Argentaffinoma as Endocrine Tumour

Argentaffinoma as Endocrine Tumour

372 one there YBD=307 |>" " XBD=1710 XBD=1905 XBD=2177 XBD=2614 XBD=2709 XBD=2318 XHG=1478 XHG=1694 XHG=1791 XHG=1962 XHG=2375 XHG=2658 XHG=2233 YBD=2...

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372 one there YBD=307 |>" " XBD=1710 XBD=1905 XBD=2177 XBD=2614 XBD=2709 XBD=2318 XHG=1478 XHG=1694 XHG=1791 XHG=1962 XHG=2375 XHG=2658 XHG=2233 YBD=294 YBD=308 YBD=307 YHG=272>followed, YHG=273>5 YHG=274>Both YHG=275>scrotonin YHG=273>enteramine YHG=285>are YHG=274>and children, emerged dominating factor—the of the mother. If she failed her children capacity " XBD=2029 XHG=1479 YBD=369 YHG=323>5-hydroxy-tryptamine If she coped with life skilfully and pluckily, she suffered. In spite of lapses and was a safeguard of their health.

:

failures the mother stands out as the cornerstone of the family structure, and our experience confirms that in all sections of society she remains the chief guardian of child welfare, a fact which is sometimes in danger of being forgotten. A family with a good mother can withstand a feckless or even a vicious father, but rarely can a family survive if the mother fails." XBD=1580 XBD=1810 XBD=1921 XBD=2063 XBD=2298 XBD=2435 XBD=2652 XBD=2709 XHG=1480 XHG=1616 XHG=1844 XHG=1956 XHG=2099 XHG=2333 XHG=2468 XHG=2678 YBD=692 YBD=691 YBD=702 YBD=693 YHG=657>This YHG=656>material YHG=657>has YHG=657>been YHG=657>detected YHG=657>with YHG=658>certainty YHG=659>in

" XBD=1668 XBD=1740 XBD=1830 XBD=2026 XBD=2097 XBD=2189 XBD=2331 XHG=1480 XHG=1691 XHG=1756 XHG=1853 XHG=2048 XHG=2114 XHG=2211 YBD=741 YBD=752 YHG=711>extracts YHG=707>of YHG=708>the YHG=717>mucosa YHG=706>of YHG=707>the YHG=707>dog’s " XBD=2709 XBD=2663 XHG=2561 YBD=742 YBD=743 YHG=707>6 and In theXHG=2679 of theYHG=710>in first year survey (when the National "|>"XBD=2709 XBD=2589 XBD=2645 XHG=2362 XHG=2607 XHG=2655 YBD=803 YBD=793 YBD=794 YHG=761>arguments YHG=758>of YHG=759>the XBD=1667 XBD=1736 XBD=1807 XBD=2213 XHG=1480 XHG=1688 XHG=1751 XHG=1825 YBD=803 YHG=761>extracts YHG=757>of YHG=769>an YHG=757>argentaffinoma. the Health Service had not begun) family doctor was " XBD=2707 XBD=1794 XBD=1873 XBD=1965 XBD=2139 XBD=2208 XBD=2300 XBD=2509 XBD=2566 XHG=1480 XHG=1815 XHG=1890 XHG=1985 XHG=2161 XHG=2224 XHG=2321 XHG=2527 YBD=842 YBD=853 YBD=843 YBD=844 YHG=808>histochemists YHG=820>on YHG=811>nature YHG=807>of YHG=808>the YHG=808>granules YHG=809>in YHG=811>enteroand called XHG=2584 of for 56% in 87% of these he illnesses, " XBD=2709 XBD=1728 XBD=1851 XBD=1963 XBD=2030 XBD=2457 XBD=2606 XHG=1480 XHG=1755 XHG=1877 XHG=1987 XHG=2057 XHG=2480 XHG=2626 YBD=892 YBD=903 YBD=893 YBD=894 YHG=858>chromaffin YHG=857>cells YHG=857>and YHG=859>in YHG=858>argentaffinomata YHG=858>would YHG=870>seem without treated the patient specialist or hospital help. " XBD=2709 XBD=1575 XBD=1647 XBD=1726 XBD=1970 XBD=2087 XBD=2309 XBD=2406 XBD=2484 XBD=2672 XHG=1479 XHG=1600 XHG=1673 XHG=1752 XHG=2013 XHG=2114 XHG=2336 XHG=2431 XHG=2509 XHG=2692 YBD=953 YBD=942 YBD=951 YBD=943 YHG=919>now YHG=911>to YHG=908>be YHG=908>settled YHG=908>the YHG=909>granules YHG=920>are YHG=919>an YHG=907>artefact, YHG=921>a 8 : admitted was the infant In only of the illnesses 5% " XBD=2709 XBD=1731 XBD=2005 XBD=2288 XBD=2537 XBD=2624 XHG=1478 XHG=1773 XHG=2048 XHG=2330 XHG=2574 XHG=2656 YBD=993 YBD=992 YBD=1003 YHG=957>fluorescent YHG=958>harmaline YHG=958>derivative YHG=960>the YHG=958>produced YHG=959>by to hospital, butYBD=994 maternal incompetence doubled the " XBD=2707 XBD=1735 XBD=1826 XBD=2385 XBD=2506 XHG=1480 XHG=1779 XHG=1861 XHG=2425 XHG=2542 YBD=1054 YBD=1043 YBD=1045 YHG=1009>interaction YHG=1008>of YHG=1008>5-hydroxy-tryptamine YHG=1008>and YHG=1007>formalin. likelihood of admission. Attendance at child-welfare " XBD=2710 XBD=1569 XBD=1913 XBD=1981 XBD=2068 XBD=2224 XBD=2485 XBD=2673 XHG=1481 XHG=1586 XHG=1934 XHG=1993 XHG=2084 XHG=2243 XHG=2502 YBD=1104 YHG=1061>is YBD=1103 YBD=1093 YBD=1094 YHG=1059>The YHG=1058>pharmacology YHG=1058>of YHG=1059>the YHG=1058>newly YHG=1059>discovered YHG=1059>hormone clinics XHG=2685 was disappointing : two-thirds of the infants " XBD=2710 XBD=1655 XBD=1798 XBD=2103 XBD=2167 XBD=2317 XBD=2531 XBD=2603 XBD=2678 XHG=1480 XHG=1674 XHG=1816 XHG=2122 XHG=2187 XHG=2340 XHG=2566 XHG=2619 XHG=2692 YBD=1154 YBD=1142 YBD=1153 YBD=1143 YBD=1144 YHG=1108>already YHG=1108>being YHG=1109>investigated YHG=1109>in YHG=1120>many YHG=1109>centres.9 YHG=1109>It YHG=1108>has YHG=1121>a were taken at least once in the first year, but only a " XBD=2710 XBD=1649 XBD=1959 XBD=2138 XBD=2229 XBD=2433 XBD=2618 XHG=1480 regularly. XHG=1684 XHG=1993 XHG=2173 XHG=2264 XHG=2467 XHG=2648 YBD=1204 YHG=1160>and YBD=1193 YBD=1200 YBD=1194 YHG=1159>general YHG=1159>constricting YHG=1159>action YHG=1170>on YHG=1158>smooth YHG=1160>muscle, fifth attended Mothers from good homes " XBD=2710 XBD=1528 XBD=1658 XBD=1726 XBD=1865 XBD=2046 XBD=2095 XBD=2420 XBD=2574 XBD=2640 XHG=1482 XHG=1551 XHG=1682 XHG=1749 XHG=1889 XHG=2069 XHG=2119 XHG=2443 XHG=2595 XHG=2658 YBD=1254 YBD=1243 YBD=1255 YBD=1244 YBD=1245 YHG=1212>at YHG=1208>least YHG=1210>in YHG=1220>some YHG=1210>species YHG=1220>a YHG=1209>hypertensive YHG=1210>action YHG=1220>on YHG=1210>the were the most frequent attenders, and those most in " XBD=2708 XBD=1681 XBD=1963 XBD=2080 XBD=2325 XBD=2443 XBD=2524 XBD=2618 XHG=1482 XHG=1713 XHG=1993 XHG=2113 XHG=2358 XHG=2475 XHG=2555 XHG=2644 YBD=1305 YBD=1294 YBD=1306 YHG=1260>systemic YHG=1259>circulation YHG=1259>and YHG=1260>probably YHG=1260>also YHG=1271>on YHG=1260>the YHG=1260>pulneed of advice and help were the least likely to go. " XBD=2710 XBD=1661 XBD=1978 XBD=2161 XBD=2249 XBD=2445 XHG=1482 XHG=1705 XHG=2039 XHG=2204 XHG=2292 YBD=1354 YBD=1351 YBD=1344 YBD=1343 YBD=1345 YHG=1321>monary YHG=1310>circulation YHG=1310>while YHG=1311>in YHG=1309>man YHG=1309>intradermal 10 ;everyThis isXHG=2484 the pattern of welfare-clinic attendance " XBD=2708 XBD=1686 XBD=1909 XBD=2033 XBD=2303 XBD=2407 XBD=2575 XHG=1481 XHG=1703 XHG=1929 XHG=2056 XHG=2322 XHG=2425 XHG=2591 YBD=1404 YBD=1395 YBD=1394 YBD=1405 YHG=1360>injection YHG=1360>produces YHG=1359>local YHG=1360>congestion YHG=1359>and YHG=1371>venous YHG=1367>spasm. it underlines the importance of selective where, and " XBD=2710 XBD=1776 XBD=1898 XBD=2076 XBD=2145 XBD=2257 XBD=2387 XBD=2460 XBD=2556 XBD=2643 XHG=1537byYBD=1445 XHG=1794 XHG=1915 XHG=2098 XHG=2164 XHG=2277 XHG=2405 XHG=2476 XHG=2572 XHG=2657 YBD=1455 YBD=1443 YBD=1444 YHG=1409>Seemingly YHG=1419>very YHG=1412>remote YHG=1413>at YHG=1409>first YHG=1409>from YHG=1409>all YHG=1410>this YHG=1421>was YHG=1409>the health visitors. home-visiting "|>"XBD=2710 XBD=1626 XBD=1763 XBD=1966 XBD=2037 XBD=2300 XBD=2347 XBD=2617 XBD=2222 XHG=1481 XHG=1652 XHG=1791 XHG=1992 XHG=2251 XHG=2322 XHG=2378 XHG=2637 XHG=2066 YBD=1505 YBD=1494 YBD=1493 YBD=1504 YBD=1495 YBD=1494 YHG=1463>report YHG=1459>from YHG=1459>Sweden YHG=1461>in YHG=1459>of YHG=1472>a YHG=1460>19-year-old YHG=1471>man YHG=1459>195211 The authors conclude with suggestions for improving " XBD=2714 XBD=1724 XBD=1852 XBD=2083 XBD=2195 XBD=2245 XBD=2374 XBD=2553 XBD=2662 XHG=1482 XHG=1747 XHG=1876 XHG=2109 XHG=2219 XHG=2270 XHG=2399 XHG=2574 XHG=2682 YBD=1556 YBD=1555 YBD=1554 YBD=1545 YBD=1544 YHG=1511>presenting YHG=1510>with YHG=1510>dyspnoea YHG=1510>and YHG=1522>a YHG=1521>very YHG=1511>curious YHG=1509>form YHG=1510>of the standard of child care in this country. In recom" XBD=2711 XBD=1703 XBD=1835 XBD=1949 XBD=2105 XBD=2320 XBD=2395 XBD=2517 XBD=2613 XHG=1484 XHG=1749 XHG=1864 XHG=1977 XHG=2133 XHG=2348 XHG=2421 XHG=2544 XHG=2635 YBD=1605 YHG=1560>with YBD=1594 YBD=1601 YBD=1595 YHG=1561>cyanosis YHG=1560>this YHG=1572>was YHG=1560>fairly YHG=1560>uniform YHG=1563>at YHG=1563>rest, YHG=1560>but ; of the medical curriculum mending reorganisation " XBD=2711 XBD=1674 XBD=1737 XBD=2012 XBD=2251 XBD=2294 XBD=2563 XHG=1482 XHG=1692 XHG=1756 XHG=2031 XHG=2269 XHG=2311 XHG=2578 YBD=1644 YBD=1645 YBD=1656 YHG=1611>exertion YHG=1622>or YHG=1611>excitement YHG=1610>exhibited YHG=1622>a YHG=1610>remarkable YHG=1613>pattern with closer attention to the needs of the family doctor, " XBD=2712 XBD=1530 XBD=1731 XBD=1977 XBD=2244 XBD=2422 XBD=2503 XHG=1483 XHG=1563 XHG=1771 XHG=2018 XHG=2283 XHG=2458 XHG=2537 YBD=1706 YBD=1696 YBD=1695 YHG=1660>of YHG=1661>rapidly YHG=1661>changing YHG=1661>coin-sized YHG=1661>bluish YHG=1672>or YHG=1661>vermilion out that a third of his patients are about they point "|>|>" XBD=1679 XBD=1981 XBD=2207 XBD=2711 XBD=2454 XHG=1483 XHG=1763 XHG=2035 XHG=2504 XHG=2261 YBD=1756 YBD=1745 YBD=1757 YBD=1745 YHG=1711>macules. YHG=1711>Necropsy YHG=1710>showed YHG=1711>pulmonary YHG=1711>valvular children and that a high of illnesses in proportion " XBD=2710 XBD=1688 XBD=1848 XBD=1957 XBD=2068 XBD=2150 XBD=2456 XBD=2565 XHG=1482 XHG=1729 XHG=1872 XHG=1981 XHG=2093 XHG=2171 XHG=2476 XHG=2585 YBD=1802 YBD=1797 YBD=1806 YBD=1795 YBD=1807 YHG=1762>stenosis YHG=1761>there YHG=1772>was YHG=1760>also YHG=1773>an YHG=1761>unsuspected YHG=1761>ileal YHG=1764>argent; like children are treated by him alone. They would " XBD=2712 XBD=1684 XHG=2680 XBD=1813 XBD=1944 XBD=2234 XBD=2381 XBD=2569 XBD=2660 XHG=1483 YBD=1845 XHG=1709 XHG=1838 XHG=1970 XHG=2292 XHG=2406 XHG=2591 YBD=1846 YHG=1811>affinoma YHG=1811>with YHG=1811>liver YHG=1815>metastases. YHG=1811>The YHG=1814>tumour YHG=1823>was YHG=1814>at wider recognition of the fact that infection in the first " XBD=2713 XBD=1580 XBD=1813 XBD=1896 XBD=2141 XBD=2472 XBD=2581 XBD=2647 XHG=1482 YBD=1895 XHG=1610 XHG=1851 XHG=1934 XHG=2182 XHG=2510 XHG=2611 XHG=2674 YBD=1898 YHG=1872>an YBD=1907 YBD=1908 YBD=1903 YBD=1896 YHG=1860>first YHG=1861>regarded YHG=1872>as YHG=1862>probably YHG=1861>coincidental, YHG=1862>but YHG=1862>in year of life is almost always an expression of family " XBD=2715 XBD=1728 XBD=1801 XBD=1904 XBD=2110 XBD=2286 XBD=2398 XBD=2542 XBD=2660 XHG=1482 XHG=1756 XHG=1830 XHG=1934 XHG=2139 XHG=2312 XHG=2427 XHG=2567 XHG=2683 YBD=1947 YBD=1945 YBD=1957 YBD=1946 YHG=1912>addendum YHG=1915>to YHG=1912>the YHG=1912>original YHG=1911>article YHG=1914>two YHG=1911>other YHG=1923>cases YHG=1910>of infection. They advise closer liaison between family " XBD=2713 XBD=1833 XBD=1969 XBD=2164 XBD=2449 XBD=2639 XHG=1484 XHG=1866 XHG=2000 XHG=2197 XHG=2478 XHG=2663 YBD=1997 YBD=1996 YBD=2007 YBD=1995 YHG=1962>argentaffinoma YHG=1962>with YHG=1961>related YHG=1962>circulatory YHG=1961>changes doctors and the staffs YHG=1972>are of local-authority health " XBD=2714 XBD=1631 XBD=1900 XBD=2141 XBD=2288 XBD=2484 XBD=2564 XHG=1483 XHG=1671 XHG=1970 XHG=2178 XHG=2324 XHG=2521 YBD=2047 YBD=2057 YHG=2011>briefly YHG=2012>described. YHG=2011>Several YHG=2011>local YHG=2015>reports YHG=2011>of servicesXHG=2594 : healthYBD=2046 visitors YHG=2011>similar would achieve a much more " XBD=2714 XBD=1597 XBD=1728 XBD=1972 XBD=2081 XBD=2128 XBD=2226 XBD=2426 XBD=2519 XBD=2620 XHG=1485 XHG=1617 XHG=1749 XHG=1995 XHG=2102 XHG=2147 XHG=2246 XHG=2445 XHG=2536 XHG=2635 YBD=2108 YBD=2097 YBD=2096 YHG=2074>cases YHG=2062>have YHG=2063>appeared, YHG=2062>and YHG=2074>a YHG=2061>full YHG=2065>account YHG=2062>has YHG=2073>now YHG=2062>been intimate relationship with families if they did more " XBD=2712 XBD=1859 XBD=1992 XBD=2054 XBD=2129 XBD=2256 XBD=2381 XBD=2492 XBD=2550 XHG=1786 XHG=1878 XHG=2009 XHG=2071 XHG=2145 XHG=2275 XHG=2398 XHG=2509 XHG=2565 YBD=2147 YBD=2146 YHG=2111>Six YHG=2124>cases YHG=2112>all YHG=2112>have YHG=2112>been YHG=2123>seen YHG=2113>in YHG=2111>Sweden, XBD=1740 XHG=1483 YBD=2158 YHG=2112>published. homeYBD=2152 children’s And finally they propose nursing. " XBD=2714 XBD=1569 XBD=1679 XBD=1828 XBD=1975 XBD=2120 XBD=2360 XBD=2502 XHG=1484 XHG=1603 XHG=1714 XHG=1866 XHG=2012 XHG=2157 XHG=2394 YBD=2197 YBD=2196 YBD=2207 YHG=2163>and YHG=2166>ten YHG=2174>cases YHG=2162>have YHG=2162>been YHG=2162>collected YHG=2161>from YHG=2160>published medical care that aXHG=2534 children’s council should be " XBD=2714 XBD=1659 XBD=1844 XBD=1912 XBD=2046 XBD=2183 XBD=2315 XBD=2637 XHG=1483 XHG=1711 XHG=1865 XHG=1926 XHG=2068 XHG=2203 XHG=2335 XHG=2652 YBD=2257 YBD=2247 YBD=2246 YBD=2245 YHG=2216>reports. YHG=2211>Series YHG=2212>of YHG=2213>three YHG=2223>cases YHG=2212>from YHG=2212>Switzerland YHG=2209>and 12 for regular consultation established in each area " XBD=2714 XBD=1568 XBD=1703 XBD=1972 XBD=2106 XBD=2463 XBD=2547 XBD=2609 XHG=1483 XHG=1592 XHG=1728 XHG=1994 XHG=2130 XHG=2483 XHG=2567 XHG=2628 YBD=2307 YBD=2296 YHG=2265>two YHG=2261>from YHG=2262>America YHG=2262>have YHG=2262>independently YHG=2261>led YHG=2265>to YHG=2271>more 13 between all concerned with the promotion of child " XBD=2713 XBD=1696 XBD=1992 XBD=2123 XBD=2242 XBD=2310 XBD=2368 XBD=2489 XHG=1484 YBD=2357 XHG=1728 XHG=2025 XHG=2155 XHG=2275 XHG=2342 XHG=2398 YBD=2345 YHG=2311>syndrome. YBD=2346 YHG=2313>tentative YHG=2312>suggestions YHG=2312>that YHG=2312>this YHG=2312>is YHG=2323>a YHG=2323>new health.XHG=2519

