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Association of APOL1 genetic variants with longitudinal blood pressure from young adulthood to middle age: The coronary artery risk development in young adults study (CARDIA)
Abstracts / Journal of the American Society of Hypertension 10(4S) (2016) e39–e55
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Figure 1.
Material and Methods: We chose 12 women between 25-40 weeks gestation with diagnosed mild preeclampsia to the study group and 12 healthy women with uncomplicated pregnancies. Patients from both groups were matched for maternal age, number of pregnancies, gestational age at collecting and body mass in order to make sure that two groups comparable and there are no statistically significant differences between them. The protein determination in plasma we used quantitative protein macroarray method that allows the analysis of the 60 angiogenic proteins per sample simultaneously. Results: We showed a statistically significant increase in the concentration of 14 proteins: IFN-gamma (p-value¼ 0,0209), IL-6 (p-value¼ 0,0068), IL-8 (p-value¼0,0332), LIF (p-value¼ 0,0038), MCP-1 (p-value¼ 0,012), AgRP (p-value¼ 0,0204), Hb-EGF (p-value¼ 0,0241), HGF (p-value¼ 0,0018), IL-2 (p-value¼ 0,0479), IL-17 (p-value¼ 0,0317), IP-10 (p-value¼ 0,0006), Leptin (p-value¼ 0,0018), PDGF-BB (p-value¼ 0,0016), G-CSF (p-value¼ 0,0414) and a significant decrease in the concentration of 3 proteins: VEGF (p-value¼ 0,0317), PlGF (p-value¼0,0183), Follistatin (p-value¼ 0,0476) in the plasma of women with PE in comparison to the group of women with uncomplicated pregnancy. We included these angiogenic factors in later analyses and created ROC curves for them, which set the threshold values and allowed predicting the likelihood of PE with specific sensitivity and specificity - minimal sensitivity was set to 0.7. Applying this threshold of sensitivity and specificity we received 7 proteins and we created ROC curves (Figure 1.) Conclusion: The obtained results largely confirmed the information available in the literature and identified a number of new directions of protein research in etiology of PE. Keywords: preeclampsia; protein array; biomarkers; angiogenic factors
Blacks are more likely to have hypertension, difficult to control blood pressure (BP), and hypertension-attributed end stage renal disease, compared to Whites. Whether genetic polymorphisms associated with higher risk for ESRD contribute to the increased burden of hypertension in this population is unknown. Among Blacks, we evaluated whether APOL1 risk variants (high-risk [2 risk alleles] vs. low-risk [0-1 risk alleles]) are associated with longitudinal BP changes (systolic BP, diastolic BP, mid-BP [defined as (systolic BP + diastolic BP)/2]) over 25 years of follow-up (8 possible CARDIA exams). We then examined differences in longitudinal BP between Blacks (overall and by APOL1 status) vs. Whites using linear mixed-effects models while adjusting for demographics, traditional hypertension risk factors, socioeconomic factors, and kidney function. Among 1700 Whites and 1330 Blacks (13% APOL1 high-risk), mean baseline age was 25 years, 46% were male, and 1% were on anti-hypertensive medications while mean systolic, diastolic and mid-BPs were 110, 69, and 89 mmHg, respectively. Among Blacks, longitudinal mid-BP changes did not differ significantly by APOL1 risk status (p¼0.71). Compared to Whites, Blacks were overall more likely to experience greater increases in mid-BP over time
P-56 Association of APOL1 genetic variants with longitudinal blood pressure from young adulthood to middle age: The coronary artery risk development in young adults study (CARDIA) Teresa Chen,1 Michelle Estrella,1 Eric Vittinghoff,7 Feng Lin,7 Orlando Gutierrez,6 Holly Kramer,2 Jeffrey Kopp,4 Norinna Allen,5 Cheryl Winkler,3 Kirsten Bibbins-Domingo,7 Cora Lewis,6 Carmen Peralta.7 1Johns Hopkins University, MD, United States; 2Loyola University, IL, United States; 3NCI/NIH, MD, United States; 4NIDDK/NIH, MD, United States; 5Northwestern University, IL, United States; 6 University of Alabama at Birmingham, AL, United States; 7University of California San Francisco, CA, United States
Figure 1.
