- Email: [email protected]
ATRIAL FIBRILLATION AND INCIDENCE DEMENTIA AMONG OLDER ADULTS: A POPULATION-BASED STUDY
P238
Poster Presentations: Sunday, July 16, 2017
Background: Several studies have demonstrated the positive effects of art-based interventions, but study design and small sample sizes have tended to limit their value. The results do, however, indicate the need for additional research into the therapeutic potential of art. Methods: Performed in cooperation with the Frankfurt St€adel Museum, the practice-based research project ARTEMIS (ART Encounters: Museum Intervention Study) is the first randomized waitlist controlled study to explore the influence of a combination of museum visits and artistic activity on the emotional state, well-being, and quality of life of dementia patients and their informal caregivers in a German speaking country. People with mild to moderate dementia (n ¼ 44) and their care partners (n ¼ 44) visited the St€adel Museum once a week on six pre-arranged occasions. The intervention consisted of different guided art tours that introduced participants to pictures taken from 700 years of art history. This was followed by art-making in the studio. The creative activity acquainted the participants with a large variety of artistic materials (e.g. acrylic paint, oil pastel, and clay), and simple techniques such as collage and styrofoam printing, whereby the tasks were designed to be carried out in pairs. Using a mixed-methods design, the assessed outcomes included cognitive status, situational well-being, particular aspects of quality of life, and subjective evaluation of the caregiver-patient relationship, pre-, and post-intervention, and at follow-up. Results: In the pre-post-assessment, we found significant improvements in self-rated quality of life (z ¼ -2.51, p < .05) and emotional well-being with medium to high effect sizes for persons with dementia (d ¼ 0.74 – 0.77) and their caregivers (d ¼ 0.35 – 0.77). Caregivers also reported a positive impact on relationships with their relatives suffering from dementia. Conclusions: The results show that art-based museum interventions are able to raise the subjective well-being and quality of life of people with dementia, and encourage them to interact more with their caregivers.
P1-015
ATRIAL FIBRILLATION, COGNITIVE DECLINE, AND DEMENTIA AMONG OLDER PEOPLE: A LONGITUDINAL POPULATION-BASED STUDY
Mozhu Ding1, Laura Fratiglioni1,2, Kristina Johnell1, Alessandra Marengoni1,3, Petter Ljungman1, Chengxuan Qiu1, 1Karolinska Institutet, Stockholm, Sweden; 2Stockholm Gerontology Research Center, Stockholm, Sweden; 3Universita degli Studi di Brescia, Brescia, Italy. Contact e-mail: [email protected] Background: Population-based follow-up studies assessing the relationship of atrial fibrillation (AF) with cognitive decline and dementia have yielded conflicting results. In this study, we aim to investigate the longitudinal association of AF with cognitive decline and dementia among 60+ old people. Methods: This longitudinal study included 2685 participants from the population-based Swedish National Study on Aging and Care in Kungsholmen (SNAC-K), who were free of dementia and with Mini-Mental State Examination (MMSE) score over 23 at baseline (2001-2004). Participants were followed from 2001-2004 to 2007-2010, and data on demographics, lifestyle factors, cardiovascular risk factors (e.g., hypertension and diabetes), chronic health conditions (e.g., heart diseases), global cognitive function (e.g., MMSE), and genetic factors (e.g., APOE genotype) were collected through interviews, clinical examinations, laboratory tests, psychological tests, and hospital records. Dementia was diagnosed according to the DSMIV criteria, and AF was identified through electrocardiogram and
ICD-10 codes (I48) from physician’s diagnosis and hospital records. Data were analyzed using linear mixed-effects models and Cox regression models controlling for multiple potential confounders. Results: The mean age of the 2865 participants at baseline was 73.1 years, of whom 62.9% were women. At baseline, 243 (9.1%) participants were identified as having AF. During a median follow-up of 5.7 years, incident dementia was diagnosed in 317 (11.8%) participants, and incident AF was ascertained in 227 (8.5%) persons. Multiple linear mixed-effects models showed that baseline AF was significantly associated with a faster annual decline in MMSE score (b coefficient ¼ -0.18, 95% confidence interval [CI]: -0.27, -0.08). Multiple Cox regression models showed that AF, when used as a time-varying variable, was significantly associated with an increased risk of dementia (hazard ratio [HR] ¼ 1.53, 95% CI: 1.15-2.02), and this association was more statistically evident among APOE ε4 carriers (HR¼1.84, 95% CI: 1.162.92) than non-carriers (HR¼1.24, 95% CI: 0.83-1.84). Conclusions: AF is associated with an increased risk of dementia and a faster decline in global cognitive function among older people, especially among APOE ε4 allele carriers. Further studies are needed to investigate whether optimal treatment in AF can postpone the adverse cognitive consequences.
