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Antinociception produced by spinal delivery of the S and R enantiomers of flurbiprofen in the formalin test
eJp ELSEVIER
European Journal of Pharmacology 260 (1994) 283
Corrigendum
Antinociception produced by spinal delivery of the S and R enantiomers of flurbiprofen in the formalin test European Journal of Pharmacology, 256 (1994) 205-209 Annika B. Malmberg a
*'a'b,
Tony L. Yaksh
a
Department of Anesthesiology, University of California, San Diego, La JoUa, CA 92093-0818, USA b Department of Clinical Pharmacology, Sahlgrenska University Hospital, G6teborg, Sweden Received 16 February 1994; accepted 18 February 1994
Abstract
The antinociceptive effect of spinally delivered S- and R-flurbiprofen, enantiomers of 2-arylpropionic acid, was studied in rats using the formalin test. Intrathecal injections of S- or R-flurbiprofen produced a significant reduction of the second phase of the formalin test, with no effect on the first phase. The maximal suppression of the second phase was similar for both agents (about 50% at the highest doses). While both agents were active, S-flurbiprofen was significantly more potent than R-flurbiprofen. The potency ratio between the dose-response curves was 10 (6-20; 95% confidence intervals). These results demonstrate that both Sand R-flurbiprofen produce antinociception after spinal administration. The potency difference is similar to that for inhibition of cyclooxygenase in brain tissue and supports the hypothesis that cyclooxygenase products are involved in prolonged spinal nociceptive transmission. Key words: S-Flurbiprofen; R-Flurbiprofen; Formalin test; Antinociception, intrathecal; Spinal cord; Cyclooxygenase, inhibition
In our above-mentioned paper, we unfortunately failed to note the contribution of Dr. William J. Wechter (Department of Medicine, Loma Linda University, Loma Linda, CA 92350, USA) from whom came the suggestion to compare the isomers of flurbiprofen in our intrathecal model, based on his insight into the rapid R ~ S conversion of ibuprofen which can occur in the rat. The Authors
* Corresponding author. Dept. Clinical Pharmacology, Sahlgrenska Univ. Hospital, S-41345 G6teborg, Sweden. Tel. + 46 31 602974, fax + 46 31 826723. Elsevier Science B.V. SSDI 0014-2999(94)00339-9
European Journal of Pharmacology 260 (1994) 283
Corrigendum
Antinociception produced by spinal delivery of the S and R enantiomers of flurbiprofen in the formalin test European Journal of Pharmacology, 256 (1994) 205-209 Annika B. Malmberg a
*'a'b,
Tony L. Yaksh
a
Department of Anesthesiology, University of California, San Diego, La JoUa, CA 92093-0818, USA b Department of Clinical Pharmacology, Sahlgrenska University Hospital, G6teborg, Sweden Received 16 February 1994; accepted 18 February 1994
Abstract
The antinociceptive effect of spinally delivered S- and R-flurbiprofen, enantiomers of 2-arylpropionic acid, was studied in rats using the formalin test. Intrathecal injections of S- or R-flurbiprofen produced a significant reduction of the second phase of the formalin test, with no effect on the first phase. The maximal suppression of the second phase was similar for both agents (about 50% at the highest doses). While both agents were active, S-flurbiprofen was significantly more potent than R-flurbiprofen. The potency ratio between the dose-response curves was 10 (6-20; 95% confidence intervals). These results demonstrate that both Sand R-flurbiprofen produce antinociception after spinal administration. The potency difference is similar to that for inhibition of cyclooxygenase in brain tissue and supports the hypothesis that cyclooxygenase products are involved in prolonged spinal nociceptive transmission. Key words: S-Flurbiprofen; R-Flurbiprofen; Formalin test; Antinociception, intrathecal; Spinal cord; Cyclooxygenase, inhibition
In our above-mentioned paper, we unfortunately failed to note the contribution of Dr. William J. Wechter (Department of Medicine, Loma Linda University, Loma Linda, CA 92350, USA) from whom came the suggestion to compare the isomers of flurbiprofen in our intrathecal model, based on his insight into the rapid R ~ S conversion of ibuprofen which can occur in the rat. The Authors
* Corresponding author. Dept. Clinical Pharmacology, Sahlgrenska Univ. Hospital, S-41345 G6teborg, Sweden. Tel. + 46 31 602974, fax + 46 31 826723. Elsevier Science B.V. SSDI 0014-2999(94)00339-9