Autoimmunity

966

Autoimmunity

Antigenic

determinant

expression on antigen-presenting

Shlmmiya N, Kumai M, Marsh DC. Huang SK: Detection of Specific IgbSecreting Cells with an Enzyn~Linked hnmumspd Assay. / A//eqy C/in fmmunol 1993, 92479-467. Soparkar CR, Pate1 PC. Cockcroh DW: inhalant Atopic Semitivity to Grashoppzn in Research laboratories. /A//ergy C//n /mmuno/ 1993. 9261-65. Sorva R, Makinenkiljunen S, lunhmenbackman K: ktaLactogldwlin Secretion in Human Milk Varies Widely after Cow Milk ingestion in Mothers of tnfants with Cows Milk Allergy, / Akrgy C/in lmmunol 1994, 93:787-792. Stewart GE, Lcckey RF: Reduction of Side Effects of Spedic hnmunothcrapy - - Reply [Lelterl. / A//erfiy C/in /mmuno/ 1993,92:498. Sutton El, Could HI: The Human IgE Network. Nature 1993, 366:421-42&l. Takeda K, Shibasakt M, Taklta H: Relation Between Bronchial Responsiveness to Methachdinc and

cells

Levels of tgE Antibody Against Dcnnatophagoidesfariluc and Senm tgE in Asthmatic Childrm. Exp A//qy 1993, 23:45&454.

C/in

Tedexhi A, Arquati M, Palella M, Milazzo N, Miadunna A: Ionic Regulation of Human Basophil Releas&ility. 2. Non-Releasing Baophilr arc Converted into Releasing Baophik in a Low-Na+ Medium. C/in Fxp Allergy 1994, 246672. Thyphronitis G, Katona IM, Cause WC, Finkelman FD: Gentdim and Productive C-epsilon-Gene Expression During tnvivo tgE Responses. I lmmunol 1993, 151:4128-%136. Walsh GM: The Anti-Inflammatory Effects of Cetiririne. C/in Exp A//qy 1994. 24:81-85. Wantke F, Gotz M, Jansch R: Histamine-Free Diet Treatment ofChoice for Histamine-tnduced Food Intolerance and Supporting Treatment for Chronical Headaches. C/in Exp A//qy 1993, 23:982-985.

.

Warner JO: longitudinal Reactivity [Letter].

Changes in Skin-Prick Test C/in Exp A/&y

1993, 23:1045.

Wever AMI, Weverhess I: Testing for Inhalant Allergy in Asthma. C/in Exp A//qy White MV: Nasal Chdincrgic in Atopic Subjects Stikd C/in /mmuno/ 1993, Wxkern

GM: Ftnariwn

1993, 23:976-981. Hyperrespansiveness Out of Season. /A/&y

92:27a287.

Allergic Fungal Sinusitis.

/ Allergy

C/in frnmuno/ 1993, 92:624425.

: Task

Force on Allergic Reactions to Latex. /A//q+

C/in

/mmuno/lP93,92:16-18.

: Abstracts

of the Annual Meeting of the British

Society

for Allctgy and Clinical hmmunology, Nottingham, UK, August 1993. C/in Exp A//eqqy1994, Z&166-195. Guidelines to Minimize

the Risk from Systemic Reactions

Cased

by lmnwotherapy

A//qy

C/in lrnmund 1994, 93:81 l-81 2.

with Allergenic Extracts. /

Autoimmunity Antigenic determinant expression on antigen-presenting cells Related review: The expression of self antigenic determinants: implications for tolerance and autoimmunity (pp 8824386) Benichou C. Fedaeyeva E, Ok00 CA, Geysera HM, . McMillan M. Sercan EE: Dirrtmtim cd the Detennirunt Hierarchy on a &lf-MHC Peptide: Concondtant Tderanc~ Induction to the dominant Detmnilunt and P&da to the Cryptic Sdfdeterminant. /nf lmmund 1994, 6:131-138. [3]. Bhardwaj V, Kumar V, Grewal IS, Dao T, Lehmann PV. Gevsen Hhl. Sercarz EE: T Cell Detemdnant S&C& d My&n Basic Roteht in BlO.Pl, Sil/f, and Their F0)S. I lmmur~ol lPP4,151:3711-3719. Bcdmer l-l, Viville S, Benoirt C. Mathis D: Diversity . of Emdogemu Epitqes Bound to MHC Class It Mdeades Limited by Invariant Chain. Science 994, 263:1284-l 286. [331. DenR HK, Apple R, Claresalzler M, Trembleau 5, Mathis D, Adorini L, Sercarz E: Determinant Capture as t Possihk Mtchaokm of Rote&on Afforded bv Maia Hiioc-tibilitv Camdex Class-tt hide& in Autt&nwne iIIk&. I Exp Med 1993, 17&1675-1660. Fairchild PI, Wildgoose R, Arherton E, Webb 5, Wrath DC: An Autoantigedc T-Cell Epitopc Fomts Unstahk Cmpkxn with Class-II MHC _ a Novel Route for Ewape from Tdnancc htduction. Irrf /rnmuno/ 1993, 5:1151-115&I. Fatenejad S, Mamula MI, Craft I: Rok of tntermdecular/lntrastmctuml B-Cell and T-Cell Det~natts in the Diversif~ation of Autoantibodies to Ribottuckopmtcin Rrticles. Pra Nat/ Acad Sci U SA 1993,90:12010-12014. Cue Y, MenRchao W, Chen H, Wang X, Liu C, Li G, Ma ?? I, Man-Sun S: Effective Tumor Vrcin Generated by Flaion of Hepatonta Ceils with Activated B Cells. Science 1994, 263:518-520. [2B]. Hathack KS, Larzlo G, F’ucillo C, Linsley P, H&s RI: ?? Compatatiw An+& d B7-1 and 87.2 Costimulatory li@ Expmsion and Function. J Exp Med 1994, lBf~z631-640. [21]. Ho WH, Cooke MP, Goodnow CC, Davis MM: Resting and ?? F B Cells are pefective in CD2Bdependmt c&mda&n of Nave CD& T Cells. I Exp Med 1994, 17%1539-1549.1241. Katz IF, hnt Al: T Cell Receptw Recognition d MHC Class II Alkatigens is Highly Cell Type Dependent. I lmmund 1994,151:1629-1640. Kauhnan DL, Clar&alzier M, Tian 1, Forsthuber 1, Ting ?? * CR Robinson p, Atkinson MA, Sercarz EE, Tobin Al, Lehmann w: spmtuwour Larc d T-cell Tderance to Chttanic Acid tkcarboxvlac in h&wine Insulindqtmdmt Diabetes. Nat& 1993,36&69-72. IlOl. MamulaM:Tiwln&$itytOF+mce9saselfPeptide ?? Allow T Cclr to Escape Tdeattce. I Exp Med 1993. 17?567-571.[4]. McudRil KD, Sercarz EE: Dominant fktemtinants in t&n E@te lywzyme Cormpond to the Cryptic Deknninanb Within Its Self-Homdaeue. htauw @cayme - lnpliutions in Shaping or’& TCell Reputdrr and AutoimmunQ. I Exp h&d 1993, 178:2131-2138.

I

Moudgil KD, 5ercarz EE: Dominant Determinants in . Hen Eggwhite Lysozymc Correspond to the Cryptic Determinants Within 11sSelf-horndog, Mouse Lysoqme: hnpliutiom in the Shaping of the T Cell Repertoire and Autoimmunity. I Exp Med 1993, 17&2131-2138. [Z]. Myers LK, Rosloniec EF, Sever IM, Stuart IM, KanR AH: A Synthetic Pepthk k&guc ofa Determinant of TypeII Collagen prevents the Onset of Cdlagen-Induced Arthritis. I fmmuno/ 1993,150:4652-4658. Shlmizu 1, Kanagawa 0, Unanue ER: Presentation of Beta-Cell Antkens to CD4+ and CDB+ T-Cells d Non-Obese”Diabetic Mice. / lmmund 1993, 151:1723-1730. Watts C, Lanzavcchia A: Suppressive Effect of Antibody ?? * on Processing of T Cell Epitopcs. / Exp Med 1993, 178:1459-1463. 1161.