P1-016
ATRIAL FIBRILLATION AND INCIDENCE DEMENTIA AMONG OLDER ADULTS: A POPULATION-BASED STUDY
Lina Ryden1, Ingmar Skoog2, 1Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, M€olndal, Sweden; 2Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, M€olndal, Sweden. Contact e-mail: [email protected] Background: The aim of this study was to examine the association between atrial fibrillation and incidence dementia among older adults. The advantages of the study are the longitudinal design, the ability to look at the association in a general population and to be able to exclude participants that suffer from stroke. Methods: Data was obtained from two population-based, longitudinal studies in Gothenburg, Sweden (H70 and PPSW). The participants were sampled from the Swedish population register on the basis of birth date in 2000, aged 70 years old at baseline, and followed up in 2005 and 2009. The atrial fibrillation status of the participants was identified through ECG, proxy informant interview or the national patient register (NPR) at baseline. Incidence dementia was identified at follow up according to the DSM-III-R criteria based on neuropsychiatric examinations and proxy informant interviews in 2005 and 2009 together with data from the NPR until 2012. All participants that were demented at baseline were excluded. Cox-regression analyses were performed both including and excluding participants suffering from stroke before baseline or during the time of follow-up. Results: A total number of 559 participants were eligible for this study (60% women). HR (adjusted for sex) for incidence dementia in those with baseline atrial fibrillation was 2.7 (95% CI 1.3-5.4; p¼0.007). Excluding participants with stroke before baseline or during follow-up did not change the association HR¼2.7 (95% CI 1.2-6.3; p¼0.019). Conclusions: Our study showed an association between atrial fibrillation and incidence dementia. The HR did not change when excluding participants suffering from stroke. Possible reasons for our finding that atrial fibrillation was related to dementia in individuals without stroke could be silent stroke, microembolism, hypoperfusion or
Poster Presentations: Sunday, July 16, 2017
inflammation. Treatment of atrial fibrillation may be one way to prevent dementia among the elderly. P1-017
SF-DEM: A NEW INSTRUMENT FOR ASSESSING SOCIAL FUNCTIONING IN DEMENTIA
Andrew Sommerlad1, David Singleton1, Rebecca Jones1, Sube Banerjee2, Gill Livingston1, 1University College London, London, United Kingdom; 2Brighton and Sussex Medical School, Brighton, United Kingdom. Contact e-mail: [email protected] Background: There is no standardised instrument for assessing so-
cial functioning in dementia despite decline in social functioning being one of the diagnostic criteria for dementia and important to patients and their families. We aimed to develop a valid, reliable, acceptable instrument for assessing social function in people with dementia. Methods: We conducted qualitative interviews with 18 dyads of people with dementia and their family carers, a literature review, and focus groups with expert health-care professionals to develop the patient-rated and carer-rated versions of the Social Functioning in Dementia (SF-DEM) instrument. We tested the acceptability and psychometric properties of these measures in structured interviews at baseline and at 4 weeks’ and 6–8 months’ follow-up in a cohort of 30 dyads of people with mild dementia and their carers, recruited from London memory services. Results: SF-DEM had content validity. The instrument was acceptable to both patients and carers, who all rated it as acceptable or very acceptable. Inter-rater agreement was good or very good for all questions. Test–retest reliability was very strong (Intraclass correlation coefficient (ICC)¼0$89, 95% CI [0.73, 0.96]) for the carer-rated SF-DEM and (ICC¼0$80, 95% CI [0.54, 0.92]) patient-rated version, and both versions had internal consistency (Cronbach’s a¼0$71 for carer-rated SF-DEM and a¼0$64 for patient-rated). SF-DEM had concurrent validity, since it was moderately correlated with a question about overall social (r¼0$60, 95% CI [0.29, 0.78] for carer-rated; r¼0$44, 95% CI [0.07, 0.68] for patient-rated). SF-DEM also had convergent validity, as evidenced by a moderate correlation between patient and carer ratings (r¼0$59, 95% CI [0.07, 0.81]). At follow-up (mean duration 7.2 months), patient-rated SF-DEM score increased by 1.3 points (95% CI [-0.3, 2.9], p¼0.10) and caregiver-rated SF-DEM score increased by 1.4 points (95% CI [-0.1, 2.9], p¼0.06) for each point on a five point ordinal scale of social change. Conclusions: Patient-rated and carer-rated versions of the SF-DEM are reliable, valid, and acceptable measures of social function in people with mild dementia and there are indications of its responsiveness to detect change. These measures are freely available to other researchers. Further research should test the generalisability to other populations.
