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ARE THE IMPROVEMENTS IN LIPID PARAMETERS AFTER GASTRIC BANDING DURABLE IN THE LONG-TERM: FIVE YEARS OF FOLLOW-UP
E1426 JACC March 12, 2013 Volume 61, Issue 10
Prevention Are the Improvements in Lipid Parameters after Gastric Banding Durable in the LongTerm: Five Years of Follow-Up Poster Contributions Poster Sessions, Expo North Sunday, March 10, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Prevention: Obesity, Hepatic Steatosis Abstract Category: 24. Prevention: Clinical Presentation Number: 1231-3 Authors: Amita Singh, Sean Heffron, Jonathan Zagzag, Heekoung Youn, George Fielding, Christine Ren-Fielding, James Underberg, NYU Langone Medical Center, New York, NY, USA Background: Bariatric surgery has become an increasingly utilized treatment for obesity, with short-term trials suggesting improvements in cardiovascular risk factors, including lipid profile. However, the longterm sustainability of these results are less clear. Methods: Fifty patients with BMI of 30-40 who underwent laparoscopic gastric banding (LGB) were followed for five years, with measurement of lipids and anthropometrics at baseline and annual followup. Results: Of 50 subjects included for analysis, subjects were predominantly women (96%), with a mean age of 43.8 years and mean BMI 35.1. BMI was significantly reduced at five years (mean 27.9+/-4.1, p= 0.003), as was waist circumference (p< 0.001). There was significant improvement in total cholesterol, LDL-C, triglycerides (TG) and HDL-C at year one and two (P<0.001). At five years there was only significant reduction in TG (153.9 vs. 104.9) and HDL-C (56 vs. 70.2). [see figure]Lipid changes did not correlate with % loss BMI or waist circumference. Subjects with the metabolic syndrome (MetS) had greater relative change in TG (-28.6% vs. -34.4%) and HDL-C(+20.9% vs. +34.3%) than those without MetS at five years (P<0.002). Conclusions: Obese subjects undergoing LGB have significant improvement in lipids, including reduced TG and increased HDL-C, which persist for at least 5 years, with greater benefit in those with MetS. Despite significant sustained weight loss, there was no significant decrease in total cholesterol and LDL-C.
Prevention Are the Improvements in Lipid Parameters after Gastric Banding Durable in the LongTerm: Five Years of Follow-Up Poster Contributions Poster Sessions, Expo North Sunday, March 10, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Prevention: Obesity, Hepatic Steatosis Abstract Category: 24. Prevention: Clinical Presentation Number: 1231-3 Authors: Amita Singh, Sean Heffron, Jonathan Zagzag, Heekoung Youn, George Fielding, Christine Ren-Fielding, James Underberg, NYU Langone Medical Center, New York, NY, USA Background: Bariatric surgery has become an increasingly utilized treatment for obesity, with short-term trials suggesting improvements in cardiovascular risk factors, including lipid profile. However, the longterm sustainability of these results are less clear. Methods: Fifty patients with BMI of 30-40 who underwent laparoscopic gastric banding (LGB) were followed for five years, with measurement of lipids and anthropometrics at baseline and annual followup. Results: Of 50 subjects included for analysis, subjects were predominantly women (96%), with a mean age of 43.8 years and mean BMI 35.1. BMI was significantly reduced at five years (mean 27.9+/-4.1, p= 0.003), as was waist circumference (p< 0.001). There was significant improvement in total cholesterol, LDL-C, triglycerides (TG) and HDL-C at year one and two (P<0.001). At five years there was only significant reduction in TG (153.9 vs. 104.9) and HDL-C (56 vs. 70.2). [see figure]Lipid changes did not correlate with % loss BMI or waist circumference. Subjects with the metabolic syndrome (MetS) had greater relative change in TG (-28.6% vs. -34.4%) and HDL-C(+20.9% vs. +34.3%) than those without MetS at five years (P<0.002). Conclusions: Obese subjects undergoing LGB have significant improvement in lipids, including reduced TG and increased HDL-C, which persist for at least 5 years, with greater benefit in those with MetS. Despite significant sustained weight loss, there was no significant decrease in total cholesterol and LDL-C.