intestine The

1

" XBD=2715 XBD=1538 XHG=2638 XBD=1609 XBD=1745 XBD=1877 XBD=2013 XBD=2118 XBD=2192 XBD=2454 XBD=2626 XHG=1484 YBD=2396 XHG=1554 XHG=1625 XHG=1764 XHG=1894 XHG=2031 XHG=2135 XHG=2208 XHG=2468 YBD=2397 YHG=2360>with YHG=2362>In YHG=2362>all YHG=2362>these YHG=2373>cases YHG=2362>there YHG=2373>was YHG=2373>an YHG=2361>abdominal YHG=2365>tumour

" XBD=2715 XBD=1652 XBD=1956 XBD=2056 XBD=2141 XBD=2464 XBD=2570 XHG=1484 YBD=2447 XHG=1683 XHG=2004 XHG=2093 XHG=2278 XHG=2491 XHG=2595 YBD=2457asYHG=2412>known YBD=2458 YBD=2446 YHG=2412>hepatic YHG=2412>secondaries. YHG=2413>In YHG=2414>11 YHG=2413>primary YHG=2423>was Endocrine Tumour Argentaffinoma

the

" XBD=2713 XBD=1529 XHG=2510 XBD=1611 XBD=1699 XBD=1947 XBD=2202 XBD=2311 XBD=2384 XBD=2482 XHG=1484 YBD=2500 XHG=1559 XHG=1642 XHG=1728 XHG=1976 XHG=2225 XHG=2339 XHG=2411 YBD=2502 YHG=2462>remainder, YBD=2496 YHG=2464>to YHG=2462>be YHG=2473>an YHG=2462>intestinal YHG=2462>carcinoid, YHG=2461>and YHG=2462>in YHG=2461>the

