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APSC2015-1121 Reverse Effect of S-Amlodipine on Microalbuminuria in Patients With Poorly-Controlled Blood Pressure
ORAL ABSTRACTS
Results: The mean age of the study cohort was 57.2 10.6 years (55% males). Fifty-six patients (56%) had significant CAD by coronary angiography, of whom 28 (28%) had single-vessel CAD, and 28 (28%) had multi-vessel CAD. ROC curve analysis showed that the optimal cutoff value of stress-induced LAVI that best discriminates significant CAD was 30.1 ml/m2. Using this cutoff value, significant CAD was identified with a sensitivity of 85.7%, specificity 95.5%, PPV 96%, and NPV 84%. The optimal cutoff value of stressinduced LAVI that best discriminates multi-vessel CAD was 32.7 ml/m2. Using this cutoff value, multi-vessel CAD was identified with a sensitivity of 88.7%, specificity 96.5%, PPV 97%, and NPV 89%. Conclusion: In symptomatic patients who underwent DSE for suspected CAD and had no resting WMA, stress-induced LAVI predicted angiographically significant CAD with acceptable sensitivity and high specificity; and predicted multi-vessel CAD with high sensitivity and specificity. Disclosure of Interest: None Declared Keywords: Dobutamine Stress Echocardiography; Left Atrial Volume Index; Coronary Artery Disease
Results: From 65 patients, 35 patients were successfully followed up. Description of the research result: the mean METs using Cahalin Equation, Primary PCI group was 4,20 (0,47) and pharmacological therapy group was 4,32 (0,43). Data analyzed with T test and showed that the mean difference between the two groups was not significant. Discussion: Based on these results it can be concluded that the functional capacity in STEMI patients who treated with Primary PCI performed no better result than pharmacological therapy. Disclosure of Interest: None Declared Keywords: 6MWT, Functional Capacity, STEMI APSC2015-1121 Reverse Effect of S-Amlodipine on Microalbuminuria in Patients With Poorly-Controlled Blood Pressure Yuanyaun Chen*1, zhiyi ma1 1 Hypertension Clinic, Peking University People’s Hospital, Beijing, China
APSC2015-1075
Objective: To observe the reverse effect of different combined regimens on blood pressure and microalbuminuria in hypertensive patients. Methods: Ninety-four hypertensive patients with blood pressure>140/90 mmHg (1 mmHg¼0.133 kPa) and positive microalbuminuria after treatment with inhibitors of angiotensin invertase and antagonists of angiotensin II receptor were included in this study. The patients were randomly divided into S-amlodipine group (n¼52) and diuretics ((hydrochlorothiazide) group (n¼42). After the patients were treated with S-amlodipine (2.5-5 mg/d) and hydrochlorothiazide (12.5-25mg/d) respectively for 12 weeks，the reverse effect of different regimens on blood pressure and microalbuminuria was observed. Results: The normal blood pressure was achieved in 35(67.3%) and 27 patients (64.3%) respectively (P>0.05), the negative microalbuminuria rate was 53.8% and 19.0% respectively (P<0.01), the blood pressure was<140/90 mmHg and the microalbuminuria was30% in 80.8% and 64.3% of the patients in the two groups 12 weeks after treatment(P<0.05). Conclusion: The effect of renin and angiotensin blocking agents in combination with calcium antagonists or hydrochlorothiazide is similar to that of other regimens on blood pressure and other parameters， and is better than that of renin and angiotensin blocking agents in combination with hydrochlorothiazide on microalbuminuria. It shows that the combination of renin and angiotensin blocking agents and calcium antagonists (including S-amlodipine) is suitable for hypertensive patients with microalbuminuria. Disclosure of Interest: None Declared Keywords: Microalbuminuria, S-amlodipine
Bicuspid Aortic Valve in Qatar 1
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3
