- Email: [email protected]
Application of the rhEGF on burn wounds
Burns 3 3 S ( 2 0 0 7 ) S1–S172
S13
to their function. Reconstruction of a complete burned palmar of the hand using an instep of the foot as innervated free fasciocutaneous flap. During seven years, we evaluated 168 burned hand that 36 palmar hand have involved. Five palmar hands have treated with free instep flap and seven hands with groin flap, four with abdominal flap, four with island radial forearm flap, three with ulnar flap, seven with posterior interosseous flap, three with skin graft and three with side finger flap. We have evaluated different methods and have found that the best results is using an instep of the resurface palmar of the hand. Foot as an innervated free fasciocutaneous flap for. doi:10.1016/j.burns.2006.10.033 Preventing donor of split skin scarring with epidermal grafting in people of Asia Zhu Z., Zhu M., Li W. Second Hospital of Shen Zhen, PR China E-mail address: [email protected] (Z. Zhu). Although split thickness skin grafting has been a very common technique used in the fields of plastical surgery and other surgeries, the harvesting of the split skin did leave ugly scar disfigurement on the donor area especially for people of yellow color of Asia. Unfortunately this matter was ignored somehow while paid all attention to the survival of skin transplantation on grafting bed. This paper introduces a new technique of preventing split skin donor sites from scarring with large sheets of epidermal grafts, which thickness was from 0.0028 in. to 0.0048 in. harvested using the electric or airpower dermatome without scar left in the donor sites. The split skin of thickness ranging from 0.012 in. to 0.020 in. were harvested by drum-dermatome or electric power dermatome rarely. The edge of the epidermis sheet covered the donor of split skin attached together with the verges of the donor wound using nanoparticles-Ag gauze stripe adding sutures of 5–0 threads or skin stapler. Both the epidermal grafted area and epidermal donor area were dressed with vaseline gauzes in the inner layer and the nanoparticles Ag gauze on the outer surfaces. This technique of epidermal harvesting and grafting was used for 209 donor sites of both split skin and epidermal sheet for 133 reconstructed sites of 118 cases which suffered from scar deformities in the face, neck, trunk and extremities that admitted to the Center of Plastic Surgery & Burns, Second Hospital, Shen Zhen, PR China from November 1999 to November 2003. Favorably and near normal skin appearance was obtained in the epidermal grafting on the split skin donor area without scarring healing in the epidermal donor area also. doi:10.1016/j.burns.2006.10.034 Application of the rhEGF on burn wounds Zhang L. a,b , Li X. a,b , Wing C. a,b , Xie S. a,b a
Second Hospital of Shen Zhen, PR China Shen Zhen Watsin Genetech Ltd., PR China E-mail address: [email protected] (L. Zhang).
b
Although the treatment of burns had been got great progressive, the burn wound healing remained challenging for the burn doctors so that the studies of application of Recombinant Human Epidermal Growth Factors (rhEGF made by Shenzhen Watsin ` ` Genetech Co. Ltd., PR China) was carried out to observe the effect used rhEGF on both the shallow¢oand deep¢odegree burn wound and granulation. And the result is effects and satisfactory, especially used the rhEGF on ¢o` degree burn. Wounds were supported by these studies. Method: One hundred and ninety-two patients suffering from burn injuries admitted in Second Hospital of Shen Zhen, Guangdong, PR China from January 2004 to December 2005 was divided randomly into two groups: group 1 of rhEGF treatment study and group 2 as the auto-control. The wounds in group 1 were treated with mist spray of 400 IU/10 cm2 of rhEGF and 1% sulfadiazine silver cream for 2–4 times each day while the cases of group 2 were treated with 1% sulfadiazine silver only. Of two groups the healing time, the healing rate after treating and effects were observed and investigated at days of 7¡¢10¡¢14 and 18. ` ` Result: Of total 192 cases there were 64 superficial ¢odegree wounds, 76 deep ¢odegree wound sand 52 granulation wounds), 96 ` patients were of group 2, with 98 patients were group 1. The healing time of both superficial and deep ¢odegree burn wound and granulation in group 1 were shortened than that in group 2 (p < 0.01), were about 3–5 and 13 days compared with 6–8 and 21 days ` respectively. The healing rate was significantly difference in superficial ¢odegree wound and granulation wounds between two groups. In group 1, for 7¡¢10¡¢14 and 18 days were respectively higher than that of the control group (p < 0.01); Table 1. doi:10.1016/j.burns.2006.10.035