Autoimmune disorders of the nevous system Related review: Self-determinants in autoimmune demyelinating disease: changes in l-cell response specificity (pp 887-891) Amor S, Baker D, Croome N, Turk IL: tdentitication of a Major Enccphalitogenic Epitope of Rotcdipfd Protein (ftesiducs-56-70) for the Induction of Expedmmtal Alkr@c EnccpMomyelitis in BiouiM/H and Norwbesc Diabetic Mice. / /mmuno/l993. 150x566&5672. Beck RW: Corticosteroids, Optic Neuritis, and Multiple Sclerosis - Reply [Letter]. N Err/$ I Med 1994, 330:1239. Bhardwai V, Kurnar V, Gevsen HM, Sercarr EE: DeRmcrate Rec&iticm of a Diimilar Antignic Peptideiy lmdications Mvelin Basic Rotein-Reactive T-Cdk f& Thy&c and Autoinwnunity. j lmmunol 1993,151:500%5010. Bhardwaj V, Kumar V, Grewal IS. Dao T, Lehmann ?? * PV, Geysen HM, Sercarz EA: T Cdl Determinant Structwe of Myelin Basic R&in in BlO.Pl, SIL/I, and Their F,s. / /mrnuno/ 1992, 152:3711-3719. 1411. Bhardwaj V, Kumar V, Grewal IS, Dao T, Lehmann W, Geysen HM, Sercarz EE: T Cdl Detrrmirunt Stmctttm of Myelin Bask Rotein in BlO.Pl, Sjl/f, and Tkk F(lK. J /mmunollP94,152:3711-3719. Bourdette DN, Whitham RH, Char YK, Morrison WI, Atherton 1, Kenny C, Liefeld D, Hashim GA, Offner H, Vandenbark AA: knmwdty TCR pcplidn in MultipkSckrc&1.Swc&fuftmmuni&iid F’atii with Synthetic V Beta 5.2 and V beta 6.1 C&2 Peptidcr / hnmuno/lPP4,152:251~2519. Brocke 5, Gaur A, Piercy C, Gautam A, Gijbels K, Fathman CC, Steinman L: Inbdim of R&&g hralysis inExp&mmtalAntobmmlne Enceph&myditi by Backrid Supmantigm. Nature 1993, 365:642-643. Chou YK, Morrison WI, Weinbere AD, D&rick R, Whitham R, Bwrdette DN, &shim G, Offner H, Vandenbark AA bmwtity to TCR Peptides in MultiiSckm&2.TCellReco@iondVBeta 5.2 and V Beta 6.1 Cdr2 Peptikr. / lmmund 1994, 152:252&2529. Cratchfield IM, Racke MK, Zuniga-Pflucker IC, Cannella B. Raine CS, Goverman I, Lenardo MI: T Cdl Deletion

.

Education

to

in High Antigen Dose Therapy of Autoimmune Encephalomyditis. Science 1994, 263:1139-l 142. Cross AH, Tuohy VK, Raine CS: Development of Reactivity ?? * to New Myelin Antigens During Chronic Relapsing Autdmmnw Ekmyclination. Cell fmmunol 1993, 146:261-269.1441. Derosbo NK, Mile R, Leer MB, Burger D, Bernard CCA, Bennun A: Reactivity to Myelin Antigens in Muhiic Sckrasis - Peripheral Blood lymphocytes Respond predominantly to Myelin Oligodendrocyte Glycoproteih I c/in /rIvesI 1993, 92:2602-26a. Ffrench-Constant C: P&ogenesis of Multiple Sclemsir. Lancet 1994, 342271-274. Franto A, Southwood 5, Arrhenius T, Kuchroo VK, Grey HM, Sew A, lshioka GY: T Cell Receptor Antagmkt peptides are Highly Effective Inhibitors of Experimental Aflergic Encephlomyelitk. Ew / lmmunollPP4,24:94&946. fredrikscm S, Sun JB, Huang WX, Li EL, Olsson T, link H: Cord Obod Containr High Numbers of Autoimmune TCdk Recogniziq Mdtiplc Myclin Pmtrinr and Acetyicbdim Receptor. I lmmund 1993, 151:2217-2224. Fntz RB, Zhao M-L: Enccphalitogenicity of Myelin Basic ?? * Rotein Exon-2 Peptide in Mice. J Neuroimmunol 1994,51:1-6. [la]. Hart RC: Corticmterdds, Optic Neuritis, and Multiple Sckrosis [Letter]. N Enp/ / Med 1994, 3303123ai239. Held W. Mevermann R. Oin Y. Mueller C: Perforin and Tut& &rxosis F&&ha in the Pltholenesis of Expetimental A&rrgic En&pbalamyelitis -&rnparison of Autoantigen Induced and Transferred Disease in Lewis Rats. /Aufoimmun 1993, 6:311-322. loner RE, Bourdette DN, Whitham RH, Offner H, Vardenbark AA: Induction of Experimental Aui&tmune Encenhalomvefitk in Severe Combined Immunodctiicnt &e R&mstituted with Allogeneic or Xmogenic Hematopoictic Cells. / /mmuno/ 1993, 150:4620-4629. Karussis DM, Lehmann D, Slavin 5, Vourkakarussis U, Mizrachikoll R, Ovadia H, Kalland T, Abramsky 0: Treatmeat of Chronic-R&p&g Erperimental Autoinnnc Encephdomyclitis with the Synthetic I&tor Linonridc Quinaline-3Cabmankk). F’mc Nat/ Acad SC; U 5 A 1993, 90:64w+l04. Karuss~s DM, Vourkakarusrrr U, Lehmann D, Ovadia H, Mizrachikdl R. Bennun A, Abramsky 0, Slavin S: l’revmtion and Reversal of Adoptivefy Tramferred, Chronic Relqsiq Expuimmtal Atttcdmmune Enc+hxnydftis with a Singk Hi Dose Cytweductin Treatment Fdkwed by Syngmeic Bone Marrow Transplantation. I C/in /west 1993, 92765-772. Kerlero De Rosbo N, Mile R, Lees MB, Burger D, Bernard ?? * CC, Ben-Nun A: Reactivity to My&n Antigens in Multi+ Sckrask. Peripheral Blood Lymphcqtes Resfxmd Redaminntly to My&n Oligadmdrocyic Glycopmtein. /c/in /nvey 1993, 92:2602-2608. [241. Kuchroo VK, Collins M, Alsabbagh A, Sdxl RA, Whitters Ml, Zamvil SS, Dorf ME, Ha/k% DA, Seidman IG, Weiner HL, Rimm II: T Cell Receptor (TCR) Usage Detcrminn Disease Susceptibility in Exfwimmtal Autoimmune Encephalamyelitk - Studies with TCR V Beta 8.2 Transgmic Mice. / Exp Med 1994, 179:1659-1664.

Autoimmunity Kuchroo VK, Martin CA, Creer JM, Ju ST, 5obel RA, Dori Contribute ME: Cvlokines and Adhcrin Mdwda to the’Ability d Myelin Rotedipid Protein-Specifc T-Cdl Cl& to Mediate Erperi&ntai Ailer$c Enccph&myelitio. I /mmuno/ 1993, 151:4371-4382. Kumar V, Sercarz E: Holes in the T Cell Rcwrtoirr to Mydin Basic Protein Owing to the A&ence of the D Beta 2-j Beta 2 Gene Cluster Implications for T Cdl Receptor Recognition and Autoinwnunity. / Fxp Med1994, 179~1637-1643. Lehmann P V, Forslhuber T, Miller A, Sercarz EE: Spreading ?? * d T Cell Autdmmunitv to Crvotic Determinank of an Autoantigen. Nat& 1992,‘j5B:i 55-157. (401. Lehmann PV, Sercarr EE, Forsthuber T, Dayan CM, ?? Gammon C: Determinant Spreading and the Dywnia of tbe Autoimmune T-cell Repertoire. lmmunol Today 1993,11:203-208. (371. Lm RF, Lin TS, Tilton RC, Cross AH: Nitric Oxide Localized to Spinal Cords of Mice with Experimental Allergic Encephdomyelitis - an Electron Paramagnetic Re&nce S&y. I E&I Med 1993, 17Bx643-648: Linineton C. Bemer T. Pew L. Weerth 5. HinzeSelch ?? * Y;‘Lu HC, Lassmann H, Wekerle H: T Cdk Specific for the Myelin OliRodendrocyic Cly~qmtein Mediate &I l/tn.&l Autdn&me InflamutowResmmeintheCentralNervow System. Eur j /mn;“no/ 1993, 2X1364-1372.1271. Manfredi AA, Yuen Ml-l, M&la 1, Protti MP, Contilronconl BM: Human Acetvlchdine Recmtor F’mentation in Myasthmia CR& - Dr Restrict& d Autoimmune T Epitopes and Binding d Synthetic Receptor Efi!a;,D; M0lecdes. I /Inmono/ 1994.