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Nazar Mohammed* , Shady Mohammed , Magdi Yacoub , Sherif Helmy , Cornelia S. Carr , Abdulaziz M. Alkhulaifi4 1 cardiology, Hamad Medical Corportation. Heart hospital, 2Cardiac surgery, Hamad Medical Corporation, 3Cardiac surgery, Qatar Foundation, 4Cardiac surgery, Hamad Medical Corportation. Heart hospital, Doha, Qatar Background: Bicuspid Aortic Valve (BAV) is the commonest cardiac anomaly (1% of the population), with differing phenotypes, and most patients will require surgery in their lifetime. We studied patients with BAV in terms of demographics, valve phenotype, valve dysfunction, ejection fraction and aortic dilatation. Methods: BAV patients were identified from an existing echocardiography database in Qatar. The echocardiograms were assessed for phenotype, aortic dilatation, ejection fraction and degree of valvular dysfunction. Associated conditions such as coarctation were also noted. Results: 128 BAV patients were identified (September 2011 to August 2014), with 108 males (84%) and 20 females (16%), with age range 16 to 74 years (median 47, mean 45). The phenotypes were 64 horizontal (right-left) and 64 vertical (right-non coronary). Males had 50% horizontal and 50% vertical compared to females 40% horizontal and 60% vertical. 25% had significant (moderate and above) stenosis and 50% had no evidence of stenosis. 21% had significant regurgitation and 50% had no evidence of regurgitation. The left ventricular ejection fractions were 83% good, 14% moderate and 3% poor. 40% of the BAV patients had aortic dilatation, (vertical 44% dilated, horizontal 37% dilated). There were 8coarctations, (4vertical, 4 horizontal). Conclusion: BAV patients in Qatar are predominantly male with similar numbers of horizontal and vertical phenotypes, with similar degrees of stenosis and regurgitation. 50% of patients had no valvular dysfuction. Poor left ventricular ejection fraction was rare at presentation. Aortic dilatation was slightly more common in the vertical group and 8 coarctations were seen. BAV is a common cardiac anomaly that is likely to require cardiac surgery and study in an Asian population has not previously been performed and we intend to expand our cohort further. Disclosure of Interest: None Declared Keywords: Aortic Dilatation, Aortic Valve, Bicuspid
APSC2015-1125 A Review of Outcome Following Valve Surgery for Rheumatic Heart Disease in Australia Elizabeth A. Russell*1, Graeme Maguire2 1 School of Public Health and Preventive Medicine, Monash University, 2Clinical Research, Baker IDI, Melbourne, Australia Background: Globally, rheumatic heart disease (RHD) remains an important cause of heart disease. In Australia it particularly affects older non-Indigenous Australians and Aboriginal Australians and Torres Strait Islander peoples. Despite its impact there is limited understanding of the factors influencing outcome following surgery for RHD. Methods: The Australian and New Zealand Society of Cardiac and Thoracic Surgeons Cardiac Surgery Database was analysed for outcome following RHD and non-RHD surgery.
APSC2015-1081 Comparison of Functional Capacity Using Primary PCI With Pharmacological Therapy on Stemi Patients Andini N. Wardhani*1, Chaerul Achmad2, Sunaryo B. Sastradimaja3 1 Faculty of Medicine, 2Cardiology and Vascular Medicine, 3Physical Medicine and Rehabilitation, Padjadjaran University, Bandung, Indonesia Background: Acute Coronary Syndrome is a shift manifestations pattern of ischemic myocardium include angina pectoris then developed into myocardial infarction. Myocardial infarction needs an accurate procedure to reopen the coronary vessels which were blocked. Revascularization either with Primary PCI or pharmacological therapy is a treatment option for STEMI patients. Medical evaluation, especially direct measurement upon physical and functional capacity evaluation is important to medically determine the stability of the patient’s condition. Unfortunately, there hasn’t been a lot of data to evaluate the functional capacity of STEMI patients. This study aims to compare functional capacity in STEMI patients who are treated with Primary PCI and pharmacological therapy. Methods: This study used cross sectional design. Total sampling data were obtained from STEMI patients who had treatment after two years therapy and instructed to implement six minute walking test (6MWT) which will measure the maximal or submaximal capacity to know patient’s fitness level or aerobic capability using height, weight, age, and gender as well as length of the track as the predictor factors. This method is one of the objective methods to measure functional capacity which was proven to show significant correlation between best walk distance with the results of the functional capacity.
