- Email: [email protected]
Association of novel inflammatory biomarkers with coronary collateral development and SYNTAX score
Association of novel inflammatory biomarkers with coronary collateral development and SYNTAX score Mesut Gitmez PII: DOI: Reference:
S0167-5273(16)33191-6 doi:10.1016/j.ijcard.2016.11.270 IJCA 24132
To appear in:
International Journal of Cardiology
Received date: Accepted date:
24 October 2016 7 November 2016
Please cite this article as: Gitmez Mesut, Association of novel inflammatory biomarkers with coronary collateral development and SYNTAX score, International Journal of Cardiology (2016), doi:10.1016/j.ijcard.2016.11.270
This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT Title page Association of novel inflammatory biomarkers with coronary collateral development
IP
T
and SYNTAX score
Batman State Hospital, Department of Cardiology, Batman, Turkey.
MA
NU
1
SC R
Mesut Gitmez, MD1,
TE
Mesut Gitmez, MD,
D
Corresponding author
CE P
Batman State Hospital, Department of Cardiology, Batman, Turkey.
AC
E-mail: [email protected]
ACCEPTED MANUSCRIPT To the Editor, I read the recent article entitled “Effect of serum YKL-40 on coronary collateral
T
development and SYNTAX score in stable coronary artery disease” by Akboga and
IP
colleagues with great interest [1]. They demonstrated that YKL-40 could be used as a
SC R
predictor of good collateral development and high SYNTAX score [1]. Presence of coronary collaterals has been shown to play critical roles on cardiovascular outcomes of patients with severe coronary artery disease (CAD). Well-developed collateral arteries may limit infarct
NU
size, improve cardiovascular outcomes and survival [2]. A significant role of angiogenesis
MA
and inflammation in the pathophysiology of coronary collateral development (CCD) has been previously reported [1,2]. Recently, YKL-40, high-sensitivity C-reactive protein (hs-CRP), neutrophil, monocyte, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio
TE
D
(PLR), and monocyte to high-density lipoprotein (HDL) cholesterol (MHR) have been used as easily available inflammatory biomarkers, and have been shown to be independent risk factors
CE P
for CCD, CAD, and cardiovascular events [4-8]. In this well presented study by Akboga et al. serum YKL-40 levels were significantly
AC
higher in the poor collateral group. Besides, white blood cells and hs-CRP levels were also higher whereas HDL-cholesterol levels were lower in the poor collateral group. However, in this study there is not any data regarding other easily available biochemical parameters associated with inflammation such as neutrophil, lymphocyte, monocyte, NLR, PLR and MHR. We believe that the combined information of multiple inflammatory biomarkers could be more useful and more reliable for evaluating the CCD in patients with severe CAD. Conflicts of interest: The authors have no conflicts of interest to disclose
ACCEPTED MANUSCRIPT References 1. M.K. Akboga, R. Yalcin, A. Sahinarslan, C. Yilmaz Demirtas, A. Abaci, Effect of serum
T
YKL-40 on coronary collateral development and SYNTAX score in stable coronary
IP
artery disease, Int. J. Cardiol. 224 (2016) 323-327. [Epub ahead of print]
SC R
2. C. Seiler, M. Stoller, B. Pitt, P. Meier, The human coronary collateral circulation: development and clinical importance, Eur. Heart J. 34 (2013) 2674–2682. 3. O.K. Uysal, C. Turkoglu, D.Y. Sahin, M. Duran, A. Yildirim, Z. Elbasan, et al., The
NU
relationship between neutrophil-to-lymphocyte ratio and coronary collateral circulation,
MA
Clin. Appl. Thromb. Hemost. 21 (2015) 329-333.
4. M.K. Akboga, U. Canpolat, K.G. Balci, A. Akyel, F. Sen, C. Yayla, et al., Increased platelet to lymphocyte ratio is related to slow coronary flow, Angiology. 67 (2016) 21-26.
TE
D
5. S. Yilmaz, M.K. Akboga, F. Sen, K.G. Balcı, D. Aras, A. Temizhan, et al., Usefulness of the monocyte-to-high-density lipoprotein cholesterol ratio to predict bare metal stent
AC
CE P
restenosis Biomark. Med. 10 (2016) 959-966.