" XBD=2713 XBD=615 XHG=632 XBD=888 XBD=1094 XBD=1194 XBD=1415 XBD=1528 XBD=1669 XBD=1748 XBD=1907 XBD=2235 XBD=2345 XBD=2474 XHG=177 XHG=901YBD=2557 XHG=1109 XHG=1204 XHG=1484 XHG=1556 XHG=1699 XHG=1772 XHG=1927 XHG=2258 XHG=2369 XHG=2491 YBD=2552 YBD=2551 YBD=2544YHG=2510>pulmonary YBD=2546 YBD=2556 YBD=2545 YBD=2557 YHG=2511>ARGENTAFFINOMA, YHG=2510>stenosis, YHG=2511>and YHG=2511>transient YHG=2511>in YHG=2514>most YHG=2510>of YHG=2511>which YHG=2511>investigation YHG=2511>had YHG=2511>been YHG=2511>incomplete, XBD=313 XHG=804 XBD=524 XBD=590 XBD=676 XBD=789 XBD=904 XBD=1036 XBD=1082 XBD=1209 XBD=1415 XHG=120 XHG=330 XHG=542 XHG=600 XHG=692 XHG=922YBD=2605 XHG=1057 XHG=1103 XHG=1225 YBD=2597 YBD=2606 YBD=2596 YBD=2595 YBD=2594 YBD=2593YHG=2571>may YBD=2606 YHG=2562>macular YHG=2562>cyanosis YHG=2560>of YHG=2562>the YHG=2561>skin YHG=2571>seem YHG=2572>a YHG=2572>very YHG=2561>unlikely " XBD=2715 XBD=1556 XBD=1784 XBD=1863 XBD=1985 XBD=2032 XBD=2227 XBD=2293 XBD=2384 XBD=2478 XBD=2542 XHG=1484 XHG=1587 XHG=1814 XHG=1883 XHG=2007 XHG=2051 XHG=2246 XHG=2311 XHG=2403 XHG=2497 XHG=2558 YBD=2607 YBD=2594 YBD=2596 YBD=2605 YBD=2595 YHG=2572>presence YHG=2561>of YHG=2562>such YHG=2571>a YHG=2563>tumour YHG=2561>in YHG=2561>the YHG=2563>gut YHG=2572>or YHG=2560>elswhere "|>"XBD=2717 XBD=1569 XBD=1633 XBD=1749 XBD=2093 XBD=2419 XHG=1484 XHG=1608 XHG=1671 XHG=1787 XHG=2141 XHG=2504 YBD=2644 YBD=2643 YBD=2646 YBD=2645 YBD=2656 YBD=2654 YHG=2621>was YHG=2622>a YHG=2607>not YHG=2611>unreasonable YHG=2611>assumption. YHG=2600>Pulmonary XBD=263 XBD=384 XBD=501 XBD=566 XBD=853 XBD=909 XBD=1120 XBD=1415 XBD=1414 XHG=119 XHG=310 XHG=415 XHG=532 XHG=597 XHG=883 XHG=939 XHG=1150 XHG=1400 YBD=2654 YBD=2656 YBD=2646 YBD=2645 YBD=2657 YBD=2644 YBD=2655 YBD=2655 YBD=2632 YHG=2613>triad YHG=2615>yet YHG=2611>this YHG=2612>is YHG=2609>apparently YHG=2622>a YHG=2610>genuine YHG=2610>syndrome, YHG=2611>I ; " XBD=2717 XBD=1661 XBD=1805 XBD=2090 XBD=2320 XBD=2421 XBD=2610 XHG=1484 XHG=1719 XHG=1873 XHG=2149 XHG=2377 XHG=2476 XHG=2654 YBD=2693YHG=2659>of YBD=2705 YBD=2695 YBD=2694 YHG=2660>stenosis YHG=2671>was YHG=2659>definitely YHG=2663>present YHG=2660>in YHG=2659>eleven YHG=2656>and XBD=207 XHG=880 XBD=264 XBD=572 XBD=703 XBD=850 XBD=929 XBD=1412 XHG=121 XHG=237 XHG=293 XHG=600 XHG=732 XHG=954YBD=2694 YBD=2696 YBD=2695 YBD=2705 YBD=2697 YBD=2706 YBD=2706 YHG=2662>and YHG=2674>a YHG=2661>particularly YHG=2664>neat YHG=2662>piece YHG=2659>clinico-pathologico" XBD=2717 XBD=1691 XBD=1867 XBD=1937 XBD=2083 XBD=2345 XBD=2468 XBD=2655 XHG=1486 XHG=1716 XHG=1892 XHG=1962 XHG=2143 XHG=2386 XHG=2507 XHG=2686 YBD=2744YHG=2710>is YBD=2742 YBD=2754 YBD=2743 YHG=2709>certainly YHG=2709>absent YHG=2710>in YHG=2720>none. YHG=2709>Cyanosis YHG=2719>was YHG=2711>present YHG=2709>in XBD=506 XHG=853 XBD=807 XBD=888 XBD=1151 XBD=1319 XBD=1415 XHG=120 XHG=555 XHG=938YBD=2744 XHG=1199 XHG=1358 YBD=2756 YBD=2745 YBD=2754 YHG=2711>pharmacological YHG=2711>correlation YHG=2710>emerging YHG=2709>from YHG=2711>its " XBD=2716 XBD=1552 XBD=1660 XBD=1734 XBD=1817 XBD=1959 XBD=2305 XBD=2443 XBD=2504 XBD=2575 XBD=2664 XHG=1484 XHG=1576 XHG=1690 XHG=1762 XHG=1848 XHG=1989 XHG=2334 XHG=2469 XHG=2531 XHG=2588 XHG=2685 YBD=2801 YBD=2793 YBD=2792 YHG=2759>all, YHG=2758>and YHG=2759>in YHG=2759>its YHG=2762>most YHG=2759>characteristic YHG=2758>form YHG=2759>it YHG=2759>isYHG=2758>said YHG=2761>to XBD=357 XHG=695 XBD=665 XBD=898 XBD=1002 XBD=1415 XHG=121 XHG=417 XHG=928YBD=2805 XHG=1031 YBD=2803 YBD=2793 YBD=2794YHG=2759>studying YHG=2760>discovery. YHG=2759>RAPPORT,2 YHG=2759>the YHG=2759>vasoconstrictive " XBD=2717 XBD=1653 XBD=1771 XBD=2025 XBD=2181 XBD=2404 XBD=2619 XBD=2687 XHG=1484 XHG=1695 XHG=1811 XHG=2066 XHG=2222 XHG=2444 XHG=2668 XHG=2700 YBD=2842 YBD=2843 YBD=2853 YBD=2852 YBD=2821 YBD=2841 YHG=2811>present YHG=2808>the YHG=2808>following YHG=2811>most YHG=2808>striking YHG=2808>picture: YHG=2807>&dquo; YHG=2817>a XBD=357 XHG=912 XBD=435 XBD=624 XBD=792 XBD=883 XBD=939 XBD=1144 XBD=1414 XHG=120 XHG=385 XHG=457 XHG=651 XHG=822 XHG=968YBD=2844 XHG=1176 YBD=2855 YBD=2845 YBD=2853 YBD=2850 YBD=2854YHG=2821>a YHG=2810>properties YHG=2809>of YHG=2811>normal YHG=2822>serum YHG=2810>(as YHG=2808>control, YHG=2809>originally, " XBD=2717 XBD=1627 XBD=1689 XBD=1811 XBD=1977 XBD=2117 XBD=2244 XBD=2460 XBD=2571 XHG=1485 XHG=1642 XHG=1707 XHG=1828 XHG=1991 XHG=2134 XHG=2260 XHG=2474 XHG=2585 YBD=2902 YBD=2899 YBD=2903 YBD=2892 YBD=2901 YHG=2857>bright YHG=2860>to YHG=2857>deep YHG=2858>purple YHG=2857>flush, YHG=2858>later YHG=2858>mingling YHG=2858>with YHG=2857>heavily XBD=187 XHG=747 XBD=233 XBD=475 XBD=639 XBD=727 XBD=996 XBD=1177 XBD=1243 XBD=1414 XHG=120 XHG=207 XHG=254 XHG=495 XHG=661 XHG=1016YBD=2904 XHG=1196 XHG=1260 YBD=2893 YBD=2895 YBD=2894 YBD=2894YHG=2860>circulating YBD=2904 YHG=2858>for YHG=2870>a YHG=2860>projected YHG=2861>search YHG=2859>for YHG=2859>factors YHG=2859>in YHG=2859>hyper" XBD=1416 XBD=323 XBD=535 XBD=606 XBD=739 XBD=793 XBD=1005 XBD=1171 XBD=1253 XHG=121 XHG=352 XHG=561 XHG=636 XHG=820 XHG=1032 XHG=1198 XHG=1281 YBD=2950 YBD=2943 YBD=2944 YBD=2944 YBD=2942 YBD=2943 YHG=2909>tension), YHG=2909>isolated YHG=2910>in YHG=2911>1948 YHG=2909>fraction YHG=2908>which YHG=2908>he YHG=2908>called XBD=1681XHG=768 XBD=1794 XBD=1949 XBD=2168 XBD=2283 XBD=2413 XBD=2591 XBD=2715 XHG=1485YBD=2944 XHG=1708 XHG=1820 XHG=1976 XHG=2196 XHG=2309 XHG=2438 XHG=2614 YBD=2952YHG=2922>a YHG=2908>cyanotic YHG=2907>white YHG=2907>blotches YHG=2907>and YHG=2918>very YHG=2907>intense YHG=2907>brickshown " XBD=352 XBD=509 XBD=620 XBD=897 XBD=976 XBD=1058 XBD=1224 XHG=121 XHG=409 XHG=535 XHG=809 XHG=1001 XHG=1082 XHG=1250 YBD=2992 YBD=2993 YBD=2995 YBD=2993 YHG=2958>serotonin. YHG=2958>This YHG=2970>was YHG=2959>3 YHG=2959>be YHG=2971>an YHG=2958>indole YHG=2958>derivato " XBD=1413 XBD=1559XHG=922 XBD=1716 XBD=1802 XBD=1877 XBD=2018 XBD=2292 XBD=2536 XBD=2637 XBD=2716 XHG=1484YBD=2994 XHG=1585 XHG=1747 XHG=1828 XHG=1898 XHG=2046 XHG=2323 XHG=2561 XHG=2657 YBD=2990 YBD=3002 YBD=3003 YBD=2991 YBD=2992 YHG=2956>red YHG=2960>spots, YHG=2956>all YHG=2956>of YHG=2958>these YHG=2958>appearing, YHG=2957>changing, YHG=2957>and YHG=2957>dis4 " XBD=2716 XBD=1758 XBD=1869 XBD=2016 XBD=2162 XBD=2311 XBD=2517 XBD=2637 XHG=1485 XHG=1815 XHG=1896 XHG=2046 XHG=2190 XHG=2341 XHG=2544 XHG=2658 YBD=3052 YBD=3040 YBD=3051 YBD=3041 YHG=3006>appearing.&dquo; YHG=3006>In YHG=3007>three YHG=3017>cases YHG=3007>these YHG=3007>changes YHG=3017>were YHG=3007>disXBD=225 XHG=681 XBD=404 XBD=596 XBD=662 XBD=755 XBD=1012 XBD=1309 XBD=1416 XHG=120 XHG=250 XHG=424 XHG=617 XHG=776YBD=3043 XHG=1059 XHG=1328 YBD=3048 YBD=3052 YBD=3051 YBD=3042 YBD=3054 YBD=3043YHG=3009>the YBD=3042 YHG=3007>tive, YHG=3007>chiefly YHG=3012>present YHG=3009>in YHG=3008>platelets.4 YHG=3008>ERSPAMER YHG=3008>had " XBD=1416 XBD=373 XBD=636 XBD=705 XBD=956 XBD=1139 XBD=1237 XHG=121 XHG=416 XHG=679 XHG=1000 XHG=1182 XHG=1282 YBD=3091 YBD=3090 YBD=3093 YBD=3092 YBD=3091 YHG=3056>meanwhile YHG=3056>identified YHG=3069>a YHG=3058>which YHG=3058>he YHG=3057>called XBD=1663XHG=748 XBD=1861 XBD=1936 XBD=2088 XBD=2194 XBD=2322 XBD=2396 XBD=2623 XBD=2684 XBD=2719 XHG=1484YBD=3099 XHG=1694 XHG=1889 XHG=1967 XHG=2120 XHG=2224 XHG=2350 XHG=2426 XHG=2646 XHG=2701 YBD=3101YHG=3058>material, YBD=3089 YBD=3100 YBD=3090 YBD=3087 YHG=3056>tinctive YHG=3056>enough YHG=3056>point YHG=3056>the YHG=3067>way YHG=3059>to YHG=3055>diagnosis YHG=3056>of YHG=3065>a " XBD=2719 XBD=1609 XBD=1710 XBD=2009 XHG=1485 XHG=1624 XHG=1724 XHG=2025 YBD=3141 YBD=3140 YBD=3149 YBD=3150 YHG=3104>silent YHG=3104>and YHG=3105>unsuspected YHG=3102>argentaffinoma-circumstantial XBD=399 XHG=759 XBD=621 XBD=712 XBD=985 XBD=1079 XBD=1200 XBD=1413 XHG=122 XHG=449 XHG=668 XHG=1032YBD=3142 XHG=1124 XHG=1249 YBD=3147 YBD=3151 YBD=3140 YBD=3142YHG=3107>mammals YHG=3106>enteramine, YHG=3110>present YHG=3107>in YHG=3109>in YHG=3108>the YHG=3110>entero" XBD=2717 XBD=1685 XBD=1770 XBD=1825 XBD=1967 XBD=2140 XBD=2330 XBD=2549 XBD=2636 XHG=1486 XHG=1721 XHG=1801 XHG=1862 XHG=2003 XHG=2177 XHG=2366 XHG=2580 XHG=2664 YBD=3188 YBD=3199 YBD=3200 YBD=3189 YBD=3190 YHG=3154>evidence YHG=3153>of YHG=3166>a YHG=3154>kind YHG=3155>which YHG=3154>speaks YHG=3155>strongly YHG=3154>for YHG=3155>the XBD=373 XHG=634 XBD=506 XBD=611 XBD=787 XBD=1070 XBD=1137 XBD=1234 XBD=1417 XHG=122 XHG=397 XHG=532 XHG=810YBD=3202 XHG=1092 XHG=1158 XHG=1256 YBD=3190 YBD=3196 YBD=3189 YBD=3192 YBD=3192YHG=3155>widely YBD=3191 YHG=3154>chromaffin YHG=3154>cells, YHG=3155>but YHG=3156>distributed YHG=3157>in YHG=3157>the YHG=3156>animal " XBD=1417 XBD=354 XHG=710 XBD=463 XBD=673 XBD=937 XBD=1079 XBD=1191 XHG=120 XHG=411 XHG=501 XHG=973YBD=3250 XHG=1115 XHG=1228 YBD=3238 YBD=3241 YBD=3240YHG=3206>especially YBD=3250 YHG=3205>kingdom YHG=3204>he YHG=3205>worked YHG=3208>with YHG=3207>the ; YHG=3207>salivary 5. Hamlin, K. E., Fischer, F. E. J. Amer. chem. Soc. 1951, 73, 5007. Erspamer, V., Asero, B. Nature, Lond. 1952, 169, 800. " XBD=1416 XBD=274 XHG=768 XBD=339 XBD=427 XBD=637 XBD=750 XBD=955 XBD=1078 XBD=1310 XHG=121 XHG=292 XHG=351 XHG=446 XHG=686 XHG=972YBD=3299 XHG=1095 XHG=1330 YBD=3288 YBD=3289 YBD=3298 YBD=3287 YBD=3289 YBD=3290YHG=3254>identity YBD=3289 YHG=3254>glands YHG=3254>of YHG=3255>the YHG=3257>octopus. YHG=3253>Its YHG=3256>with YHG=3256>serotonin YHG=3266>was 6. Dalgliesh, C. E., Toh, C. C., Work, T. S. J. Physiol. 1953, 120, 298. " XBD=1418 XBD=226 XHG=693 XBD=525 XBD=652 XBD=819 XBD=1065 XHG=121 XHG=265 XHG=567 XHG=861YBD=3337 XHG=1104 YBD=3338 YBD=3349 YBD=3338 YBD=3339YHG=3306>exact YHG=3315>soon YHG=3303>recognised, YHG=3303>and YHG=3304>chemical YHG=3304>identification 7. Lembeck, F. Nature, Lond. 1953, 172. 910. Thorson, Å., Biörck, G.. Björkman, G., Waldenström, J. Amer. Heart J. 1954, 47, 795. Rapport, M. M., Green, A. A., Page, J. H. J. biol. Chem. 1948, 174, 735. 3. Rapport, M. M. Ibid, 1949, 180, 461. 4. Rand, M., Reid, G. Nature, Lond. 1951. 168, 385. Humphrey, J. H., Toh, C. C. J. Physiol. 1954, 124, 300. 1.