e2
GHEART Vol 10/2S/2015
j
June, 2015
j
ORAL/20th Asian Pacific Society Cardiology Congress Orals
Results: The mean age of the study cohort was 57.2 10.6 years (55% males). Fifty-six patients (56%) had significant CAD by coronary angiography, of whom 28 (28%) had single-vessel CAD, and 28 (28%) had multi-vessel CAD. ROC curve analysis showed that the optimal cutoff value of stress-induced LAVI that best discriminates significant CAD was 30.1 ml/m2. Using this cutoff value, significant CAD was identified with a sensitivity of 85.7%, specificity 95.5%, PPV 96%, and NPV 84%. The optimal cutoff value of stressinduced LAVI that best discriminates multi-vessel CAD was 32.7 ml/m2. Using this cutoff value, multi-vessel CAD was identified with a sensitivity of 88.7%, specificity 96.5%, PPV 97%, and NPV 89%. Conclusion: In symptomatic patients who underwent DSE for suspected CAD and had no resting WMA, stress-induced LAVI predicted angiographically significant CAD with acceptable sensitivity and high specificity; and predicted multi-vessel CAD with high sensitivity and specificity. Disclosure of Interest: None Declared Keywords: Dobutamine Stress Echocardiography; Left Atrial Volume Index; Coronary Artery Disease
Results: From 65 patients, 35 patients were successfully followed up. Description of the research result: the mean METs using Cahalin Equation, Primary PCI group was 4,20 (0,47) and pharmacological therapy group was 4,32 (0,43). Data analyzed with T test and showed that the mean difference between the two groups was not significant. Discussion: Based on these results it can be concluded that the functional capacity in STEMI patients who treated with Primary PCI performed no better result than pharmacological therapy. Disclosure of Interest: None Declared Keywords: 6MWT, Functional Capacity, STEMI APSC2015-1121 Reverse Effect of S-Amlodipine on Microalbuminuria in Patients With Poorly-Controlled Blood Pressure Yuanyaun Chen*1, zhiyi ma1 1 Hypertension Clinic, Peking University People’s Hospital, Beijing, China
APSC2015-1075
Objective: To observe the reverse effect of different combined regimens on blood pressure and microalbuminuria in hypertensive patients. Methods: Ninety-four hypertensive patients with blood pressure>140/90 mmHg (1 mmHg¼0.133 kPa) and positive microalbuminuria after treatment with inhibitors of angiotensin invertase and antagonists of angiotensin II receptor were included in this study. The patients were randomly divided into S-amlodipine group (n¼52) and diuretics ((hydrochlorothiazide) group (n¼42). After the patients were treated with S-amlodipine (2.5-5 mg/d) and hydrochlorothiazide (12.5-25mg/d) respectively for 12 weeks，the reverse effect of different regimens on blood pressure and microalbuminuria was observed. Results: The normal blood pressure was achieved in 35(67.3%) and 27 patients (64.3%) respectively (P>0.05), the negative microalbuminuria rate was 53.8% and 19.0% respectively (P<0.01), the blood pressure was<140/90 mmHg and the microalbuminuria was30% in 80.8% and 64.3% of the patients in the two groups 12 weeks after treatment(P<0.05). Conclusion: The effect of renin and angiotensin blocking agents in combination with calcium antagonists or hydrochlorothiazide is similar to that of other regimens on blood pressure and other parameters， and is better than that of renin and angiotensin blocking agents in combination with hydrochlorothiazide on microalbuminuria. It shows that the combination of renin and angiotensin blocking agents and calcium antagonists (including S-amlodipine) is suitable for hypertensive patients with microalbuminuria. Disclosure of Interest: None Declared Keywords: Microalbuminuria, S-amlodipine
Bicuspid Aortic Valve in Qatar 1
2
3
1
4
