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Association between obstructive pulmonary function abnormalities and brain cortical thickness
Abstracts / Journal of the Neurological Sciences e629 (2013) e629–e678
doi:10.1016/j.jns.2013.07.2241
Abstract — WCN 2013 No: 1860 Topic: 36 — Other Topic A fast method for determination of the parameters of pulsed-CEST MRI G. Xiaoa, Z. Daib, P.Z. Sunc, R. Wub. aDepartment of Mathematics and Applied Mathematics, Hanshan Normal University, Chaozhou, China; b Department of Radiology, 2nd Affiliated Hospital of Shantou University Medical College, Shantou, China; cAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
DP
Objective: The object of the research is to demonstrate a fast method for simultaneous determination of labile proton fraction ratio and exchange rate and other parameters of pulsed chemical exchange saturation transfer (pulsed-CEST) MRI. Methods: Mathematical models have been developed to describe pulsed-CEST contrast. We simulated pulsed-CEST MRI in MatLab (MathWorks, Natick, MA) for Z-spectra and asymmetry spectra using matrix exponential algorithm. The number of repetition of the sequence is 256. Each Gaussian-shaped pulse was divided into 101 steps, and the evolution within each step was modeled assuming a constant amplitude. We also calculated the above spectra by using the fourth/fifth-order RKF(ode45 in MatLab; MathWorks, Natick, MA, USA) with an absolute error tolerance for each integration step of 10− 6, and compared with the results obtained by our method. Calculations were performed using MatLab on Pentium® Dual-Core CPU (2.2 GHz) with 2-GB RAM. There was a good agreement between them, and this method was much faster than the RKF method (by a factor of approximately 1000 in this study). We simulated that the error of the labile proton fraction ratio, exchange rate and other parameters less than 5%. Results: This method will be useful for determination of labile proton fraction ratio and exchange rate and other parameters, and for analyzing the pulsed-CEST contrast mechanism and/or investigating the optimal RF pulse parameters such as the RF pulse duration or pulse flip angle.
thickness, in individuals with obstructive pulmonary function abnormalities. Objective: We assessed the association between obstructive pattern of pulmonary function abnormality and brain cortical thickness using Magnetic Resonance Imaging (MRI). Materials and methods: Among the individuals who participated in the medical examination at the Samsung Medical Center, 392 subjects who underwent T1-weighted MRI were included in the analyses after excluding those with technical errors, anatomical lesions on MRI and missing values. The cortical thickness (mm) was measured using Euclidean distance. Pulmonary function was categorized as normal, obstructive, restrictive, or mixed pattern, and those with restrictive and mixed patterns were excluded from the analysis. We performed multiple linear regression analysis adjusting for age, gender, the duration of education (years), smoking history (pack years), drinking status (never, former, and current), the history of hypertension, diabetes, and hyperlipidemia, and intracranial volume (10− 3 mL). Results: There was a significant difference in frontal cortical thickness between those with obstructive pattern of pulmonary function abnormality (n = 14; Mean, 3.05; SD, 0.10) and those with normal pulmonary function (n = 378; Mean, 3.12; SD, 0.11) (p = 0.02). Those with obstructive pattern had thinner frontal cortical thickness compared to those with normal pulmonary function (β = − 0.06, p = 0.02). Conclusion: The presence of obstructive pattern in the pulmonary function test was inversely associated with cortical thickness in brain MRI.
OF
strong color and a strong sound do not have the same significant influence when the person is happy (strong emotion). Therefore a positive activation of the limbic system (happiness) may inhibit visual and auditory hyperexcitability. This is important to make a decision.
