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Atherosclerosis: mechanisms as a guide to prevention
Book Reviews Herzauskultation Thieme, Leipzig,
by 1963,
R. ZUCKERMANN, M.D. pp. 287, $22.50.
-@ Peripheral Circulation in Man, edited by HENRY BARCROFT, M.D., Medical Department, The British Council, London, England, 1963, pp. 168, $5.00.
G.
Dr. Zuckermann’s name is well known internationally for his scholarly contributions to electrocardiography. A disciple of the great school of Ignazio Chavez of Mexico, he has now added another most scholarly publication on cardiac auscultation. The approach is clinical, presenting the auscultatory findings with adequate dynamic and anatomic Fundamental discussions of the explanations.
This volume is composed of 12 articles bv research workers in England, Ireland and the Briiish Commonwealth, dealing primarily with the physiology of Only one chapter the peripheral circulation in man. The format is is devoted to clinical implications. actually that of an issue of a scientific journal, even to the use of a paperback cover and to the inclusion ot The type is small and all the advertisements. figures are line drawings. Included are papers on the various methods of measuring peripheral blood flow, on the nervous control of cutaneous and muscle circulations, on autonomic transmitter mechanisms, on the vascular effects of adrenaline and noradrenaline, on vascular responses to exercise, heat and cold, on changes in venous tone and on the critical closure in human limbs. For the most part, the articles are well written and contain material that should be of interest to the research worker in the field. However, the); would have little direct application to the problems of the physician in clinical practice. DAVID I. ABRAMSON, M.D.
physics and physiology of sound transmission are only very briefly discussed. This appears to have been done intentionally, with the emphasis on teaching clinical auscultation. The numerous diagrams and differential diagnostic tables are most instructive. The large volume of knowledge which had to be compressed into 200 pages of text often required a concentrated presentation. This is helpful to the well informed cardiologist but may be at times tedious to the novice, student as well as physician. Certainly all the information useful is presented. An extensive bibliography supplements the text, extending the usefulness of the monograph. A series of characteristic phonocardiograms are to be found at the end of the book, a technic customary with the Thieme publishing house. The printing of text and particularly of illustrations is of the usual very high standards of the Thieme publishers. The book is excellent, scholarly and informative, and it is highly recommended. ARTHUR GRISHMAN, M.D.
Atherosclerosis: Mechanisms as a Guide Prevention by CAMPBELL MOSFS, M.D. Lea Febiger, Philadelphia, 1963, pp. 239, $8.00.
This is a scholarly and a valuable book. The ambitious subtitle notwithstanding, the material is presented unpretentiously. The author stresses in his introduction, “It must be clearly understood that on the basis of evidence currently available. we cannot prove in man that symptomatic atherosclerosis is a preventable process.” The organization of the book is systematic, with emphasis on biochemical factors. Each of the 13 chapters is documented with an impressive bibliography, notably the sections on pathogenesis and hormonal control of lipid metabolism. Numerous reviews in the literature have treated the topics presented in competent fashion, but it is convenient to have the many facets of the subject collated, as has been done in this book, and oriented toward the possibility (if not yet reality) of control of coronary heart disease. A relatively brief and important chapter is that on distribution and severity of atherosclerotic lesions, in which Dr. Moses presents in some detail the important contributions from his own laboratory. It is useful to be reminded that atherosclerosis and coronary attacks go hand-in-hand but not quite hand-in-glove. Coronary atherosclerosis is a reccssary condition of
