- Email: [email protected]
Atherogenic indexes as predictors of stenotic complication after percutaneous coronary interventions or coronary artery bypass graft
e212
Abstracts / Atherosclerosis 241 (2015) e149ee229
Conclusion: We conclude that increased serum fetuin-A in aged patients associates with atherosclerotic aortic valve stenosis, independently from the presence of DM. Circulating fetuin-A may represent an important inhibitor of dystrophic calcification in aged persons with symptomatic aortic stenosis. This work was supported by IGA MH CR NT/12287-5, PRVOUK P37/12.
EAS-0258. METABOLIC RISK FACTORS AS PREDICTORS OF RESTENOSIS CORONARY ARTERIES STENTING AT PATIENTS WITH OBESITY N. Veselovskaya 1, *, G. Chumakova 2, O. Gritzenko 1. 1 Multifocal Atherosclerosis, Science Research Institute of Complex Problems of Cardiovascular Diseases, Kemerovo, Russia; 2 Internal Medicine, Altai State Medical University, Barnaul, Russia
* Corresponding author. Aim of study: to assess the prognostic predictive value of the metabolic risk factors (RF) at development restenosis the coronary arteries (CA) after their stenting at patients with obesity. Material and methods: Research included 186 men (54,4 ± 9,1 years) with body mass index >30 kg/m2 during their planned preparation for the percutaneous coronary intervention (PCI) with stenting bare metal stent. To all patients laboratory research with determination of the main and additional metabolic risk factors and thickness of epicardial fat tissue (tEFT) was calculated in millimeters (mm) on the free wall of the right ventricle (RV). Restenosis CA considered narrowing of a gleam of a vessel >50% in an intervention place. Results: Restenosis in a zone stent was revealed at 17,3% of patients (n¼32). The method of logistic regression was applied to an assessment of communication of studied risk factors with the restenosis. The maximum module of the standardized coefficient of the regression, reflecting force of a contribution of each predictor in risk of development restenosis was received at LPa (0,4095), further as it should be decrease on force of a contribution to risk of development restenosis - leptin (0,3394), glucose (0,2083), IL-6 (0,2023), tEFT (0,1936) and HDL (0,1612). The area under a ROC -curve was equal 0,8150 that testifies to high quality of the mathematical model. Conclusions: obtained predictors will allow to choosing more perspective and rational schemes of complex preoperative preparation before a myocardial revascularization that will allow increasing efficiency of stenting at patients with obesity.
EAS-0259. ATHEROGENIC INDEXES AS PREDICTORS OF STENOTIC COMPLICATION AFTER PERCUTANEOUS CORONARY INTERVENTIONS OR CORONARY ARTERY BYPASS GRAFT O. Gritzenko 1, *, G. Chumakova 2, N. Veselovskaya 1. 1 Multifocal Atherosclerosis, Science Research Institute of Complex Problems of Cardiovascular Diseases, Kemerovo, Russia; 2 Internal Medicine, Altai State Medical University, Barnaul, Russia
* Corresponding author. Aim: To assess the prognostic ability atherogenic indexes or lipoprotein ratio in development stenotic complications after revascularization (percutaneous coronary interventions (PCI) or coronary artery bypass graft [CABG]) in patients with metabolic syndrome (MS). Materials and methods: Study included 108 man (56,8±6,1) with angina II-III functional class and the clinical signs of angina pectoris. In the preoperative period (PCI - 49 patients or CABG - 59 patients) was determined lipoproteins ration of total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-C). Apolipoprotein B (Apo B)/Apolipoprotein AI (Apo AI), low-density lipoprotein cholesterol (LDL-C)/HDL-C, cholesterol - non high-density. Coronary angiography was performed in a year after.
