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Associations between depressive and anxiety symptoms severity and decline in cognitive domains among patients with type 2 diabetes without dementia: cross-sectional study
S360
P.1.l. Basic and clinical neuroscience − Other
of epileptic patients comparing to controls (p < 0.001). On the contrary the remnants CB cells in TLE have larger reactive areas (p < 0.001) with stronger CB staining intensity reaction and higher CB sprouting in co-morbid TLE+D (p < 0.001). Conclusion: In this preliminary study both groups of patients with TLE showed a reduction of the total number of CB positive cells in dentate gyrus layers. In patients with co-morbid depression the remnants CB cells showed higher expression of CB in somas and fibers. The role of CB in granular cells is controversial, while several studies reported a neuroprotective role through buffering intracellular calcium, others suggested that the decrease of CB might protect granule cells from excitotoxicity, while CB content increases the susceptibility to seizure-induced cell death. References [1] Danzer, S.C., 2012. Depression, stress, epilepsy and adult neurogenesis. Experimental Neurology, 233(1), 22−32. doi:10.1016/ j.expneurol.2011.05.023. [2] Hester, M.S., Danzer, S.C., 2014. Hippocampal granule cell pathology in epilepsy − A possible structural basis for comorbidities of epilepsy? Epilepsy & Behavior 2−13. doi:10.1016/j.yebeh.2013.12.022. [3] Kandratavicius, L., Hallak, J.E., Young, L.T., Assirati, J.A., Carlotti, C.G., & Leite, J.P., 2011. Differential aberrant sprouting in temporal lobe epilepsy with psychiatric co-morbidities. Psychiatry Research. doi:10.1016/j.psychres.2011.06.005. [4] D’Alessio L, Konopka H, Escobar E, Acu˜na A, Oddo S, Sol´ıs P, Seoane E, Kochen S., 2015 Dentate gyrus expression of nestinimmunoreactivity in patients with drug-resistant temporal lobe epilepsy and hippocampal sclerosis. Seizure 27: 75−79. ISSN: 1059–1311. [5] Martinian, L., Catarino, C.B., Thompson, P., Sisodiya, S.M., & Thom, M., 2012 Calbindin D28K expression in relation to granule cell dispersion, mossy fibre sprouting and memory impairment in hippocampal sclerosis : A surgical and post mortem series. Epilepsy Research, 98(1), 14−24. doi:10.1016/j.eplepsyres.2011.08.011.
P.1.l.008 Associations between depressive and anxiety symptoms severity and decline in cognitive domains among patients with type 2 diabetes without dementia: cross-sectional study V. Audarait˙e1 ° , D. Lukosiute2 , R. Verkauskiene3 , V. Adomaitiene1 , V. Steibliene1 1 Psychiatry Clinic at Lithuanian University of Health Sciences, Kaunas, Lithuania; 2 Lithuanian University of Health Sciences, Kaunas, Lithuania; 3 Department and Institute of Endocrinology at Lithuanian University of Health Sciences, Kaunas, Lithuania Introduction: Type 2 diabetes (T2DM) is a metabolic disorder, getting endemic tendencies; one of T2DM complications is a cognitive impairment. T2DM is associated with cognitive declines, mostly in the domains of memory, psychomotor speed, and executive function [1]. Longer duration of T2DM, poor glycemic control, vascular complications linked with a greater probability to cognitive impairment [2]. There are known the relations among depression and anxiety symptoms severity and cognitive decline in patients with T2DM [3], but the most affected cognitive domains still remained unclear. The aim of this study was to evaluate the associations between severity of depressive and anxiety symptoms and decline in cognitive domains among patients with T2DM without dementia. Study population and Methods: One hundred sixty-one patients − 64 men (39.8%) and 97 women (60.2%), 59.4±11.2 years old (mean±SD), with diagnosis of T2DM, mean illness duration of 13.1±9.4 years; and poor glycaemia control (HbA1c>7.0) hospitalized in Endocrinology Department at Hospital of Lithuanian University of Health Sciences (LUHS) were evaluated for the