Nazar Mohammed* , Shady Mohammed , Magdi Yacoub , Sherif Helmy , Cornelia S. Carr , Abdulaziz M. Alkhulaifi4 1 cardiology, Hamad Medical Corportation. Heart hospital, 2Cardiac surgery, Hamad Medical Corporation, 3Cardiac surgery, Qatar Foundation, 4Cardiac surgery, Hamad Medical Corportation. Heart hospital, Doha, Qatar Background: Bicuspid Aortic Valve (BAV) is the commonest cardiac anomaly (1% of the population), with differing phenotypes, and most patients will require surgery in their lifetime. We studied patients with BAV in terms of demographics, valve phenotype, valve dysfunction, ejection fraction and aortic dilatation. Methods: BAV patients were identified from an existing echocardiography database in Qatar. The echocardiograms were assessed for phenotype, aortic dilatation, ejection fraction and degree of valvular dysfunction. Associated conditions such as coarctation were also noted. Results: 128 BAV patients were identified (September 2011 to August 2014), with 108 males (84%) and 20 females (16%), with age range 16 to 74 years (median 47, mean 45). The phenotypes were 64 horizontal (right-left) and 64 vertical (right-non coronary). Males had 50% horizontal and 50% vertical compared to females 40% horizontal and 60% vertical. 25% had significant (moderate and above) stenosis and 50% had no evidence of stenosis. 21% had significant regurgitation and 50% had no evidence of regurgitation. The left ventricular ejection fractions were 83% good, 14% moderate and 3% poor. 40% of the BAV patients had aortic dilatation, (vertical 44% dilated, horizontal 37% dilated). There were 8coarctations, (4vertical, 4 horizontal). Conclusion: BAV patients in Qatar are predominantly male with similar numbers of horizontal and vertical phenotypes, with similar degrees of stenosis and regurgitation. 50% of patients had no valvular dysfuction. Poor left ventricular ejection fraction was rare at presentation. Aortic dilatation was slightly more common in the vertical group and 8 coarctations were seen. BAV is a common cardiac anomaly that is likely to require cardiac surgery and study in an Asian population has not previously been performed and we intend to expand our cohort further. Disclosure of Interest: None Declared Keywords: Aortic Dilatation, Aortic Valve, Bicuspid
APSC2015-1125 A Review of Outcome Following Valve Surgery for Rheumatic Heart Disease in Australia Elizabeth A. Russell*1, Graeme Maguire2 1 School of Public Health and Preventive Medicine, Monash University, 2Clinical Research, Baker IDI, Melbourne, Australia Background: Globally, rheumatic heart disease (RHD) remains an important cause of heart disease. In Australia it particularly affects older non-Indigenous Australians and Aboriginal Australians and Torres Strait Islander peoples. Despite its impact there is limited understanding of the factors influencing outcome following surgery for RHD. Methods: The Australian and New Zealand Society of Cardiac and Thoracic Surgeons Cardiac Surgery Database was analysed for outcome following RHD and non-RHD surgery.
APSC2015-1081 Comparison of Functional Capacity Using Primary PCI With Pharmacological Therapy on Stemi Patients Andini N. Wardhani*1, Chaerul Achmad2, Sunaryo B. Sastradimaja3 1 Faculty of Medicine, 2Cardiology and Vascular Medicine, 3Physical Medicine and Rehabilitation, Padjadjaran University, Bandung, Indonesia Background: Acute Coronary Syndrome is a shift manifestations pattern of ischemic myocardium include angina pectoris then developed into myocardial infarction. Myocardial infarction needs an accurate procedure to reopen the coronary vessels which were blocked. Revascularization either with Primary PCI or pharmacological therapy is a treatment option for STEMI patients. Medical evaluation, especially direct measurement upon physical and functional capacity evaluation is important to medically determine the stability of the patient’s condition. Unfortunately, there hasn’t been a lot of data to evaluate the functional capacity of STEMI patients. This study aims to compare functional capacity in STEMI patients who are treated with Primary PCI and pharmacological therapy. Methods: This study used cross sectional design. Total sampling data were obtained from STEMI patients who had treatment after two years therapy and instructed to implement six minute walking test (6MWT) which will measure the maximal or submaximal capacity to know patient’s fitness level or aerobic capability using height, weight, age, and gender as well as length of the track as the predictor factors. This method is one of the objective methods to measure functional capacity which was proven to show significant correlation between best walk distance with the results of the functional capacity.
e2
GHEART Vol 10/2S/2015
j
June, 2015
j
ORAL/20th Asian Pacific Society Cardiology Congress Orals