A Primer of Water, Electrolyte and Acid-Base Balance, ed. 2, by E. GOLDBERGER, M.D. Lea and Febiger, Philadelphia, 1962, pp. 374, $6.00. Only the publication of this brief review can He enexpiate this reviewer’s guilty conscience. joyed this primer so much that he kept rereading it and loaning it out to impecunious house staff and until now never fulfilled the urging of the publisher to review this book “promptly and critically in an early issue.” He hopes that the reader, if he has not already stumbled upon this gem, will rush out and buy it. This primer is an unpretentious little book which is well worth its weight in gold. Its value is that it imparts practical concepts and basic insight about water, electrolyte and acid-base balance in a simple yet perceptive manner, carefully avoiding the pedantic and ponderous shoals upon which so many other It is a book tomes on this subject have foundered. worth reading and owning, both for content and for style. RAYMOND HARRIS, M.D. NOVEMBER 1963
to &
745
746
Book Reviews
coronary attacks, but not the only condition. The enormous disparity in the coronary attack rate between men and women is perhaps the most striking and best documented fact we know about coronary heart disease. Yet, the difference in the degree of atherosclerosis between male and female is relatively slight in the coronary arteries and other vessels, and no difference is evident after the fourth decade. Consequently, as the author suggests, “It may be the factors responsible for vascular catastrophe that are sex-related rather than those responsible for atheroOr, as stated to the reviewer a little sclerosis itself.” differently by Dr. George Meneely, “One has to have two things to have a coronary attack, coronary artery sclerosis and bad luck.” Dr. Moses’ presentation is “aimed solely at influencing the lipoprotein-cholesterol-triglyceride aspects of the pathogenesis of atherosclerosis.” Although not directly related, a discussion of prophylactic, long term anticoagulation, which is being widely employed to avert the “bad luck” catastrophic complications of atherosclerosis, would have been a welcome chapter. If further editions of this book appear, it is hoped the author may see fit to survey this measure, whose value is not universally accepted. RICHARD S. GUBNER, M.D. The Peripheral Blood Vessels, edited by J. LOWELL ORBISON, M.D. and DAVY E. SMITH, M.D. Williams and Wilkins, Baltimore, Md., 1963, pp. 357, $13.00. This excellent monograph on the peripheral blood vessels is composed of 13 chapters, written by 15 It is the fourth of the series on Monocontributors. initiated by the Internatgraphs in Pathology, ional Academy of Pathology in 1959. The subject matter is an expansion of the material given at an The authors annual meeting of the academy in 1962. are qualified investigators in the various fields of anatomy, physiology, pathology, internal medicine, surgery and dermatology. The material has been divided into two main categories: normal and abnormal responses, with some overlapping occurring. The first part consists of six chapters devoted to the development of blood vessels, the fine structure of blood capillaries, the chemistry of the vascular wall of the artery, the properties and functional organization of vascular smooth muscle, and the local and central nervous control of blood flow. The second portion of the book is devoted to hormones and metabolic, nutritional and immunologic factors in peripheral vascular diseases, infectious angiitis, purpura, thrombosis and vascular changes in collagen diseases. For the most part, the figures are excellent, particularly the numerous electron micrographs. The bibliography at the end of each chapter is extensive Indexes of both authors and subject and current. matter are included. The emphasis throughout the book is on recent contributions, the material being presented in a con-
cise and clear manner. The format of the book is The volume is recommended to the research good. workers in the various fields represented and to the specialists with other interests who are anxious to keep in touch with advancements in knowledge in medicine. DAvm I. ABRAMSON, M.D. BOOKS RECEIVED
FOR REVIEW
All books received will be acknowledged in this column. Insofar as possible, as space permits, books of special interest will receive more extensive reviews. Clinical
Disorders
M.D. Lea $28.00. Clinical
of the Heart
& Febiger,
Metabolism
of
Beat,
Philadelphia, Body
Water
by Samuel Bellet, 1963, pp. 1105, by Co., Philadel-
and
Electrolytes,
John H. Bland, M.D. W. B. Saunders phia, 1963, pp. 623, $16.50.
of Cardiology,
A Primer
M.D. $6.00.
Lea
& Febiger,
3rd ed., by George E. Burch, Phildelphia, 1963, pp. 366,
Current Therapy, by Howard F. Corm, M.D. W. B. Saunders Co., Philadelphia, 1963, pp. 775, $12.50. Heparin,
Metabolism,
Physiology
and Clinical
by Hyman Engelberg, M.D. Charles Springfield, Ill., 1963, pp. 218, $8.50.