severity of depressive symptoms (Beck’s Depression Scale (BD)) and anxiety symptoms (Beck Anxiety Scale (BA)). BA and BD are self-report inventories based on 21-questions, each about the subject’s feelings in the last week. Sum of BD scores 0−18 were evaluated as minimal-mild; 19−63, as moderate-severe depressive symptoms. Sum of BA scores 0−15 were evaluated as nonemild; 16−63, as moderate-severe anxiety symptoms. The Mini Mental State Examination was administered to exclude patients with dementia (MMSE 20 was exclusion criteria). To evaluate the different domains of cognitive functions Word list memory task, Digit-Span, Number repeating, Trail Making, Digit Symbol and Verbal fluency tests were used. Statistical data analysis was performed using SPSS 17.0. For comparison of cognitive domains among two groups’ variables, GLM with covariates (age, duration of T2DM and HbA1c) was used. Statistical significance level was set at 5% (P < 0.05). Results: Moderate-severe depressive symptoms were determined in 24.8%; moderate-severe anxiety symptoms-58.4% of patients. Patients with moderate-severe depressive symptoms in comparison with none-mild depressive symptoms had significant worse results of the Digit Symbol test (34.05±13.41 vs 26.29±12.97; p = 0.001, respectively), repetition of numbers backwards test (3.98±1.23 vs 3.36±1.03; p = 0.004, respectively), Digit table test (3.22±1.42 vs 2.48±1.64; p = 0.006, respectively), Word list memory task (7.07±1.57 vs 6.55±1.33; p = 0.053, respectively) and Verbal fluency subtest (17.53±6.69 vs 13.17±4.82; p < 0.001, respectively). Patients with moderatesevere anxiety symptoms in comparison to none-mild anxiety symptoms had significant worse results in Ten Words test (4.82±1.29 vs 4.37±1.1; p = 0.018, respectively) and Verbal fluency subtest (17.63±6.47 vs 15.59±6.49; p = 0.048, respectively). Conclusions: Patients with T2DM without dementia and moderate-severe depressive/anxiety symptoms, independently from age, duration of T2DM and HbA1c, showed greater cognitive decline. Moderate-severe depressive symptoms were linked to worse working memory, information processing speed, visual memory, short term memory and verbal fluency cognitive domains. Moderate-severe anxiety symptoms were linked to worse short term memory and verbal fluency domains. These sugest usefullness of anxiety/depression treatment interventions to decrease of cognitive decline in patients with T2DM. References [1] Mayeda, E.R., Whitmer, R.A., Yaffe, K., 2015. Diabetes and cognition. Clin Geriatr Med 31(1), 101–115. [2] Moheet, A., Mangia, S., Seaquist, E.R., 2015. Impact of diabetes on cognitive function and brain structure. Ann N Y Acad Sci 1353, 60−71. [3] Sullivan, M.D., Katon, W.J., Lovato, L.C., Miller, M.E., Murray, A.M., Horowitz, K.R., et al., 2013. Association of depression with accelerated cognitive decline among patients with type 2 diabetes in the ACCORDMIND trial. JAMA psychiatry 70(10), 1041–1047.
