- Email: [email protected]
ASSOCIATION BETWEEN PM10 EXPOSURE, COFFEE OR TEA CONSUMPTION, AND DEMENTIA RISK IN THE ELDERLY
P1196
Poster Presentations: Tuesday, July 18, 2017
Germany; 3Alzheimer’s Disease and Other Cognitive Disorders Unit, Hospital Clınic, Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; 4Department of Medical Humanities, VU University Medical Center/EMGO+, Amsterdam, Netherlands; 5 Alzheimer’s Disease Unit and Other Cognitive Disorders Unit, Hospital Clinic de Barcelona, Barcelona, Spain; 6Barcelonabeta Brain Research Center, Barcelona, Spain; 7German Center for Neurodegenerative Diseases (DZNE), Bonn-Cologne, Germany; 8Department of Psychiatry, University of Cologne, Cologne, Germany; 9Alzheimer Center and Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, Netherlands; 10Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands. Contact e-mail: [email protected] Background: As a first step towards the development of an online
lifestyle program (OLP) targeting brain health, we investigated the needs and preferences of individuals with subjective cognitive decline (SCD) for such a program. Methods: This study is part of the European Euro-SCD study (JPND_PS_FP-689019). Subjects were recruited at memory clinics in Amsterdam, Cologne and Barcelona. To get insight in the OLP preferences of SCD subjects on a larger scale, we conducted an (online) selfreport 29-item survey. This survey was spread among subjects (N¼238) at the three memory clinics. For more in-depth understanding of the Internet usage and preferences for an OLP, semistructured interviews were conducted (N¼22: n¼14 Amsterdam, n¼8 Cologne). Interviews were audiotaped and transcribed verbatim. Data were subjected to thematic analysis. Results: A total of 176/238 (74%) participants completed the survey (46% female, 93% within age range 50-80y, 73% education beyond secondary school; Amsterdam N¼126; Cologne N¼32; Barcelona N¼18). The majority (78%) used the Internet on a daily basis. Almost all respondents (98%) reported that lifestyle could contribute to brain health and reported willingness to use an OLP targeting brain health (93%). Major topics of interest included nutrition (82%), cognitive activity (81%) and physical activity (79%). Motivating facilitating factors were ‘trustworthiness’ and ‘ease of use’, whereas the need for an account was considered a barrier. We found no major differences between countries. Interview participants reported to value scientifically grounded information which would strengthen trustworthiness of information in their perception. Optional reminders for the use of the program and optional notifications of new content were also reported to be of importance. Additionally, participants reported to value an attractive and user-friendly design. Conclusions: Our findings indicate that individuals with SCD are highly interested in using an OLP across different European countries. The results form the basis for development of an OLP fitting the preferences of the users. P3-567
PROSPECTIVE RELATIONSHIP BETWEEN OBJECTIVELY ASSESSED SEDENTARY TIME AND COGNITIVE IMPAIRMENT IN LATER LIFE
Po-Wen Ku1, Li-Jung Chen2, Wen-Jung Sun3, 1National Changhua University of Education, Changhua, Taiwan; 2National Taiwan University of Sport, Taichung, Taiwan; 3Taipei City Hospital Zhongxing Branch, Taipei, Taiwan. Contact e-mail: [email protected] Background: There is an increasing evidence base suggesting that
sedentary behavior is independent from physical activity associated with a plethora of outcomes such as cardiovascular disease, metabolic syndromes, diabetes, cancer, and mortality in aged popula-
tion. However, the use of self-report measures of time spent in sedentary behaviors is a serious methodological weakness in the literature. It is still equivocal whether too much sedentary time will increase the risk of cognitive impairment in later life. This study aimed to examine whether objectively measured sedentary time is prospectively associated with cognitive impairment in older adults. Methods: This was a two-year prospective cohort study. A total of 285 community-dwelling Taiwanese older adults aged 65 or older were interviewed and assessed in 2012. A second wave of assessment was carried out in 2014 involving 274 (96.1%) participants. Time spent in sedentary behaviors was measured using waist worn triaxial accelerometer monitors (GT3X+, ActiGraph) for 7 days. The sedentary time was divided into four levels (< 8, 8-9.99, 10-11.99, 12 or more hours/day). Cognitive impairment was obtained using a Chinese version of the Ascertain Dementia 8-item Questionnaire (AD8) by participants with a potential range between 0 and 8. Multivariable negative binomial regression analyses were conducted because the AD8 score was an over-dispersed count with a highly skewed distribution. Negative binomial regression models with adjustment for baseline cognitive status, accelerometer wear time, socio-demographic variables, lifestyle behaviors, chronic disease conditions, and time spent in moderate-to-vigorous physical activity were performed (a¼0.05). Results: After adjusting for baseline cognitive status and accelerometer wear time (Model 1), participants with sedentary time ‘12 hours/day’ (Risk Ratio [RR] ¼ 3.633, 95C%CI¼ 1.952-6.760, p¼ <0.001) and those with ‘10-11.99 hours/day’ (RR¼ 1.670, 95%CI¼1.074-2.597, p¼ 0.023) possessed high risks of subsequent cognitive impairment. The association for older adults with ‘12 hours/day’ remained significant (RR¼ 2.067, 95%CI¼1.009-4.236, p¼ 0.047) after further adjusting for socio-demographic variables, lifestyle behaviors, chronic conditions, and time spent in moderate-to-vigorous physical activity (Model 2). Conclusions: The 2-year longitudinal data analyses suggest that too much sedentary time, especially 12 hours or more per day, is associated with worse cognitive function in later life.
