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Association of blood lead and blood pressure in the NHANES 1999–2006
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Abstracts / Toxicology Letters 196S (2010) S37–S351
both LM and MM genotypes of L55M polymorphism were more frequently observed in cases, and along with the haplotypes 112, 221 and 222 (for −108CT, L55M and Q192R, respectively) were associated with a risk for having a SB-affected child (p < 0.02). The heterozygous CT genotype was associated only maternally, whereas the heterozygous LM genotype was relevant only in fathers. The RR homozygous genotype was relevant both in mothers and fathers, suggesting the importance of this substrate-specific polymorphism. Together, these results suggest that PON1 polymorphisms are relevant risk factors for having offspring affected with SB in this population from Southeaster Mexico (supported by CONACYT-2004-115). doi:10.1016/j.toxlet.2010.03.188
P102-005 Analysis of gender-related differences among the patients with suicidal drug intoxication S. Ilgın 1 , A. Sarac¸o˘glu 1 , Ö. Atlı 1 , N. Acar 2 Anadolu University, Faculty of Pharmacy, Turkey, 2 Osmangazi University, Faculty of Medicine, Turkey
1
High dose drug intake is the most common method for suicidal attempts. In this study, gender-related differences of 1019 suicidal cases, which had been admitted to Emergency Service of Osmangazi University Hospital between 2003 and 2008, were investigated. Of these cases, 68.4% were women and 31.6% were men. The mean age of all cases was 27.63 ± 10.13 whereas the mean age was 26.20 ± 8.87 for women and 30.69 ± 11.86 for men. While hypotension was more common in women, hypertension incidence was higher in men. Tachycardia incidence was more in women than men. 51.55% of men and 36.29% of women had taken psychiatric drugs for suicidal purpose. In addition to these drugs, 22.67% of men and 8.46% of women had used alcohol. Substance dependence incidence in men was four-fold of women. Four men and one woman had died. According to these results, although the incidence of suicidal attempts by drugs was 2.6-fold higher in women, it could be concluded that the intoxications developed was more serious and severe in men. doi:10.1016/j.toxlet.2010.03.189
P102-006 Association of blood lead and blood pressure in the NHANES 1999–2006 F. Scinicariello, H. Abadin, H.E. Murray CDC/ATSDR Background: A relationship between blood pressure (BP) and blood lead concentrations has been reported and this relationship appeared to be influenced by the sex and/or race of the participants. The objective of this study was to evaluate whether low blood-lead levels (BLLs ≤ 10 g/dL) were associated with BP among adults aged 20 years and older in the U.S. population. Methods: We analyzed data from NHANES 1999–2006 participants aged 20 years or older who were white non-Hispanic or black non-Hispanic with BLLs ≤ 10 g/dL. Outcome variables were systolic and diastolic BP measurements and hypertension status. Results: In multiple regression analyses, BLLs were significantly correlated with higher systolic BP among black men and women, but not white, participants. The change in systolic BP associated
with a two-fold increase of blood-lead concentration was 1.59 mm Hg in black men, and 1.66 mm Hg in black women. BLLs were significantly associated with higher diastolic BPs among white men and women and black men, but not among black women. Black men with BLLs = 5.01–10 g/dL had an adjusted prevalence odds ratio of 1.98 (95% CI: 1.11–3.50) to have hypertension compared with black men with BLL < 5 g/dL. Conclusions: BLLs among black non-Hispanic men participants were associated with increased systolic and diastolic BP and higher hypertension risk. Despite the decline in blood-lead concentrations in the U.S. population, lead exposure remains a major public health priority and is still a health risk. Disclaimers: The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers of Disease Control and Prevention/Agency for Toxic Substances and Disease Registry. doi:10.1016/j.toxlet.2010.03.190
P102-007 Clinical presentations skin by biting spiders genus Loxosceles. Toxicology service experience from children’s hospital of the blessed trinity, province of Cordoba, Argentina, during 2006–2009 M. Aliaga, N. Gait, R. Llebeili, M. Pierotto, A. Suarez, A. Gait Hospital de ni˜ nos de la Santisima Trinidad, Spain Introduction: Accidents of this kind of spider can relate with two forms of clinical presentation, cutaneous loxoscelism, 84–97%, represented with the presence of serohematic blister, liveloide plate and then to eschar and loxoscelism cutaneous and visceral, severe. It is necessary, this review, for the purpose of optimizing the recognition and diagnosis of this condition. In our hospital, there has been an increase in accidents caused by spiders in urban areas and within them a high percentage represented by the genus Loxosceles. Objectives: To identify the lesion for the diagnosis, know clinical forms of presentation most common in our environment, assess early diagnosis, analyze clinical data and experience in our Toxicology Service at Children’s Hospital, develop reflective skills, from statistical data. Material and methods: A retrospective, descriptive and exploratory, observational and longitudinal study of a universe of 96 cases of injuries consistent with spider bites, in the period 2006–2009. Results: In our series of 39 patients with cutaneous loxoscelism, clinical presentation was in 77% of the ampoule serohematic followed by necrosis in 59% and plaque liveloide in 51% and in only 35.90% of cases eschar evolved. The 25.64% localized pain-burning rate at the time of the bite and 15.38% with systemic disorders. The above-mentioned would explain our experience that early diagnosis and prompt treatment limit natural evolution and circumscribe the lesion. Conclusions: We conclude that the increased incidence of cases in the last year, is that through the recognition of the injury, training implemented, taxonomic identification of the spider, epidemiological surveillance, in order to plan preventive measures for accurate reporting, timely to ensure an early diagnosis, thus improving clinical outcome, avoiding complications and consequences that carry a high cost of health care. doi:10.1016/j.toxlet.2010.03.191