2.

8. Barter, R., Pearse, A. G. E. Ibid, p. 810. 9. Woolley, D. W., Shaw, E. Brit. med. J. July 17, 1954, p. 122. 10. Reid, G., Rand, M. Lond. 1952, 169, 800. Nature, 11. Biörck, G., Axen, O., Thorson, Å. Amer. Heart J. 1952, 44, 143. 12. Isler, P., Hedinger, C. Schweiz. med. Wschr. 1953, 83, 5. 13. Rosenbaum, F. F. Santer, D. G., Claudon, D. B. J. Lab. clin. Med. 1953, 42, 941.

373 the syndrome. " XBD=2662 XBD=1410 XBD=1742 XBD=1802 XBD=2020 XBD=2256 XBD=2313 XBD=2399 XHG=1368 XHG=1424 XHG=1759 XHG=1816 XHG=2035 XHG=2271 XHG=2328 YBD=338 Altogether YBD=337 YBD=347 YHG=307>of it seems clear YHG=306>bronchospasm YHG=317>or YHG=305>increased YHG=305>exudation YHG=305>in YHG=305>the YHG=304>respiratory reality of XHG=2412 have established their case. "|>"XBD=2662 XBD=1488 XBD=1902 XBD=2219 XBD=2299 XBD=2523 XBD=1575 the Swedish XHG=1366 XHG=1615 XHG=1941 XHG=2257 XHG=2339 XHG=2562 XHG=1532 workers YBD=389 YBD=393 YBD=383 YBD=392 YBD=384 YBD=383 YHG=349>tract, YHG=351>precipitating YHG=351>heart-failure YHG=351>in YHG=352>patients YHG=350>with YHG=362>,.,0 that " XBD=2177 XBD=1530 XBD=1776 XBD=1881 XHG=1367 XHG=1555 XHG=1800 XHG=1903 YBD=428 YBD=429 YHG=398>chronic YHG=396>bronchitis YHG=398>and YHG=398>en-iphysema. theirYBD=438 What raises description above the level of " XBD=2659 XBD=1460 XBD=1587 XBD=1808 XBD=1941 XBD=2183 XBD=2479 XHG=1420 XHG=1503 XHG=1629 XHG=1848 XHG=1984 XHG=2225 XHG=2524 YBD=491 YBD=482 YBD=492 YBD=493 YBD=484 YHG=451>It YHG=461>was YHG=450>unlikely YHG=451>that YHG=451>anything YHG=452>unexpected the suggestion that the another syndrome isYHG=450>would "just " XBD=2659 XBD=1481 XBD=1604 XBD=1692 XBD=1976 XBD=2165 XBD=2266 XBD=2389 XHG=1366 XHG=1499 XHG=1621 XHG=1709 XHG=1991 XHG=2184 XHG=2282 XHG=2405 YBD=527 YBD=528 YBD=538 YBD=529 YHG=506>come YHG=497>from YHG=496>the YHG=496>committee’s YHG=496>inquiry, YHG=498>and YHG=497>their YHG=498>conclusions of hypersecretion of are YBD=530 the result vascular lesions " XBD=2661 XBD=1518 XHG=2578 XBD=1718 XBD=1866 XBD=1939 XBD=2108 XBD=2395 XBD=2546 XHG=1365 YBD=576 XHG=1553 XHG=1749 XHG=1897 XHG=1970 XHG=2140 XHG=2459 YBD=583 YHG=544>this YBD=573 YBD=574 YBD=575 YHG=542>largely YHG=542>confirm YHG=542>those YHG=542>of YHG=542>earlier YHG=542>discussions. YHG=545>But "

tumour. It seems highly by theYHG=599>new 5-hydroxy-tryptamine " XBD=2546 XBD=2662 XBD=1518 XBD=1722 XBD=1792 XBD=1887 XBD=2018 XBD=2122 XBD=2262 XBD=2334 XBD=2386 XHG=1367 XHG=1547 XHG=1750 XHG=1816 XHG=1912 XHG=2043 XHG=2149 XHG=2289 XHG=2362 XHG=2412 XHG=2574 YBD=618 YBD=627 YBD=619 YBD=620 YBD=621 YBD=622 YHG=581>careful YHG=587>analysis YHG=588>of YHG=588>the YHG=588>facts YHG=588>will YHG=598>serve YHG=598>as YHG=599>a YHG=589>useful is this well founded. Proof should be that probable XHG=2364 " XBD=2663 XBD=1470 XBD=1527 XBD=1633 XBD=1708 XBD=1898 XBD=1964 XBD=2132 XBD=2226 XBD=2340 XBD=2427 XHG=2449 XHG=1366 XHG=1496 XHG=1554 XHG=1658 XHG=1733 XHG=1922 XHG=1989 XHG=2155 XHG=2250 YBD=668 YBD=663 YBD=672 YBD=664 YBD=670 YBD=665 YBD=676 YBD=666 YBD=677 YHG=634>text, YHG=632>if YHG=642>any YHG=632>be YHG=634>needed, YHG=633>in YHG=634>urging YHG=635>the YHG=644>case YHG=635>for YHG=635>purifying is a There well-established obtainableXHG=1679 fairly easily. " XBD=1805 XBD=1437 XBD=1513 XBD=1573 XBD=1662 XHG=1366 XHG=1455 XHG=1532 XHG=1589 YBD=709 YHG=678>cities. YBD=710 YHG=678>the YHG=677>air YHG=678>of YHG=687>our of route of breakdown tryptophane via 5-hydroxytryptamine to 5-hydroxy-indole-acetic acid, which is excreted in the urine. In patients producing an excess of a raised excretion of this acid should be the amine,XHG=2564 "|>"XBD=2658 XBD=1752 XBD=1891 XBD=2034 XBD=2095 XBD=2323 XBD=2470 XBD=2535 XBD=1616 XHG=1649 XHG=1781 XHG=1920 XHG=2062 XHG=2124 XHG=2352 XHG=2501 XHG=1420YBD=922 YBD=910 YBD=911 YBD=921 YBD=918 YBD=912 YBD=910YHG=891>any, YHG=879>after YHG=878>birth YHG=879>there YHG=879>is YHG=880>normally YHG=880>little, YHG=881>if YHG=879>SHORTLY excessYHG=926>factors excretion has already Some demonstrable. " XBD=2660 XBD=1599 XBD=1804 XBD=1902 XBD=2077 XBD=2336 XBD=2478 XHG=1367 XHG=1628 XHG=1832 XHG=1932 XHG=2107 XHG=2392 XHG=2507 YBD=965 YBD=956 YBD=957 YBD=958 YHG=923>blood-flow YHG=924>through YHG=925>the YHG=925>ductus YHG=925>arteriosus. YHG=926>The with various forms of been demonstrated " XBD=2660 XBD=1547 XBD=1807 XBD=1885 XBD=2043 XBD=2101 XBD=2187 XBD=2352 XBD=2413 XBD=2538 XHG=1365 in XHG=1566 XHG=1822 XHG=1900 XHG=2060 XHG=2117 XHG=2206 XHG=2368 XHG=2431 XHG=2554 YBD=1011 YBD=1002 YBD=1003 YBD=1004 YHG=970>possibly YHG=964>accounting YHG=970>for YHG=971>failure YHG=971>of YHG=971>the YHG=971>ductus YHG=973>to YHG=972>close patientsYHG=972>have be especially it should "|>"XBD=2659 XBD=1466 XBD=1680 XBD=1750 XBD=1922 XBD=2022 XBD=2515 XBD=2573 XBD=2291XHG=2590 XHG=1366 XHG=1483 XHG=1696 XHG=1770 XHG=1942 XHG=2322 XHG=2532 YBD=1057 YBD=1058 YBD=1048 YBD=1049 YBD=1049 YHG=1017>been YHG=1016>reviewed YHG=1017>by YHG=1016>Record YHG=1016>and YHG=1016>Eldridge YHG=1019>et YHG=1017>al.2 YHG=1017>JB1cKeown.1 cancer,14 butXHG=2038 high in this "|>"XBD=2659 XBD=1781 XBD=2043 XBD=2248 XBD=2311 XBD=2402 XBD=2545 XBD=1635 XHG=1657 XHG=1803 XHG=2064 XHG=2270 XHG=2330 XHG=2421 XHG=2565 XHG=1367 YBD=1102 YBD=1093 YBD=1094 YBD=1103 YBD=1102 YHG=1050>noted YHG=1062>differential YHG=1062>cyanosis YHG=1062>of YHG=1063>the YHG=1062>lower YHG=1064>part YHG=1062>occasionally is difficult to It imagine any exceedingly syndrome. XHG=2588 " XBD=2659 XBD=1408 XBD=1494 XBD=1619 XBD=1678 XBD=1885 XBD=2080 XBD=2194 XBD=2280 XBD=2511 XBD=2572 XHG=1367 XHG=1424 XHG=1511 XHG=1637 XHG=1695 XHG=1901 XHG=2113 XHG=2209 XHG=2296 YBD=1145 YHG=1108>the YBD=1138 YBD=1147 YBD=1139 YHG=1108>of YHG=1107>body YHG=1107>in YHG=1107>newborn YHG=1107>infants YHG=1108>and YHG=1107>the YHG=1107>similarity YHG=1109>to ; valvular hormonal XHG=2527 action producing pulmonary " XBD=2659 XBD=1541 XHG=2470 XBD=1605 XBD=1811 XBD=1934 XBD=1982 XBD=2150 XBD=2322 XBD=2446 XHG=1365 YBD=1184 XHG=1567 XHG=1630 XHG=1834 XHG=1960 XHG=2006 XHG=2175 XHG=2346 YBD=1194 YHG=1152>reversed YBD=1185 YHG=1153>findings YHG=1153>ill YHG=1152>patients YHG=1153>with YHG=1163>a YHG=1155>patent YHG=1153>ductus YHG=1152>with