P3-568
WITHDRAWN
P3-569
ASSOCIATION BETWEEN PM10 EXPOSURE, COFFEE OR TEA CONSUMPTION, AND DEMENTIA RISK IN THE ELDERLY
Shu-Mei Yang1, Yuan-Chien Lin2, Hwa-Lung Yu3, Jen-Hau Chen4, Ta-Fu Chen5, Yu Sun6, Ping-Keung Yip7, Yen-Ching Chen1,8,9, 1Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; 2Department of Civil Engineering, National Central University, Taoyuan, Taiwan; 3Department of Bioenvironmental System Engineering, National Taiwan University, Taipei, Taiwan; 4Department of Geriatrics and Gerontology, National Taiwan University Hospital, Taipei, Taiwan; 5Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan; 6Department of Neurology, En Chu Kong Hospital, Taipei, Taiwan; 7Department of Neurology and Cardinal Tien’s Hospital, Taipei, Taiwan; 8Research Center for Genes, Environment and Human Health, National Taiwan University, Taipei, Taiwan; 9Department of Public Health, National Taiwan University, Taipei, Taiwan. Contact e-mail: [email protected]
Poster Presentations: Tuesday, July 18, 2017 Background: Our previous study showed that exposure to high levels of PM10 (particulate matter<10 mm in diameter) increased the risk of dementia. Coffee and tea consumption has shown protection to neurological diseases. Tea is more popular in Chinese elders than in the western countries. However, it remains unclear how coffee and tea consumption modify the association between PM10 and dementia risk. Methods: This was multi-center case-control study. A total of 236 late-onset Alzheimer’s disease (LOAD) and 105 vascular dementia (VaD) patients, and 455 healthy controls aged 60 were recruited from three teaching hospitals in Taiwan (2007-2010). PM10 data were obtained from Taiwan Environmental Protection Administration for 12 years. The space/time distribution of PM10 was estimated by Bayesian maximum entropy method. A self-reported questionnaire was administered to collect the information on coffee and tea consumption. Multivariable logistic regression model was used to explore the association of PM10 with dementia risk and how coffee and tea consumption modified this association adjusting for important covariates (e.g., APOE e4 status and comorbidities, etc.). Results: Exposure to the highest tertile PM10 (>49.12mg/m3) was associated with increased risk of LOAD [adjusted odds ratio (aOR)¼1.96, 95% confidence interval (CI)¼1.12-3.43] and VaD [aOR¼2.06, 95% CI¼0.99-4.27] compared with the lowest tertile of PM10 (<44.44mg/m3) exposure. Current consumption of 1 cup/day of coffee or 3 cups/day of tea protected against LOAD risk than non-drinkers [aOR¼0.36 and 0.43, respectively]. Similar findings were observed for VaD. Exposure to lower level of PM10 (<49.12mg/m3) and consuming 1 cup/day of coffee or 3 cups/day of tea protected LOAD risk further [aOR¼0.27 and 0.24, respectively]. Similar findings were observed for VaD while the elders exposed to lower level of PM10 (<49.12mg/m3) and previous and current coffee drinking or current tea drinking [aOR¼0.30 and 0.26, respectively]. Significant protective trend was observed when the PM10 exposure decrease and consumption of tea or coffee increased (Ptrend¼0.001-0.007). No significant interactions were found between PM10 exposure and coffee/tea consumption on the risk of dementia. Conclusions: Coffee or tea consumption may protect against the risk of dementia (LOAD and VaD) in Chinese elders exposure to high level of PM10.