P.1.l.011 Neutrophil-lymphocyte and plateletlymphocyte ratios as inflammation markers for delirium E. Guliyev1 ° , T. Kalelioglu2 , A. Mustafa3 , G. G¨ozde1 , Y. Erhan1 , E. Murat1 1 Cerrahpa¸sa faculty of medicine, Psychiatry, Istanbul, Turkey; 2 Bakırk¨oy Mental Health Research and Training State Hospital, Psychiatry, Istanbul, Turkey; 3 Cerrahpa¸sa faculty of medicine, Intensive care unit, Istanbul, Turkey Objective: Delirium is commonly observed in critically ill patients and associated with negative outcomes. The pathophysiology
P.1.l. Basic and clinical neuroscience − Other
of epileptic patients comparing to controls (p < 0.001). On the contrary the remnants CB cells in TLE have larger reactive areas (p < 0.001) with stronger CB staining intensity reaction and higher CB sprouting in co-morbid TLE+D (p < 0.001). Conclusion: In this preliminary study both groups of patients with TLE showed a reduction of the total number of CB positive cells in dentate gyrus layers. In patients with co-morbid depression the remnants CB cells showed higher expression of CB in somas and fibers. The role of CB in granular cells is controversial, while several studies reported a neuroprotective role through buffering intracellular calcium, others suggested that the decrease of CB might protect granule cells from excitotoxicity, while CB content increases the susceptibility to seizure-induced cell death. References [1] Danzer, S.C., 2012. Depression, stress, epilepsy and adult neurogenesis. Experimental Neurology, 233(1), 22−32. doi:10.1016/ j.expneurol.2011.05.023. [2] Hester, M.S., Danzer, S.C., 2014. Hippocampal granule cell pathology in epilepsy − A possible structural basis for comorbidities of epilepsy? Epilepsy & Behavior 2−13. doi:10.1016/j.yebeh.2013.12.022. [3] Kandratavicius, L., Hallak, J.E., Young, L.T., Assirati, J.A., Carlotti, C.G., & Leite, J.P., 2011. Differential aberrant sprouting in temporal lobe epilepsy with psychiatric co-morbidities. Psychiatry Research. doi:10.1016/j.psychres.2011.06.005. [4] D’Alessio L, Konopka H, Escobar E, Acu˜na A, Oddo S, Sol´ıs P, Seoane E, Kochen S., 2015 Dentate gyrus expression of nestinimmunoreactivity in patients with drug-resistant temporal lobe epilepsy and hippocampal sclerosis. Seizure 27: 75−79. ISSN: 1059–1311. [5] Martinian, L., Catarino, C.B., Thompson, P., Sisodiya, S.M., & Thom, M., 2012 Calbindin D28K expression in relation to granule cell dispersion, mossy fibre sprouting and memory impairment in hippocampal sclerosis : A surgical and post mortem series. Epilepsy Research, 98(1), 14−24. doi:10.1016/j.eplepsyres.2011.08.011.
P.1.l.008 Associations between depressive and anxiety symptoms severity and decline in cognitive domains among patients with type 2 diabetes without dementia: cross-sectional study V. Audarait˙e1 ° , D. Lukosiute2 , R. Verkauskiene3 , V. Adomaitiene1 , V. Steibliene1 1 Psychiatry Clinic at Lithuanian University of Health Sciences, Kaunas, Lithuania; 2 Lithuanian University of Health Sciences, Kaunas, Lithuania; 3 Department and Institute of Endocrinology at Lithuanian University of Health Sciences, Kaunas, Lithuania Introduction: Type 2 diabetes (T2DM) is a metabolic disorder, getting endemic tendencies; one of T2DM complications is a cognitive impairment. T2DM is associated with cognitive declines, mostly in the domains of memory, psychomotor speed, and executive function [1]. Longer duration of T2DM, poor glycemic control, vascular complications linked with a greater probability to cognitive impairment [2]. There are known the relations among depression and anxiety symptoms severity and cognitive decline in patients with T2DM [3], but the most affected cognitive domains still remained unclear. The aim of this study was to evaluate the associations between severity of depressive and anxiety symptoms and decline in cognitive domains among patients with T2DM without dementia. Study population and Methods: One hundred sixty-one patients − 64 men (39.8%) and 97 women (60.2%), 59.4±11.2 years old (mean±SD), with diagnosis of T2DM, mean illness duration of 13.1±9.4 years; and poor glycaemia control (HbA1c>7.0) hospitalized in Endocrinology Department at Hospital of Lithuanian University of Health Sciences (LUHS) were evaluated for the