S13
to their function. Reconstruction of a complete burned palmar of the hand using an instep of the foot as innervated free fasciocutaneous flap. During seven years, we evaluated 168 burned hand that 36 palmar hand have involved. Five palmar hands have treated with free instep flap and seven hands with groin flap, four with abdominal flap, four with island radial forearm flap, three with ulnar flap, seven with posterior interosseous flap, three with skin graft and three with side finger flap. We have evaluated different methods and have found that the best results is using an instep of the resurface palmar of the hand. Foot as an innervated free fasciocutaneous flap for. doi:10.1016/j.burns.2006.10.033 Preventing donor of split skin scarring with epidermal grafting in people of Asia Zhu Z., Zhu M., Li W. Second Hospital of Shen Zhen, PR China E-mail address: [email protected] (Z. Zhu). Although split thickness skin grafting has been a very common technique used in the fields of plastical surgery and other surgeries, the harvesting of the split skin did leave ugly scar disfigurement on the donor area especially for people of yellow color of Asia. Unfortunately this matter was ignored somehow while paid all attention to the survival of skin transplantation on grafting bed. This paper introduces a new technique of preventing split skin donor sites from scarring with large sheets of epidermal grafts, which thickness was from 0.0028 in. to 0.0048 in. harvested using the electric or airpower dermatome without scar left in the donor sites. The split skin of thickness ranging from 0.012 in. to 0.020 in. were harvested by drum-dermatome or electric power dermatome rarely. The edge of the epidermis sheet covered the donor of split skin attached together with the verges of the donor wound using nanoparticles-Ag gauze stripe adding sutures of 5–0 threads or skin stapler. Both the epidermal grafted area and epidermal donor area were dressed with vaseline gauzes in the inner layer and the nanoparticles Ag gauze on the outer surfaces. This technique of epidermal harvesting and grafting was used for 209 donor sites of both split skin and epidermal sheet for 133 reconstructed sites of 118 cases which suffered from scar deformities in the face, neck, trunk and extremities that admitted to the Center of Plastic Surgery & Burns, Second Hospital, Shen Zhen, PR China from November 1999 to November 2003. Favorably and near normal skin appearance was obtained in the epidermal grafting on the split skin donor area without scarring healing in the epidermal donor area also. doi:10.1016/j.burns.2006.10.034 Application of the rhEGF on burn wounds Zhang L. a,b , Li X. a,b , Wing C. a,b , Xie S. a,b a
Second Hospital of Shen Zhen, PR China Shen Zhen Watsin Genetech Ltd., PR China E-mail address: [email protected] (L. Zhang).
b
Although the treatment of burns had been got great progressive, the burn wound healing remained challenging for the burn doctors so that the studies of application of Recombinant Human Epidermal Growth Factors (rhEGF made by Shenzhen Watsin ` ` Genetech Co. Ltd., PR China) was carried out to observe the effect used rhEGF on both the shallow¢oand deep¢odegree burn wound and granulation. And the result is effects and satisfactory, especially used the rhEGF on ¢o` degree burn. Wounds were supported by these studies. Method: One hundred and ninety-two patients suffering from burn injuries admitted in Second Hospital of Shen Zhen, Guangdong, PR China from January 2004 to December 2005 was divided randomly into two groups: group 1 of rhEGF treatment study and group 2 as the auto-control. The wounds in group 1 were treated with mist spray of 400 IU/10 cm2 of rhEGF and 1% sulfadiazine silver cream for 2–4 times each day while the cases of group 2 were treated with 1% sulfadiazine silver only. Of two groups the healing time, the healing rate after treating and effects were observed and investigated at days of 7¡¢10¡¢14 and 18. ` ` Result: Of total 192 cases there were 64 superficial ¢odegree wounds, 76 deep ¢odegree wound sand 52 granulation wounds), 96 ` patients were of group 2, with 98 patients were group 1. The healing time of both superficial and deep ¢odegree burn wound and granulation in group 1 were shortened than that in group 2 (p < 0.01), were about 3–5 and 13 days compared with 6–8 and 21 days ` respectively. The healing rate was significantly difference in superficial ¢odegree wound and granulation wounds between two groups. In group 1, for 7¡¢10¡¢14 and 18 days were respectively higher than that of the control group (p < 0.01); Table 1. doi:10.1016/j.burns.2006.10.035