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Abstracts / Journal of the American Society of Hypertension 10(4S) (2016) e39–e55
(p<0.01). When stratified by APOL1 status, both high-risk and low-risk Blacks were at higher risk for rising mid-BP compared to Whites (Figure 1). Similar results were obtained when using systolic or diastolic BP as the outcome. In conclusion, APOL1 was not associated with BP change over time. While Blacks are more likely to have greater increases in BP with aging compared to Whites, this difference is not explained by APOL1 risk variants or traditional risk factors for hypertension. Keywords: APOL1; Apolipoprotein L1; CARDIA; Hypertension
EPIDEMIOLOGY/SPECIAL POPULATIONS P-57 The association between napping and hypertension: A meta-analysis Wisit Cheungpasitporn, Charat Thongprayoon, Narat Srivali, Priya Vijayvargiya, Wonngarm Kittanamongkolchai, Sean M. Caples, Stephen B. Erickson. Mayo Clinic, Rochester, MN, United States Background: The risk of hypertension in adults who regularly take a nap is controversial. The objective of this meta-analysis was to assess the associations between napping and hypertension. Methods: A literature search was performed using MEDLINE, EMBASE, and Cochrane Database of Systematic Reviews from inception through October, 2015. Studies that reported relative risks, odd ratios or hazard ratios comparing the risk of hypertension in individuals who regularly take nap were included. Pooled risk ratios (RR) and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method. Results: Nine observational studies with 112,267 individuals were included in the analysis to assess the risk of hypertension in nappers. The pooled RR of hypertension in nappers was 1.13 (95% CI, 0.981.30). When meta-analysis was limited only to studies assessing the risk of hypertension in daytime nappers, the pooled RR of hypertension was 1.19 (95% CI, 1.06-1.35). The data on association between nighttime napping in individuals who work night shift and hypertension were limited; 1 observational study reported reduced risk of hypertension in nighttime nappers with odds ratio of 0.79 (0.63-1.00). Conclusion: Our meta-analysis demonstrates a significant association between daytime napping and hypertension. This finding may impact clinical management and primary prevention of hypertension. Keywords: Blood pressure; Hypertension; Napping; Sleep
CARDIAC STRUCTURE AND FUNCTION/IMAGING
P-58 Changes of geometry left ventricle compared to the left atrial enlargement in patients over 70 yy with atrial fibrillation combined with arterial hypertension Vito Chimienti,2 Stefania Gabrieli.1 1Bolognini Hospital, Seriate, Italy; 2 Cardiology Outpatients, MOA Locatelli Hospital, Piario, Italy 1) The arterial hypertension (IA) is the most common cardiovascular disease affecting between 20% to 50% of the general population The IA is the cause of left ventricular hypertrophy, which is one of the greatest expressions of subclinical damage The IA is the disease that most often is associated with atrial fibrillation (AF), it was indeed found that affects more than 90% of participants in the trials for the FA and the prevalence of their association progresses greatly with age. 2) The Atrial fibrillation (AF) is the most common heart rhythm disorder, affects about 1% of the world population, an adult every four , after the age of 40 is affected by this disease in their lifetime, but this percentage reaches 10% for people over the age of 80 years. The Atrial Fibrilation determines structural alterations of the heart, such as increased ventricular mass, atrial enlargement with atrial remodeling that causes electrical dissociation between muscle structures and alterations of physiological conduction intraatriale. The increase in atrial size is a well-known as ssociation of Left Ventricular Geometry with Left Atrial Enlargement in patientes over 70 yy with Hypertension and Atrial Fibrillation. In our research, we wanted to study the correlation between one of the geometric patterns of hypertension, atrial dimensions and atrial fibrilation in elderly male and female (age > 70 yy) with coexistence of both diseases, in the absence of other cardiovascular diseases and diabetes mellito. We reviewed retrospectively report of 400 patients (pts) were referred to Cardiology Outpatientes or Emergency Department of our hospital, for no cronic atrial fibrillation and subjected at that time to echocardiographic exam So from our database, we extrapolated echocardiographic data concerning: left ventricular mass (LVMI), the relative thickness of the left ventricle (RWT) and dimensions of parasternal-long-axis 2-D (Las) and we selected 120 patients,of which 69 male patients, 51 female patients; the average age was 73 years (from 70 yy > max 78 yy) The selected data, showed the following results: > 45% of patients: 65% of males and 35% females had concentric hypertrophy( CH ) with severe atrial size increase; the average age was 76 years > 35% of patients: 60% males and 40% of females had a concentric remodelling ( CR) with moderate increase in atrial dimensions, the average age was 73 years
Figure 1.
e41
Figure 1.