P1-018
THE EFFECTS OF HORTICULTURAL THERAPY ON THE PSYCHONEUROIMMUNOLOGICAL MARKERS OF ELDERLY IN SINGAPORE: SECOND-WAVE FINDINGS FROM THE RANDOMIZED CONTROLLED TRIAL
Kheng Siang Ted Ng1, Crystal Tze Ying Tan2, Hui Yu Chan1,3, Angelia Sia4, Maxel Kian-Wee Ng4, Chay Hoon Tan1,3, Lei Feng1, Rathi Mahendran1,3, Ee Heok Kua1,3, Anis Larbi2, Roger Chun-Man Ho1,3, Jurong Aging Study, 1National University of Singapore, Singapore, Singapore; 2Agency for Science, Technology and Research, Singapore,
P239
Singapore; 3National University Hospital, Singapore, Singapore; 4National Parks Board, Singapore, Singapore. Contact e-mail: khengsiang_1988@ yahoo.com Background: There is currently a paucity of research examining bio-
markers in Horticultural Therapy (HT) studies. We proposed this pilot randomized controlled trial (RCT) in Singapore to investigate the effects of HT on the biomarkers of elderly. We hypothesized that HT could improve the levels of psychoneuroimmunological markers of the participants. Methods: Per inclusion and exclusion criteria, 69 community-dwelling elderly were recruited from TaRA@JP. Participants were randomized into either the active treatment (HT) or waitlist control arms. HT programmes were conducted weekly for the first three months and monthly for the subsequent three months. To assess the levels of the biomarkers of the participants, fasting blood were withdrawn by the research nurses at three time-points: baseline, three-month and six-month after interventions. Using enzyme-linked immunosorbent assay (ELISA), nine plasma biomarkers were measured. The measurements of 3 additional biomarkers,ACTH, oxytocin and IGF-1, are on-going and may be included in the presentations. Results: In the active treatment arm, there was a significant increase (p¼0.045) in Stromal Cell-Derived Factor 1-alpha (SDF-1a) from third to sixth month post-interventions. In contrast, the waitlist control arm experienced a significant decrease of SDF-1a from baseline to 3rd month (p¼0.002). Across the three time-points, there were no significant changes in RANTES for the active treatment arm. Notably, from baseline to 6th month, a significant decrease in RANTES was observed (p¼0.028). Furthermore, BDNF in the active treatment arm showed no significant differences across all the time-points. However, in the waitlist control arm, BDNF decreased significantly from third- to sixth-month time-points (p¼0.001). Conclusions: HT had significant effect on increasing the levels of SDF-1a and maintaining RANTES and BDNF levels. Similar to previously reported IL-6, the effect of HT on these biomarkers was also significant at sixth month time-point. This may indicate a cumulative effect of participation in HT. Our results indicate that HT, a form of communal gardening, may be promising in reducing the risks of developing psychiatric conditions, acute infection and cancers by modulating the levels of these biomarkers. With these positive findings, the government of Singapore is planning to develop therapeutic gardens in phases across the nation to extend its benefits.
