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Auditory P300 changes and third ventricle enlargement in outpatient schizophrenics
Eleca'ophysiology
a ~ ~VCntATRV [99| ~'~ 43A- | 85A
I63A
Semaline is an experimental drug that potemly and selectively "ml~ibits s e r a t ~ ~uptake. Its clinical efficacy in the treatment of depression has recently been establish¢~4° To date, no ~ have been p,ab~ished describing effects of semaline on sleep architecture. We report here on prel~minary sleep architecture findings on the first 12 patients entered into an ongoLag 6-week, dc~able-bILrgl, p|aceho,-c(mtrof~ st~y~ "twelve outpatienls (six men and six women) who met DSM-III-R criteria far mawr depcess~, sinL~e or recurrent episode, with a minimum score of 18 on the 17-item Hamilton Rating Scale fat Depression, were randomly assigned to active drug treatment with sevuraline ~500-200 rag) ol~ ptaceho° T~o consecutive nights of polysomnography (PSG) and an MSLT were came~i out at baseline ~ a g ~ after 2 weeks of treatment. Clinical depression ratings were obtained ~'ough 6 weeks of treatment. Compared with placebo, sertraline produced potent effects in inhibiting various parameters of REM sleep, i~luding REM densi~ (p = 0.001L REM minutes (p = 0.009). and REM % of Total Sleep Time (p = O o ~ L Other sleep variables, including Sleep Efficiency and Delta Sleep. were not significancy affected by serwali~ administration. The patients in the sertraline group, besides showing potent suppression of REM steep variables at 2 weeks, also demonstrated significantly greater reduction in HAM-D scores at week 6 than did placebo group.
263 AUDITORY P300 CHANGE5 AND THIRD VENTRICLE ENLARGEMENT IN OUTPATIENT S C H I Z O P ~ N I C S Louis W. Kraft, B.S., Steven B. Schwarzkopf, M.D., Michael W. Torello, Ph.D., Stephen C. Olson, M.D., Henry A. Nasrallah, M.D. The Ohio State Universi~. , Department of Psychiatr3', Columbus, OH 43210. Previous studies have demonstrated left temporal scalp voltage attenuation of the audkorv P300 wavefatm in medicated chronic male schizophrenic inpatients. In an attempt to replicate Faux et at, we used a full set of 28 scalp electrodes and examined the auditory "'oddball" P300 waveform in medicated ch~nic ~ e schizophrenic outpatients. As p a r of a larger study that included magnetic resonance imaging L.MRI), 29 male schizophrenic subjects (DSM-III-R diagnosed) (21-44 years, mean age 30.6) were compar.,~:l with 22 male control subjects (without psychiatric diagnosis) (2 !-47 yeats, mean age 26.8). Using the SPM analysis technique (296-396 msecL we found a broad central and posterior symmetrical attenuation of P300 in the schizophrenic group. This was confirmed using a subset of ten electrodes (Cz, Pz, C3, (24, P3, P4~ T3, T4, T5, T6) (MANOVA, p < 0.05). However, we were unable to dernonstra~ the b e t w e e n - ~ p left temporal attenuation. Although analysis of left versus right electrodes within '-,heschizophrenic group showed significantly smaller left temporal P300 amplitudes (paired T-test, p < 0.05), this was not the case. w~thin the control group. This result is compafibie with previous P300 topographic findings. Additionally. no significant differences in P31gJ amplitude based on third venmcie size were found; however, s i ~ c a n f i y increased P3.~ latency at the Cz electrode (electrode shewing highest signal-to-noise) was seen in schizophrenics with enlarged veah~cles ( F-test. p < 0.05). Taese results suggest that P300 is attenuated over the left temporal lobe in schizophrenic outpatients and P300 latency is related to third v e h i c l e enlargement.