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IN THE LIFE

FIRST HOURS OF

little of the action of the

very YHG=1199>arterial-oxygen " XBD=2658 XBD=1456 XBD=1721 XBD=1883 XBD=1975 XBD=2147 XBD=2266 XHG=1365 XHG=1504 XHG=1770 XHG=1931 XHG=2024 XHG=2195 XHG=2315 YBD=1231 YBD=1239 YBD=1230 YBD=1240 YHG=1200>flow YHG=1199>prompted YHG=1199>them YHG=1200>to YHG=1199>study YHG=1198>the the lesser and none of the hormone on circulation, " XBD=2657 XBD=1593 XHG=2464 XBD=1656 XBD=1805 XBD=1905 XBD=2045 XBD=2312 XBD=2374 XBD=2443 XHG=1366 YBD=1276 XHG=1614 XHG=1677 XHG=1825 XHG=1925 XHG=2064 XHG=2331 XHG=2398 YBD=1285 YBD=1277 YBD=1275 YHG=1245>saturation YHG=1245>in YHG=1254>upper YHG=1245>and YHG=1244>lower YHG=1244>extremities YHG=1244>in YHG=1245>12 YHG=1244>newborn accounts clear description give anyYHG=1290>capillary very published "|>"XBD=2658 XBD=1580 XBD=1767 XBD=1899 XBD=2019 XBD=2156 XBD=2446 XBD=1520XHG=2462 XHG=1538 XHG=1596 XHG=1781 XHG=1915 XHG=2034 XHG=2185 XHG=1365YBD=1331 YBD=1332 YBD=1323 YBD=1322 YBD=1322 YHG=1294>at YHG=1291>varying YHG=1290>times YHG=1290>after YHG=1290>birth. YHG=1290>Arterialised YHG=1291>infants either of the of the valve microscopic " XBD=2658 XBD=1488 XHG=2587 XBD=1609 XBD=1699 XBD=1823 XBD=1952 XBD=2051 XBD=2155 XBD=2255 XBD=2467 XBD=2569 XHG=1365 XHG=1504 XHG=1629 XHG=1716 XHG=1841 XHG=1971 XHG=2067 XHG=2171 XHG=2273 XHG=2486 YBD=1378appearance YBD=1368 YBD=1367 YHG=1337>blood YHG=1336>from YHG=1337>the YHG=1336>right YHG=1337>hand YHG=1337>and YHG=1337>foot YHG=1346>was YHG=1335>collected YHG=1336>and YHG=1336>the lesions or of the state of the vessels. " XBD=2657 XBD=1524 XHG=2547 XBD=1722 XBD=1832 XBD=2050 XBD=2326 XBD=2415 XBD=2518 XHG=1365 YBD=1413 XHG=1556 XHG=1751 XHG=1864 XHG=2079 XHG=2359 XHG=2444 YBD=1414 pulmonary YBD=1423 YBD=1422 YHG=1392>oxygen YHG=1384>content YHG=1383>and YHG=1382>capacity YHG=1381>determined YHG=1381>by YHG=1381>the YHG=1381>techIf this proves a true bill it will be a gift to the " XBD=2657 XBD=1488 XBD=1545 XBD=1760 XBD=1858 XBD=2084 XBD=2163 XBD=2233 XBD=2402 XBD=2486 XHG=1363 XHG=1503 XHG=1562 XHG=1776 XHG=1874 XHG=2116 XHG=2179 XHG=2246 XHG=2415 XHG=2502 YBD=1470 YBD=1469 YBD=1460 YBD=1459 YBD=1468 YHG=1428>nique YHG=1428>of YHG=1429>Hultgren YHG=1428>and YHG=1428>Hackett.3 YHG=1427>In YHG=1428>all YHG=1427>infants YHG=1427>the YHG=1427>sample " XBD=2657 XBD=1470 XBD=1564 XBD=1689 XBD=1821 XBD=2000 XBD=2049 XBD=2226 XBD=2405 XHG=1363 XHG=1492 XHG=1583 XHG=1711 XHG=1842 XHG=2024 XHG=2069 XHG=2246 XHG=2426 YBD=1515 YBD=1506 YBD=1514 YBD=1505 will YHG=1474>from YHG=1473>the YHG=1474>right YHG=1474>hand YHG=1474>showed YHG=1484>a YHG=1473>normal YHG=1483>oxygen YHG=1473>saturation find the material for a pharmacologists. They " XBD=2657 XBD=1541 XBD=1658 XBD=1806 XBD=1900 XBD=1940 XBD=1999 XBD=2085 XBD=2151 XBD=2343 XBD=2463 XBD=2554 XHG=1368 XHG=1558 XHG=1677 XHG=1852 XHG=1919 XHG=1960 XHG=2015 XHG=2107 XHG=2168 XHG=2357 XHG=2481 XHG=2568 YBD=1561 YBD=1560 YBD=1550 YBD=1551 YHG=1521>(greater YHG=1520>than YHG=1520>90%). YHG=1520>In YHG=1522>8 YHG=1520>of YHG=1520>the YHG=1521>14 YHG=1520>samples YHG=1519>from YHG=1519>the new hormone ready to study of the action of their YHG=1519>foot " XBD=2657 XBD=1435 XBD=1690 XBD=1800 XBD=2095 XBD=2242 XBD=2369 XBD=2490 XBD=2560 XHG=1365 XHG=1463 XHG=1717 XHG=1826 XHG=2122 XHG=2265 XHG=2396 XHG=2517 XHG=2586 YBD=1597 YBD=1605 YBD=1598 YBD=1596 YBD=1595 YHG=1566>the YHG=1565>saturation YHG=1575>was YHG=1565>significantly YHG=1565>lower YHG=1564>than YHG=1564>that YHG=1564>in YHG=1564>the hand in at least one species—man. The evidence " XBD=2653 XBD=1488 XBD=1629 XBD=1804 XBD=1921 XBD=2017 XBD=2078 XBD=2135 XBD=2237 XBD=2413 XBD=2535 XHG=1364 YBD=1651 XHG=1509 XHG=1647 XHG=1821 XHG=1947 XHG=2037 XHG=2099 XHG=2156 XHG=2255 XHG=2429 XHG=2559 YBD=1653 YHG=1610>10% YBD=1643 YBD=1649 YBD=1652 YBD=1642 YHG=1611>hand, YHG=1611>being YHG=1613>greater YHG=1611>than YHG=1611>5% YHG=1611>in YHG=1613>4, YHG=1610>and YHG=1612>greater YHG=1610>than collected so far does not support the hypothesis of |>" " XBD=1405 XBD=1470 XBD=1653 XBD=1699 XBD=1832 XBD=2036 XBD=2316 XBD=2493 XBD=2656 XBD=2145 XHG=1363 XHG=1434 XHG=1526 XHG=1679 XHG=1723 XHG=1848 XHG=2162 XHG=2332 XHG=2513 XHG=2053 YBD=1689 YBD=1688 YBD=1689 YHG=1657>in YHG=1659>2. YHG=1657>These YHG=1660>8 YHG=1667>cases YHG=1656>included YHG=1657>infants YHG=1656>studied YHG=1656>within YHG=1657>all 5 9 and SHAW WOOLLEY XHG=2611 thatYHG=1703>to serotonin has wide" XBD=2589 XBD=2656 XBD=1478 XBD=1623 XBD=1688 XBD=1831 XBD=1937 XBD=1982 XBD=2047 XBD=2092 XBD=2266 XBD=2451 XHG=1365 XHG=1501 XHG=1646 XHG=1709 XHG=1856 XHG=1962 XHG=2005 XHG=2070 XHG=2113 XHG=2289 XHG=2473 YBD=1739 YBD=1734 YBD=1733 YHG=1703>three YHG=1702>hours YHG=1703>of YHG=1703>birth, YHG=1703>and YHG=1704>3 YHG=1702>of YHG=1706>5 YHG=1702>infants YHG=1702>studied YHG=1702>three the in central nervous system : ranging importance " XBD=2657 XBD=1637 XHG=2553 XBD=1786 XBD=1918 XBD=2067 XBD=2174 XBD=2226 XBD=2406 XBD=2526 XHG=1366 YBD=1779 XHG=1664 XHG=1814 XHG=1944 XHG=2124 XHG=2202 XHG=2251 XHG=2432 YBD=1789 YHG=1757>were YBD=1780 YHG=1750>seventy-two YHG=1749>hours YHG=1748>after YHG=1748>birth. YHG=1748>Of YHG=1751>4 YHG=1748>infants YHG=1747>who the sixteen cases of hyperserotoninæmia presumptive " XBD=2657 XBD=1526 XHG=2493 XBD=1608 XBD=1745 XBD=1894 XBD=2030 XBD=2169 XBD=2315 XBD=2456 XHG=1365 YBD=1826 XHG=1565 XHG=1642 XHG=1780 XHG=1930 XHG=2065 XHG=2204 XHG=2350 YBD=1835 YBD=1825 YHG=1794>studied YHG=1795>at YHG=1794>least YHG=1794>three YHG=1794>days YHG=1794>after YHG=1793>birth YHG=1803>none YHG=1793>showed " XBD=2656 XBD=1565 XBD=1639 XBD=1691 XBD=2011 XBD=2186 XBD=2305 XBD=2357 XBD=2525 XHG=1365showed XHG=1598 XHG=1668 XHG=1727 XHG=2051 XHG=2257 XHG=2340 XHG=2389 XHG=2565 YBD=1871 YBD=1872 YHG=1840>evidence YHG=1839>of YHG=1849>a YHG=1840>veno-arterial YHG=1840>shunt. YHG=1840>In YHG=1841>1 YHG=1839>infant hitherto reported no YHG=1839>who evidence of any neural " XBD=2657 XBD=1447 XBD=1637 XBD=1776 XBD=1920 XBD=2060 XBD=2166 XBD=2219 XBD=2412 XHG=1364 YBD=1917 XHG=1474 XHG=1663 XHG=1803 XHG=1947 XHG=2084 XHG=2194 XHG=2246 YBD=1918 YHG=1885>difference YHG=1885>studied YHG=1885>three YHG=1886>times YHG=1885>there YHG=1895>was YHG=1895>a YHG=1885>distinct disorder. XHG=2440