P1-019
MULTIDOMAIN LIFESTYLE INTERVENTION BENEFITS A LARGE ELDERLY POPULATION AT RISK FOR COGNITIVE DECLINE: SUBGROUP ANALYSES OF THE FINNISH GERIATRIC INTERVENTION STUDY TO PREVENT COGNITIVE IMPAIRMENT AND DISABILITY (FINGER)
Anna Rosenberg1, Alina Solomon1,2,3, Tiia Ngandu4,5, Esko Lev€alahti6, Tiina Laatikainen6,7, Teemu Paajanen8, Tuomo H€anninen9, Riitta Antikainen10,11,12, Timo Strandberg10,13, Hilkka Soininen1,2, Miia Kivipelto1,4,14,15, the FINGER Study Group, 1University of Eastern Finland, Kuopio, Finland; 2Institute of Clinical Medicine, Kuopio, Finland; 3 Aging Research Center, Karolinska Institutet-Stockholm University, Stockholm, Sweden; 4National Institute for Health and Welfare, Helsinki, Finland; 5Karolinska Institutet Center for Alzheimer Research, Stockholm, Sweden; 6Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland; 7Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; 8Finnish Institute of Occupational Health, Helsinki, Finland; 9Department of
Poster Presentations: Sunday, July 16, 2017
Background: Several studies have demonstrated the positive effects of art-based interventions, but study design and small sample sizes have tended to limit their value. The results do, however, indicate the need for additional research into the therapeutic potential of art. Methods: Performed in cooperation with the Frankfurt St€adel Museum, the practice-based research project ARTEMIS (ART Encounters: Museum Intervention Study) is the first randomized waitlist controlled study to explore the influence of a combination of museum visits and artistic activity on the emotional state, well-being, and quality of life of dementia patients and their informal caregivers in a German speaking country. People with mild to moderate dementia (n ¼ 44) and their care partners (n ¼ 44) visited the St€adel Museum once a week on six pre-arranged occasions. The intervention consisted of different guided art tours that introduced participants to pictures taken from 700 years of art history. This was followed by art-making in the studio. The creative activity acquainted the participants with a large variety of artistic materials (e.g. acrylic paint, oil pastel, and clay), and simple techniques such as collage and styrofoam printing, whereby the tasks were designed to be carried out in pairs. Using a mixed-methods design, the assessed outcomes included cognitive status, situational well-being, particular aspects of quality of life, and subjective evaluation of the caregiver-patient relationship, pre-, and post-intervention, and at follow-up. Results: In the pre-post-assessment, we found significant improvements in self-rated quality of life (z ¼ -2.51, p < .05) and emotional well-being with medium to high effect sizes for persons with dementia (d ¼ 0.74 – 0.77) and their caregivers (d ¼ 0.35 – 0.77). Caregivers also reported a positive impact on relationships with their relatives suffering from dementia. Conclusions: The results show that art-based museum interventions are able to raise the subjective well-being and quality of life of people with dementia, and encourage them to interact more with their caregivers.
P1-015
ATRIAL FIBRILLATION, COGNITIVE DECLINE, AND DEMENTIA AMONG OLDER PEOPLE: A LONGITUDINAL POPULATION-BASED STUDY
Mozhu Ding1, Laura Fratiglioni1,2, Kristina Johnell1, Alessandra Marengoni1,3, Petter Ljungman1, Chengxuan Qiu1, 1Karolinska Institutet, Stockholm, Sweden; 2Stockholm Gerontology Research Center, Stockholm, Sweden; 3Universita degli Studi di Brescia, Brescia, Italy. Contact e-mail: [email protected] Background: Population-based follow-up studies assessing the relationship of atrial fibrillation (AF) with cognitive decline and dementia have yielded conflicting results. In this study, we aim to investigate the longitudinal association of AF with cognitive decline and dementia among 60+ old people. Methods: This longitudinal study included 2685 participants from the population-based Swedish National Study on Aging and Care in Kungsholmen (SNAC-K), who were free of dementia and with Mini-Mental State Examination (MMSE) score over 23 at baseline (2001-2004). Participants were followed from 2001-2004 to 2007-2010, and data on demographics, lifestyle factors, cardiovascular risk factors (e.g., hypertension and diabetes), chronic health conditions (e.g., heart diseases), global cognitive function (e.g., MMSE), and genetic factors (e.g., APOE genotype) were collected through interviews, clinical examinations, laboratory tests, psychological tests, and hospital records. Dementia was diagnosed according to the DSMIV criteria, and AF was identified through electrocardiogram and
ICD-10 codes (I48) from physician’s diagnosis and hospital records. Data were analyzed using linear mixed-effects models and Cox regression models controlling for multiple potential confounders. Results: The mean age of the 2865 participants at baseline was 73.1 years, of whom 62.9% were women. At baseline, 243 (9.1%) participants were identified as having AF. During a median follow-up of 5.7 years, incident dementia was diagnosed in 317 (11.8%) participants, and incident AF was ascertained in 227 (8.5%) persons. Multiple linear mixed-effects models showed that baseline AF was significantly associated with a faster annual decline in MMSE score (b coefficient ¼ -0.18, 95% confidence interval [CI]: -0.27, -0.08). Multiple Cox regression models showed that AF, when used as a time-varying variable, was significantly associated with an increased risk of dementia (hazard ratio [HR] ¼ 1.53, 95% CI: 1.15-2.02), and this association was more statistically evident among APOE ε4 carriers (HR¼1.84, 95% CI: 1.162.92) than non-carriers (HR¼1.24, 95% CI: 0.83-1.84). Conclusions: AF is associated with an increased risk of dementia and a faster decline in global cognitive function among older people, especially among APOE ε4 allele carriers. Further studies are needed to investigate whether optimal treatment in AF can postpone the adverse cognitive consequences.