.

6, Zha&

,.

Malhisen PM, Pease 5, Carvey I, Hood L, Readhead C: Identification cd an Embwonic kdorm of Mvelin Batic Ratein that k Exp&ed Widely in & Mane Embryo. Ptuc Nad Acad SC; U S A 1993, 90:10125-10129. Meinl E, WeIxr F, Drexler K, MorelIe C, 011 M, bruhandireskeneli C, Goebels N, Ertl B, Jechart G, Giwerich G. Schonbeck 5. Bannwarth W, Wekerle H, l%hlfeld R: My&n Bask Protein S&ific T-Lynphoeyte R&lo&e in Multiple &msir . Complexity d the Response and Dominance of Nested Epitopes Due to Recruitment of Multiple TCdl fltntes. I C/in lnvesll993,92:2633-2643. Miller A, Lider 0, Abmmaky 0, Weiner HL: Orally Acbnidstered Myelii Basic Protein in Neonates RknnfO?lmnuKR~ndEnhme¶ Exwrhnend Autdmmtme Encedulamvelitk in Adult Ahmak. Eurl lmmund 1994,2;:102~1032. Mar F, Cohen TR: Shifts in the Epitopn of Mydin Basic Rotein Recogttized by Lewis Rat TCdk Before, thuiw and after the induction of Erperimmtal Autdmrun Encephal~elitis. /C/in lnvesf 1993, 922199-2206. Murphy W, Mann R, Mcgrath BP, Bell C: Newonal Antibodin and Autonomic F&we [letis]. Lawet 1993, 342:563. Mustafa M, Vin+o C, Olsson T, Ljungdahl A, Hojelxrg B, Holmdahl R: The Major Histocxmpatibility Complex lnfhtences Mydin Bait Rat&~ 63-88Induced TCell Cytdrine Profile and Experimental Autabnmtme Enqbdomyelitk. Fur / lmmund 1993, 23:3089-3095. JP, Ron y: lnvfvo Antigen Myen Kl, Dou&ny m bv Both Brain Parenchvmal Celk ad Htrmtopo’icEiully Derived Cell; During the tttdwtkm d Expe?imental Mabmnune Encephalm@itk I lmmund 1993, 151:2252-2260. Olek MI. Khan OA: Ca&odaoib, Optic Neuritk, and Multiple Sclemsk Iletter]. N Ens/ I Med 1994, 330~1238. Pelfrey CM, Trotter IL, Tranquil1 LR. McFarland HF: ?? . Itkntifi&omdaNovefTCelfEpi(opcdHwnan Rotedipid Protein kcsidN¶ 4o-k) itecognlzed bv Pmlifemtive and Cvidvlic CM + T Celk from tipk Sdnoak R&t; 1 Neuroimmuno/ 1993, 46:3342. 1171. Plddlesden 0. Starch MK, Hibbs M, Freeman AM, Lassmann ti. Morgan BP: Sdubk Recombinant Clx+nmtllmporllnhibiklnRnnulianaml Demyelii in Antib&y-tw&ted Demydbuting Expnimnlll Alkrgic Encepb&myditk. 1 lmmunol 1994,152:5477-54B4. Prlbyl TM, Campagnoni CW, Kamp/ K, Kashima T, Handkv VW. h4cmahon I. Camwmcmi AT: The Human’Myeiin Basic tiein G;ney k included Wltbin a 179-Kibbase Tramcriptian Unit -Expression intluktmnutendCwtralNervaus5~enw.Pmc Nafl Awd Sci U S A 1993,9Oz10695-10699. RX&I E, Rumbach L, Bataillard M, C&niche 1, Henhn IL. T~ttmann M. Herve P. Wiidenes I: Twatment d Multiple Sc&sk witit An&CD4Monocl0cul Antibody-aF’tdinimuyRepwttmCF5in21 Patients. I Auroimmun 1993,6:771-786.

Racke MK, QuiRley L, Cannella B, Raine CS, Mciarlm DE, Scott DE: Sunerantitten Modulation of Exwrimental AlI& E&hal~yelitis - Activation d Anergy Determines Outcome. / lmmunoll994, 152:2051-2059. Ransdwif RM, Tuohy V. Lehman” P: The Immunology of ?? Multiple Sclerosis: New Intricacies and New ImiRhk. curr *in Neumll994, 7:242-249.pB). Renno T. Zeme R. Guard IM. Cillani 5. Dodelet V. Owens T: S&tive Enrichment d T(h)1 &845RB(l&) CD4+ TCelk in Autoimmune lnfiltrata in Experimental Allergic Encepblanyelitis. Inr lmmunol 1994, c:347-354. Roth MP, Riond ), Champxne E, Essaket 5, Cambonlhomsen A,‘Ciayton 1, Clanet M, Coppin H: TcrbV Gene Usace in Monozveotic Twins Oiiordant for Sclerask. Immunogenetics 1994, 39:2Bl-285. Salvetti M, Rirtori G, Damalo M, Buttinelli C, F&one M, Fiexhi C. Wekerle H, Pozzilli C: Predominant and Stabk T-Cell Responses to Regions d Myclin Basic mein can be D&e&d in I&iv&al htienk with Mdtide Sclerosk. Ew / lmmund 1993. 23:1232-1’239. San(ambrogio 1. Hochwald GM, Saxena B, Leu CH, Maw IE. Carlim, IA. Ruddle NH. Palladino MA. Cold LI. Tlwbecke Studies on ihc ~~~bn&s by Which Trandwming Growth Factor-beta (TGFbeta) Rote& Against Allergic Encephdomyelitk Antagodkm Behveen TGF-beta and Tumor Necrosis Factor.//mmuno/1993, 151:1116-1127. Schsffenbauer 1, Johnson HM, Budiloski El, Wegrzyn L, Soos JM: 5taphylococcal Enterotoxim can Reactivate Experimental Allergic Encephdomyditk. Pmc Narl Acad Sci U S A 1993, 90~8543-0546. Seral BM. Raine CS. h&&din DE. Vwkuhl RR. McFarland ?? vu HF: Experimental Allergic Encephdomyelitir Induced by the Peptide Encoded by Exon 2 of the MBP Gene. a Peptide lmdiuted in Remvelination. I Newoimmunoil994, 5i:7-19.1471. , 5ercarz EE, Lehman” PV, Ametani A, Benichcu G, Miller ?? A, Mwdgil K: Dominance and Ctypticity of T Cell Antigenic Determinants. Annu Rev fmmunoll993, 11:729-766. [32]. Scderrtrom M, Link H, Sun I, Fredrikson 5, Kostulas V, ?? * Hojeberg B, Li B, Olsson T: T Celk Recognizing Multiple Peptidn d Myelin Basic Protein are Found in Blood and Enriched in Cerebowinal Fluid in Optic Neuritis and Multiple Scle&ir. Stand /mmuno/ 1993. 373355-368. 1111. Steinman L: Com&iom Bet&z”& Immune Swem and NCWOUS System. Proc Nat/ Acad Sci U 5 A 1993.90:7912-7914. Tam Ati: Experimental Paracatein Neuropathv, ?? * Demydi&tion by Pa& Transfer d H&n& IgM Anti-mydin-aswciated Clycoprotein. Ann Neurd 1993, 33:502-506. 126). Tuohy VK: Peptide Detendnantr of Myelin Rotroripid ?? Rotcin VIP) in Autoimmune Demyeliiting Dkease: a Review. Newxhem Res 1994, 191935-944. [lSl. Utz U, Brooks IA, Mcfarland HF. Martin R, Biddison WE: Heterogeneity d T-cdl Receptor Alpha-chain Crmpknmtrityd&mtining Region 3 in Mydin B&c Pmtehwp&fic T Celk Increases with Severity Of Mdtipk S&m&s. PPX Nat/ Acad Sci U S A 1994. 91:5567-5571. Voskuhl RR, McFarlin DE, Stone R, McFarland HF: T** Inmbocvle Recc&tkm of a Pwtion of Mvelin En&d by an Exon Express& During Myelination. I Neumimmuno/l993,42:1B7-191.

