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rhaboid tumour arising in association with a pleomorphic xanthoastrocytoma: a case report
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Pathology (2011), 43(S1)
PATHOLOGY 2011 ABSTRACT SUPPLEMENT
Discussion: We report a robust, precise and automated massspectrometry based assay for the measurement of plasma hepcidin-25. Further investigations into sample handling and storage conditions will be carried out. COMPARATIVE IN VITRO SUSCEPTIBILITY OF BURKHOLDERIA PSEUDOMALLEI TO DORIPENEM, ERTAPENEM, TIGECYCLINE AND MOXIFLOXACIN Patrick Harris, Cathy Engler, Robert Norton Pathology Queensland, Townsville Hospital, Douglas, Qld, Australia Background: Melioidosis continues to present therapeutic challenges in endemic areas, including tropical Australia. A number of clinical issues have prompted the search for alternative antimicrobial therapies. These include stability in 24 hour infusion pumps, broad spectrum coverage in the empiric treatment of community acquired pneumonia, cost, the need for effective oral agents and rare reports of emerging resistance. Objectives: To examine the in vitro susceptibility of Burkholderia pseudomallei to four new antimicrobial agents, including moxifloxacin, tigecycline, ertapenem and doripenem. Methods: A total of 100 clinical isolates were tested using Etest and disc diffusion. As there are no interpretative standards for these antimicrobials, MIC90 values were compared to those for meropenem. MIC values were correlated with zone of inhibition diameters. Results: The MIC values for doripenem were broadly similar to those for meropenem, demonstrating a MIC90 of 1.5 mg/mL (MIC range 0.38–4 mg/mL). There was good correlation (r ¼ –0.71; p < 0.001) between the MIC and disc diffusion for doripenem. Ertapenem, tigecycline and moxifloxacin had limited in vitro activity in this study, although no interpretative criteria exist for these agents. Conclusions: Further in vitro, animal and clinical studies are suggested to validate the efficacy of doripenem in the management of melioidosis. FATAL EPIGLOTTIC ABSCESS FOLLOWING RADIOTHERAPY FOR LARYNGEAL CARCINOMA Matthew J. Harvey, Gary Quagliotto, Nathan Milne Forensic and Scientific Services, Pathology Queensland, Brisbane, Qld, Australia Acute epiglottitis is a rare condition, especially in adults, largely due to widespread vaccination against Haemophilus influenzae. Traumatic epiglottitis as a result of thermal or caustic insults are well documented. Epiglottic abscess formation is described as a sequela of epiglottitis in some cases. The development of epiglottic abscess from epiglottitis secondary to radiotherapy has not previously been described in the literature. We present an unusual case of an adult sudden death due to epiglottic abscess formation subsequent to radiotherapy for laryngeal squamous cell carcinoma. PATHOLOGY AS THE CORNERSTONE OF HUMAN TISSUE BANKING: EXPERIENCES IN THE POST-GENOMICS ERA A. Johns1, A. Gill1,2, C. Toon1,3, C. Forrest4, M. Texler4, A. Clouston5, D. McLeod8, A. Ruszkiewicz6, J. Kench7, N. Zeps9, S. Grimmond10, A. Biankin1, for the Australian Pancreatic Cancer Genome Initiative
1
Garvan Institute of Medical Research, Sydney, NSW, 2Royal North Shore Hospital, Sydney, NSW, 3South Eastern Area Laboratory Services, Prince of Wales Hospital, Sydney, NSW, 4PathWest Laboratory Medicine, Fremantle Hospital, Perth, WA, 5Envoi Specialist Pathologists, Brisbane, Qld, 6Royal Adelaide Hospital, SA Pathology, Adelaide, SA, 7Royal Prince Alfred Hospital, Sydney, NSW, 8Westmead Hospital, Sydney, NSW, 9St John of God Pathology, Perth, WA, and 10QLD Centre for Medical Genomics, Brisbane, Qld, Australia Unprecedented advances in biomolecular technology have greatly increased the power and precision of analytical tools used in cancer research and have accelerated the drive toward personalised medicine. Human specimens that are analysed using these new and developing technology platforms have emerged as a critical resource for basic and translational research in cancer because they are a direct source of molecular data from which targets for therapy, detection, and prevention are identified. As a result this has stimulated a growing demand for carefully collected, appropriately stored and well-annotated tumour specimens worldwide. This requirement has put pathologists in the centre of the personalised medicine world as providers of information identifying tissues and also