P3-570
NEURAL BASIS OF COGNITIVE RESERVE IN DEMENTIA: ROLE OF BILINGUALISM
Suvarna Alladi1, Shailaja Mekala2, Vani K. Kasyap2, Suneel Kumar Bagadi2, Sireesha Jala2, Shruti Naik3, Bapiraju Surampudi3, Ram Mohan Vadapalli4, Kenchaih Raghavendra5, Michael Hornberger6, Subhash Kaul2, 1 National Institute of Mental Health and Neurosciences, Bangalore, India; 2Nizam’s Institute of Medical Sciences, Hyderabad, India; 3 International Institute of Information Technology, Hyderabad, India; 4Vijaya Diagnostics, Hyderabad, India; 5National Institute of Mental Health and Neurosciences, Bangalore, India; 6University of East Anglia, Norwich, United Kingdom. Contact e-mail: [email protected] Background: With the rising burden of dementia globally, there is a need to identify strategies to prevent dementia or delay its onset. Recent studies report the protective role of life-course experiential factors such as education, occupation and physical exercise. Recently bilingualism has emerged as potential pro-
P1197
tective factor. How these factors protect against dementia continues to be a matter of debate. In this study, we aimed to study the neural basis for a protective role for bilingualism against cognitive decline, using a multimodality approach. Methods: 85 subjects with a range of cognitive status from normal cognition (n¼32), to Mild Cognitive Impairment and dementia (n¼53) participated. Subjects were recruited from an ongoing community based longitudinal study of cognitive decline in India. The cohort consisted of subjects of varying educational levels – from illiterate to highly literate and subjects with varying levels of language use, from monolingual to high levels of bilingualism. All subjects underwent detailed evaluation that included cognitive testing on a range of tasks, demographic evaluation, educational, occupation and language profiles. Fractional anisotropy measures derived from high-resolution diffusion- tensor imaging (DTI) on a 3 Tesla MRI was used as an indicator of white matter integrity. Results: Our study showed that in participants with normal cognition, being bilingual conferred an advantage in cognitive tasks that were indictors of conflict resolution in attentional/executive demands and visuospatial functions. On regression analysis, accounting for education, age and gender, lower FA values were noted in corpus callosum, anterior thalamic radiation, uncinate and inferior fronto-occipital fasciculus in bilingual compared to monolingual patients with cognitive impairment, for the same severity of impairment. Cognitively normal bilinguals had higher FA values in similar white matter areas compared to their monolingual counterparts. Conclusions: Reduced white matter integrity in bilinguals with cognitive impairment compared to monolinguals with similar level of impairment, and higher fiber tract integrity in cognitive normal bilinguals is consistent with the hypothesis that the bilingualism plays a role in enhancing cognitive reserve.The underlying neural mechanism is likely to be related to integrity in tracts that have a role in inter-hemispheric and intra-hemispheric connectivity, semantic processing and executive control.