Abstracts / Toxicology Letters 196S (2010) S37–S351
both LM and MM genotypes of L55M polymorphism were more frequently observed in cases, and along with the haplotypes 112, 221 and 222 (for −108CT, L55M and Q192R, respectively) were associated with a risk for having a SB-affected child (p < 0.02). The heterozygous CT genotype was associated only maternally, whereas the heterozygous LM genotype was relevant only in fathers. The RR homozygous genotype was relevant both in mothers and fathers, suggesting the importance of this substrate-specific polymorphism. Together, these results suggest that PON1 polymorphisms are relevant risk factors for having offspring affected with SB in this population from Southeaster Mexico (supported by CONACYT-2004-115). doi:10.1016/j.toxlet.2010.03.188
P102-005 Analysis of gender-related differences among the patients with suicidal drug intoxication S. Ilgın 1 , A. Sarac¸o˘glu 1 , Ö. Atlı 1 , N. Acar 2 Anadolu University, Faculty of Pharmacy, Turkey, 2 Osmangazi University, Faculty of Medicine, Turkey
1
High dose drug intake is the most common method for suicidal attempts. In this study, gender-related differences of 1019 suicidal cases, which had been admitted to Emergency Service of Osmangazi University Hospital between 2003 and 2008, were investigated. Of these cases, 68.4% were women and 31.6% were men. The mean age of all cases was 27.63 ± 10.13 whereas the mean age was 26.20 ± 8.87 for women and 30.69 ± 11.86 for men. While hypotension was more common in women, hypertension incidence was higher in men. Tachycardia incidence was more in women than men. 51.55% of men and 36.29% of women had taken psychiatric drugs for suicidal purpose. In addition to these drugs, 22.67% of men and 8.46% of women had used alcohol. Substance dependence incidence in men was four-fold of women. Four men and one woman had died. According to these results, although the incidence of suicidal attempts by drugs was 2.6-fold higher in women, it could be concluded that the intoxications developed was more serious and severe in men. doi:10.1016/j.toxlet.2010.03.189
P102-006 Association of blood lead and blood pressure in the NHANES 1999–2006 F. Scinicariello, H. Abadin, H.E. Murray CDC/ATSDR Background: A relationship between blood pressure (BP) and blood lead concentrations has been reported and this relationship appeared to be influenced by the sex and/or race of the participants. The objective of this study was to evaluate whether low blood-lead levels (BLLs ≤ 10 g/dL) were associated with BP among adults aged 20 years and older in the U.S. population. Methods: We analyzed data from NHANES 1999–2006 participants aged 20 years or older who were white non-Hispanic or black non-Hispanic with BLLs ≤ 10 g/dL. Outcome variables were systolic and diastolic BP measurements and hypertension status. Results: In multiple regression analyses, BLLs were significantly correlated with higher systolic BP among black men and women, but not white, participants. The change in systolic BP associated
with a two-fold increase of blood-lead concentration was 1.59 mm Hg in black men, and 1.66 mm Hg in black women. BLLs were significantly associated with higher diastolic BPs among white men and women and black men, but not among black women. Black men with BLLs = 5.01–10 g/dL had an adjusted prevalence odds ratio of 1.98 (95% CI: 1.11–3.50) to have hypertension compared with black men with BLL < 5 g/dL. Conclusions: BLLs among black non-Hispanic men participants were associated with increased systolic and diastolic BP and higher hypertension risk. Despite the decline in blood-lead concentrations in the U.S. population, lead exposure remains a major public health priority and is still a health risk. Disclaimers: The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers of Disease Control and Prevention/Agency for Toxic Substances and Disease Registry. doi:10.1016/j.toxlet.2010.03.190
P102-007 Clinical presentations skin by biting spiders genus Loxosceles. Toxicology service experience from children’s hospital of the blessed trinity, province of Cordoba, Argentina, during 2006–2009 M. Aliaga, N. Gait, R. Llebeili, M. Pierotto, A. Suarez, A. Gait Hospital de ni˜ nos de la Santisima Trinidad, Spain Introduction: Accidents of this kind of spider can relate with two forms of clinical presentation, cutaneous loxoscelism, 84–97%, represented with the presence of serohematic blister, liveloide plate and then to eschar and loxoscelism cutaneous and visceral, severe. It is necessary, this review, for the purpose of optimizing the recognition and diagnosis of this condition. In our hospital, there has been an increase in accidents caused by spiders in urban areas and within them a high percentage represented by the genus Loxosceles. Objectives: To identify the lesion for the diagnosis, know clinical forms of presentation most common in our environment, assess early diagnosis, analyze clinical data and experience in our Toxicology Service at Children’s Hospital, develop reflective skills, from statistical data. Material and methods: A retrospective, descriptive and exploratory, observational and longitudinal study of a universe of 96 cases of injuries consistent with spider bites, in the period 2006–2009. Results: In our series of 39 patients with cutaneous loxoscelism, clinical presentation was in 77% of the ampoule serohematic followed by necrosis in 59% and plaque liveloide in 51% and in only 35.90% of cases eschar evolved. The 25.64% localized pain-burning rate at the time of the bite and 15.38% with systemic disorders. The above-mentioned would explain our experience that early diagnosis and prompt treatment limit natural evolution and circumscribe the lesion. Conclusions: We conclude that the increased incidence of cases in the last year, is that through the recognition of the injury, training implemented, taxonomic identification of the spider, epidemiological surveillance, in order to plan preventive measures for accurate reporting, timely to ensure an early diagnosis, thus improving clinical outcome, avoiding complications and consequences that carry a high cost of health care. doi:10.1016/j.toxlet.2010.03.191