Mdti>e

‘GJ:

the

bk R&in WJI.

Voskuhl RR, McFarlin DE, Tranauill LR, Deibler G, Stone ?? * R, Maloni H, McFarland Hi: A Novel Candidate Autcavtken in a Mdtidex Fanilv with Mdtide Sckm&F%?vtie oi T-lymph&es Sped& for an MBP E+pe Unique to Myelination. / Neumimmunol 1993,46:137-144.1311. W&en MHM, loosten I, 5chlief A, Vanderzee R, Bcog CJP, Vaneden W: Inhibition d Expe+entd Mdnmnune Enccphlmyclitk tiy MHC Class llBbtdingcampetilwPeptidesL&pentkonthe Relatin MHC Binding Affinity d tbe DkeacIntbtdng F’eptii. I lmmund 1994,152:4211-4220. Wauben MHM. Kozhich A. loosten I. Schlief A. Ba CIP. Van&n &: Inhibit& br Entire’ Myelin B&k Proteinimbtced Expcriarnw Aurohmnc Emeph&nyelitk in Lewk Rats by Majav Hktocw&bRity Conplcx cla Ii-binding competitor Peptaes. Fur / lmmuno/ 1994,21:105)_1txO. Weinberg AD, Wallin II, Iones RE, Sullivan T], Bwrdette DN, V&e&ark AA, Offner H: Target &.gs rxegdatim d MRC 01-40 Mwker hodurtion of Thl L)m@&ine Mrna by Encepbalii T Helper Cdk k&ted fmm the SpindCwddRakwitbE+r&ntdAutoimmune Enceph&my&tii I lmmuno/ 1994, 152:4712-4721

the

T-cell tolerance and autoimmunity

Wucherpfennig KW. Zhang IW, Wltek C. Matwi M, Modabber Y, Ota K, Hafler DA: Clonal Expami,,n and F’e&tcncc of Human T Celk Specific for an tnmnodmwnurt Mydin Basic Protein Peptide. / lmmund 1994, lSZ:SSBl-5592. Zhang IW, tirkovicplese S, Lacet B, Raus I, Weiner HL, Ha&r DA: Increased Frequency of Interleukin Z-Respcdvc T Celk SpecifK for Myelin Basic Protein and Pmtedipid Protein in Peripheral Blood and Cerebms@nai Fluid of Patimk with Multiple Sckrosk. 1 EXD h4ed 1994. 179:973-984. Zhang IW, Med.& R, Srinisren P. Hafler D, Raus /: MHC. Re&ctcd DepktMn of Human hiyelin ~asii Protein Reactive TCelk by T-Ceil Vaccination. Science 26131451-1454. Zhang Y, Buwr D. Saruhan C, Jeannet M, St& Al: The ?? * TJyn&cyle Response Against My&n-associated Glvconrotein and Mvelin Basic Protein in Pat&k wih &tide Scler&. Neurdo~v 1993, 43:403-t07. I191. Lhou SR, Han Q, Laganke CC, Whitaker IN: Comparison of Roarties of Mwinc Monoclonal Anti-ldiotvdc Antib&lks Generated with Idiotypc-Bearing ” Mamockmd Antibodies to Myelin Basii Protein Patides or Their Comdemen~ Pentides. C/tin 76:25i-259.

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Ik~nof fmmunopath~ll994,

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Diabetes Related review: Genetic and pathogenic basis of autoimmune diabetes in NOD mice (pp 900-906) Aguilardmsdado M, Parkinson D, CO&H IA, Kwon G, Marshall CA, Gingeroch RL, Santiago IV, Mcdamel ML: Potmtid Autoantigens in tDDM - Expression of CarboxypqtidawH aad tnulin But not Glutamate Decarbory+ase m the Beta-Cell Surface. Diaberes 1994, 4341 B-425. Atkmwn MA, Maclaren NK: lrlet Cdl Autoantigens in h&in-wt Diabetes. / C/in /west 92:16Oa1616. Eansal AS, Wilson PB, Pumphrey RSH, 8oulton AIM. Mahk RA: C&far and Humoral hnmunitv in Patients with InuJin-Deae&nt o*aco Iletteri. Lancec 1993. 342~246. . Baron IL, Reich EF’, Visintin I, Janeway CA: Tbe Patof Adwtive Murinc Autoimmune Diab& Rquirrr & Interaction Between Alpha 4. Integrbn and Vrculr Cell Adhuioa Mdecuk-1. ! C/in Inca 1994, 93:1700-l 708. Baxter AC, Cooke A: Campfawnt Lylic Activity Has no Dii in RdeintbePat&n&sdAutobmnme NOD Mice. D/at&es 1993, 41:1574-1578. Bellgrau D, Redd l&t, Sellins KS: Pea&r T-Cell Signaling DoasmtPrecbdeP&tiveSdectirmintheDiabetesProw BB Rat. Dia6ef.s 1994,4x47-52. Bendelac A: T-Cell Receptor Specificity and Diitn in Nowbase Diabetk Mke. science 1993. 262:1582-l 583. Bergman B, Harkins K: Islet-Specifk T-Ceff Clones tiom the Nod Mouoc Respmd to Beta-Gr~e Antigen. Diabetes 1994, 43:197-203. Benrand 5, Vigeant C, Yak IF: F+re&tive V&w of 1yll+CyttAn(ibodinftWtbtAppe-tUf Diabeta in BB k Diabetes 1994,43:137-142. Bjork E, Velloso IA. Kampe 0. Karlsron FA: GAD A&un&&J in IDDM, Stiff-Mn syndmme, and Moinnnc Pdyendo~rinc Syndrome Type