P3-571
THE EFFECT OF ADHERENCE TO SCREENING GUIDELINES ON THE RISK OF ALZHEIMER’S DISEASE IN ELDERLY INDIVIDUALS NEWLY DIAGNOSED WITH DIABETES MELLITUS
Arseniy Pavlovich Yashkin, Igor Akushevich, Svetlana Ukraintseva, Anatoliy I. Yashin, Duke University, Durham, NC, USA. Contact e-mail: [email protected] Background: The 2016 Alzheimer’s Association report and several
other recent studies suggest that age-adjusted incidence of Alzheimer’s disease (AD) may have been decreasing over recent decades. However, the mechanisms responsible for this decrease have not been fully explored. Type 2 Diabetes Mellitus (T2D) is a common chronic condition that has both epidemiological and metabolic similarities to AD and has been identified as an AD risk. Adherence to T2D screening guidelines has been shown to reduce the risk of mortality and many other serious complications of T2D. Whether such health-conscious behavior can reduce the risk of AD remains unknown. Methods: Using data from the Health and Retirement Study (HRS), 1992-2012, linked to Medicare Administrative Claims data, we studied the relationship between adherence to T2D screening guidelines and receiving an incident diagnosis of AD in a sample of U.S. Medicare FFS beneficiaries age 66+ with a new diagnosis
Poster Presentations: Tuesday, July 18, 2017
Germany; 3Alzheimer’s Disease and Other Cognitive Disorders Unit, Hospital Clınic, Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; 4Department of Medical Humanities, VU University Medical Center/EMGO+, Amsterdam, Netherlands; 5 Alzheimer’s Disease Unit and Other Cognitive Disorders Unit, Hospital Clinic de Barcelona, Barcelona, Spain; 6Barcelonabeta Brain Research Center, Barcelona, Spain; 7German Center for Neurodegenerative Diseases (DZNE), Bonn-Cologne, Germany; 8Department of Psychiatry, University of Cologne, Cologne, Germany; 9Alzheimer Center and Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, Netherlands; 10Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands. Contact e-mail: [email protected] Background: As a first step towards the development of an online
lifestyle program (OLP) targeting brain health, we investigated the needs and preferences of individuals with subjective cognitive decline (SCD) for such a program. Methods: This study is part of the European Euro-SCD study (JPND_PS_FP-689019). Subjects were recruited at memory clinics in Amsterdam, Cologne and Barcelona. To get insight in the OLP preferences of SCD subjects on a larger scale, we conducted an (online) selfreport 29-item survey. This survey was spread among subjects (N¼238) at the three memory clinics. For more in-depth understanding of the Internet usage and preferences for an OLP, semistructured interviews were conducted (N¼22: n¼14 Amsterdam, n¼8 Cologne). Interviews were audiotaped and transcribed verbatim. Data were subjected to thematic analysis. Results: A total of 176/238 (74%) participants completed the survey (46% female, 93% within age range 50-80y, 73% education beyond secondary school; Amsterdam N¼126; Cologne N¼32; Barcelona N¼18). The majority (78%) used the Internet on a daily basis. Almost all respondents (98%) reported that lifestyle could contribute to brain health and reported willingness to use an OLP targeting brain health (93%). Major topics of interest included nutrition (82%), cognitive activity (81%) and physical activity (79%). Motivating facilitating factors were ‘trustworthiness’ and ‘ease of use’, whereas the need for an account was considered a barrier. We found no major differences between countries. Interview participants reported to value scientifically grounded information which would strengthen trustworthiness of information in their perception. Optional reminders for the use of the program and optional notifications of new content were also reported to be of importance. Additionally, participants reported to value an attractive and user-friendly design. Conclusions: Our findings indicate that individuals with SCD are highly interested in using an OLP across different European countries. The results form the basis for development of an OLP fitting the preferences of the users. P3-567
PROSPECTIVE RELATIONSHIP BETWEEN OBJECTIVELY ASSESSED SEDENTARY TIME AND COGNITIVE IMPAIRMENT IN LATER LIFE
Po-Wen Ku1, Li-Jung Chen2, Wen-Jung Sun3, 1National Changhua University of Education, Changhua, Taiwan; 2National Taiwan University of Sport, Taichung, Taiwan; 3Taipei City Hospital Zhongxing Branch, Taipei, Taiwan. Contact e-mail: [email protected] Background: There is an increasing evidence base suggesting that
sedentary behavior is independent from physical activity associated with a plethora of outcomes such as cardiovascular disease, metabolic syndromes, diabetes, cancer, and mortality in aged popula-
tion. However, the use of self-report measures of time spent in sedentary behaviors is a serious methodological weakness in the literature. It is still equivocal whether too much sedentary time will increase the risk of cognitive impairment in later life. This study aimed to examine whether objectively measured sedentary time is prospectively associated with cognitive impairment in older adults. Methods: This was a two-year prospective cohort study. A total of 285 community-dwelling Taiwanese older adults aged 65 or older were interviewed and assessed in 2012. A second wave of assessment was carried out in 2014 involving 274 (96.1%) participants. Time spent in sedentary behaviors was measured using waist worn triaxial accelerometer monitors (GT3X+, ActiGraph) for 7 days. The sedentary time was divided into four levels (< 8, 8-9.99, 10-11.99, 12 or more hours/day). Cognitive impairment was obtained using a Chinese version of the Ascertain Dementia 8-item Questionnaire (AD8) by participants with a potential range between 0 and 8. Multivariable negative binomial regression analyses were conducted because the AD8 score was an over-dispersed count with a highly skewed distribution. Negative binomial regression models with adjustment for baseline cognitive status, accelerometer wear time, socio-demographic variables, lifestyle behaviors, chronic disease conditions, and time spent in moderate-to-vigorous physical activity were performed (a¼0.05). Results: After adjusting for baseline cognitive status and accelerometer wear time (Model 1), participants with sedentary time ‘12 hours/day’ (Risk Ratio [RR] ¼ 3.633, 95C%CI¼ 1.952-6.760, p¼ <0.001) and those with ‘10-11.99 hours/day’ (RR¼ 1.670, 95%CI¼1.074-2.597, p¼ 0.023) possessed high risks of subsequent cognitive impairment. The association for older adults with ‘12 hours/day’ remained significant (RR¼ 2.067, 95%CI¼1.009-4.236, p¼ 0.047) after further adjusting for socio-demographic variables, lifestyle behaviors, chronic conditions, and time spent in moderate-to-vigorous physical activity (Model 2). Conclusions: The 2-year longitudinal data analyses suggest that too much sedentary time, especially 12 hours or more per day, is associated with worse cognitive function in later life.