Results: Was revealed that levels of all atherogenic indexes defined in the group of patients with MS, regardless held myocardial revascularization. According to the results of discriminant analysis revealed that a significant predictor of the development of restenosis after PCI is the ratio of TC/HDLC (Lambda Wilkes ¼0.27, p<0,001) On the results of the ROC analysis revealed that the specificity of TC/HDL-C accounted for 94.6%, sensitivity 75.0% and cut-off > 7,11. So, as a significant predictor of the development of stenotic complications in patients after CABG is the cholesterol - non high-density (Lambda Wilkes ¼0,58; p¼0.01; sensitivity-82,4%, specificity-69,0%, the cut-off >4,99). Conclusion: Atherogenic index may be necessary to risk assessment before PCI and CABG. Levels of total cholesterol/HDL-C > 7,11 and the level of cholesterol - non - high-density cholesterol > 4,99 are predictors of development stenotic complications after PCI and CABG respectively. EAS-0261. NEUROPSYCHOLOGICAL DYSFUNTIONS ARTERY BYPASS GRAFTING
AMONG
PATIENTS
WITH
J. Chugunova 1, *, G. Chumakova 1, O. Gritzenko 2, N. Veselovskaya 2. Internal Medicine, Altai State Medical University, Barnaul, Russia; 2 Multifocal Atherosclerosis, Science Research Institute of Complex Problems of Cardiovascular Diseases, Kemerovo, Russia 1
* Corresponding author. The aim: Was to learn psychological and cognitive dysfunctions in patients undergoing artery bypass grafting (CABG). Methods: Were included 57 patients, age was 58.4±0.9. Psychological factors were evaluated with the use of Zung Self-Rating Depression Scale, health self-concept scale and the Short Form General Health Survey (SF36). Hardware-software complex “Status PF” (Kemerovo) was used for an evaluation of cognitive functions before CABG and 6 months after it. Results: There was improvement of memory (5.2±1.4 points vs. 4.6±1.9 points, p¼0.02), thinking (19.9±7.2 points vs. 17.9±6.3 points, p<0.01), neurodynamics (1.4±1.2% of mistakes vs. 2.1±1.5% of ones, p<0.01) in 6 months after CABG. Before CABG about 40% of patients had depressive symptoms those remained after it. Physical Health (PCH) (37.9±9.4 points vs. 34.0±8.0 points, p¼0.008) and Mental Health (MCH) (45.3±10.7 points vs. 44.1±10.5 points, p¼0.3) improved in 6 months after CABG. Patients with depression had worse MCH (36.3±8.5 points vs. 48.7±8.7 points, p<0.0001) before CABG and worse PCH (34.7±7.6 points vs. 40.0±9.9 points, p¼0.03) and MCH (37.4±8.5 points vs. 50.5±8.5 points, p<0.0001) in comparison with patients without depression. Mean while patients with higher PCH had better memory (r¼0.31, p¼0.02) and thinking (r¼0.38, p¼0.04) and patients with higher MCH had better attention (r¼0.26, p¼0.04) and neurodynamics (r¼-0.37, p¼0.004) in 6 months after CABG. After surgery people had significantly better self-concept (before CABG 57.1±18.9 points, after it - 65.5±19.1 points, p¼0.005). Conclusion: Was found that strong relationship between CABG and patients’ psychological functions. Depression has negative effect on cognitive functions before CABG after it. EAS-0265. PREVALENCE OF CORONARY ARTERY DISEASE IN PATIENTS UNDERGOING CARDIAC SURGERY FOR NON-CORONARY LESIONS IN A SUPERSPECIALIZED CENTRE T. Rahman*, A. Rahman, A. Islam. Clinical and Interventional Cardiology, National Institute of Cardiovascular Diseases(NICVD), Dhaka, Bangladesh
* Corresponding author. Background: Many patients with valvular and non-valvular heart disease have concomitant coronary artery disease (CAD). The unfavorable impact of untreated CAD on perioperative and long term postoperative outcome makes preoperative identification of CAD mandatory even in asymptomatic patients. Our study aimed to see the prevalence of coronary artery disease (CAD) in patients undergoing surgery for various non- coronary lesions like valvular and non-valvular cardiac pathologies.
