98, 1992
0891-5849/92 $5.00 + .00 Copyright © 1992 Pergamon Press pie
Printed in the USA. All rights reserved.
Book Review ANTIMUTAGENESIS
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ANTICARCINOGENESIS MECHANISMS, V O L U M E II xiii + 485 pp, 1990. Price: $95.00 us; $95.00 + 20% Outside US
Y. KURODA, D. M. SHANKEL, AND M. D. WATERS, EDITORS Plenum Press, 233 Spring St., New York, NY 10013, U.S.A. Reviewed by William A. Pryor Biodynamics Institute, Louisiana State University, Baton Rouge, LA 70803, U.S.A.
in environmental toxicology, includes 3 chapters, authored by M. Sorsa et al., M. D. Waters et al., and J. H. Weisburger and R. C. Jones, which cover biomonitoring, activity profiles, and mutagens in human food. The third main section, which will be of particular interest to the readers of this journal, reports the involvement of free radicals in antimutagenic mechanisms. There are 3 chapters, with articles by R. P. Mason et al., M. C. Simic and S. V. Jovanovic, and T. Osawa et al. The chapters cover the reactions of DNA and nucleotides with radicals and the inactivation of radicals by dietary antioxidants. The fourth main section involves antitumor initiators and carcinogens and includes 4 chapters written by L. W. Wattenburg, M. W. Pariza and Y. L. Ha, D. Kritchevsky, and N. Ito et al. The chapters cover inhibition of carcinogenesis by natural and synthetic compounds, anticarcinogenic fatty acids, the role of caloric restriction in carcinogenesis, and the effect on carcinogenicity by antioxidants. The fifth main section covers antitumor promoters and carcinogenesis and involves 3 chapters by A. K. Verma, H. Fujiki et al., and R. C. Moon and R. G. Mehta. The sixth main section involves aspects of human and mammalian genetics and includes 3 chapters by W. Troll et al., Y. Kuroda, and E. C. Friedberg et al. Subjects covered include tumor promotion, the antimutagenic effect of vitamins, including vitamins C and E, and microcell-mediated chromosomal transfer. The seventh main section treats molecular aspects
This book is Volume 52 in the Basic Life Sciences series edited by E. H. Y. Chu for Plenum Press. The first volume in this series (Volume 39 in the Basic Life Sciences series) consisted of papers presented at a Symposium held in Lawrence, Kansas in 1985. I was fortunate enough to be able to attend that symposium, and I found it to be unusually stimulating because it involved persons with a wide variety of backgrounds, all of whom were interested in some aspect of the complex field of antimutagenesis and anticarcinogenesis. This second volume reports papers from the Second International Conference on Mechanisms of Antimutagenesis and Anticarcinogenesis, which was held in December, 1988, in Ohito, Japan. This volume is dedicated to the memory of Dr. Tsuneo Kada and Dr. Alexander Hollaender, both of whom were strong and influential forces in this field. Alexander Hollaender was a remarkable man, whose influence will be felt in biology for decades to come. Dr. Kada devoted a great deal of his energy and enthusiasm to the study of mutagens and antimutagens, and he was an active and vigorous participant in the first conference held in Kansas and one of the editors of the first volume in this series. This is an excellent book, divided into ten main sections. The first section, antimutagens in food, ineludes 3 chapters, written by H. W. Renner, M. P. Rosin, and M. E. Wall et al., covering mammalian assays, carotinoids, and plant antimutagens. The second main section, antimutagens and anticarcinogens
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of mutagenesis and involves 4 chapters by J. R. Battista et al., D. Burnouf et al., D. C. Thomas et al., and H. Maki et al. The eighth section involves oncogenes and antioncogenes and includes 3 chapters by N. Shindo-Okada et al., M. Terada et al., and T. Yamanashi et al. The final section involves 23 short papers that were presented as posters at the meeting. Of particular note in this section are discussions ofbleomycin, the use of Drosophila to study mutagenesis, the role of linoleic acid hydroperoxides, and a very useful chapter on the classification of mechanisms of inhibitors of mutagenesis and carcinogenesis. As is true in books of this sort, the chapters are not uniformly written. Some authors have been careful to present an introduction to their field and define all the
symbols they use; others are less thorough in this regard, and there are chapters with acronyms that are never defined. Some chapters include an abstract but many do not. I particularly object to a book like this not having at least a brief summary of each chapter, particularly when the number of chapters is so large. The subjects covered are of considerable interest and the authors are, in general, well known names. Many of the chapters are by Japanese authors, since this has been an active field for research in Japan for many years. The collection in one volume of chapters by the leading Japanese workers in this field is one of the strengths of this volume. This book, and the previous volume in this series, can be enthusiastically recommended to persons interested in the fascinating study of antimutagenesis.