I993,

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Diabetes

for Pathogenesk of IDDM. Diabetes 1993, 42:1656-l 662. Hanninen A, Taylor C, Streeter PR, Stark L5. Sarte IM, Shizuru IA, Sirnell 0, Michie SA: Vascubr Ad&es&s are Induced on ldet Vessels During Ins&is in Nonobese Diabetic Mice and are Involved in Lympboid Cell Binding to Istet Endotbelium. I C/in /nvesr 1993,92:2509-2515. Hao W, Serreze DV, Mcculloch DK, Neiting IL, Palmer JP: Insulin (Auto)Antibodia from Human IDDM CrossReact with Rctroviral Antigen P73. I Auroimmun 1993, 6x787-798. Hawke 5, Harcouri C, Pantic N, Beeson D, Willcox N, Newsomdavir I: Cellular and Humoral lmmunitv in Patients with Inwlin-Dependent Diabetes [L&I. Lances 1993,342:246. Hayward AR, Shriber M, Cooke A, Waldrnann H: Prevention of Diabetes But not tnsutitis in NOD Mice tniccted with Antibody to CD4. I Auroimmun 1993,6:301-310. Holers VM, Hollir CF. Schwartz LID, Evans RI, Straursschoentxmer I, Care1 IC. Barnev DL. Li 8. Staffordhollis I, L&PE: h&ion of ~eri-&ulitir But not Diabetes in Islet Transplants Expressing a Single Foreign Antigen - a Multi-Stage Model of Dkease. / lmmund 1993, 151:504-5052. Hw 1, Sheikh 5, Martin DL, Chatter@ NK: Coxsackievirur-B4 Alters Rmreatic Glutamate Decarboxytac Exprusion in Mice Soon after Infection. / Aufoimmun 1993,6:529-542. lkematw H, lchiyoshi Y, Schettino EW, Nakamura M, Carali P: V(H) and V(kappa&gmeat Structure of Anti-Insulin IaC Autoantibodtes in Rtients with ImuliwDepe&ent Diabatn Mellihn Evidence for Somatic Selection. / lmmund 1994,152:1430-1441. lmura H, Nakao K, Shimatsu A, Ogawa Y, 5ando T, Fujiraw I, Yamabe H: Lympbocytic lnfwuJilwlomumhypophysitis a a Cause of Central Diabetes-lnsipidu. N Eng// Med 1993,329:683-689. lto Y, Nieda M, Uchigata Y, Nirhimura M, Tokunaga K, Kuwata 5, Obata F, Tadokom K, Hirata Y, Omori Y, luji T: Recognition of Human hwlin in the Context of HLA-DRBlYUB6 Producb bv T-Cells d lmulin Autoimmune Syndrome Patie& and Healthy Donors. I /mmuno/ 1993,151:5770-5776. ltoh N, Hanafura T, Miyazaki A, Miyagawa 1, Yamagata K, Yamamcio K, Waguri M, lmagawa A, Tamura 5, lnada M. Kawata S, Tarui 5, Kono N, Matsuzawa Y: ~onoauclear Cell Infiltration and lb Retation of Maior Hktocomnatibilitv to the Ewre&oa compkr’Anti~em and idbesion M&cd” in Paw& Bigly Specbnms from Newly Diagnosed hmdin-Deaendent Diies-Mdlitus Rtients. I C/in hv3d i99j. 922313-2322. Jackson DC, Capra ID: TAP1 Alleles in Insulin-Dependent Diabetes-Mellitw - a Newlv Defbwd Cmtmmeric Boundary of Dkease Sus&ibility. Proc Narl Acad SC; USA 1993,90:11079-110.93. Ilang Z, Makowiecki I, Mordes JP, Woda BA: Cyidysin Gene Expression in the kkts of Diabetic Biobweding/Worcester Rats. / /mmuno/ 1994, 152:322-329. Katz 1, Benoist C, Mathis D: Major Hktocampatibility Comdex Class-l Mdecuks are Rewired for the Dev&pmmt of tnrulitk in Non-Obese Dtabetic Mice. Eur / lmmund 1993,23:335a3360. Katz ID, WanR B, Haskinr K, Ben& C, Mathis D: Follmvi~ a Diabetogerdc T Cell fmm Gene& Thm& F’athqenesk. Cell 1993, 74:1089-1100. Kaufman DL, Claw-Salzler M, Tian 1, Forsthuber T, Ting ?? GSP, Robinson P, Atkinson MA, Sexarz EE, Tobin Al, Lehmann w: Spontaneous La of T-cell Tolerance to Clutrnic A&i Decarbmv*r in Murina Insulin. depmdent Diabetas. Nat& 1993, 366:69-72. [SBI. Kawasaki E, Takino H, Yano M, Uotani 5, Matsumoto K. T&o Y, Yamaguchi Y, Akazlawa 5, Nagataki S: Autoanttbodfa to Ctutwnic Acid Deurboxvtase in Patienb with IDW nd Autobnrnme Thyroid Dkease. Diabetes 1994,43:B&%. laufer TM, Vonherrath MC, Crusby Ml, Oldstone MBA, Glimcher LH: Autobnmww Db&tescanbe hducad in Tramgedc Major Hkt~ibility crmqlkx ctass-lt-Deficii Mice. / Exp Med 1993. 1711:589-596. Lee MS, Wogensen L, Shizuru I, O&tone MBA, Sawetnick N: Rnnulic t&t Pmductii d Muin InterkukinIO Da, sot hlbibit Inmuw-Mcd*tcd Tii De&wtkm. I c/ill /fwesI 1994,93:1332-1338. Lepault F, Faveeuw C, Luan II, Cagnerauk MC: Lyqb NodeTCdkdonotOptbwtlyTnmferDi&tesin Nod Mice. Diabetes 1993. 42:-1623-l 828. L5. Hawoian WA. Brashear HR. Daniels T, Lernmark A: idt&wtio. 2 Autd Epi@pes d Glutvnic Acid Decarboxytaie in stifi-Man Syndrome Patients. I lmnwnd 1994,152:930-934.

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Autoimmunity Genes and molecular Lo D, Reilly CR, Scott B, Liblau R, Mcdevitt HO, Burkly LC: Antigen-Presenting Cells in Moptivdy Tramferred and Smmtaneous Autoimmunc Diabetes. Eurj lmmunoi 19i3,23:1693-1698. Lohma”” T, Leslie RD. Hawa M, Geysen M, Rodda 5, Londei M: Immunodominant E&tows of Glut&c Acid Decarboxylase 65 and 6i in insulin-Dependent Diabetes Mellitus. Lancer 1994, 343:1607-1608. Loper EPA, Et Al: Exacerbation of Type 2 Diabetes Mettitus During Interferon Alfa Therapy for Chronic Hepatitis B [Lettal. Lancer 1994,343:244. Marlignat L, Few B, Ouary M, Pqtu S, Charbamel 8. Sai P: T-Sdenocvles from Non-Obe$e Diabetic Mice Bin&g to’Xenogeneic Pancreatic Beta-Cells in Vitro - implication of tbe A&a/beta T-Cell receptor and of M&r Hktocompatibility Complex Class II Molecules firm Tamt Cdk. I Autoimmun 1993,6:753-769. Mcduffie M, Ostrowska A: Supemntigewlike Effects and incidence of Diabetes in NOD Mice. Diaberes 1993. 42:1094-1098 Nag& M, Santamaria P, Kawamura T, Utsugi T, Yom? JW: Evidence fw the Rdc of CdB+ Cvtotoxic T Cells in the Destruction of Pancreatic Bet&elk in Nonobese Diabetic Mice. / fmmu”o/l994,152:2042-2050. Pearce RB. Trider L. Svaasand EK. Peterson CM: Pdvmwphkm in Mouse Tap1 Gene. / fmmunoll993, lSi:533iJ-5347. 1271. Pennline KI. Rmueeaffnev E. Monahan M: Recombinant Human IL-i0 y&ve.b’tbe Onset of Diibeta in tbe Nonobese Diabetic Mouse. C/i” lmmonol lmmunopatholl994, 71:169-l 75. Petersen IS, Hejnaes KR, Moody A, K&e” AE, Marshall MO, Hoiermadsen M, Boel E, Michelren BK, Dy&rg T: Detection of CAD(65) Antibadks in Diabetes and Other Autoimmune DikeUsing a Simple Raddiynd Assay. Diabetes 1994,43:459-l67. Pietropaolo M, Casta”o L, Babe S, Buelow R, Kuo YLS, Martin 5, Martin A, Powers AC, Prochazb M, Naggert I, Leiter EH, Eisenbarth CS: klet Cell Autoantigen 69. kD (ICA69) -Mdecufar Cloniq and Chractnization of a Novel Diabetes-Associated Moantircn. / C/i” hwesf 1993,92:359-371. Pociot F. Wilson AC. Nemo I. Duff CW: No tndeandent Be&cm ; &nor Necrosk Fact&-alpha Promotor ttegton Pdynwpbkm awl InsulinMellitus. Eur / lmmund 1993, 23:3050-3053. Poddin PL, Pressey A, Delarato NH, Fischer PA, Pewson LB. Wicker LS: I-E+ Nonobese Diabetic Mice Develop I&litk and Diabetes. / Exp Med 1993, 178:793-803. Rabm DU, Pleasic SM. Shapiro’JA, Yoavarren H, Oler 1, Hicks j&l, Goldsrein DE, Rae PMM: Islet Cell Antigen 512 is a Dt&@fic lJ?t Autoantigei~ Related to Rotein Tymsinc phosphatases. I lmmunoll994, 1.52:3183-3188. Reich E-P, Von Crafenstein H, Barlow A, Swenson KE, ?? Williams K, laneway CA: Self Pef#tides kdated from MHC Civcwroteim of Non-abese Diabetic Mice. / fmmu"a19'94,151:2279-2288. ]17]. Richter W, Seirsler 1, Northernann W, Wdfahn 5, Meinck HM, Schwbaum WA: Cylaplamic Islet Cefl Antfbodicr Recognize Dtttnct l&t Antigens in IDDM But not in Stiff Man Syndmmc. Diabetes 1993, 42:1642-1648. Rtrch N, Chosh 5, Todd I: Statistical Evaluation of Multiple ?? Locus Linkage Data in Expetintentd Species and Relevance Studin: Appkcation to Mwin and Human IDDM. Am / Hum Genet 1993, 53:702-714. 1421. Roe” BO. Heidenthal E. De Vries RR. Kolb l-t. Martin S: ‘Sol&k Fomw of t&cellufu Adbeston Mdecdc-1 in Insulin-[kpndmt Dies Mellitus. Lancef 1994, 343:1590-l 592. Roll U, Christie MR. Stand1 E, Zienler AC: Associations of