Abstracts / Atherosclerosis 241 (2015) e149ee229
Conclusion: We conclude that increased serum fetuin-A in aged patients associates with atherosclerotic aortic valve stenosis, independently from the presence of DM. Circulating fetuin-A may represent an important inhibitor of dystrophic calcification in aged persons with symptomatic aortic stenosis. This work was supported by IGA MH CR NT/12287-5, PRVOUK P37/12.
EAS-0258. METABOLIC RISK FACTORS AS PREDICTORS OF RESTENOSIS CORONARY ARTERIES STENTING AT PATIENTS WITH OBESITY N. Veselovskaya 1, *, G. Chumakova 2, O. Gritzenko 1. 1 Multifocal Atherosclerosis, Science Research Institute of Complex Problems of Cardiovascular Diseases, Kemerovo, Russia; 2 Internal Medicine, Altai State Medical University, Barnaul, Russia
* Corresponding author. Aim of study: to assess the prognostic predictive value of the metabolic risk factors (RF) at development restenosis the coronary arteries (CA) after their stenting at patients with obesity. Material and methods: Research included 186 men (54,4 ± 9,1 years) with body mass index >30 kg/m2 during their planned preparation for the percutaneous coronary intervention (PCI) with stenting bare metal stent. To all patients laboratory research with determination of the main and additional metabolic risk factors and thickness of epicardial fat tissue (tEFT) was calculated in millimeters (mm) on the free wall of the right ventricle (RV). Restenosis CA considered narrowing of a gleam of a vessel >50% in an intervention place. Results: Restenosis in a zone stent was revealed at 17,3% of patients (n¼32). The method of logistic regression was applied to an assessment of communication of studied risk factors with the restenosis. The maximum module of the standardized coefficient of the regression, reflecting force of a contribution of each predictor in risk of development restenosis was received at LPa (0,4095), further as it should be decrease on force of a contribution to risk of development restenosis - leptin (0,3394), glucose (0,2083), IL-6 (0,2023), tEFT (0,1936) and HDL (0,1612). The area under a ROC -curve was equal 0,8150 that testifies to high quality of the mathematical model. Conclusions: obtained predictors will allow to choosing more perspective and rational schemes of complex preoperative preparation before a myocardial revascularization that will allow increasing efficiency of stenting at patients with obesity.
EAS-0259. ATHEROGENIC INDEXES AS PREDICTORS OF STENOTIC COMPLICATION AFTER PERCUTANEOUS CORONARY INTERVENTIONS OR CORONARY ARTERY BYPASS GRAFT O. Gritzenko 1, *, G. Chumakova 2, N. Veselovskaya 1. 1 Multifocal Atherosclerosis, Science Research Institute of Complex Problems of Cardiovascular Diseases, Kemerovo, Russia; 2 Internal Medicine, Altai State Medical University, Barnaul, Russia
* Corresponding author. Aim: To assess the prognostic ability atherogenic indexes or lipoprotein ratio in development stenotic complications after revascularization (percutaneous coronary interventions (PCI) or coronary artery bypass graft [CABG]) in patients with metabolic syndrome (MS). Materials and methods: Study included 108 man (56,8±6,1) with angina II-III functional class and the clinical signs of angina pectoris. In the preoperative period (PCI - 49 patients or CABG - 59 patients) was determined lipoproteins ration of total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-C). Apolipoprotein B (Apo B)/Apolipoprotein AI (Apo AI), low-density lipoprotein cholesterol (LDL-C)/HDL-C, cholesterol - non high-density. Coronary angiography was performed in a year after.
