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Atypical Unhealing Ulcer in HIV-Infection Patient: A Case Report
OOOO Volume 119, Number 3 Study Design: 40 cases of OLP and 20 cases of normal oral mucosa were included in the study. The sections were immunostained for CD31 and CD34 antibodies and the microvessel density (MVD) was counted in ten selected areas of high inflammatory. The mean value represented the final MVD. Results: The MVD was significantly higher in OLP than normal mucosa (p<0.05). The number of the microvessels increased particularly in the inflammatory infiltrate areas and epithelium-connective tissue interface in comparison with deep connective tissue. Conclusions: Anti-angiogenic therapy might be a possible therapeutic target for patients with OLP, especially showing poor response to immunosuppressive agents. Keywords: angiogenesis, lichen planus, microvessel density, oral squamous cell carcinoma
ATYPICAL UNHEALING ULCER IN HIV-INFECTION PATIENT: A CASE REPORT Yu Hsien Lee1, Chuan Hang Yu2, Ming Yung Chou2, Yu Feng Huang1, 1College of Oral Medicine, Chung Shan Medical University, Taichung City, Taiwan; 2College of Oral Medicine Center, Chung Shan Medical University Hospital, Taichung city, Taiwan Biopsy should be performed on unhealing ulcers because either infection or neoplasm may be present. The present case showed a 32-year-old male patient complaining about a painful ulcer over left border of tongue for 3 weeks. Intraoral examination revealed a crater-like ulcer about 10*10 mm in diameter with induration. Microscopically, the lesion showed ulcer with atypical lymphocyte infiltrated in muscle layer of tongue and the immunoprofiles of atypical cells are CK(-), CD20(-), CD79a(-), CD3(+), CD8(+), MPO(-), CD68(-), CD1a(-), S-100(-), CD34(-), CD56(-), CD30 scatter cell(+) and CD4 scatter cell(+). After biopsy, the ulcer has almost healed completely with some white coating which was wipeable with gauze. Further hematological examination showed low white count with atypical lymphocyte and anti-HIV positive. The diagnosis of HIV infection was established. Keywords: Oral ulcer, HIV, Atypical lymphocyte, Candidosis
LAUGIER-HUNZIKER SYNDROME: A CASE REPORT Nazanin Mortazavi, Hamed Hossein Kazemi, Department of Oral Medicine, Dental School, Babol University of Medical Sciences, Babol, Iran The LaugiereHunziker syndrome (LHS) is a benign acquired macular hyperpigmentation of the oral mucosa with no underlying disease. Affected individuals may also have nail pigmentation. We present the case of a 66-year-old non-smoking caucasian man with conjunctival brownish pigmentation in both his eyes and no signs of nail involvement. Oral lesions consisted of multifocal, well-cicumscribed, uniformly pigmented brown macules, less than 5 mm in diameter, located on the hard palate, labial and buccal mucosa. He was considered healthy with regard to his blood count, endocrinopathic and gastrointestinal investigations. Furthurmore, he had neither a relevant drug history, nor a familial history of abnormal pigmentation. Histopathologic examination revealed melanin accumulation confined to the basal layer of epithelium. It is important to include this condition in the differential diagnoses of multifocal oral melanosis to prevent unnecessary clinical concern. On the basis of clinical findings and absence of systemic involvement, the diagnosis was consistent with LHS. Keywords: Laugier-Hunziker syndrome, multifocal oral melanosis, macule
ABSTRACTS Abstracts e169 ORAL MALIGNANT MELANOMA: A CASE REPORT AND LITERATURE REVIEW Camilla Borges Ferreira Gomes, Alan Roger Dos Santos Silva, Pablo Agustin Vargas, Oslei Paes De Almeida, Márcio Ajudarte Lopes, Karina Gottardello Zecchin, Piracicaba Dental School, University of Campinas e Oral Diagnosis, Brazil Oral malignant melanoma (OMM) is a rare neoplasm originated from melanocytes, usually diagnosed at advanced stages. OMM is considered more aggressive and with a worse prognosis than the cutaneous counterpart. A 59-year-old female was referred for evaluation of an asymmetric and dark brown lesion on the hard palate under the complete denture. The