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Association of vitamin D with lean mass and handgrip strength
S198
Abstracts
Analysis shows strong significant relationships between bone and lean mass in adult males (BMC = 0.0387X + 1124; r = 0.6853; P b 0.0001; RMSE = 303) and females (BMC= 0.03078X + 1577; r = 0.5456 P b 0.0001; RMSE = 289). Examining the relationship between bone and fat mass reveals a relatively strong relationship in adult females (BMC= 0.0175X + 2336; r = 0.4742; P b 0.0001; RMSE = 304) and a more moderate relationship in adult males (BMC= 0.0146X + 3207; r = 0.3603; P b 0.001; RMSE= 388). The data indicate that–as observed in children–bone mass is significantly related to lean mass in men and women and that a significant relationship also exists between bone and fat in the women. This article is part of a Special Issue entitled ECTS 2012. Disclosure of Interest: None Declared. doi:10.1016/j.bone.2012.02.629
PP441 Association of vitamin D with lean mass and handgrip strength V. Strazdienea,⁎, M. Tamulaitieneb, A. Mastaviciuteb, V. Aleknaa a State Research Institute Centre for Innovative Medicine, Lithuania b Medical Faculty, Vilnius University, Vilnius, Lithuania Abstract: Introduction and aims: Vitamin D deficiency is common among elderly people and is found to be associated with reduced muscle strength, although, data is inconsistent. The aim of this study was to investigate the association between serum vitamin D, lean mass and handgrip strength. Methods: This was a cross-sectional study on subjects aged 40 years and older who consecutively had visited the National Osteoporosis Center (Vilnius, Lithuania). Exclusion criteria were conditions known to affect muscle metabolism and muscle strength in upper extremities or taking any
vitamin D supplements. Serum vitamin D (25(OH)D) and PTH were measured by automated immunoassay (Cobas E411, Roche Diagnostic). The standard threshold was used for vitamin D levels: optimal (≥30 ng/ml), insufficient (20–29 ng/ml), and deficient (b 20 ng/ml). Laboratory measurements were conducted after fasting for at least 12 h. Blood sampling was performed from 8:00 till 11:00 a.m. Total body dualenergy X-ray radioabsorptiometry was used to measure body composition and to evaluate lean mass (iDXA, GE Lunar). Handgrip strength was measured in kilograms (kg), using hand dynamometer. The statistical analysis was performed with SPSS software for Windows (Version 18.0). Results: A total of 287 participants were included in this study: 164 men and 123 women aged in average 63.4 ± 13.2 and 62.4 ± 15.2 years, respectively. Approximately 80% of subjects were vitamin D deficient, 15% was insufficient, and in 5% vitamin D status was optimal. We haven't found significant differences of serum vitamin D values between men and women (14 ± 7.6 ng/ml and 12.9 ± 8.5 ng/ml, respectively). Negative relationship was found between PTH and vitamin D (r= −0.3, p b 0.001). Handgrip strength values were higher in men, comparing with women (37.8± 12.3 kg and 18.2 ± 7.8 kg respectively, p b 0.001). Lean mass was also higher in men than in women (56.4 ± 7.2 kg and 41.7± 6.3 kg, respectively, p b 0.001). We have not found significant differences in lean mass and hand grip strength between vitamin D deficiency groups. For all subjects combined, handgrip strength showed a weak significant positive correlation with vitamin D (r= 0.1, p b 0.05). Although a strong positive relationship was found between lean mass and handgrip strength (r= 0.7, p b 0.001), no relationship was observed between lean mass and serum vitamin D. Conclusions: Our data suggest that serum vitamin D is associated with handgrip strength and not related to lean mass. This article is part of a Special Issue entitled ECTS 2012. Disclosure of interest: None declared.
doi:10.1016/j.bone.2012.02.630
Abstracts
Analysis shows strong significant relationships between bone and lean mass in adult males (BMC = 0.0387X + 1124; r = 0.6853; P b 0.0001; RMSE = 303) and females (BMC= 0.03078X + 1577; r = 0.5456 P b 0.0001; RMSE = 289). Examining the relationship between bone and fat mass reveals a relatively strong relationship in adult females (BMC= 0.0175X + 2336; r = 0.4742; P b 0.0001; RMSE = 304) and a more moderate relationship in adult males (BMC= 0.0146X + 3207; r = 0.3603; P b 0.001; RMSE= 388). The data indicate that–as observed in children–bone mass is significantly related to lean mass in men and women and that a significant relationship also exists between bone and fat in the women. This article is part of a Special Issue entitled ECTS 2012. Disclosure of Interest: None Declared. doi:10.1016/j.bone.2012.02.629
PP441 Association of vitamin D with lean mass and handgrip strength V. Strazdienea,⁎, M. Tamulaitieneb, A. Mastaviciuteb, V. Aleknaa a State Research Institute Centre for Innovative Medicine, Lithuania b Medical Faculty, Vilnius University, Vilnius, Lithuania Abstract: Introduction and aims: Vitamin D deficiency is common among elderly people and is found to be associated with reduced muscle strength, although, data is inconsistent. The aim of this study was to investigate the association between serum vitamin D, lean mass and handgrip strength. Methods: This was a cross-sectional study on subjects aged 40 years and older who consecutively had visited the National Osteoporosis Center (Vilnius, Lithuania). Exclusion criteria were conditions known to affect muscle metabolism and muscle strength in upper extremities or taking any
vitamin D supplements. Serum vitamin D (25(OH)D) and PTH were measured by automated immunoassay (Cobas E411, Roche Diagnostic). The standard threshold was used for vitamin D levels: optimal (≥30 ng/ml), insufficient (20–29 ng/ml), and deficient (b 20 ng/ml). Laboratory measurements were conducted after fasting for at least 12 h. Blood sampling was performed from 8:00 till 11:00 a.m. Total body dualenergy X-ray radioabsorptiometry was used to measure body composition and to evaluate lean mass (iDXA, GE Lunar). Handgrip strength was measured in kilograms (kg), using hand dynamometer. The statistical analysis was performed with SPSS software for Windows (Version 18.0). Results: A total of 287 participants were included in this study: 164 men and 123 women aged in average 63.4 ± 13.2 and 62.4 ± 15.2 years, respectively. Approximately 80% of subjects were vitamin D deficient, 15% was insufficient, and in 5% vitamin D status was optimal. We haven't found significant differences of serum vitamin D values between men and women (14 ± 7.6 ng/ml and 12.9 ± 8.5 ng/ml, respectively). Negative relationship was found between PTH and vitamin D (r= −0.3, p b 0.001). Handgrip strength values were higher in men, comparing with women (37.8± 12.3 kg and 18.2 ± 7.8 kg respectively, p b 0.001). Lean mass was also higher in men than in women (56.4 ± 7.2 kg and 41.7± 6.3 kg, respectively, p b 0.001). We have not found significant differences in lean mass and hand grip strength between vitamin D deficiency groups. For all subjects combined, handgrip strength showed a weak significant positive correlation with vitamin D (r= 0.1, p b 0.05). Although a strong positive relationship was found between lean mass and handgrip strength (r= 0.7, p b 0.001), no relationship was observed between lean mass and serum vitamin D. Conclusions: Our data suggest that serum vitamin D is associated with handgrip strength and not related to lean mass. This article is part of a Special Issue entitled ECTS 2012. Disclosure of interest: None declared.
doi:10.1016/j.bone.2012.02.630