P1-016
ATRIAL FIBRILLATION AND INCIDENCE DEMENTIA AMONG OLDER ADULTS: A POPULATION-BASED STUDY
Lina Ryden1, Ingmar Skoog2, 1Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, M€olndal, Sweden; 2Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, M€olndal, Sweden. Contact e-mail: [email protected] Background: The aim of this study was to examine the association between atrial fibrillation and incidence dementia among older adults. The advantages of the study are the longitudinal design, the ability to look at the association in a general population and to be able to exclude participants that suffer from stroke. Methods: Data was obtained from two population-based, longitudinal studies in Gothenburg, Sweden (H70 and PPSW). The participants were sampled from the Swedish population register on the basis of birth date in 2000, aged 70 years old at baseline, and followed up in 2005 and 2009. The atrial fibrillation status of the participants was identified through ECG, proxy informant interview or the national patient register (NPR) at baseline. Incidence dementia was identified at follow up according to the DSM-III-R criteria based on neuropsychiatric examinations and proxy informant interviews in 2005 and 2009 together with data from the NPR until 2012. All participants that were demented at baseline were excluded. Cox-regression analyses were performed both including and excluding participants suffering from stroke before baseline or during the time of follow-up. Results: A total number of 559 participants were eligible for this study (60% women). HR (adjusted for sex) for incidence dementia in those with baseline atrial fibrillation was 2.7 (95% CI 1.3-5.4; p¼0.007). Excluding participants with stroke before baseline or during follow-up did not change the association HR¼2.7 (95% CI 1.2-6.3; p¼0.019). Conclusions: Our study showed an association between atrial fibrillation and incidence dementia. The HR did not change when excluding participants suffering from stroke. Possible reasons for our finding that atrial fibrillation was related to dementia in individuals without stroke could be silent stroke, microembolism, hypoperfusion or
Poster Presentations: Sunday, July 16, 2017
inflammation. Treatment of atrial fibrillation may be one way to prevent dementia among the elderly. P1-017
SF-DEM: A NEW INSTRUMENT FOR ASSESSING SOCIAL FUNCTIONING IN DEMENTIA
Andrew Sommerlad1, David Singleton1, Rebecca Jones1, Sube Banerjee2, Gill Livingston1, 1University College London, London, United Kingdom; 2Brighton and Sussex Medical School, Brighton, United Kingdom. Contact e-mail: [email protected] Background: There is no standardised instrument for assessing so-
cial functioning in dementia despite decline in social functioning being one of the diagnostic criteria for dementia and important to patients and their families. We aimed to develop a valid, reliable, acceptable instrument for assessing social function in people with dementia. Methods: We conducted qualitative interviews with 18 dyads of people with dementia and their family carers, a literature review, and focus groups with expert health-care professionals to develop the patient-rated and carer-rated versions of the Social Functioning in Dementia (SF-DEM) instrument. We tested the acceptability and psychometric properties of these measures in structured interviews at baseline and at 4 weeks’ and 6–8 months’ follow-up in a cohort of 30 dyads of people with mild dementia and their carers, recruited from London memory services. Results: SF-DEM had content validity. The instrument was acceptable to both patients and carers, who all rated it as acceptable or very acceptable. Inter-rater agreement was good or very good for all questions. Test–retest reliability was very strong (Intraclass correlation coefficient (ICC)¼0$89, 95% CI [0.73, 0.96]) for the carer-rated SF-DEM and (ICC¼0$80, 95% CI [0.54, 0.92]) patient-rated version, and both versions had internal consistency (Cronbach’s a¼0$71 for carer-rated SF-DEM and a¼0$64 for patient-rated). SF-DEM had concurrent validity, since it was moderately correlated with a question about overall social (r¼0$60, 95% CI [0.29, 0.78] for carer-rated; r¼0$44, 95% CI [0.07, 0.68] for patient-rated). SF-DEM also had convergent validity, as evidenced by a moderate correlation between patient and carer ratings (r¼0$59, 95% CI [0.07, 0.81]). At follow-up (mean duration 7.2 months), patient-rated SF-DEM score increased by 1.3 points (95% CI [-0.3, 2.9], p¼0.10) and caregiver-rated SF-DEM score increased by 1.4 points (95% CI [-0.1, 2.9], p¼0.06) for each point on a five point ordinal scale of social change. Conclusions: Patient-rated and carer-rated versions of the SF-DEM are reliable, valid, and acceptable measures of social function in people with mild dementia and there are indications of its responsiveness to detect change. These measures are freely available to other researchers. Further research should test the generalisability to other populations.