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Inn&n w in Fimt-Decree Rdatives of Type I Di;rbaic P&en& Diab*e;r994,43:154-160. Santamaria P, Lewis C, Jersurun J, Sutherland DER, Bar&a II: Skewed TCd Recefstw t.kage Junctimd nd m-d l+anslncitrm C&sum E&ila.TCelk in Hsmum IDDM. Diabetes 1994,13:599-f&. Schmidli RS, Deaizpurua HJ, Haniron LC, Colman PC: A&OdiU(oGlutrnicACii~in At-Rkk nd Cuniul l+ocpn*nt Diabetk wects-u&bmbtptoAge,Sexandkktcell AnUbody Stab% nd Tempwd P&k% I Auroimmun 1994,?55-66. Schumad?er TNM, Kantesaria DV, Serreze DV, Rwpenian ?? DC.F%mhHL:Trammwtmfmmw2Af,H-2D,

5ci USA 1994, in bar:. [2tl].. Seirrier I, Amann 1, Mauch 1, Hadxuck H, wdfahn S, Bieg S, Richter W, Hdl R, Heinze E, Nolthemann

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,

,.

’ .

.

interactions

in autoimmunity

PetersonLB: a2microglobdin-defKicnt NOD Mice do not Dcvdop lnsditis cw Diabetes. Diabetes 1994, 43:500-504.1321. Wogensen L, Lee MS, SarvetnickN: Reduction d Interleukin-10 by Islet Celk Accelerates ImnuneMediated Destruction of Beta-Cells in Nonobese Diibetii Mit?. / Exp Med 1994,179:1379-1384. Yamada K, Takane N, Otabe S, lnada C, lnwe M, Nonaka K: Pancreatic Beta-Cell Selective Production of Tumor Necrosis Factwalpba Induced by Interlwkin-t. Diaberes 1993,42:1026-1031. Yang XD, Karin N, Tixh R, Steinman L, Mcdevitt HO Inhibition of lmutitk and Prevention of Diabetes in Nonobese Diibetic Mice by Bfocking L-Selectin and Very Late Antigen-4 Adhesion Receptors. Proc Narl AcadSci USA 1993,90:10494-10498. Zhang S:T-Cell Receptor Sfsecifwity and Diabetes in Nonobese Diabetic Mice. Science 1993, 262:1582.

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ExpMed

Alf@tta M, Nicklas’tA &ram 5, Albertini RI: T Celk Respomtve to M&I Bask f’rotetn in Paticnb with Muilip(eS&r& Science 1994,247:71a721. AltersSE,Song HK, Fathman CC: Evickncetbat Clod ?? Assergy k Induced in Tbymtc Migrant Celk after Anti-CDCMedtated Tramp*ntation Tdaance. Transo/an?arion 1993, 56:633438. Bendtzen’K, Svenso” M, Hansen M: Autoantibodies CyMinu in lvig [Letter]. / Rheumarol 1993, 20:2176-2177. Berschick P, Fehrel K, Welt&n HU, Kolb H: Molecular Andy& d theT-Cdl Recepta V(beta)S and V&eta)8 Repertoire in Pancreatic Lesions of Autoimmune Diabetii Nod Mice. / Aufoimmun 1993, k405-422. Benoletti A, Sette A, Chisari FV, Penna A, Lavrero M, De v Carli M. Flaccadwi F. Ferrari C: Natural V&ants of Cylotoxic T Cdk. Nature 1994, 369:407-%10. Bonomo A, Kehn PI, Shevach EM: Prematve Escape of Dwbk.Pmitivc Thvmocvin of Young Mice -PO&C Rde in Autdnws&ity.‘l /mmu”o/1994,152:150%1514. Bwrdette DN, Whitham RH, Chw YK, Morrison WI, Athenon I, Kenny C, Liefeld D, Hashim GA, Offnel H. Vandenbxk LA: lmnmmity to TCR Pefstides in Multipfe Sclemsk. 1. Succe&ul lmmniution of Patienk wttb Svntbetic V Beta 5.2 and V beta 6.1 Cdr2 Peptides. j lmmu”d 1994, 152:2510-2519. Bradley DS, knnette iC, Cohen PL, Eisenbwg RA: Chronic Craft Versus Host Diiase-Awxiated Autoiwmnme Madihtims w Independently Regulated by Db%ent MHC Class II Loci. I lmmuno/l994, 152:1960-1969. Brocke S, Gaur A, Piercy C, Gautam A, GijbelsK, Fathman ?? * CC, Steinman L: Induction d Relapsing Paralysis in Experimental Autoimmune EncepMomyelitk by Bacterial SwcrantiRen. Narure 1993, 365:642-644. [23tl. . ” Broker BM, Kmthauer U, Heppt P,Weseloh G, D&camp R. Kroczek RA. Emmrich F: Biased T&II RecwtorV Gene Usage in Rbesmutdd Arlkritk - Oliilonal ExpamiondTCefkExpmsin(lVAlfsba2Gmin Svnovid Fhsid But not in Peridwal Blood. Arrhritis &w” 1993, x1234-1243.’ Bucy RP, Xu XY, U IM, Huang GQ: Cycfaspmin AInduced Moinmnc Disease in Mice. / lmmunol 1993,151:1039-1050. Buzz& R, Nistico L, Osbwn IF, Giovannini C, Cherri A, Sorrentino R: HLA-DQAl and DQBl Gene Pdwswd&u in Tvat Diabetk Patknb from

to

tothePeriohm

Diabetes 1+33,42:1173-1178. Caravanniotir G. Chro”oaou IouE.R~~vP:D~~~~c~ d i&use S&qtttbiftty to Tbyroidftk I&cd by P Novel Tbjqbb&n Peptide. lmmunogeoeCics 1994, 3921-28.

&neticP&m

969

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t? Angeletti RH, Nathenson I: A Na&wnw&c M&J, Co”& &s’ttt Md&le