RO
e646
doi:10.1016/j.jns.2013.07.2243
CO
RR
EC
TE
Abstract — WCN 2013 No: 1837 Topic: 36 — Other Topic Spg4 mutations in Brazilian patients with hereditary spastic paraplegia
doi:10.1016/j.jns.2013.07.2242
UN
Abstract — WCN 2013 No: 1859 Topic: 36 — Other Topic Association between obstructive pulmonary function abnormalities and brain cortical thickness J. Choa, J. Sohna, S.-K. Choa, H. Kima, C. Kima, D.-C. Shina, S. Seob. a Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea; bDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea Background: Many epidemiological studies have suggested that chronic obstructive pulmonary disease is associated with cognitive dysfunction, mainly focusing on neuropsychological tests. A few brain imaging studies have been conducted, especially on cortical
M. França Jr.a, A. D'Abreua, D.B. Doginib, H.A.G. Teivec, J.A.M. Sauted, L.B. Jardimd, I. Lopes-Cendesb. aDepartment of Neurology, University of Campinas (UNICAMP), Campinas, Brazil; bDepartment of Medical Genetics, University of Campinas (UNICAMP), Campinas, Brazil; cDepartment of Internal Medicine, Universidade Federal do Paraná (UFPR), Curitiba, Brazil; d Department of Internal Medicine, Universidade Federal do Rio Grande do Sul (UFRS), Porto Alegre, Brazil Background: Hereditary spastic paraplegia (HSP) is a heterogeneous group of neurodegenerative disorders characterized by progressive lower limb weakness and spasticity. There are 31 causative genes identified to date, but mutations in the SPG4 gene are the major cause of autosomal dominant (AD) HSP in Europe/the USA accounting for 40–50% of all patients. Little is known about the frequency of SPG4-related HSP in Brazil. Objective: To determine the frequency of SPG4-HSP among Brazilian patients with AD-HSP and to describe the mutational spectrum in this population. Patients and methods: We recruited 34 unrelated families with ADHSP from three university hospitals; patients underwent a complete clinical evaluation as well as detailed family history. Genomic DNA was extracted from lymphocytes and used in PCR reactions with primers designed to cover the 17 exons of the SPG4 gene. Mutation screening was performed by automatic sequencing and multiplex ligand probe amplification (MLPA). Results: We found eight previously described mutations in SPG4: c.839delAG (frameshift), c.1267GNT (missense), c.1378CNT (missense), c.1413+5GNA (splicing-site mutation), c.1495CNT (missense), c.1651GNC
doi:10.1016/j.jns.2013.07.2241
Abstract — WCN 2013 No: 1860 Topic: 36 — Other Topic A fast method for determination of the parameters of pulsed-CEST MRI G. Xiaoa, Z. Daib, P.Z. Sunc, R. Wub. aDepartment of Mathematics and Applied Mathematics, Hanshan Normal University, Chaozhou, China; b Department of Radiology, 2nd Affiliated Hospital of Shantou University Medical College, Shantou, China; cAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
DP
Objective: The object of the research is to demonstrate a fast method for simultaneous determination of labile proton fraction ratio and exchange rate and other parameters of pulsed chemical exchange saturation transfer (pulsed-CEST) MRI. Methods: Mathematical models have been developed to describe pulsed-CEST contrast. We simulated pulsed-CEST MRI in MatLab (MathWorks, Natick, MA) for Z-spectra and asymmetry spectra using matrix exponential algorithm. The number of repetition of the sequence is 256. Each Gaussian-shaped pulse was divided into 101 steps, and the evolution within each step was modeled assuming a constant amplitude. We also calculated the above spectra by using the fourth/fifth-order RKF(ode45 in MatLab; MathWorks, Natick, MA, USA) with an absolute error tolerance for each integration step of 10− 6, and compared with the results obtained by our method. Calculations were performed using MatLab on Pentium® Dual-Core CPU (2.2 GHz) with 2-GB RAM. There was a good agreement between them, and this method was much faster than the RKF method (by a factor of approximately 1000 in this study). We simulated that the error of the labile proton fraction ratio, exchange rate and other parameters less than 5%. Results: This method will be useful for determination of labile proton fraction ratio and exchange rate and other parameters, and for analyzing the pulsed-CEST contrast mechanism and/or investigating the optimal RF pulse parameters such as the RF pulse duration or pulse flip angle.