Application,
C
Thomas,
du Coeur Bibliotica Cardiologica, (Vol. 3), by C. Hahn, M.D.. A. G. Brom, M.D. and J. Nauta, M.D. S. Karger (Albert .I. Phiebig, New York), 1963, pp. 398, $19.25. Chirurgie
Dzyeerential Diagnose inner Krankleiten ftir Arzte und Studierende, by Robert Hegglin, M.D. Georg Thieme
Verlag, Stuttgart, 1963, pp. 814. Atlas of Vascular Surgery,
Carl H. Calman, M.D. 1963, pp. 307, $18.00.
by Falls B. Hershey, M.D. and C!. V. Mosby Co., St. Louis,
Inte@retation, by J. Willis Hurst, M.D., Nanette Kass Wenger, M.D., Enrique Cobrera, M.D., E. Harvey Estes, M.D. and Herman K. Hellerstein, M.D. McGraw Hill, New York, 1963, pp. 308, $12.95. Electrocardiographic
The Pneumoconioses, by A. J. Lanza, M.D. Stratton, New York, 1963, pp. 154, $7.50. Medical
Laboratory
M.D. W. B. 735, $12.00.
Grune
by Matthew Co., Philadelphia,
J. Lynch, 1963, pp.
Technology,
Saunders
&
and the State, by Matthew J. Lynch, M.D. and Charles C Thomas, SpringStanley S. Raphael, M.D. field, Ill., 1963, pp. 449, $9.75. Medicine
The Management of the Anxious Patient, by Ainslie Meares, M.D. W. B. Saunders Co., Philadelphia, 1963, pp. 493, $9.00. by Spyridon D. Moulopoulos, M.D. Cardiomechanics, Charles C Thomas, Springfield, Ill., 1963, pp. 193, $7.75. Counseling
Genetics, 2nd ed., by Sheldon C. W. B. Saunders Co., Philadelphia, 1963,
in Medical
Reed. Ph.D. pp. 2?8, $5.50.
1
The Stress of Life, by Hans &lye, New York, 1963, pp. 324, $2.75.
M.D.
McGraw
Hill,
Physiology of the Circulation in Human Limbs in Health and Disease, by John T. Shepherd, M.D. W. B. Saunders
Co., Philadelphia, 1963, pp. 179, $12.00. THE
AMERICAN
JOURNAL
OF CARDIOLOGY
by 1963,
R. ZUCKERMANN, M.D. pp. 287, $22.50.
-@ Peripheral Circulation in Man, edited by HENRY BARCROFT, M.D., Medical Department, The British Council, London, England, 1963, pp. 168, $5.00.
G.
Dr. Zuckermann’s name is well known internationally for his scholarly contributions to electrocardiography. A disciple of the great school of Ignazio Chavez of Mexico, he has now added another most scholarly publication on cardiac auscultation. The approach is clinical, presenting the auscultatory findings with adequate dynamic and anatomic Fundamental discussions of the explanations.
This volume is composed of 12 articles bv research workers in England, Ireland and the Briiish Commonwealth, dealing primarily with the physiology of Only one chapter the peripheral circulation in man. The format is is devoted to clinical implications. actually that of an issue of a scientific journal, even to the use of a paperback cover and to the inclusion ot The type is small and all the advertisements. figures are line drawings. Included are papers on the various methods of measuring peripheral blood flow, on the nervous control of cutaneous and muscle circulations, on autonomic transmitter mechanisms, on the vascular effects of adrenaline and noradrenaline, on vascular responses to exercise, heat and cold, on changes in venous tone and on the critical closure in human limbs. For the most part, the articles are well written and contain material that should be of interest to the research worker in the field. However, the); would have little direct application to the problems of the physician in clinical practice. DAVID I. ABRAMSON, M.D.
physics and physiology of sound transmission are only very briefly discussed. This appears to have been done intentionally, with the emphasis on teaching clinical auscultation. The numerous diagrams and differential diagnostic tables are most instructive. The large volume of knowledge which had to be compressed into 200 pages of text often required a concentrated presentation. This is helpful to the well informed cardiologist but may be at times tedious to the novice, student as well as physician. Certainly all the information useful is presented. An extensive bibliography supplements the text, extending the usefulness of the monograph. A series of characteristic phonocardiograms are to be found at the end of the book, a technic customary with the Thieme publishing house. The printing of text and particularly of illustrations is of the usual very high standards of the Thieme publishers. The book is excellent, scholarly and informative, and it is highly recommended. ARTHUR GRISHMAN, M.D.