" XBD=2537 XBD=2657 XHG=2556 XBD=1548 XBD=1652 XBD=1751 XBD=1854 XBD=1952 XBD=2090 XBD=2211 XBD=2337 XBD=2436 XHG=1365 YBD=1972 XHG=1566 XHG=1670 XHG=1766 XHG=1871 XHG=1969 XHG=2106 XHG=2227 XHG=2355 XHG=2452 YBD=1963 YHG=1932>days YBD=1964 YHG=1932>between YHG=1941>arm YHG=1931>and YHG=1932>foot YHG=1934>two YHG=1931>hours YHG=1932>after YHG=1932>birth YHG=1932>and YHG=1933>two " XBD=2656 XBD=1471 XHG=2545 XBD=1610 XBD=1705 XBD=1773 XBD=2004 XBD=2063 XBD=2158 XBD=2290 XBD=2528 XBD=2586 XHG=2605 YBD=2008 XHG=1365 XHG=1487 XHG=1629 XHG=1722 XHG=1793 XHG=2021 XHG=2079 XHG=2175 XHG=2334 YBD=2014 YHG=1977>al. YBD=2017 YBD=2018 YHG=1977>after YHG=1976>birth, YHG=1977>but YHG=1987>no YHG=1977>difference YHG=1979>at YHG=1977>five YHG=1977>days. YHG=1976>Eldridge YHG=1978>et " XBD=2656 XBD=1561 XHG=2614 XBD=1681 XBD=1779 XBD=1953 XBD=2209 XBD=2412 XBD=2586 XHG=1365 Annotations XHG=1587 XHG=1708 XHG=1807 XHG=1981 XHG=2236 XHG=2437 YBD=2053 YHG=2022>in YBD=2054 YBD=2063 YBD=2055 YHG=2022>conclude YHG=2021>that YHG=2022>the YHG=2023>ductus YHG=2022>commonly YHG=2022>remains YHG=2024>patent " XBD=2656 XBD=1522 XHG=2531 XBD=1691 XBD=1748 XBD=1834 XBD=1937 XBD=2028 XBD=2163 XBD=2285 XBD=2423 XBD=2515 XHG=1363 YBD=2100 XHG=1538 XHG=1707 XHG=1764 XHG=1849 XHG=1952 XHG=2043 XHG=2180 XHG=2300 XHG=2441 YBD=2098 YHG=2067>shunt YBD=2105 YBD=2099 YHG=2067>normal YHG=2067>infants YHG=2067>in YHG=2068>first YHG=2068>few YHG=2068>hours YHG=2067>after YHG=2068>birth, YHG=2068>the 1952 YHG=2114>three FOG " XBD=2656 XBD=1485 XHG=2541 XBD=1616 XBD=1887 XBD=2050 XBD=2121 XBD=2265 XBD=2356 XBD=2437 XBD=2513 XHG=1364 THE XHG=1511 XHG=1644 XHG=1914 XHG=2077 XHG=2148 XHG=2291 XHG=2383 XHG=2467 YBD=2153 YBD=2144 YBD=2154 YBD=2146 YBD=2155 YBD=2145 YHG=2113>being YHG=2113>from YHG=2113>pulmonary YHG=2115>artery YHG=2115>to YHG=2115>aorta YHG=2114>for YHG=2124>up YHG=2116>to " XBD=1499 XHG=1363 YBD=2190 YHG=2158>hours. "|>"XBD=1295 XBD=237 XBD=338 XBD=462 XBD=568 XBD=859 XBD=1046 XBD=1143 XBD=1233 XBD=781XHG=817 XHG=127 XHG=267 XHG=370 XHG=496 XHG=897 XHG=1082 XHG=1179 XHG=1270 XHG=601YBD=2208 YBD=2209 YBD=2218 YBD=2207 YBD=2208 YBD=2208YHG=2177>of YBD=2218 YBD=2209 YHG=2178>EARLY YHG=2177>last YHG=2186>year YHG=2176>the YHG=2177>Health YHG=2176>Minister YHG=2178>set YHG=2187>up YHG=2187>a "" XBD=2655 XBD=1544 XBD=1804 XBD=2103 XBD=2292 XBD=2340 XBD=2447 XHG=1415 XHG=1567 XHG=1826 XHG=2124 XHG=2315 XHG=2361 XHG=2470 YBD=2241 YBD=2251 YBD=2242 YHG=2209>These YHG=2208>interesting YHG=2210>observations YHG=2209>provide YHG=2219>a YHG=2210>link YHG=2210>between XBD=264 XHG=824 XBD=325 XBD=482 XBD=591 XBD=799 XBD=896 XBD=1026 XBD=1290 XHG=95 XHG=286 XHG=350 XHG=510 XHG=616 XHG=921YBD=2255 XHG=1052 YBD=2255 YBD=2253 YBD=2254 YBD=2254 YBD=2264 YHG=2223>committee YHG=2224>to YHG=2222>collect YHG=2222>and YHG=2222>examine YHG=2222>the YHG=2223>facts YHG=2222>concerning "" XBD=2656 XBD=1654 XBD=1755 XBD=2048 XBD=2280 XBD=2415 XHG=1361 XHG=1675 XHG=1776 XHG=2066 XHG=2329 XHG=2436 YBD=2287 YBD=2297 YBD=2288 YBD=2296 YHG=2253>physiological YHG=2256>and YHG=2255>pathological YHG=2265>processes. YHG=2256>The YHG=2256>syndrome XBD=138 XHG=840 XBD=284 XBD=360 XBD=417 XBD=660 XBD=807 XBD=920 XBD=1008 XBD=1293 XHG=94 XHG=150 XHG=299 XHG=377 XHG=432 XHG=685 XHG=937YBD=2301 XHG=1026 YBD=2301 YBD=2309 YBD=2304 YBD=2305 YBD=2300 YBD=2299 YBD=2301 YHG=2269>the YHG=2269>London YHG=2268>fog YHG=2269>of YHG=2269>December, YHG=2269>1952 YHG=2268>and YHG=2268>the YHG=2268>committee’s ; "" XBD=2655 XBD=1405 XBD=1571 XBD=1735 XBD=1969 XBD=2085 XBD=2346 XHG=1363 XHG=1422 XHG=1589 XHG=1754 XHG=1985 XHG=2102 XHG=2363 YBD=2331 YBD=2332 YBD=2333 YBD=2342 YBD=2341 YHG=2300>of YHG=2301>patent YHG=2300>ductus YHG=2301>arteriosus YHG=2301>with YHG=2301>pulmonary YHG=2301>hypertension XBD=225 XHG=833 XBD=279 XBD=507 XBD=619 XBD=774 XBD=955 XBD=1056 XBD=1293 XHG=94 XHG=250 XHG=307 XHG=538 XHG=651 XHG=985YBD=2356 XHG=1084 YBD=2354 YBD=2345 YBD=2346 YBD=2345 YBD=2354 YHG=2314>report YHG=2314>is YHG=2313>published YHG=2313>this YHG=2314>week. YHG=2314>From YHG=2314>the YHG=2313>mortality 15 "" XBD=2656 XBD=1445 XBD=1655 XBD=1803 XBD=1900 XBD=2037 XBD=2161 XBD=2375 XBD=2439 XBD=2538 XHG=1363 XHG=1468 XHG=1680 XHG=1827 XHG=1925 XHG=2060 XHG=2184 XHG=2398 XHG=2464 XHG=2561 YBD=2379 YBD=2388 YBD=2377 YBD=2378 YBD=2387 YHG=2346>and YHG=2346>reversed YHG=2346>shunt YHG=2346>has YHG=2346>often YHG=2347>been YHG=2347>reported YHG=2346>in YHG=2346>the YHG=2349>past XBD=200 XHG=740 XBD=420 XBD=509 XBD=616 XBD=707 XBD=929 XBD=1029 XBD=1291 XHG=93 XHG=232 XHG=450 XHG=547 XHG=652 XHG=959YBD=2402 XHG=1059 YBD=2391 YBD=2390 YBD=2399 YBD=2400 YBD=2391 YBD=2391 YHG=2360>figures, YHG=2359>originally YHG=2361>set YHG=2364>out YHG=2360>by YHG=2360>I,ogan,16 YHG=2360>the YHG=2359>committee XBD=1439XHG=832 XBD=1656 XBD=1946 XBD=2251 XBD=2407 XBD=2589 XBD=2655 XHG=1361 XHG=1459 XHG=1700 XHG=1965 XHG=2269 XHG=2426 XHG=2610 YBD=2423 YBD=2431 YBD=2433 YBD=2424 YHG=2390>few YHG=2393>years.4-6 YHG=2392>Pulmonary YHG=2391>hypertension YHG=2400>severe YHG=2392>enough YHG=2394>to "" XBD=1289 XBD=230 XBD=339 XBD=547 XBD=681 XBD=797 XBD=932 XBD=1107 XBD=1183 XHG=95 XHG=257 XHG=371 XHG=584 XHG=716 XHG=967 XHG=1141 XHG=1219 YBD=2438 YBD=2436 YBD=2437 YBD=2446 YBD=2437 YHG=2407>conclude YHG=2405>that YHG=2405>between YHG=2406>3500 YHG=2405>and YHG=2405>4000 YHG=2405>people YHG=2406>in YHG=2404>the "" XBD=2656 XBD=1541 XBD=1595 XBD=1886 XBD=2039 XBD=2102 XBD=2290 XBD=2498 XBD=2574 XHG=1361 XHG=1571 XHG=1624 XHG=1915 XHG=2068 XHG=2132 XHG=2320 XHG=2530 XHG=2605 YBD=2467 YBD=2478 YBD=2468 YBD=2477 YBD=2479 YBD=2469 YHG=2437>produce YHG=2446>a YHG=2436>right-to-left YHG=2437>shunt YHG=2437>is YHG=2437>usually YHG=2437>thought YHG=2439>to YHG=2438>be XBD=310 XHG=901 XBD=422 XBD=535 XBD=607 XBD=656 XBD=806 XBD=874 XBD=971 XBD=1077 XBD=1182 XBD=1292 XHG=94 XHG=334 XHG=447 XHG=564 XHG=633 XHG=682 XHG=834 XHG=996YBD=2493 XHG=1131 XHG=1211 YBD=2483 YBD=2482 YBD=2481 YBD=2491 YBD=2483 YBD=2482 YHG=2451>Metropolitan YHG=2460>area YHG=2450>died YHG=2460>as YHG=2460>a YHG=2450>result YHG=2450>of YHG=2450>the YHG=2450>fog. YHG=2451>Of YHG=2450>this "" XBD=2652 XBD=1441 XBD=1536 XBD=1790 XBD=2081 XBD=2316 XBD=2617 XHG=1363 XHG=1491 XHG=1586 XHG=1837 XHG=2128 XHG=2363 XHG=2638 YBD=2513 YBD=2523 YBD=2514 YBD=2502 YHG=2482>due YHG=2484>to YHG=2482>increased YHG=2483>pulmonary YHG=2482>vascular YHG=2483>resistance.5 YHG=2484>6 XBD=170 XHG=834 XBD=266 XBD=382 XBD=494 XBD=585 XBD=676 XBD=740 XBD=811 XBD=915 XBD=1046 XBD=1167 XBD=1288 XHG=93 XHG=189 XHG=289 XHG=403 XHG=515 XHG=607 XHG=699 XHG=762 XHG=936YBD=2535 XHG=1067 XHG=1192 YBD=2538 YBD=2536 YBD=2527 YBD=2528 YBD=2528 YBD=2528 YBD=2538 YHG=2497>total, YHG=2497>90% YHG=2506>were YHG=2506>over YHG=2496>the YHG=2506>age YHG=2496>of YHG=2498>45 YHG=2496>and YHG=2506>more YHG=2496>than YHG=2496>60% "" XBD=2656 XBD=1523 XBD=1622 XBD=1824 XBD=1990 XBD=2062 XBD=2170 XBD=2406 XHG=1361 XHG=1552 XHG=1650 XHG=1853 XHG=2020 XHG=2089 XHG=2200 XHG=2434 YBD=2568 YBD=2559 YBD=2560 YHG=2528>Among YHG=2527>the YHG=2527>possible YHG=2537>causes YHG=2528>of YHG=2527>this YHG=2527>increased YHG=2527>resistance XBD=160 XHG=708 XBD=257 XBD=337 XBD=510 XBD=679 XBD=800 XBD=1026 XBD=1138 XBD=1291 XHG=93 XHG=180 XHG=284 XHG=391 XHG=538 XHG=828YBD=2575 XHG=1056 XHG=1167 YBD=2575 YBD=2582 YBD=2574 YBD=2583 YBD=2573 YBD=2582 YHG=2552>were YHG=2553>over YHG=2544>65. YHG=2542>Many YHG=2542>people YHG=2541>died YHG=2542>suddenly YHG=2542>and YHG=2551>many "" XBD=2656 XBD=1428 XBD=1705 XBD=1780 XBD=2016 XBD=2089 XBD=2188 XBD=2380 XHG=1362 XHG=1458 XHG=1736 XHG=1808 XHG=2048 XHG=2117 XHG=2219 XHG=2406 YBD=2604 YBD=2605 YBD=2613 YHG=2582>are YHG=2572>thrombosis YHG=2583>or YHG=2573>embolism YHG=2574>of YHG=2572>the YHG=2572>smaller YHG=2573>pulmonary XBD=165 XHG=888 XBD=260 XBD=390 XBD=508 XBD=566 XBD=672 XBD=867 XBD=938 XBD=1073 XBD=1180 XBD=1292 XHG=94 XHG=177 XHG=274 XHG=409 XHG=524 XHG=584 XHG=710 XHG=956 XHG=1089 XHG=1200 YBD=2620 YBD=2620 YBD=2618 YBD=2619 YBD=2619 YBD=2619 YBD=2620 YHG=2597>more YHG=2598>were YHG=2588>found YHG=2575>dead YHG=2588>in YHG=2588>bed. YHG=2588>Almost YHG=2588>all YHG=2588>those YHG=2587>who YHG=2587>died "" XBD=2654 XBD=1527 XBD=1655 XBD=1920 XBD=2283 XBD=2523 XHG=1362 XHG=1577 XHG=1706 XHG=1969 XHG=2303 XHG=2573 YBD=2649 YBD=2659 YBD=2655 YBD=2650 YHG=2618>arteries YHG=2619>and YHG=2618>arterioles, YHG=2619>pulmonary YHG=2617>arteritis,&dquo; YHG=2618>and &dquo; XBD=160 XHG=946 XBD=308 XBD=389 XBD=564 XBD=624 XBD=791 XBD=925 XBD=990 XBD=1104 XBD=1288 XHG=93 XHG=174 XHG=324 XHG=408 XHG=585 XHG=643 XHG=811 XHG=1008 XHG=1123 YBD=2666 YBD=2673 YBD=2665 YBD=2664 YBD=2673 YBD=2665 YHG=2642>were YHG=2634>already YHG=2633>the YHG=2633>victims YHG=2632>of YHG=2633>serious YHG=2633>heart YHG=2643>or YHG=2633>lung YHG=2632>disease: "" XBD=2655 XBD=1606 XBD=1685 XBD=1789 XBD=1940 XBD=2074 XBD=2152 XBD=2430 XHG=1360 XHG=1643 XHG=1719 XHG=1824 XHG=1975 XHG=2111 XHG=2185 XHG=2468 YBD=2695 YBD=2704 YBD=2703 YBD=2694 YHG=2663>persistence YHG=2664>of YHG=2663>the YHG=2664>foetal YHG=2665>type YHG=2663>of YHG=2663>pulmonary YHG=2663>arteriole XBD=121 XHG=872 XBD=193 XBD=418 XBD=616 XBD=751 XBD=850 XBD=955 XBD=1017 XBD=1129 XBD=1178 