as decision makers on what materials should be biobanked, on the preservation conditions, and on the timeline of events that precede preservation and storage. This critical position in the research process places extraordinary demands on all aspects of pathology practice, in particular as pathology laboratories are ultimately key players in delivering new medicines through molecular diagnostics. We present a national biobank network infrastructure that promotes multi-disciplinary research and has pathology underpinning tumour banking in order to facilitate multi-institutional, high throughput genomic studies. This new era of medicine requires a strategic view of ways forward for better integration of pathology, not only as ‘tissue providers’ but also as essential participants in the design, performance, interpretation, and implementation of research and clinical trials. ATYPICAL TERATOID/RHABOID TUMOUR ARISING IN ASSOCIATION WITH A PLEOMORPHIC XANTHOASTROCYTOMA: A CASE REPORT V. Kamath1, E. Sugo1, D. S. Ziegler2, B. Kwok3, R. Lukeis4 Department of Anatomical Pathology, South East Area Laboratory Services (SEALS), Prince of Wales Hospital, 2 Centre for Children’s Cancer and Blood Disorders, Sydney Children’s Hospital, and School of Women’s and Children’s Health, University of New South Wales, 3Department of Neurosurgery, Sydney Children’s Hospital, and 4Department of Haematology, Cytogenetics Laboratory, SydPath, St Vincent’s Hospital, Sydney, NSW, Australia 1
Atypical teratoid rhabdoid tumour (AT/RT) is a rare, highly malignant embryonal tumour most often occurring in the posterior fossa in children under 3 years of age. We report a case of a supratentorial AT/RT arising in association with a pleomorphic xanthoastrocytoma (PXA). A 6-year-old girl presented with a 1 month history of headache and vomiting. An MRI showed a heterogeneously enhancing mass involving the posterior left frontal lobe associated with marked local mass effect. Following a subtotal resection of the tumour she commenced treatment with chemoradiation. Histological sections showed a tumour with two distinct but focally intermixed morphological appearances, a high grade component with cellular morphology typical of an AT/RT
Copyright © Royal College of pathologists of Australasia. Unauthorized reproduction of this article is prohibited.
Pathology (2011), 43(S1)
PATHOLOGY 2011 ABSTRACT SUPPLEMENT
Discussion: We report a robust, precise and automated massspectrometry based assay for the measurement of plasma hepcidin-25. Further investigations into sample handling and storage conditions will be carried out. COMPARATIVE IN VITRO SUSCEPTIBILITY OF BURKHOLDERIA PSEUDOMALLEI TO DORIPENEM, ERTAPENEM, TIGECYCLINE AND MOXIFLOXACIN Patrick Harris, Cathy Engler, Robert Norton Pathology Queensland, Townsville Hospital, Douglas, Qld, Australia Background: Melioidosis continues to present therapeutic challenges in endemic areas, including tropical Australia. A number of clinical issues have prompted the search for alternative antimicrobial therapies. These include stability in 24 hour infusion pumps, broad spectrum coverage in the empiric treatment of community acquired pneumonia, cost, the need for effective oral agents and rare reports of emerging resistance. Objectives: To examine the in vitro susceptibility of Burkholderia pseudomallei to four new antimicrobial agents, including moxifloxacin, tigecycline, ertapenem and doripenem. Methods: A total of 100 clinical isolates were tested using Etest and disc diffusion. As there are no interpretative standards for these antimicrobials, MIC90 values were compared to those for meropenem. MIC values were correlated with zone of inhibition diameters. Results: The MIC values for doripenem were broadly similar to those for meropenem, demonstrating a MIC90 of 1.5 mg/mL (MIC range 0.38–4 mg/mL). There was good correlation (r ¼ –0.71; p < 0.001) between the MIC and disc diffusion for doripenem. Ertapenem, tigecycline and moxifloxacin had limited in vitro activity in this study, although no interpretative criteria exist for these agents. Conclusions: Further in vitro, animal and clinical studies are suggested to validate the efficacy of doripenem in the management of melioidosis. FATAL EPIGLOTTIC ABSCESS FOLLOWING RADIOTHERAPY FOR LARYNGEAL CARCINOMA Matthew J. Harvey, Gary Quagliotto, Nathan Milne Forensic and Scientific Services, Pathology Queensland, Brisbane, Qld, Australia Acute epiglottitis is a rare condition, especially