Atherosclerosis: Mechanisms as a Guide Prevention by CAMPBELL MOSFS, M.D. Lea Febiger, Philadelphia, 1963, pp. 239, $8.00.
This is a scholarly and a valuable book. The ambitious subtitle notwithstanding, the material is presented unpretentiously. The author stresses in his introduction, “It must be clearly understood that on the basis of evidence currently available. we cannot prove in man that symptomatic atherosclerosis is a preventable process.” The organization of the book is systematic, with emphasis on biochemical factors. Each of the 13 chapters is documented with an impressive bibliography, notably the sections on pathogenesis and hormonal control of lipid metabolism. Numerous reviews in the literature have treated the topics presented in competent fashion, but it is convenient to have the many facets of the subject collated, as has been done in this book, and oriented toward the possibility (if not yet reality) of control of coronary heart disease. A relatively brief and important chapter is that on distribution and severity of atherosclerotic lesions, in which Dr. Moses presents in some detail the important contributions from his own laboratory. It is useful to be reminded that atherosclerosis and coronary attacks go hand-in-hand but not quite hand-in-glove. Coronary atherosclerosis is a reccssary condition of
A Primer of Water, Electrolyte and Acid-Base Balance, ed. 2, by E. GOLDBERGER, M.D. Lea and Febiger, Philadelphia, 1962, pp. 374, $6.00. Only the publication of this brief review can He enexpiate this reviewer’s guilty conscience. joyed this primer so much that he kept rereading it and loaning it out to impecunious house staff and until now never fulfilled the urging of the publisher to review this book “promptly and critically in an early issue.” He hopes that the reader, if he has not already stumbled upon this gem, will rush out and buy it. This primer is an unpretentious little book which is well worth its weight in gold. Its value is that it imparts practical concepts and basic insight about water, electrolyte and acid-base balance in a simple yet perceptive manner, carefully avoiding the pedantic and ponderous shoals upon which so many other It is a book tomes on this subject have foundered. worth reading and owning, both for content and for style. RAYMOND HARRIS, M.D. NOVEMBER 1963
to &
745
746
Book Reviews
coronary attacks, but not the only condition. The enormous disparity in the coronary attack rate between men and women is perhaps the most striking and best documented fact we know about coronary heart disease. Yet, the difference in the degree of atherosclerosis between male and female is relatively slight in the coronary arteries and other vessels, and no difference is evident after the fourth decade. Consequently, as the author suggests, “It may be the factors responsible for vascular catastrophe that are sex-related rather than those responsible for atheroOr, as stated to the reviewer a little sclerosis itself.” differently by Dr. George Meneely, “One has to have two things to have a coronary attack, coronary artery sclerosis and bad luck.” Dr. Moses’ presentation is “aimed solely at influencing the lipoprotein-cholesterol-triglyceride aspects of the pathogenesis of atherosclerosis.” Although not directly related, a discussion of prophylactic, long term anticoagulation, which is being widely employed to avert the “bad luck” catastrophic complications of atherosclerosis, would have been a welcome chapter. If further editions of this book appear, it is hoped the author may see fit to survey this measure, whose value is not universally accepted. RICHARD S. GUBNER, M.D. The Peripheral Blood Vessels, edited by J. LOWELL ORBISON, M.D. and DAVY E. SMITH, M.D. Williams and Wilkins, Baltimore, Md., 1963, pp. 357, $13.00. This excellent monograph on the peripheral blood vessels is composed of 13 chapters, written by 15 It is the fourth of the series on Monocontributors. initiated