patient was unsure about the evolution time. Incisional biopsy was performed and histolopathological analysis revealed proliferation of atypical melanocytes. Nuclear shape varies from spindle to oval, and melanin pigment was presented in almost all cells. Tumor cells were positive for S100, melan and HMB45 imunomarkers, confirming the diagnosis of OMM. Patient underwent surgery, chemoradiotherapy and prosthetic rehabilitation. The patient is in follow-up for 12 months and no recurrence or metastasis was observed. The current case highlights that OMM first manifest as an intraoral pigmentation, and early diagnosis and prompt treatment are essential to provide better outcomes. Keywords: oral malignant melanoma, pigmented lesions, hard palate
EVALUATION OF THE EFFICACY OF A CHAMOMILE (MATRICARIA CHAMOMILLA) AND FLAX SEED (LINUM USITATISSIMUM) BASED SALIVA SUBSTITUTE FORMULATED FOR THE RELIEF OF XEROSTOMIA: A PRELIMINARY REPORT Irene Cecilia Morales Bozo1, Blanca Regina Urzúa1, Gonzalo Alberto Rojas2, Claudia Andrea Lefimil1, José Manuel Manríquez1, Ana Verónica Ortega2, Juan Pablo Aitken2, Juana Olga Salinas3, 1Institute for Research in Dental Sciences, Faculty of Dentistry, Universidad de Chile; 2Department of Pathology, Faculty of Dentistry, Universidad de Chile; 3Centro de Referencia de Salud Peñalolén Cordillera Oriente, Santiago Metropolitan Region, Chile Objective: To evaluate the efficacy of a new chamomile and flax seed based saliva substitute in the reduction of xerostomía-associated symptomatology. Study Design: Fifteen adult subjects presenting xerostomia of diverse origin were selected. Herbal saliva substitute and based carboxymethylcellulose conventional artificial saliva were tested using a double-blind, randomized, cross-over clinical trial with an intervining wash out period. Results: 100% of subjects presented sensation of dry mouth and 47% stated sensation of thick saliva, need to drink liquids to swallow and sensation of swallowing difficulty. Burning tongue sensation was recorded in 20% of the patients. The most frequent pathologies in the sample were depression, arthritis and arterial hypertension. Results of the clinical tests showed that herbal saliva substitute significantly relieves sensation of dry mouth (Wilcoxon test p<0.05). Conclusions: New chamomile and flax seed based saliva substitute was effective in relieving xerostomia symptoms, thereby improving the quality of life of population affected. Grant: SA12I2207 Keywords: Chamomile, flax seed, saliva, substitute, xerostomia
ATYPICAL UNHEALING ULCER IN HIV-INFECTION PATIENT: A CASE REPORT Yu Hsien Lee1, Chuan Hang Yu2, Ming Yung Chou2, Yu Feng Huang1, 1College of Oral Medicine, Chung Shan Medical University, Taichung City, Taiwan; 2College of Oral Medicine Center, Chung Shan Medical University Hospital, Taichung city, Taiwan Biopsy should be performed on unhealing ulcers because either infection or neoplasm may be present. The present case showed a 32-year-old male patient complaining about a painful ulcer over left border of tongue for 3 weeks. Intraoral examination revealed a crater-like ulcer about 10*10 mm in diameter with induration. Microscopically, the lesion showed ulcer with atypical lymphocyte infiltrated in muscle layer of tongue and the immunoprofiles of atypical cells are CK(-), CD20(-), CD79a(-), CD3(+), CD8(+), MPO(-), CD68(-), CD1a(-), S-100(-), CD34(-), CD56(-), CD30 scatter cell(+) and CD4 scatter cell(+). After biopsy, the ulcer has almost healed completely with some white coating which was wipeable with gauze. Further hematological examination showed low white count with atypical lymphocyte and anti-HIV positive. The diagnosis of HIV infection was established. Keywords: Oral ulcer, HIV, Atypical lymphocyte, Candidosis