thickness, in individuals with obstructive pulmonary function abnormalities. Objective: We assessed the association between obstructive pattern of pulmonary function abnormality and brain cortical thickness using Magnetic Resonance Imaging (MRI). Materials and methods: Among the individuals who participated in the medical examination at the Samsung Medical Center, 392 subjects who underwent T1-weighted MRI were included in the analyses after excluding those with technical errors, anatomical lesions on MRI and missing values. The cortical thickness (mm) was measured using Euclidean distance. Pulmonary function was categorized as normal, obstructive, restrictive, or mixed pattern, and those with restrictive and mixed patterns were excluded from the analysis. We performed multiple linear regression analysis adjusting for age, gender, the duration of education (years), smoking history (pack years), drinking status (never, former, and current), the history of hypertension, diabetes, and hyperlipidemia, and intracranial volume (10− 3 mL). Results: There was a significant difference in frontal cortical thickness between those with obstructive pattern of pulmonary function abnormality (n = 14; Mean, 3.05; SD, 0.10) and those with normal pulmonary function (n = 378; Mean, 3.12; SD, 0.11) (p = 0.02). Those with obstructive pattern had thinner frontal cortical thickness compared to those with normal pulmonary function (β = − 0.06, p = 0.02). Conclusion: The presence of obstructive pattern in the pulmonary function test was inversely associated with cortical thickness in brain MRI.
OF
strong color and a strong sound do not have the same significant influence when the person is happy (strong emotion). Therefore a positive activation of the limbic system (happiness) may inhibit visual and auditory hyperexcitability. This is important to make a decision.
RO
e646
doi:10.1016/j.jns.2013.07.2243
CO
RR
EC
TE
Abstract — WCN 2013 No: 1837 Topic: 36 — Other Topic Spg4 mutations in Brazilian patients with hereditary spastic paraplegia
doi:10.1016/j.jns.2013.07.2242
UN
Abstract — WCN 2013 No: 1859 Topic: 36 — Other Topic Association between obstructive pulmonary function abnormalities and brain cortical thickness J. Choa, J. Sohna, S.-K. Choa, H. Kima, C. Kima, D.-C. Shina, S. Seob. a Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea; bDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea Background: Many epidemiological studies have suggested that chronic obstructive pulmonary disease is associated with cognitive dysfunction, mainly focusing on neuropsychological tests. A few brain imaging studies have been conducted, especially on cortical
M. França Jr.a, A. D'Abreua, D.B. Doginib, H.A.G. Teivec, J.A.M. Sauted, L.B. Jardimd, I. Lopes-Cendesb. aDepartment of Neurology, University of Campinas (UNICAMP), Campinas, Brazil; bDepartment of Medical Genetics, University of Campinas (UNICAMP), Campinas, Brazil; cDepartment of Internal Medicine, Universidade Federal do Paraná (UFPR), Curitiba, Brazil; d Department of Internal Medicine, Universidade Federal do Rio Grande do Sul (UFRS), Porto Alegre, Brazil Background: Hereditary spastic paraplegia (HSP) is a heterogeneous group of neurodegenerative disorders characterized by progressive lower limb weakness and spasticity. There are 31 causative genes identified to date, but mutations in the SPG4 gene are the major cause of autosomal dominant (AD) HSP in Europe/the USA accounting for 40–50% of all patients. Little is known about the frequency of SPG4-related HSP in Brazil. Objective: To determine the frequency of SPG4-HSP among Brazilian patients with AD-HSP and to describe the mutational spectrum in this population. Patients and methods: We recruited 34 unrelated families with ADHSP from three university hospitals; patients underwent a complete clinical evaluation as well as detailed family history. Genomic DNA was extracted from lymphocytes and used in PCR reactions with primers designed to cover the 17 exons of the SPG4 gene. Mutation screening was performed by automatic sequencing and multiplex ligand probe amplification (MLPA). Results: We found eight previously described mutations in SPG4: c.839delAG (frameshift), c.1267GNT (missense), c.1378CNT (missense), c.1413+5GNA (splicing-site mutation), c.1495CNT (missense), c.1651GNC