XBD=1291 XHG=94 XHG=140 XHG=211 XHG=441 XHG=641 XHG=781 XHG=976YBD=2710 XHG=1044 XHG=1155 XHG=1204 YBD=2711 YBD=2715 YBD=2718 YBD=2710 YBD=2710 YBD=2710 YBD=2719 YHG=2688>as YHG=2680>the YHG=2678>committee YHG=2679>observe, YHG=2679>&dquo; YHG=2678>fog YHG=2687>was YHG=2679>in YHG=2678>fact the YHG=2688>a YHG=2688>pre"" XBD=2652 XBD=1510 XBD=1609 XBD=1660 XBD=1843 XBD=2017 XBD=2136 XBD=2245 XBD=2473 XHG=1363 XHG=1536 XHG=1637 XHG=1686 XHG=1868 XHG=2045 XHG=2163 XHG=2270 XHG=2498 YBD=2741 YBD=2739 YBD=2740 YBD=2748 YHG=2708>(which YHG=2709>has YHG=2718>a YHG=2708>thicker YHG=2708>muscle YHG=2709>coat YHG=2708>and YHG=2718>narrower YHG=2708>lumen) XBD=247 XHG=748 XBD=385 XBD=626 XBD=713 XBD=773 XBD=1050 XBD=1211 XBD=1291 XHG=94 XHG=277 XHG=422 XHG=661 XHG=809YBD=2766 XHG=1084 XHG=1248 YBD=2765 YBD=2755 YBD=2765 YBD=2764 YBD=2755 YHG=2724>cipitating YHG=2726>agent YHG=2723>operating YHG=2734>on YHG=2734>a YHG=2724>susceptible YHG=2733>group YHG=2723>of "" XBD=2654 XBD=1407 XBD=1487 XBD=1634 XBD=1790 XBD=2053 XBD=2136 XBD=2364 XHG=1361 XHG=1444 XHG=1524 XHG=1673 XHG=1827 XHG=2091 XHG=2171 XHG=2403 YBD=2784 YBD=2786 YBD=2795 YBD=2785 YHG=2753>of YHG=2763>some YHG=2754>other YHG=2754>congenital YHG=2763>or YHG=2754>neonatal YHG=2753>mechanism XBD=218 XHG=829 XBD=370 XBD=475 XBD=785 XBD=998 XBD=1144 XBD=1292 XHG=93 XHG=252 XHG=411 XHG=517 XHG=1039 XHG=1186 YBD=2808 YBD=2802 YBD=2801 YBD=2809 YBD=2811 YBD=2802 YBD=2801 YHG=2770>patients YHG=2770>whose YHG=2769>life YHG=2769>expectation, YHG=2769>judging YHG=2769>from YHG=2768>their "" XBD=2654 XBD=1552 XBD=1659 XBD=1792 XBD=2010 XBD=2088 XBD=2196 XBD=2478 XHG=1360 XHG=1589 XHG=1696 XHG=1828 XHG=2047 XHG=2125 XHG=2232 XHG=2517 YBD=2841 YBD=2840 YBD=2830 YBD=2839 YHG=2799>whereby YHG=2799>the YHG=2799>high YHG=2808>pressure YHG=2799>in YHG=2798>the YHG=2798>pulmonary YHG=2801>artery XBD=288 XBD=482 XBD=630 XBD=757 XBD=824 XBD=920 XBD=1116 XBD=1182 XBD=1289 XHG=93 XHG=311 XHG=511 XHG=658 XHG=782 XHG=849 XHG=947 XHG=1142 XHG=1208 YBD=2857 YBD=2852 YBD=2846 YBD=2847 YBD=2847 YBD=2846 YBD=2854 YHG=2815>pre-existing YHG=2815>diseases, YHG=2816>must, YHG=2824>even YHG=2814>in YHG=2815>the YHG=2816>absence YHG=2815>of YHG=2814>fog, "|>"XBD=1290 XBD=1573 XBD=1644 XBD=1884 XBD=2169 XBD=2244 XBD=2476 XBD=2551 XBD=2653 XBD=2058 XHG=1361 XHG=1603 XHG=1675 XHG=2121 XHG=2201 XHG=2273 XHG=2507 XHG=2582 XHG=1911 YBD=2876 YBD=2881 YBD=2884 YBD=2875 YBD=2875 YHG=2844>continues YHG=2844>in YHG=2843>postnatal YHG=2843>If, YHG=2853>as YHG=2843>Hultgren YHG=2845>et YHG=2844>al.5 YHG=2844>life.5-7 " XBD=161 XBD=259 XBD=421 XBD=549 XBD=703 XBD=798 XBD=863 XBD=1062 XBD=1167 XHG=93 XHG=177 XHG=280 XHG=465 XHG=572 XHG=725 XHG=822 XHG=887 XHG=1084 XHG=1188 YBD=2892 YBD=2894 YBD=2892 YBD=2893 YBD=2892 YBD=2893 YHG=2858>have YHG=2862>been YHG=2860>short.&dquo; YHG=2861>The YHG=2861>added YHG=2860>toll YHG=2860>of YHG=2861>sickness YHG=2869>was YHG=2859>hard "" XBD=2655 XBD=1536 XBD=1675 XBD=1843 XBD=2007 XBD=2126 XBD=2161 XBD=2358 XBD=2462 XHG=1360 XHG=1552 XHG=1688 XHG=1854 XHG=2019 XHG=2138 XHG=2172 XHG=2370 XHG=2475 YBD=2932 YBD=2919 YBD=2920 YBD=2921 YBD=2930 YHG=2891>suggest, YHG=2899>many YHG=2889>normal YHG=2889>infants YHG=2888>have YHG=2898>a YHG=2889>reversed YHG=2889>flow YHG=2888>through XBD=120 XHG=800 XBD=288 XBD=549 XBD=659 XBD=765 XBD=976 XBD=1058 XBD=1290 XHG=93 XHG=144 XHG=319 XHG=585 XHG=695 XHG=1016 XHG=1099 YBD=2935 YBD=2946 YBD=2937 YBD=2938 YBD=2937 YBD=2938 YHG=2905>to YHG=2915>measure YHG=2906>accurately, YHG=2906>but YHG=2906>the YHG=2905>increase YHG=2906>in YHG=2905>sickness"" XBD=2653 XBD=1431 XBD=1606 XBD=1673 XBD=1769 XBD=1881 XBD=1983 XBD=2130 XBD=2198 XBD=2302 XBD=2429 XBD=2541 XHG=1359 XHG=1458 XHG=1630 XHG=1698 XHG=1794 XHG=1904 XHG=2006 XHG=2156 XHG=2223 XHG=2329 XHG=2457 XHG=2566 YBD=2967 YBD=2966 YBD=2971 YBD=2965 YBD=2975 YBD=2974 YHG=2936>the YHG=2935>ductus YHG=2935>in YHG=2934>the YHG=2935>first YHG=2934>few YHG=2934>hours YHG=2934>of YHG=2934>life, YHG=2933>then YHG=2944>any YHG=2935>pulXBD=163 XHG=603 XBD=301 XBD=387 XBD=474 XBD=578 XBD=862 XBD=1015 XBD=1292 XHG=93 XHG=182 XHG=321 XHG=409 XHG=496 XHG=888YBD=2982 XHG=1042 YBD=2982 YBD=2993 YBD=2983 YBD=2992 YBD=2989 YBD=2992 YHG=2951>rates YHG=2951>during YHG=2951>the YHG=2951>fog YHG=2960>was YHG=2951>surprisingly YHG=2952>small, YHG=2950>considering "" XBD=2652 XBD=1532 XBD=1826 XBD=1890 XBD=1991 XBD=2110 XBD=2246 XBD=2309 XBD=2486 XHG=1360 XHG=1553 XHG=1846 XHG=1909 XHG=2010 XHG=2132 XHG=2266 XHG=2329 XHG=2508 YBD=3021 YBD=3010 YBD=3019 YBD=3020 YBD=3011 YHG=2990>monary YHG=2980>abnormality YHG=2981>at YHG=2979>this YHG=2979>time YHG=2979>(such YHG=2988>as YHG=2979>patchy YHG=2979>atelecXBD=137 XHG=481 XBD=236 XBD=406 XBD=462 XBD=634 XHG=93 YBD=3026 XHG=150 XHG=252 XHG=424 YBD=3037YHG=2993>the YBD=3028 YHG=2998>great YHG=2996>number YHG=2997>of YHG=2996>deaths. "" XBD=2655 XBD=1474 XBD=1651 XBD=1813 XBD=2115 XBD=2361 XHG=1359 XHG=1521 XHG=1695 XHG=1855 XHG=2157 XHG=2406 YBD=3066 YBD=3056 YBD=3065 YHG=3026>tasis) YHG=3025>might YHG=3034>cause YHG=3024>persistently YHG=3024>increased YHG=3024>pulmonary XBD=185 XHG=859 XBD=404 XBD=522 XBD=687 XBD=750 XBD=838 XBD=930 XBD=1083 XBD=1290 XHG=125 XHG=201 XHG=423 XHG=543 XHG=706 XHG=772 XHG=949YBD=3073 XHG=1104 YBD=3072 YBD=3081 YBD=3073 YBD=3083YHG=3042>the YHG=3040>The YHG=3040>committee YHG=3051>were YHG=3042>unable YHG=3043>to YHG=3041>lay YHG=3042>blame YHG=3041>squarely "" XBD=2653 XBD=1547 XBD=1803 XBD=1922 XBD=2098 XBD=2238 XBD=2322 XBD=2483 XHG=1359 XHG=1586 XHG=1844 XHG=1965 XHG=2138 XHG=2277 XHG=2363 XHG=2525 YBD=3101 YBD=3111 YBD=3102 YHG=3070>vascular YHG=3070>resistance YHG=3069>and YHG=3070>would YHG=3070>tend YHG=3071>to YHG=3070>bring YHG=3070>about XBD=126 XHG=633 XBD=305 XBD=596 XBD=924 XBD=1038 XBD=1212 XBD=1291 XHG=94 XHG=151 XHG=337 XHG=962YBD=3115 XHG=1075 XHG=1249 YBD=3126 YBD=3127 YBD=3123 YBD=3118 YBD=3119 YBD=3118 YHG=3092>on YHG=3095>any YHG=3086>atmospheric YHG=3087>contaminant, YHG=3087>but YHG=3086>oxides YHG=3086>of one "" XBD=2655 XBD=1489 XBD=1835 XBD=2057 XBD=2322 XBD=2576 XHG=1358 XHG=1506 XHG=1870 XHG=2093 XHG=2358 XHG=2610 YBD=3148 YBD=3147 YBD=3156 YBD=3155 YBD=3146 YHG=3116>the YHG=3114>reversed-shunt YHG=3115>ductus YHG=3115>syndrome, YHG=3114>especially YHG=3124>as &dquo; XBD=209 XHG=707 XBD=382 XBD=463 XBD=556 XBD=666 XBD=815 XBD=1052 XBD=1176 XBD=1289 XHG=93 XHG=242 XHG=422 XHG=504 XHG=595 XHG=857YBD=3169 XHG=1096 XHG=1219 YBD=3163 YBD=3168 YBD=3163 YHG=3129>sulphur YHG=3131>seemed YHG=3132>to YHG=3132>be YHG=3131>the YHG=3130>main YHG=3131>irritants, YHG=3132>and &dquo; YHG=3131>the "" XBD=2654 XBD=1508 XBD=1619 XBD=1752 XBD=1922 XBD=1979 XBD=2064 XBD=2257 XBD=2372 XBD=2459 XHG=1359 XHG=1523 XHG=1636 XHG=1769 XHG=1937 XHG=1993 XHG=2080 XHG=2288 XHG=2388 XHG=2475 YBD=3200 YBD=3191 YBD=3192 YBD=3194 YHG=3161>anoxia YHG=3170>may YHG=3159>delay YHG=3160>closure YHG=3160>of YHG=3159>the YHG=3160>ductus.1 YHG=3160>But YHG=3160>the YHG=3160>solution XBD=282 XHG=923 XBD=341 XBD=446 XBD=573 XBD=699 XBD=873 XBD=964 XBD=1071 XBD=1288 XHG=94 XHG=305 XHG=364 XHG=468 XHG=595 XHG=724 XHG=988YBD=3206 XHG=1093 YBD=3208 YBD=3207 YBD=3209 YBD=3216 YHG=3175>combustion YHG=3176>of YHG=3176>coal YHG=3176>their YHG=3176>chief YHG=3186>source. YHG=3177>It YHG=3186>was YHG=3176>probable "" XBD=2654 XBD=1402 XBD=1500 XBD=1708 XBD=1829 XBD=1904 XBD=1971 XBD=2067 XBD=2209 XBD=2478 XHG=1357 XHG=1428 XHG=1524 XHG=1733 XHG=1853 XHG=1928 XHG=1996 XHG=2092 XHG=2232 XHG=2504 YBD=3236 YBD=3246 YBD=3237 YHG=3208>to YHG=3206>the YHG=3205>problem YHG=3214>may YHG=3205>lie YHG=3205>in YHG=3205>the YHG=3206>small YHG=3206>pulmonary YHG=3205>vessels XBD=153 XHG=812 XBD=316 XBD=559 XBD=784 XBD=856 XBD=1095 XBD=1213 XBD=1288 XHG=92 XHG=177 XHG=344 XHG=588 XHG=891YBD=3249 XHG=1124 XHG=1247 YBD=3260 YBD=3258 YBD=3253 YBD=3261 YBD=3254 YBD=3253 YHG=3216>that YHG=3219>sulphur YHG=3220>trioxide, YHG=3221>dissolved YHG=3231>as YHG=3220>sulphuric YHG=3221>acid YHG=3221>in I? "" XBD=2652 XBD=1736 XBD=1949 XBD=2027 XBD=2168 XBD=2441 XHG=1358 XHG=1773 XHG=1984 XHG=2064 XHG=2207 XHG=2480 YBD=3293 YBD=3282 YBD=3283 YBD=3281 YHG=3250>themselves-and YHG=3251>perhaps YHG=3249>in YHG=3250>their YHG=3251>autonomic YHG=3249>control. XBD=136 XBD=300 XBD=563 XBD=799 XBD=888 XBD=1044 XBD=1103 XBD=1289 XHG=92 XHG=149 XHG=318 XHG=579 XHG=816 XHG=905 XHG=1063 XHG=1122 YBD=3303 YBD=3304 YBD=3305 YBD=3298 YBD=3297 YBD=3299 YBD=3299 YBD=3307 YHG=3260>fog YHG=3263>droplets, YHG=3265>appreciably YHG=3265>reinforced YHG=3266>the YHG=3266>effects YHG=3266>of YHG=3266>sulphur "|>" XBD=1532 XBD=1720 XBD=1774 XBD=2158 XBD=2337 XBD=2432 XBD=1903 XHG=1360 XHG=1547 XHG=1732 XHG=1914 XHG=2171 XHG=2350 XHG=2445 XHG=1788 YBD=3336 YBD=3327 YBD=3326 YBD=3328 YHG=3296>Organic YHG=3295>changes YHG=3295>in YHG=3295>pulmonary YHG=3296>arteries YHG=3295>and YHG=3294>arterioles YHG=3295>srr:3,ll " XBD=2654 XBD=214 XBD=302 XBD=407 XBD=693 XBD=949 XBD=1026 XBD=1210 XBD=1289 XHG=93 XHG=267 XHG=330 XHG=437 XHG=725 XHG=982 XHG=1061 XHG=1245 YBD=3340 YBD=3340 YBD=3341 YBD=3350 YBD=3351 YBD=3342 YBD=3348 YBD=3343 YHG=3305>dioxide. YHG=3309>It YHG=3319>was YHG=3311>particularly YHG=3312>important YHG=3314>to YHG=3310>decide, YHG=3321>as