264 P3 AMPLITUDE IN SCHIZOPHRENIC PATIENTS
AND THEIR FAMILY MEMBERS B.F. O'Donnell, Ph.D., M.E. Shentoa, Ph.D., R.W. McCarley, M.D., S.D. Follak, M.Ed., S.F. Faux, Ph.D., P.G. Nestor, Ph.D., R.S. Smith, B.A. Harvard Medical School, Brockton VAMC, Department of Psychiatry, Brockton, MA 02140. The auditory P3 response is generally reduced in schizophrenia (SZ). We report initial findings of P3 responses recorded from six patients with SZ (by DSM-III-R and RDC criteria) and from four of their nonschizophrenic family members (NON-SZ) drawn from three families. These two groups were compared
a ~ ~VCntATRV [99| ~'~ 43A- | 85A
I63A
Semaline is an experimental drug that potemly and selectively "ml~ibits s e r a t ~ ~uptake. Its clinical efficacy in the treatment of depression has recently been establish¢~4° To date, no ~ have been p,ab~ished describing effects of semaline on sleep architecture. We report here on prel~minary sleep architecture findings on the first 12 patients entered into an ongoLag 6-week, dc~able-bILrgl, p|aceho,-c(mtrof~ st~y~ "twelve outpatienls (six men and six women) who met DSM-III-R criteria far mawr depcess~, sinL~e or recurrent episode, with a minimum score of 18 on the 17-item Hamilton Rating Scale fat Depression, were randomly assigned to active drug treatment with sevuraline ~500-200 rag) ol~ ptaceho° T~o consecutive nights of polysomnography (PSG) and an MSLT were came~i out at baseline ~ a g ~ after 2 weeks of treatment. Clinical depression ratings were obtained ~'ough 6 weeks of treatment. Compared with placebo, sertraline produced potent effects in inhibiting various parameters of REM sleep, i~luding REM densi~ (p = 0.001L REM minutes (p = 0.009). and REM % of Total Sleep Time (p = O o ~ L Other sleep variables, including Sleep Efficiency and Delta Sleep. were not significancy affected by serwali~ administration. The patients in the sertraline group, besides showing potent suppression of REM steep variables at 2 weeks, also demonstrated significantly greater reduction in HAM-D scores at week 6 than did placebo group.
263 AUDITORY P300 CHANGE5 AND THIRD VENTRICLE ENLARGEMENT IN OUTPATIENT S C H I Z O P ~ N I C S Louis W. Kraft, B.S., Steven B. Schwarzkopf, M.D., Michael W. Torello, Ph.D., Stephen C. Olson, M.D., Henry A. Nasrallah, M.D. The Ohio State Universi~. , Department of Psychiatr3', Columbus, OH 43210. Previous studies have demonstrated left temporal scalp voltage attenuation of the audkorv P300 wavefatm in medicated chronic male schizophrenic inpatients. In an attempt to replicate Faux et at, we used a full set of 28 scalp electrodes and examined the auditory "'oddball" P300 waveform in medicated ch~nic ~ e schizophrenic outpatients. As p a r of a larger study that included magnetic resonance imaging L.MRI), 29 male schizophrenic subjects (DSM-III-R diagnosed) (21-44 years, mean age 30.6) were compar.,~:l with 22 male control subjects (without psychiatric diagnosis) (2 !-47 yeats, mean age 26.8). Using the SPM analysis technique (296-396 msecL we found a broad central and posterior symmetrical attenuation of P300 in the schizophrenic group. This was confirmed using a subset of ten electrodes (Cz, Pz, C3, (24, P3, P4~ T3, T4, T5, T6) (MANOVA, p < 0.05). However, we were unable to dernonstra~ the b e t w e e n - ~ p left temporal attenuation. Although analysis of left versus right electrodes within '-,heschizophrenic group showed significantly smaller left temporal P300 amplitudes (paired T-test, p < 0.05), this was not the case. w~thin the control group. This result is compafibie with previous P300 topographic findings. Additionally. no significant differences in P31gJ amplitude based on third venmcie size were found; however, s i ~ c a n f i y increased P3.~ latency at the Cz electrode (electrode shewing highest signal-to-noise) was seen in schizophrenics with enlarged veah~cles ( F-test. p < 0.05). Taese results suggest that P300 is attenuated over the left temporal lobe in schizophrenic outpatients and P300 latency is related to third v e h i c l e enlargement.
264 P3 AMPLITUDE IN SCHIZOPHRENIC PATIENTS
AND THEIR FAMILY MEMBERS B.F. O'Donnell, Ph.D., M.E. Shentoa, Ph.D., R.W. McCarley, M.D., S.D. Follak, M.Ed., S.F. Faux, Ph.D., P.G. Nestor, Ph.D., R.S. Smith, B.A. Harvard Medical School, Brockton VAMC, Department of Psychiatry, Brockton, MA 02140. The auditory P3 response is generally reduced in schizophrenia (SZ). We report initial findings of P3 responses recorded from six patients with SZ (by DSM-III-R and RDC criteria) and from four of their nonschizophrenic family members (NON-SZ) drawn from three families. These two groups were compared