in adults, largely due to widespread vaccination against Haemophilus influenzae. Traumatic epiglottitis as a result of thermal or caustic insults are well documented. Epiglottic abscess formation is described as a sequela of epiglottitis in some cases. The development of epiglottic abscess from epiglottitis secondary to radiotherapy has not previously been described in the literature. We present an unusual case of an adult sudden death due to epiglottic abscess formation subsequent to radiotherapy for laryngeal squamous cell carcinoma. PATHOLOGY AS THE CORNERSTONE OF HUMAN TISSUE BANKING: EXPERIENCES IN THE POST-GENOMICS ERA A. Johns1, A. Gill1,2, C. Toon1,3, C. Forrest4, M. Texler4, A. Clouston5, D. McLeod8, A. Ruszkiewicz6, J. Kench7, N. Zeps9, S. Grimmond10, A. Biankin1, for the Australian Pancreatic Cancer Genome Initiative
1
Garvan Institute of Medical Research, Sydney, NSW, 2Royal North Shore Hospital, Sydney, NSW, 3South Eastern Area Laboratory Services, Prince of Wales Hospital, Sydney, NSW, 4PathWest Laboratory Medicine, Fremantle Hospital, Perth, WA, 5Envoi Specialist Pathologists, Brisbane, Qld, 6Royal Adelaide Hospital, SA Pathology, Adelaide, SA, 7Royal Prince Alfred Hospital, Sydney, NSW, 8Westmead Hospital, Sydney, NSW, 9St John of God Pathology, Perth, WA, and 10QLD Centre for Medical Genomics, Brisbane, Qld, Australia Unprecedented advances in biomolecular technology have greatly increased the power and precision of analytical tools used in cancer research and have accelerated the drive toward personalised medicine. Human specimens that are analysed using these new and developing technology platforms have emerged as a critical resource for basic and translational research in cancer because they are a direct source of molecular data from which targets for therapy, detection, and prevention are identified. As a result this has stimulated a growing demand for carefully collected, appropriately stored and well-annotated tumour specimens worldwide. This requirement has put pathologists in the centre of the personalised medicine world as providers of information identifying tissues and also as decision makers on what materials should be biobanked, on the preservation conditions, and on the timeline of events that precede preservation and storage. This critical position in the research process places extraordinary demands on all aspects of pathology practice, in particular as pathology laboratories are ultimately key players in delivering new medicines through molecular diagnostics. We present a national biobank network infrastructure that promotes multi-disciplinary research and has pathology underpinning tumour banking in order to facilitate multi-institutional, high throughput genomic studies. This new era of medicine requires a strategic view of ways forward for better integration of pathology, not only as ‘tissue providers’ but also as essential participants in the design, performance, interpretation, and implementation of research and clinical trials. ATYPICAL TERATOID/RHABOID TUMOUR ARISING IN ASSOCIATION WITH A PLEOMORPHIC XANTHOASTROCYTOMA: A CASE REPORT V. Kamath1, E. Sugo1, D. S. Ziegler2, B. Kwok3, R. Lukeis4 Department of Anatomical Pathology, South East Area Laboratory Services (SEALS), Prince of Wales Hospital, 2 Centre for Children’s Cancer and Blood Disorders, Sydney Children’s Hospital, and School of Women’s and Children’s Health, University of New South Wales, 3Department of Neurosurgery, Sydney Children’s Hospital, and 4Department of Haematology, Cytogenetics Laboratory, SydPath, St Vincent’s Hospital, Sydney, NSW, Australia 1
Atypical teratoid rhabdoid tumour (AT/RT) is a rare, highly malignant embryonal tumour most often occurring in the posterior fossa in children under 3 years of age. We report a case of a supratentorial AT/RT arising in association with a pleomorphic xanthoastrocytoma (PXA). A 6-year-old girl presented with a 1 month history of headache and vomiting. An MRI showed a heterogeneously enhancing mass involving the posterior left frontal lobe associated with marked local mass effect. Following a subtotal resection of the tumour she commenced treatment with chemoradiation. Histological sections showed a tumour with two distinct but focally intermixed morphological appearances, a high grade component with cellular morphology typical of an AT/RT
Copyright © Royal College of pathologists of Australasia. Unauthorized reproduction of this article is prohibited.