LAUGIER-HUNZIKER SYNDROME: A CASE REPORT Nazanin Mortazavi, Hamed Hossein Kazemi, Department of Oral Medicine, Dental School, Babol University of Medical Sciences, Babol, Iran The LaugiereHunziker syndrome (LHS) is a benign acquired macular hyperpigmentation of the oral mucosa with no underlying disease. Affected individuals may also have nail pigmentation. We present the case of a 66-year-old non-smoking caucasian man with conjunctival brownish pigmentation in both his eyes and no signs of nail involvement. Oral lesions consisted of multifocal, well-cicumscribed, uniformly pigmented brown macules, less than 5 mm in diameter, located on the hard palate, labial and buccal mucosa. He was considered healthy with regard to his blood count, endocrinopathic and gastrointestinal investigations. Furthurmore, he had neither a relevant drug history, nor a familial history of abnormal pigmentation. Histopathologic examination revealed melanin accumulation confined to the basal layer of epithelium. It is important to include this condition in the differential diagnoses of multifocal oral melanosis to prevent unnecessary clinical concern. On the basis of clinical findings and absence of systemic involvement, the diagnosis was consistent with LHS. Keywords: Laugier-Hunziker syndrome, multifocal oral melanosis, macule
ABSTRACTS Abstracts e169 ORAL MALIGNANT MELANOMA: A CASE REPORT AND LITERATURE REVIEW Camilla Borges Ferreira Gomes, Alan Roger Dos Santos Silva, Pablo Agustin Vargas, Oslei Paes De Almeida, Márcio Ajudarte Lopes, Karina Gottardello Zecchin, Piracicaba Dental School, University of Campinas e Oral Diagnosis, Brazil Oral malignant melanoma (OMM) is a rare neoplasm originated from melanocytes, usually diagnosed at advanced stages. OMM is considered more aggressive and with a worse prognosis than the cutaneous counterpart. A 59-year-old female was referred for evaluation of an asymmetric and dark brown lesion on the hard palate under the complete denture. The patient was unsure about the evolution time. Incisional biopsy was performed and histolopathological analysis revealed proliferation of atypical melanocytes. Nuclear shape varies from spindle to oval, and melanin pigment was presented in almost all cells. Tumor cells were positive for S100, melan and HMB45 imunomarkers, confirming the diagnosis of OMM. Patient underwent surgery, chemoradiotherapy and prosthetic rehabilitation. The patient is in follow-up for 12 months and no recurrence or metastasis was observed. The current case highlights that OMM first manifest as an intraoral pigmentation, and early diagnosis and prompt treatment are essential to provide better outcomes. Keywords: oral malignant melanoma, pigmented lesions, hard palate
EVALUATION OF THE EFFICACY OF A CHAMOMILE (MATRICARIA CHAMOMILLA) AND FLAX SEED (LINUM USITATISSIMUM) BASED SALIVA SUBSTITUTE FORMULATED FOR THE RELIEF OF XEROSTOMIA: A PRELIMINARY REPORT Irene Cecilia Morales Bozo1, Blanca Regina Urzúa1, Gonzalo Alberto Rojas2, Claudia Andrea Lefimil1, José Manuel Manríquez1, Ana Verónica Ortega2, Juan Pablo Aitken2, Juana Olga Salinas3, 1Institute for Research in Dental Sciences, Faculty of Dentistry, Universidad de Chile; 2Department of Pathology, Faculty of Dentistry, Universidad de Chile; 3Centro de Referencia de Salud Peñalolén Cordillera Oriente, Santiago Metropolitan Region, Chile Objective: To evaluate the efficacy of a new chamomile and flax seed based saliva substitute in the reduction of xerostomía-associated symptomatology. Study Design: Fifteen adult subjects presenting xerostomia of diverse origin were selected. Herbal saliva substitute and based carboxymethylcellulose conventional artificial saliva were tested using a double-blind, randomized, cross-over clinical trial with an intervining wash out period. Results: 100% of subjects presented sensation of dry mouth and 47% stated sensation of thick saliva, need to drink liquids to swallow and sensation of swallowing difficulty. Burning tongue sensation was recorded in 20% of the patients. The most frequent pathologies in the sample were depression, arthritis and arterial hypertension. Results of the clinical tests showed that herbal saliva substitute significantly relieves sensation of dry mouth (Wilcoxon test p<0.05). Conclusions: New chamomile and flax seed based saliva substitute was effective in relieving xerostomia symptoms, thereby improving the quality of life of population affected. Grant: SA12I2207 Keywords: Chamomile, flax seed, saliva, substitute, xerostomia