P1-018
THE EFFECTS OF HORTICULTURAL THERAPY ON THE PSYCHONEUROIMMUNOLOGICAL MARKERS OF ELDERLY IN SINGAPORE: SECOND-WAVE FINDINGS FROM THE RANDOMIZED CONTROLLED TRIAL
Kheng Siang Ted Ng1, Crystal Tze Ying Tan2, Hui Yu Chan1,3, Angelia Sia4, Maxel Kian-Wee Ng4, Chay Hoon Tan1,3, Lei Feng1, Rathi Mahendran1,3, Ee Heok Kua1,3, Anis Larbi2, Roger Chun-Man Ho1,3, Jurong Aging Study, 1National University of Singapore, Singapore, Singapore; 2Agency for Science, Technology and Research, Singapore,
P239
Singapore; 3National University Hospital, Singapore, Singapore; 4National Parks Board, Singapore, Singapore. Contact e-mail: khengsiang_1988@ yahoo.com Background: There is currently a paucity of research examining bio-
markers in Horticultural Therapy (HT) studies. We proposed this pilot randomized controlled trial (RCT) in Singapore to investigate the effects of HT on the biomarkers of elderly. We hypothesized that HT could improve the levels of psychoneuroimmunological markers of the participants. Methods: Per inclusion and exclusion criteria, 69 community-dwelling elderly were recruited from TaRA@JP. Participants were randomized into either the active treatment (HT) or waitlist control arms. HT programmes were conducted weekly for the first three months and monthly for the subsequent three months. To assess the levels of the biomarkers of the participants, fasting blood were withdrawn by the research nurses at three time-points: baseline, three-month and six-month after interventions. Using enzyme-linked immunosorbent assay (ELISA), nine plasma biomarkers were measured. The measurements of 3 additional biomarkers,ACTH, oxytocin and IGF-1, are on-going and may be included in the presentations. Results: In the active treatment arm, there was a significant increase (p¼0.045) in Stromal Cell-Derived Factor 1-alpha (SDF-1a) from third to sixth month post-interventions. In contrast, the waitlist control arm experienced a significant decrease of SDF-1a from baseline to 3rd month (p¼0.002). Across the three time-points, there were no significant changes in RANTES for the active treatment arm. Notably, from baseline to 6th month, a significant decrease in RANTES was observed (p¼0.028). Furthermore, BDNF in the active treatment arm showed no significant differences across all the time-points. However, in the waitlist control arm, BDNF decreased significantly from third- to sixth-month time-points (p¼0.001). Conclusions: HT had significant effect on increasing the levels of SDF-1a and maintaining RANTES and BDNF levels. Similar to previously reported IL-6, the effect of HT on these biomarkers was also significant at sixth month time-point. This may indicate a cumulative effect of participation in HT. Our results indicate that HT, a form of communal gardening, may be promising in reducing the risks of developing psychiatric conditions, acute infection and cancers by modulating the levels of these biomarkers. With these positive findings, the government of Singapore is planning to develop therapeutic gardens in phases across the nation to extend its benefits.
P1-019
MULTIDOMAIN LIFESTYLE INTERVENTION BENEFITS A LARGE ELDERLY POPULATION AT RISK FOR COGNITIVE DECLINE: SUBGROUP ANALYSES OF THE FINNISH GERIATRIC INTERVENTION STUDY TO PREVENT COGNITIVE IMPAIRMENT AND DISABILITY (FINGER)
Anna Rosenberg1, Alina Solomon1,2,3, Tiia Ngandu4,5, Esko Lev€alahti6, Tiina Laatikainen6,7, Teemu Paajanen8, Tuomo H€anninen9, Riitta Antikainen10,11,12, Timo Strandberg10,13, Hilkka Soininen1,2, Miia Kivipelto1,4,14,15, the FINGER Study Group, 1University of Eastern Finland, Kuopio, Finland; 2Institute of Clinical Medicine, Kuopio, Finland; 3 Aging Research Center, Karolinska Institutet-Stockholm University, Stockholm, Sweden; 4National Institute for Health and Welfare, Helsinki, Finland; 5Karolinska Institutet Center for Alzheimer Research, Stockholm, Sweden; 6Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland; 7Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; 8Finnish Institute of Occupational Health, Helsinki, Finland; 9Department of