S0167-5273(16)33191-6 doi:10.1016/j.ijcard.2016.11.270 IJCA 24132
To appear in:
International Journal of Cardiology
Received date: Accepted date:
24 October 2016 7 November 2016
Please cite this article as: Gitmez Mesut, Association of novel inflammatory biomarkers with coronary collateral development and SYNTAX score, International Journal of Cardiology (2016), doi:10.1016/j.ijcard.2016.11.270
This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT Title page Association of novel inflammatory biomarkers with coronary collateral development
IP
T
and SYNTAX score
Batman State Hospital, Department of Cardiology, Batman, Turkey.
MA
NU
1
SC R
Mesut Gitmez, MD1,
TE
Mesut Gitmez, MD,
D
Corresponding author
CE P
Batman State Hospital, Department of Cardiology, Batman, Turkey.
AC
E-mail: [email protected]
ACCEPTED MANUSCRIPT To the Editor, I read the recent article entitled “Effect of serum YKL-40 on coronary collateral
T
development and SYNTAX score in stable coronary artery disease” by Akboga and
IP
colleagues with great interest [1]. They demonstrated that YKL-40 could be used as a
SC R
predictor of good collateral development and high SYNTAX score [1]. Presence of coronary collaterals has been shown to play critical roles on cardiovascular outcomes of patients with severe coronary artery disease (CAD). Well-developed collateral arteries may limit infarct
NU
size, improve cardiovascular outcomes and survival [2]. A significant role of angiogenesis
MA
and inflammation in the pathophysiology of coronary collateral development (CCD) has been previously reported [1,2]. Recently, YKL-40, high-sensitivity C-reactive protein (hs-CRP), neutrophil, monocyte, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio
TE
D
(PLR), and monocyte to high-density lipoprotein (HDL) cholesterol (MHR) have been used as easily available inflammatory biomarkers, and have been shown to be independent risk factors
CE P
for CCD, CAD, and cardiovascular events [4-8]. In this well presented study by Akboga et al. serum YKL-40 levels were significantly
AC
higher in the poor collateral group. Besides, white blood cells and hs-CRP levels were also higher whereas HDL-cholesterol levels were lower in the poor collateral group. However, in this study there is not any data regarding other easily available biochemical parameters associated with inflammation such as neutrophil, lymphocyte, monocyte, NLR, PLR and MHR. We believe that the combined information of multiple inflammatory biomarkers could be more useful and more reliable for evaluating the CCD in patients with severe CAD. Conflicts of interest: The authors have no conflicts of interest to disclose
ACCEPTED MANUSCRIPT References 1. M.K. Akboga, R. Yalcin, A. Sahinarslan, C. Yilmaz Demirtas, A. Abaci, Effect of serum
T
YKL-40 on coronary collateral development and SYNTAX score in stable coronary
IP
artery disease, Int. J. Cardiol. 224 (2016) 323-327. [Epub ahead of print]
SC R
2. C. Seiler, M. Stoller, B. Pitt, P. Meier, The human coronary collateral circulation: development and clinical importance, Eur. Heart J. 34 (2013) 2674–2682. 3. O.K. Uysal, C. Turkoglu, D.Y. Sahin, M. Duran, A. Yildirim, Z. Elbasan, et al., The
NU
relationship between neutrophil-to-lymphocyte ratio and coronary collateral circulation,
MA
Clin. Appl. Thromb. Hemost. 21 (2015) 329-333.
4. M.K. Akboga, U. Canpolat, K.G. Balci, A. Akyel, F. Sen, C. Yayla, et al., Increased platelet to lymphocyte ratio is related to slow coronary flow, Angiology. 67 (2016) 21-26.
TE
D
5. S. Yilmaz, M.K. Akboga, F. Sen, K.G. Balcı, D. Aras, A. Temizhan, et al., Usefulness of the monocyte-to-high-density lipoprotein cholesterol ratio to predict bare metal stent
AC
CE P
restenosis Biomark. Med. 10 (2016) 959-966.