" XBD=1286 XBD=132 XHG=823 XBD=178 XBD=352 XBD=459 XBD=550 XBD=637 XBD=727 XBD=802 XBD=966 XBD=1075 XHG=92 XHG=146 XHG=194 XHG=373 XHG=478 XHG=569 XHG=659 XHG=748 XHG=1003 XHG=1096 YBD=3382 YBD=3384 YBD=3393 YBD=3385 YBD=3394 YBD=3386 YBD=3387 YBD=3388 YBD=3387 YBD=3388 YHG=3349>far YHG=3362>as YHG=3353>possible, YHG=3354>how YHG=3355>the YHG=3355>fog YHG=3355>did YHG=3355>its YHG=3356>harm YHG=3356>the: YHG=3356>evidence " XBD=1289 XBD=245 XHG=657 XBD=350 XBD=444 XBD=628 XBD=859 XBD=1037 XBD=1121 XHG=93 XHG=268 XHG=376 XHG=470 XHG=890 XHG=1066 XHG=1151 YBD=3437 YBD=3430 YBD=3431 YBD=3437 YBD=3432 YBD=3437 YBD=3432 YHG=3398>suggested YHG=3398>that YHG=3399>the YHG=3399>irritant YHG=3400>produced YHG=3400>anoxia YHG=3401>by YHG=3410>means 14.

Clerc-Bory, M., Pachero, H., Mentzen, C. C.R. Acad. Sci., Paris, 1954, 238, 525. 15. Ministry of Health: Reports on Public Health and Medical Subjects ; no. 95. Mortality and Morbidity during the London Fog of December 1952. Pp. 61. H.M. Stationery Office, 2s. 6d. 16. Logan, W. P. D. Lancet, 1953, i, 336. 17. Amdur, M. O., Melvin, W.M. jun., Drinker, P. Ibid, 1953, ii, 758.

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1. Record, R. G., MeKeown, T. Brit. Heart J. 1953, 15, 376. 2. Eldridge, F. L., Hultgren, H. N., Wigmore, M. E. Science, 1954, 119, 731. 3. Hultgren, H. N., Hackett, A. J. Pediatrics, 1950, 6, 93. 4. Cosh, J. A. Brit. Heart. J. 1953, 15, 423. 5. Hultgren, H. N., Selzer, A., Purdy, A., Holman, E., Gerbodo, F. Circulation., 1953, 8, 15. 6. Smith, G. Brit. Heart J. 1954, 16, 233. 7. Civin, W. H., Edwards, J. E. Arch. Path. (Lab. Med.) 1951, 192. 51,