Material and Methods: We chose 12 women between 25-40 weeks gestation with diagnosed mild preeclampsia to the study group and 12 healthy women with uncomplicated pregnancies. Patients from both groups were matched for maternal age, number of pregnancies, gestational age at collecting and body mass in order to make sure that two groups comparable and there are no statistically significant differences between them. The protein determination in plasma we used quantitative protein macroarray method that allows the analysis of the 60 angiogenic proteins per sample simultaneously. Results: We showed a statistically significant increase in the concentration of 14 proteins: IFN-gamma (p-value¼ 0,0209), IL-6 (p-value¼ 0,0068), IL-8 (p-value¼0,0332), LIF (p-value¼ 0,0038), MCP-1 (p-value¼ 0,012), AgRP (p-value¼ 0,0204), Hb-EGF (p-value¼ 0,0241), HGF (p-value¼ 0,0018), IL-2 (p-value¼ 0,0479), IL-17 (p-value¼ 0,0317), IP-10 (p-value¼ 0,0006), Leptin (p-value¼ 0,0018), PDGF-BB (p-value¼ 0,0016), G-CSF (p-value¼ 0,0414) and a significant decrease in the concentration of 3 proteins: VEGF (p-value¼ 0,0317), PlGF (p-value¼0,0183), Follistatin (p-value¼ 0,0476) in the plasma of women with PE in comparison to the group of women with uncomplicated pregnancy. We included these angiogenic factors in later analyses and created ROC curves for them, which set the threshold values and allowed predicting the likelihood of PE with specific sensitivity and specificity - minimal sensitivity was set to 0.7. Applying this threshold of sensitivity and specificity we received 7 proteins and we created ROC curves (Figure 1.) Conclusion: The obtained results largely confirmed the information available in the literature and identified a number of new directions of protein research in etiology of PE. Keywords: preeclampsia; protein array; biomarkers; angiogenic factors
Blacks are more likely to have hypertension, difficult to control blood pressure (BP), and hypertension-attributed end stage renal disease, compared to Whites. Whether genetic polymorphisms associated with higher risk for ESRD contribute to the increased burden of hypertension in this population is unknown. Among Blacks, we evaluated whether APOL1 risk variants (high-risk [2 risk alleles] vs. low-risk [0-1 risk alleles]) are associated with longitudinal BP changes (systolic BP, diastolic BP, mid-BP [defined as (systolic BP + diastolic BP)/2]) over 25 years of follow-up (8 possible CARDIA exams). We then examined differences in longitudinal BP between Blacks (overall and by APOL1 status) vs. Whites using linear mixed-effects models while adjusting for demographics, traditional hypertension risk factors, socioeconomic factors, and kidney function. Among 1700 Whites and 1330 Blacks (13% APOL1 high-risk), mean baseline age was 25 years, 46% were male, and 1% were on anti-hypertensive medications while mean systolic, diastolic and mid-BPs were 110, 69, and 89 mmHg, respectively. Among Blacks, longitudinal mid-BP changes did not differ significantly by APOL1 risk status (p¼0.71). Compared to Whites, Blacks were overall more likely to experience greater increases in mid-BP over time
P-56 Association of APOL1 genetic variants with longitudinal blood pressure from young adulthood to middle age: The coronary artery risk development in young adults study (CARDIA) Teresa Chen,1 Michelle Estrella,1 Eric Vittinghoff,7 Feng Lin,7 Orlando Gutierrez,6 Holly Kramer,2 Jeffrey Kopp,4 Norinna Allen,5 Cheryl Winkler,3 Kirsten Bibbins-Domingo,7 Cora Lewis,6 Carmen Peralta.7 1Johns Hopkins University, MD, United States; 2Loyola University, IL, United States; 3NCI/NIH, MD, United States; 4NIDDK/NIH, MD, United States; 5Northwestern University, IL, United States; 6 University of Alabama at Birmingham, AL, United States; 7University of California San Francisco, CA, United States
Figure 1.