severity of depressive symptoms (Beck’s Depression Scale (BD)) and anxiety symptoms (Beck Anxiety Scale (BA)). BA and BD are self-report inventories based on 21-questions, each about the subject’s feelings in the last week. Sum of BD scores 0−18 were evaluated as minimal-mild; 19−63, as moderate-severe depressive symptoms. Sum of BA scores 0−15 were evaluated as nonemild; 16−63, as moderate-severe anxiety symptoms. The Mini Mental State Examination was administered to exclude patients with dementia (MMSE 20 was exclusion criteria). To evaluate the different domains of cognitive functions Word list memory task, Digit-Span, Number repeating, Trail Making, Digit Symbol and Verbal fluency tests were used. Statistical data analysis was performed using SPSS 17.0. For comparison of cognitive domains among two groups’ variables, GLM with covariates (age, duration of T2DM and HbA1c) was used. Statistical significance level was set at 5% (P < 0.05). Results: Moderate-severe depressive symptoms were determined in 24.8%; moderate-severe anxiety symptoms-58.4% of patients. Patients with moderate-severe depressive symptoms in comparison with none-mild depressive symptoms had significant worse results of the Digit Symbol test (34.05±13.41 vs 26.29±12.97; p = 0.001, respectively), repetition of numbers backwards test (3.98±1.23 vs 3.36±1.03; p = 0.004, respectively), Digit table test (3.22±1.42 vs 2.48±1.64; p = 0.006, respectively), Word list memory task (7.07±1.57 vs 6.55±1.33; p = 0.053, respectively) and Verbal fluency subtest (17.53±6.69 vs 13.17±4.82; p < 0.001, respectively). Patients with moderatesevere anxiety symptoms in comparison to none-mild anxiety symptoms had significant worse results in Ten Words test (4.82±1.29 vs 4.37±1.1; p = 0.018, respectively) and Verbal fluency subtest (17.63±6.47 vs 15.59±6.49; p = 0.048, respectively). Conclusions: Patients with T2DM without dementia and moderate-severe depressive/anxiety symptoms, independently from age, duration of T2DM and HbA1c, showed greater cognitive decline. Moderate-severe depressive symptoms were linked to worse working memory, information processing speed, visual memory, short term memory and verbal fluency cognitive domains. Moderate-severe anxiety symptoms were linked to worse short term memory and verbal fluency domains. These sugest usefullness of anxiety/depression treatment interventions to decrease of cognitive decline in patients with T2DM. References [1] Mayeda, E.R., Whitmer, R.A., Yaffe, K., 2015. Diabetes and cognition. Clin Geriatr Med 31(1), 101–115. [2] Moheet, A., Mangia, S., Seaquist, E.R., 2015. Impact of diabetes on cognitive function and brain structure. Ann N Y Acad Sci 1353, 60−71. [3] Sullivan, M.D., Katon, W.J., Lovato, L.C., Miller, M.E., Murray, A.M., Horowitz, K.R., et al., 2013. Association of depression with accelerated cognitive decline among patients with type 2 diabetes in the ACCORDMIND trial. JAMA psychiatry 70(10), 1041–1047.
P.1.l.011 Neutrophil-lymphocyte and plateletlymphocyte ratios as inflammation markers for delirium E. Guliyev1 ° , T. Kalelioglu2 , A. Mustafa3 , G. G¨ozde1 , Y. Erhan1 , E. Murat1 1 Cerrahpa¸sa faculty of medicine, Psychiatry, Istanbul, Turkey; 2 Bakırk¨oy Mental Health Research and Training State Hospital, Psychiatry, Istanbul, Turkey; 3 Cerrahpa¸sa faculty of medicine, Intensive care unit, Istanbul, Turkey Objective: Delirium is commonly observed in critically ill patients and associated with negative outcomes. The pathophysiology