Bhds a Large Array d Diverse Self-Peptides. / Fxp Med 1994,179:579-588. Kageyama Y, Koide Y, Miyanvxo S, Incue T, Yoshida TO: The Biased V Cmnu Ccnc Usage in the Synovial Fluid of Patimts witb Rbetmutoid Arthritis. Eur / lmmu”o/l994,24:1122-1129. Kaiserlian D, Vidal K, MacdoMld HR. Grosjean I: Muse lntesti”al Epithdial Cdk Express the Self SupwantiRen Mkla. Eur I Immunoll993, 23:271?-2720. Katsikis PD. Chu CO. Erennan FM, Maini RN, Feldman” M: Imnnoreg&twy Role of Interleukin 10 in Rbetmutaid Arthritis. / Fxp Med 1994, 179:1517-1527. Katz IF, hnt Al: T Cell Recepta Recogninitionof MHC Class II Alloantige”s is Highly Cell Type Dependent. / lmmund 1994,152:1629-1640. Kaul R, Shenoy M, Golurzko E, Chris&s P: Major Disrupt& Histocom~tibility Crnnpkx C*r, Prevents Expcrime”tal Autainmm Myatk”ia Gravir. / lmmund 1994, 152:3152-3157. Kawamura T, Nagata M, Utsugi T, Yoon JW: Prewntion of Autoimnvnc Typl Diabetes by CD*+ Supfweswr T-Celk in Sufwrantigm-Treated No”-Obese Diabetic Mice. / lmmurwll993, 151:43624370. Kaymaz H. Dedeoglu F, Schluter SF, Edmundron AB, Marchalonis II: Reacticms of Anti-t”wmmogl&din Sera with Syntktic T-Cell Receptor Pepttdes lrnplicati~n for Tk 3-Dimndaul Stwctwc and Function of tk TCR Beta Ch*n. /“t /mm,md 1993, 5:491-502. Khoury SI, Sayegh MH, Hancock WW, Gallon L, Carpenter CB, Weiner HL: Acquired Toknnce to Experimmtal Moinrmn Emplubmyditir by lntrathymic Injection of My&n Basic Protein or Its M&w Encephditogetic Peptide. I Exp Med 1993, 1781559-566. Kltnman DM, Holmes KL, Conover I, Chiang BL, Gershwin ME: B-la a”d Carvmtiolul B Cells from Autoimnune NZB.H-2bml2 Mice Exhibit Similar Functional Cbractnistin Intivo. Fur I lmmunol 1993, 23:1866-1871. Kobayashi R, Rassenti LZ, Meisenholder G, Carson DA, Kipps TI: Autoantigen Inhibib Apcqtosk of a Hunan B-Cell Leukmia that Produces Pathogenic Rhwnatotd Factor. / knmu”d 1993,151:7273-7283. Kohraka H, Taniguchi A, Chen PP. Olliw WER, Carson DA: The Ex@ T-Cell Rmpta V-Ce”e Reperldw d Rbeunatotd Aribrhii Monolygotic Twila - Rapid Arulysir by Anebwed Polymeraxe Cbai” Reaction and Enrymc-Linked lmmmawbent Assay. Fur/ lmmund 1993,23:1895-1901. Kotzin BL: Autobmww Dkeae: Twim atd T-cell Respo”w. Nafunz 1993, 364:187. Kuchroo VK, Collins M, Alsabbagh A, S&l RA, Whitters ML Zamvil SS, Dorf ME, Hafler DA, Seidman JG, Weiner HL, Rimm II: T Ceil Receptor (TCR) Usage Detmnimr Disease Susceptibility in Experimental Aut&mnu”e Encepbalomyelitk - Studii with 1994, TCR V Beta 8.2 Truagenic Mice. / 179:1659-1664: Kuhrober A, Schirmkck R, Reimann j: VacciMtion with . T Cdl Receptor Peptidn Prbnes A”&receptor Cytotoric T Ly”+mcytcr Ml) a”d Anylirn T Cdk Specifically Rccoyized by Tbew CTL. Fur / /mmur& 1994, 24:1172-1180. [lot]. Kumar V and Sercarz EE: The Invdvmwt d T Cdl ?? * Rcccplor F%ptiii Regulatory CM+ T Cells in Recovery ban Antige”-b&ced Autoi”~“~~m Disease. I Fxp Med 1993, 176909.916. (14tl. Kumar V, Sercarz E: Hdcr in the T Cdl Rep&&e to Myelin Basic Protein Owiq to the tie of the D~2-IB&2CmCb&r-l~katio”sforT Cdl Receptor Recogdtiort ad Moimnmity. / Exp Med 1994, 1791637-1643. Kuwa~ M, Kaburaki I, Okan Y, In&o H, Tsuji K: The HLA-DR a”d DQ Ge”es CMltml the Autdnrmnc Respasz to DNA Topobama-I in Sfle”+c SciewJ& wemdemu). I C/i” /“vest 1993, 92:129&1301. Laufer TM, Vonherrath MC, Grusby MI, Oldstone MBA, Glimcher LH: Autobmmw Di&tes ~10 be I&ed in Tramge& Major Hidocompatibility complex Cta-II-Deficient Mkt. / Exp Med 1993, 17(1:58%596. Legras F, Martin T, Knapp AM, Pasquali IL: Infihrating T cdhflumFaimkwitbPlbN?ysiognasy”dm”le Exorw Re#ri&d a U”r&ricted T Cdl Recept~ V ~RnkrrDew”dbwontkStagedtbeDheae. Eurl /r?&md l&4, 24:181-185. Li XP. Golden I. Faustman DL: Faulty Major

It Cm

ExpMed

d Mke -Me h&ids, ad %da&“itk. Diabetes 1993,42:116&1172. Zyad A, Decreusefond C, hlevel JC, St&l C, Mouton D, CouJerc I: T-cdl Ccrmp&ne”t

LmaGCD,

Autoimmunity

Involvement in Two High Antibody Responder lines of Mice (HI and Htt B&i Mice) Respectively Susceuttbk and Resktmt to CdbRen-tnduced Arthrhis. / Auroimmun 1993, 6:38”tiO4. Lopez 0, Carciahoyo R, Decastro IAL: CIOMI Analysis of Altoreactive T Cell R-es Auimt the Closelv lmplicatio& Related 8.2705 and B*27b3 Subty”&s for HLA-B27 Association to Spmdylmrthropathy. I /mmuno/l994,152:5557-5571. Lou YH, Tung KSK: T-Cell Peptidc of a Self-Protein Elicits Autoantibody to the Protein AntiRem -Implications for Specificiiy and Pathugenetic ide d Antibody in /mmuno/ 1993. 151:5790-5799. Autoimnnmitv. LUO AM, Carza KM, Hunt D, TunR KSK: Antigen Mimicry in Autoimmunc Disease 5haring of Amino Acid Residues Critical for F%thogenic T-Cell Activation. I C/in Invest 1993, 92:2117-2123. Maksvmowvch WF’, Wessler A, Schmittewwlf M. &w&lmazor M, Ritzel G, Vonbot&l RC, Pazderka F. Russell AS: Pdvmumhism in an HLA linked t&eawme C& tnfl&ces Phcnotypic Expression of Disease in HLkB27 Pusitive Individuals. I Rhwmafol 1994, 21r665-669. hldlcherek C. Falk K, Rotzschke 0, Rammensee HG, Stevanovic S, Gnau V, lung G, Melms A: Natural Peptkk Ligand Moth% of Two HLA Mdecules Associated with Myasthenia Crsvis. In/ lmmunol 1993, 5x1229-1237. Mamalaki A, Trakas N, Tzartos SI: Bacterial Expression of a Sincle-Cbain Fv Framsent Which Efticicntlv Protects the ~etylchdin Re&tw Against Antigen& Modulation Caused by Myastbmic Antibodies. Fur / lmmund 1993,23:1839-1845. Mamula Ml, Fateneiad 5, Craft I: B-Cells Rucess and Present Lupus Autumtigem that tnitiate Autubnmunc T-Cell Resmmses. I hnmund 1994. 152:1453-1461. Mao CC, O&I GE, Adams S, Dana SK: T-Cell Receptor Alpha-C&t Repertoire d hthogenic Autoantfb&tnduci~ T-Cells in Lupus Mice. / lmmunot 1994, 152~1462-1470. Marsal S, Hall MA, Panayi GS, Lanchbury IS: Assuciatim of Tao2 Pdvmwohism with Rheumatoid Arthritis is 5&und& to ~lelic Assuciatiun with HLA-Drbl. Arthritis Rheum 1994, 32504-513. Marshall B. Leelavuwat C. Abraham LI. Pinelli M. Dawkins RL:‘large Transcripts and Sequence fmm a F’dymmpbtc 170 Kb MHC Region lmdicated in 5usceotibilitv to Autubumum Disease. /m;n”rqeneficr 1944, iI S-20. Masson PL: Elimiluticm of lnfectiws Antigens and Increase d IRG catabolism a Pussible M&s of Action cd I& / Aufoimmun 1993, 6:683-689. Matsumori A. Kawai C. Yamada T. Ohkusa T. Morishima S, TamaL i, Wa&be Y, YAekura Y, &a K. Konishi 1, Yoshida A: Mechantsm and Signif%mct of Mvucanltt Uotake of Antimvosin Antibudv in My&ditb and’Crdiumplut~y - Clinical ahd Experimental Studies. C/in lmmunol /mmunopatho/ 1993,6Bz215-219. Matsuoka N, Bernard N, Conception ES, Graves PN, Bennun A, Davies TF: T&l Receptor V-Region Beta-Chain Cm Exwesatun in the Autoimmune Thyrofditk d Nun&se Diabetic Mice. / /mmuno/ 1993,151:1691-1701. Maugendre 0. Lqrand 8. Olivi M. Eedossa P, Bach IF, Carnaud C: Establklunmt d T-Cell Lines from lnffltrated NOD Web by Stfmdattm of Specifii TCell Receptor V-kta Segmmts. / Auroimmun 1993, 6:423-436. Mcintosh RS, Tan&n N, Pickerill AP, Davies R, Barnett D. Weetman AP: IL-2 Recentw-Fusitive tntrathnoidal Lymphwyies in Cmves’Dise.w - Analysis 6r V-adw Transcript Micmheterogeneity. / lmmunol 1993, 151:38-3893. Meinl E, W&w F, Drexler K, ~orelle C. Ott M, Saruhan. Direskeneli C, Go&Is N, Enl B, lechan G, Giqtench G. d Al.: Mydin Basic Ruteit%pectfii T Lymphucyte Repwt&e in MdPpk kkmsis. / C/in hvesr 1993, 91:2633-2643. [19]. Met& 8, Wraith DC: Inhibition of Experimental Autoimmune Encenhabwditk bv tdsalatkm But nut Ord Administrat&~ of lh; Encepimtitogmic Peptide MHC Bfndiq Affinity. hf /mmuno/ 1993, 5:1159-1165. Michalaki H, Romanroman 5, Nicdas IF, Mackensen A, Thivolet I, kiebel F, Hercend T, Fenadini L: In-Situ Pmfemstfal Usage d V Alplu B T-Cell Receptor Gene mts in a Patient with ~dbus Pemphigoid. I Autoimmun 1993,6:827-839. Mdler A, L&r 0, Abramsky 0, Weiner /-IL: Orally . AdmmkmdMy&nBaskPr&fninNcorvtes Primesfartpnpna=dfnhra in Mult Erp&mmtdMofmname Aninuh. Eurl lmmund 1994,2I:1026-1032. Mombaens P, Mizoguchi E, Grusby Ml, Glimckr LH, Bhan AK, Tonqawa s: vfiwloprmt