P3-568
WITHDRAWN
P3-569
ASSOCIATION BETWEEN PM10 EXPOSURE, COFFEE OR TEA CONSUMPTION, AND DEMENTIA RISK IN THE ELDERLY
Shu-Mei Yang1, Yuan-Chien Lin2, Hwa-Lung Yu3, Jen-Hau Chen4, Ta-Fu Chen5, Yu Sun6, Ping-Keung Yip7, Yen-Ching Chen1,8,9, 1Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; 2Department of Civil Engineering, National Central University, Taoyuan, Taiwan; 3Department of Bioenvironmental System Engineering, National Taiwan University, Taipei, Taiwan; 4Department of Geriatrics and Gerontology, National Taiwan University Hospital, Taipei, Taiwan; 5Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan; 6Department of Neurology, En Chu Kong Hospital, Taipei, Taiwan; 7Department of Neurology and Cardinal Tien’s Hospital, Taipei, Taiwan; 8Research Center for Genes, Environment and Human Health, National Taiwan University, Taipei, Taiwan; 9Department of Public Health, National Taiwan University, Taipei, Taiwan. Contact e-mail: [email protected]
Poster Presentations: Tuesday, July 18, 2017 Background: Our previous study showed that exposure to high levels of PM10 (particulate matter<10 mm in diameter) increased the risk of dementia. Coffee and tea consumption has shown protection to neurological diseases. Tea is more popular in Chinese elders than in the western countries. However, it remains unclear how coffee and tea consumption modify the association between PM10 and dementia risk. Methods: This was multi-center case-control study. A total of 236 late-onset Alzheimer’s disease (LOAD) and 105 vascular dementia (VaD) patients, and 455 healthy controls aged 60 were recruited from three teaching hospitals in Taiwan (2007-2010). PM10 data were obtained from Taiwan Environmental Protection Administration for 12 years. The space/time distribution of PM10 was estimated by Bayesian maximum entropy method. A self-reported questionnaire was administered to collect the information on coffee and tea consumption. Multivariable logistic regression model was used to explore the association of PM10 with dementia risk and how coffee and tea consumption modified this association adjusting for important covariates (e.g., APOE e4 status and comorbidities, etc.). Results: Exposure to the highest tertile PM10 (>49.12mg/m3) was associated with increased risk of LOAD [adjusted odds ratio (aOR)¼1.96, 95% confidence interval (CI)¼1.12-3.43] and VaD [aOR¼2.06, 95% CI¼0.99-4.27] compared with the lowest tertile of PM10 (<44.44mg/m3) exposure. Current consumption of 1 cup/day of coffee or 3 cups/day of tea protected against LOAD risk than non-drinkers [aOR¼0.36 and 0.43, respectively]. Similar findings were observed for VaD. Exposure to lower level of PM10 (<49.12mg/m3) and consuming 1 cup/day of coffee or 3 cups/day of tea protected LOAD risk further [aOR¼0.27 and 0.24, respectively]. Similar findings were observed for VaD while the elders exposed to lower level of PM10 (<49.12mg/m3) and previous and current coffee drinking or current tea drinking [aOR¼0.30 and 0.26, respectively]. Significant protective trend was observed when the PM10 exposure decrease and consumption of tea or coffee increased (Ptrend¼0.001-0.007). No significant interactions were found between PM10 exposure and coffee/tea consumption on the risk of dementia. Conclusions: Coffee or tea consumption may protect against the risk of dementia (LOAD and VaD) in Chinese elders exposure to high level of PM10.