by the Internatgraphs in Pathology, ional Academy of Pathology in 1959. The subject matter is an expansion of the material given at an The authors annual meeting of the academy in 1962. are qualified investigators in the various fields of anatomy, physiology, pathology, internal medicine, surgery and dermatology. The material has been divided into two main categories: normal and abnormal responses, with some overlapping occurring. The first part consists of six chapters devoted to the development of blood vessels, the fine structure of blood capillaries, the chemistry of the vascular wall of the artery, the properties and functional organization of vascular smooth muscle, and the local and central nervous control of blood flow. The second portion of the book is devoted to hormones and metabolic, nutritional and immunologic factors in peripheral vascular diseases, infectious angiitis, purpura, thrombosis and vascular changes in collagen diseases. For the most part, the figures are excellent, particularly the numerous electron micrographs. The bibliography at the end of each chapter is extensive Indexes of both authors and subject and current. matter are included. The emphasis throughout the book is on recent contributions, the material being presented in a con-
cise and clear manner. The format of the book is The volume is recommended to the research good. workers in the various fields represented and to the specialists with other interests who are anxious to keep in touch with advancements in knowledge in medicine. DAvm I. ABRAMSON, M.D. BOOKS RECEIVED
FOR REVIEW
All books received will be acknowledged in this column. Insofar as possible, as space permits, books of special interest will receive more extensive reviews. Clinical
Disorders
M.D. Lea $28.00. Clinical
of the Heart
& Febiger,
Metabolism
of
Beat,
Philadelphia, Body
Water
by Samuel Bellet, 1963, pp. 1105, by Co., Philadel-
and
Electrolytes,
John H. Bland, M.D. W. B. Saunders phia, 1963, pp. 623, $16.50.
of Cardiology,
A Primer
M.D. $6.00.
Lea
& Febiger,
3rd ed., by George E. Burch, Phildelphia, 1963, pp. 366,
Current Therapy, by Howard F. Corm, M.D. W. B. Saunders Co., Philadelphia, 1963, pp. 775, $12.50. Heparin,
Metabolism,
Physiology
and Clinical
by Hyman Engelberg, M.D. Charles Springfield, Ill., 1963, pp. 218, $8.50.
Application,
C
Thomas,
du Coeur Bibliotica Cardiologica, (Vol. 3), by C. Hahn, M.D.. A. G. Brom, M.D. and J. Nauta, M.D. S. Karger (Albert .I. Phiebig, New York), 1963, pp. 398, $19.25. Chirurgie
Dzyeerential Diagnose inner Krankleiten ftir Arzte und Studierende, by Robert Hegglin, M.D. Georg Thieme
Verlag, Stuttgart, 1963, pp. 814. Atlas of Vascular Surgery,
Carl H. Calman, M.D. 1963, pp. 307, $18.00.
by Falls B. Hershey, M.D. and C!. V. Mosby Co., St. Louis,
Inte@retation, by J. Willis Hurst, M.D., Nanette Kass Wenger, M.D., Enrique Cobrera, M.D., E. Harvey Estes, M.D. and Herman K. Hellerstein, M.D. McGraw Hill, New York, 1963, pp. 308, $12.95. Electrocardiographic
The Pneumoconioses, by A. J. Lanza, M.D. Stratton, New York, 1963, pp. 154, $7.50. Medical
Laboratory
M.D. W. B. 735, $12.00.
Grune
by Matthew Co., Philadelphia,
J. Lynch, 1963, pp.
Technology,
Saunders
&
and the State, by Matthew J. Lynch, M.D. and Charles C Thomas, SpringStanley S. Raphael, M.D. field, Ill., 1963, pp. 449, $9.75. Medicine
The Management of the Anxious Patient, by Ainslie Meares, M.D. W. B. Saunders Co., Philadelphia, 1963, pp. 493, $9.00. by Spyridon D. Moulopoulos, M.D. Cardiomechanics, Charles C Thomas, Springfield, Ill., 1963, pp. 193, $7.75. Counseling
Genetics, 2nd ed., by Sheldon C. W. B. Saunders Co., Philadelphia, 1963,
in Medical
Reed. Ph.D. pp. 2?8, $5.50.
1
The Stress of Life, by Hans &lye, New York, 1963, pp. 324, $2.75.
M.D.
McGraw
Hill,
Physiology of the Circulation in Human Limbs in Health and Disease, by John T. Shepherd, M.D. W. B. Saunders
Co., Philadelphia, 1963, pp. 179, $12.00. THE
AMERICAN
JOURNAL
OF CARDIOLOGY