Results: Was revealed that levels of all atherogenic indexes defined in the group of patients with MS, regardless held myocardial revascularization. According to the results of discriminant analysis revealed that a significant predictor of the development of restenosis after PCI is the ratio of TC/HDLC (Lambda Wilkes ¼0.27, p<0,001) On the results of the ROC analysis revealed that the specificity of TC/HDL-C accounted for 94.6%, sensitivity 75.0% and cut-off > 7,11. So, as a significant predictor of the development of stenotic complications in patients after CABG is the cholesterol - non high-density (Lambda Wilkes ¼0,58; p¼0.01; sensitivity-82,4%, specificity-69,0%, the cut-off >4,99). Conclusion: Atherogenic index may be necessary to risk assessment before PCI and CABG. Levels of total cholesterol/HDL-C > 7,11 and the level of cholesterol - non - high-density cholesterol > 4,99 are predictors of development stenotic complications after PCI and CABG respectively. EAS-0261. NEUROPSYCHOLOGICAL DYSFUNTIONS ARTERY BYPASS GRAFTING
AMONG
PATIENTS
WITH
J. Chugunova 1, *, G. Chumakova 1, O. Gritzenko 2, N. Veselovskaya 2. Internal Medicine, Altai State Medical University, Barnaul, Russia; 2 Multifocal Atherosclerosis, Science Research Institute of Complex Problems of Cardiovascular Diseases, Kemerovo, Russia 1
* Corresponding author. The aim: Was to learn psychological and cognitive dysfunctions in patients undergoing artery bypass grafting (CABG). Methods: Were included 57 patients, age was 58.4±0.9. Psychological factors were evaluated with the use of Zung Self-Rating Depression Scale, health self-concept scale and the Short Form General Health Survey (SF36). Hardware-software complex “Status PF” (Kemerovo) was used for an evaluation of cognitive functions before CABG and 6 months after it. Results: There was improvement of memory (5.2±1.4 points vs. 4.6±1.9 points, p¼0.02), thinking (19.9±7.2 points vs. 17.9±6.3 points, p<0.01), neurodynamics (1.4±1.2% of mistakes vs. 2.1±1.5% of ones, p<0.01) in 6 months after CABG. Before CABG about 40% of patients had depressive symptoms those remained after it. Physical Health (PCH) (37.9±9.4 points vs. 34.0±8.0 points, p¼0.008) and Mental Health (MCH) (45.3±10.7 points vs. 44.1±10.5 points, p¼0.3) improved in 6 months after CABG. Patients with depression had worse MCH (36.3±8.5 points vs. 48.7±8.7 points, p<0.0001) before CABG and worse PCH (34.7±7.6 points vs. 40.0±9.9 points, p¼0.03) and MCH (37.4±8.5 points vs. 50.5±8.5 points, p<0.0001) in comparison with patients without depression. Mean while patients with higher PCH had better memory (r¼0.31, p¼0.02) and thinking (r¼0.38, p¼0.04) and patients with higher MCH had better attention (r¼0.26, p¼0.04) and neurodynamics (r¼-0.37, p¼0.004) in 6 months after CABG. After surgery people had significantly better self-concept (before CABG 57.1±18.9 points, after it - 65.5±19.1 points, p¼0.005). Conclusion: Was found that strong relationship between CABG and patients’ psychological functions. Depression has negative effect on cognitive functions before CABG after it. EAS-0265. PREVALENCE OF CORONARY ARTERY DISEASE IN PATIENTS UNDERGOING CARDIAC SURGERY FOR NON-CORONARY LESIONS IN A SUPERSPECIALIZED CENTRE T. Rahman*, A. Rahman, A. Islam. Clinical and Interventional Cardiology, National Institute of Cardiovascular Diseases(NICVD), Dhaka, Bangladesh
* Corresponding author. Background: Many patients with valvular and non-valvular heart disease have concomitant coronary artery disease (CAD). The unfavorable impact of untreated CAD on perioperative and long term postoperative outcome makes preoperative identification of CAD mandatory even in asymptomatic patients. Our study aimed to see the prevalence of coronary artery disease (CAD) in patients undergoing surgery for various non- coronary lesions like valvular and non-valvular cardiac pathologies.