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Apoptosis, ion fluxes and oxidative stress
ABB Archives of Biochemistry and Biophysics 462 (2007) 123 www.elsevier.com/locate/yabbi
Editorial
Apoptosis, ion fluxes and oxidative stress
Apoptosis plays a major pathogenic role in liver damage triggered by viral infection, drug abuse, fat overload, or autoimmunity. Although the basic machinery of apoptosis has been elucidated, the precise mechanisms leading to apoptosis in liver disease are largely unknown. Several cellular processes, including alterations in cell hydration and ion homeostasis, osmotic and oxidative stress, lysosomal permeabilization, as well as alternate forms of cell death, may contribute to liver damage. These timely issues were addressed at the third International Conference of the Collaborative Research Center ‘Experimental Hepatology’ (SFB 575), which was held in Du¨sseldorf, Germany, October 13–14, 2006. This Highlight Issue ‘‘Apoptosis, Ion Fluxes and Oxidative Signaling’’ contains articles about state-of-the-art knowledge in multiple facets of liver biology and gives an updated survey of the advances in this burgeoning field of translational medicine. On behalf of all contributing authors, we thank the ABB Editorial Office and Helmut Sies for the opportunity of
producing this special issue. Finally, our sincerest thanks go to the Deutsche Forschungsgemeinschaft, the Falk Foundation, Biosource and the Gesellschaft von Freunden und Fo¨rderern der Heinrich-Heine Universita¨t Du¨sseldorf for supporting this excellent meeting. Guest editors Klaus Schulze-Osthoff * Sonderforschungsbereich 575 ‘Experimental Hepatology’, Institute of Molecular Medicine, Heinrich Heine University, Universita¨tsstrasse 1, D-40225 Du¨sseldorf, Germany E-mail address: [email protected] Dieter Ha¨ussinger Sonderforschungsbereich 575 ‘Experimental Hepatology’ and Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Du¨sseldorf, Germany Received 14 May 2007
*
0003-9861/$ - see front matter Ó 2007 Elsevier Inc. All rights reserved. doi:10.1016/j.abb.2007.05.009
Corresponding author. Fax: +49 211 811 5892.
Editorial
Apoptosis, ion fluxes and oxidative stress
Apoptosis plays a major pathogenic role in liver damage triggered by viral infection, drug abuse, fat overload, or autoimmunity. Although the basic machinery of apoptosis has been elucidated, the precise mechanisms leading to apoptosis in liver disease are largely unknown. Several cellular processes, including alterations in cell hydration and ion homeostasis, osmotic and oxidative stress, lysosomal permeabilization, as well as alternate forms of cell death, may contribute to liver damage. These timely issues were addressed at the third International Conference of the Collaborative Research Center ‘Experimental Hepatology’ (SFB 575), which was held in Du¨sseldorf, Germany, October 13–14, 2006. This Highlight Issue ‘‘Apoptosis, Ion Fluxes and Oxidative Signaling’’ contains articles about state-of-the-art knowledge in multiple facets of liver biology and gives an updated survey of the advances in this burgeoning field of translational medicine. On behalf of all contributing authors, we thank the ABB Editorial Office and Helmut Sies for the opportunity of
producing this special issue. Finally, our sincerest thanks go to the Deutsche Forschungsgemeinschaft, the Falk Foundation, Biosource and the Gesellschaft von Freunden und Fo¨rderern der Heinrich-Heine Universita¨t Du¨sseldorf for supporting this excellent meeting. Guest editors Klaus Schulze-Osthoff * Sonderforschungsbereich 575 ‘Experimental Hepatology’, Institute of Molecular Medicine, Heinrich Heine University, Universita¨tsstrasse 1, D-40225 Du¨sseldorf, Germany E-mail address: [email protected] Dieter Ha¨ussinger Sonderforschungsbereich 575 ‘Experimental Hepatology’ and Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Du¨sseldorf, Germany Received 14 May 2007
*
0003-9861/$ - see front matter Ó 2007 Elsevier Inc. All rights reserved. doi:10.1016/j.abb.2007.05.009
Corresponding author. Fax: +49 211 811 5892.