P3-570
NEURAL BASIS OF COGNITIVE RESERVE IN DEMENTIA: ROLE OF BILINGUALISM
Suvarna Alladi1, Shailaja Mekala2, Vani K. Kasyap2, Suneel Kumar Bagadi2, Sireesha Jala2, Shruti Naik3, Bapiraju Surampudi3, Ram Mohan Vadapalli4, Kenchaih Raghavendra5, Michael Hornberger6, Subhash Kaul2, 1 National Institute of Mental Health and Neurosciences, Bangalore, India; 2Nizam’s Institute of Medical Sciences, Hyderabad, India; 3 International Institute of Information Technology, Hyderabad, India; 4Vijaya Diagnostics, Hyderabad, India; 5National Institute of Mental Health and Neurosciences, Bangalore, India; 6University of East Anglia, Norwich, United Kingdom. Contact e-mail: [email protected] Background: With the rising burden of dementia globally, there is a need to identify strategies to prevent dementia or delay its onset. Recent studies report the protective role of life-course experiential factors such as education, occupation and physical exercise. Recently bilingualism has emerged as potential pro-
P1197
tective factor. How these factors protect against dementia continues to be a matter of debate. In this study, we aimed to study the neural basis for a protective role for bilingualism against cognitive decline, using a multimodality approach. Methods: 85 subjects with a range of cognitive status from normal cognition (n¼32), to Mild Cognitive Impairment and dementia (n¼53) participated. Subjects were recruited from an ongoing community based longitudinal study of cognitive decline in India. The cohort consisted of subjects of varying educational levels – from illiterate to highly literate and subjects with varying levels of language use, from monolingual to high levels of bilingualism. All subjects underwent detailed evaluation that included cognitive testing on a range of tasks, demographic evaluation, educational, occupation and language profiles. Fractional anisotropy measures derived from high-resolution diffusion- tensor imaging (DTI) on a 3 Tesla MRI was used as an indicator of white matter integrity. Results: Our study showed that in participants with normal cognition, being bilingual conferred an advantage in cognitive tasks that were indictors of conflict resolution in attentional/executive demands and visuospatial functions. On regression analysis, accounting for education, age and gender, lower FA values were noted in corpus callosum, anterior thalamic radiation, uncinate and inferior fronto-occipital fasciculus in bilingual compared to monolingual patients with cognitive impairment, for the same severity of impairment. Cognitively normal bilinguals had higher FA values in similar white matter areas compared to their monolingual counterparts. Conclusions: Reduced white matter integrity in bilinguals with cognitive impairment compared to monolinguals with similar level of impairment, and higher fiber tract integrity in cognitive normal bilinguals is consistent with the hypothesis that the bilingualism plays a role in enhancing cognitive reserve.The underlying neural mechanism is likely to be related to integrity in tracts that have a role in inter-hemispheric and intra-hemispheric connectivity, semantic processing and executive control.
P3-571
THE EFFECT OF ADHERENCE TO SCREENING GUIDELINES ON THE RISK OF ALZHEIMER’S DISEASE IN ELDERLY INDIVIDUALS NEWLY DIAGNOSED WITH DIABETES MELLITUS
Arseniy Pavlovich Yashkin, Igor Akushevich, Svetlana Ukraintseva, Anatoliy I. Yashin, Duke University, Durham, NC, USA. Contact e-mail: [email protected] Background: The 2016 Alzheimer’s Association report and several
other recent studies suggest that age-adjusted incidence of Alzheimer’s disease (AD) may have been decreasing over recent decades. However, the mechanisms responsible for this decrease have not been fully explored. Type 2 Diabetes Mellitus (T2D) is a common chronic condition that has both epidemiological and metabolic similarities to AD and has been identified as an AD risk. Adherence to T2D screening guidelines has been shown to reduce the risk of mortality and many other serious complications of T2D. Whether such health-conscious behavior can reduce the risk of AD remains unknown. Methods: Using data from the Health and Retirement Study (HRS), 1992-2012, linked to Medicare Administrative Claims data, we studied the relationship between adherence to T2D screening guidelines and receiving an incident diagnosis of AD in a sample of U.S. Medicare FFS beneficiaries age 66+ with a new diagnosis