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Abstracts / Journal of the American Society of Hypertension 10(4S) (2016) e39–e55
(p<0.01). When stratified by APOL1 status, both high-risk and low-risk Blacks were at higher risk for rising mid-BP compared to Whites (Figure 1). Similar results were obtained when using systolic or diastolic BP as the outcome. In conclusion, APOL1 was not associated with BP change over time. While Blacks are more likely to have greater increases in BP with aging compared to Whites, this difference is not explained by APOL1 risk variants or traditional risk factors for hypertension. Keywords: APOL1; Apolipoprotein L1; CARDIA; Hypertension
EPIDEMIOLOGY/SPECIAL POPULATIONS P-57 The association between napping and hypertension: A meta-analysis Wisit Cheungpasitporn, Charat Thongprayoon, Narat Srivali, Priya Vijayvargiya, Wonngarm Kittanamongkolchai, Sean M. Caples, Stephen B. Erickson. Mayo Clinic, Rochester, MN, United States Background: The risk of hypertension in adults who regularly take a nap is controversial. The objective of this meta-analysis was to assess the associations between napping and hypertension. Methods: A literature search was performed using MEDLINE, EMBASE, and Cochrane Database of Systematic Reviews from inception through October, 2015. Studies that reported relative risks, odd ratios or hazard ratios comparing the risk of hypertension in individuals who regularly take nap were included. Pooled risk ratios (RR) and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method. Results: Nine observational studies with 112,267 individuals were included in the analysis to assess the risk of hypertension in nappers. The pooled RR of hypertension in nappers was 1.13 (95% CI, 0.981.30). When meta-analysis was limited only to studies assessing the risk of hypertension in daytime nappers, the pooled RR of hypertension was 1.19 (95% CI, 1.06-1.35). The data on association between nighttime napping in individuals who work night shift and hypertension were limited; 1 observational study reported reduced risk of hypertension in nighttime nappers with odds ratio of 0.79 (0.63-1.00). Conclusion: Our meta-analysis demonstrates a significant association between daytime napping and hypertension. This finding may impact clinical management and primary prevention of hypertension. Keywords: Blood pressure; Hypertension; Napping; Sleep
CARDIAC STRUCTURE AND FUNCTION/IMAGING
P-58 Changes of geometry left ventricle compared to the left atrial enlargement in patients over 70 yy with atrial fibrillation combined with arterial hypertension Vito Chimienti,2 Stefania Gabrieli.1 1Bolognini Hospital, Seriate, Italy; 2 Cardiology Outpatients, MOA Locatelli Hospital, Piario, Italy 1) The arterial hypertension (IA) is the most common cardiovascular disease affecting between 20% to 50% of the general population The IA is the cause of left ventricular hypertrophy, which is one of the greatest expressions of subclinical damage The IA is the disease that most often is associated with atrial fibrillation (AF), it was indeed found that affects more than 90% of participants in the trials for the FA and the prevalence of their association progresses greatly with age. 2) The Atrial fibrillation (AF) is the most common heart rhythm disorder, affects about 1% of the world population, an adult every four , after the age of 40 is affected by this disease in their lifetime, but this percentage reaches 10% for people over the age of 80 years. The Atrial Fibrilation determines structural alterations of the heart, such as increased ventricular mass, atrial enlargement with atrial remodeling that causes electrical dissociation between muscle structures and alterations of physiological conduction intraatriale. The increase in atrial size is a well-known as ssociation of Left Ventricular Geometry with Left Atrial Enlargement in patientes over 70 yy with Hypertension and Atrial Fibrillation. In our research, we wanted to study the correlation between one of the geometric patterns of hypertension, atrial dimensions and atrial fibrilation in elderly male and female (age > 70 yy) with coexistence of both diseases, in the absence of other cardiovascular diseases and diabetes mellito. We reviewed retrospectively report of 400 patients (pts) were referred to Cardiology Outpatientes or Emergency Department of our hospital, for no cronic atrial fibrillation and subjected at that time to echocardiographic exam So from our database, we extrapolated echocardiographic data concerning: left ventricular mass (LVMI), the relative thickness of the left ventricle (RWT) and dimensions of parasternal-long-axis 2-D (Las) and we selected 120 patients,of which 69 male patients, 51 female patients; the average age was 73 years (from 70 yy > max 78 yy) The selected data, showed the following results: > 45% of patients: 65% of males and 35% females had concentric hypertrophy( CH ) with severe atrial size increase; the average age was 76 years > 35% of patients: 60% males and 40% of females had a concentric remodelling ( CR) with moderate increase in atrial dimensions, the average age was 73 years
Figure 1.