.

I

-

tnfluence d

Enmqhhnyclitb

Genes and molecular

of Inflanmnatory Bowel Disease in T-Cell Receptor Mutant Mice. Cell 1993, 75:275-282. Murphy M, InsotI RM, Plkenobile L, Derbin KS, Epstein LB: Overexpression of LFA-1 and KAM-1 in Down Syndrume Thymus Implications for Abnormal Thymucytc Matural&. / fmmunol 1993, 150:5696-5703. Myers LK, Seyer IM, Stuart IM, Terato K, David C5, Kang AH: T-Cell Epitopes of Type-tt Collagen that Regulate Murine Collagen-Induced Arthritis. / Immunol 1993, 151:5Ol-505. Nakanishi K, Kobayashi T, Murase T, Nakatsu/l T, lnoko H, Tsuji K. Kosaka K: Assuciation of HLA-A24 with Complete Beta-Cell Destruction in IDDM. Diabefes 1993,42:108~1093. Nelson IL Et Al: Matcruaf-Fed Disparity in HLA Class II Alloantipm and the Pregnancy-Induced Ameliuraticm of Rheumatoid Arthritis. N Er@ / Med 1993, 329:46&471. N~colle MW, Nag B, Sharma SD, Willcox N, Vincent A, Ferguson DIP. Newscmdavis I: 5pecifii Tderance to an Acetylchdinc Receptor Epitupe Induced in Vitro in Mvasthmii Cravis CD4(+) Lvmdwxvies bv 5duMt Ma& Histucompatibility C&i Cl& II-Piptide Co~+exes. / C/in /rives//1994, 93:1361-1369. Offner H, Buenafe AC, Vainiene M, Celnik B, Weinberg AD, Gold DP, Hashim C. Vandenbark AA: Where, When, and How to Detect Biased Expression of Diiau-Relevant V-bet&cues in Rsk with Expertmental Autuimmunc Enccphalumyditis. I /mmuno/l993, 151:50&517. Ortman RA. Hold&awn D. Qu XM. Banerjee S. Haqql TM: &b/B@ (H-2(Q)) is a TCR Deletion Mutant Mouse Swain (TCR V Beta(A), Kj16(-)) that is 5wccptiblc to Type It CdlaRen-tnduced Arthritis. I /mm”-&/ 1994,i52:4175-4182. Parish NM, HutchinRs PR, Waldmann H, Cooke A: Tdmnce to IDDM hduced by CD4 Antibodies in Nonubese Diabetic Mice is keversed by Cycluphosphmdde. Diabefes 1993,42:1601-1605. Paul C, Haas IP, Schoenwald U, Truckenbrodt H, Bettinott+ MP, Bonisch I, Brunnler G. Keller E, Nevinnystickel C, Yao Z, Albert ED: HLA Clae t/Class II tnteractiun in Eatfv Onset Pauciarttcukr luvmile Chronic Arthritis. /rn~&~~e~&s 1994, 39~61-64. Pearce RB, T&&r L, Svaarand EK, Peterson CM: Polvmorohism in tk Muuse Tawl Gene - Association with Ab&mal CDB+ T-Cell dvelopmmt in the Nunobcv Nondiabetic h4ouse. I lmmund 1993, 151:5338-5347. Pennline KJ, Roquepaffnev E, Monahan M: Recumbinant Human IL-10 Pm&k the Onset of Diabetes in the Nunobese Diabetic Mouse. C/in lmmunol /mmunwa?ho/ 1994, 71 :169-l 75. Pwrce IL, Zt&owski KA, KraiR E, lnfante Al: Highly ?? C-cd TCR win CDR3 5quences Among

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.

T Cclk in Mu&w Myas&ia Cratis.‘/nr lmmunol 1994, c:775-783. [SO]. Ploski R, Hansen T, Form 0: Lack of Association with TCell Receptor TCRBV6Sl&terisk-2 Allele in HLA-DQAl-Mnirk-0101.Paitivc Norwegian luvmilc Chronic Arthritis Patients. immunogenetics 1993,38:444-?45. Powrie F, Leach MW, Mauze 5, Caddle LB, Coffman RL: F’benutypically Dtstinct 5ubseb of CD4(+) TCelk tnduce or Protect from Chronic tntestinal lnfbmmutim in C. 817 5cid Mice. In/ lmmunol 1993, 5:1461-1471. Qoan T, Schachner R, Brendel M, Kong SS, Alejandro R: lnducttun of Donor-Specific Tderance to Rat tslet Allografts by tntmthymic Inocu~tfon of Sdubilired 5pleen Celf Membrane Antigens. Diabetes 1993, 42:1544-l 546. Kao NA, Naidu YM, Bell R, Lindsey JW, Pararajasegaraaram G, Sun YM, Steinman L: Usage uf TCelf Receptor Beta-Chain Variable Gene is Highly Restricted at the site of tnflmmutiost in Musine Autdmtmmc l/wit&. / /mmuno/ 1993, 150:5716-5721. Reynolds I, Sallie BA, Syrganir C, Pusey CD: The Role of T-Helper lvmpkocvta in Rimtng for Erpcrimental Autoimmune Clacrulmphritis in tk BN Rat. 1 Aufoimmun 1993, 6:571-585. Ronningen KS, Undlien DE, PI& R, Maouni N, Konrad RI, Jensen E, Homes E. Reijonen Ii, Cdonna M, Mown DS, Strominger IL, Thor&y E: linkage Dkequifib?ium Behveen TAP2 V&ants and HLA clals-tlAtkfes-noPstmary&u&tionBehwen TAP2 Varimb rd Inul*cDwendmt Diabcte+ MeHitus. Fuur/ /mmuno/ 1993,‘23:1050-1056. Roth MP, R&d 1. Champagne E, Essaket S, A, Clayton 1, Clanet M, Coppen H: T&-V Gene Usatte in Munuzvcotic Twinr Discfw Multi‘& kkwsk. lmmun~enettcs 1994,39:281-285.

Cambonthomse”

interactions

in autoimmunity

Rott 0, Cash E. Fieischer B: Phusphodiiterase Inhibitor Pentoxifyllinc, a Seleclivc + of T-Help, Type-l-Associated But nut Type-Z-Assuciated Lvm+hddm Ruduction, Prevents tmluction of E&&nental Autobmume Encrphalcmyclitir in Lewis Rats. Eurl lmmunoll993, 23:1745-1751. Russell II-I, WanR R: Autoimmune Gld Mutation Uncouples Suicide and Cytukinel Rdiferation Pathways in Activated, Mature T-Cells. Fur / lmmunol 1993,23:2379-2382. Sakaguchi N, Miyai K, SakaRuchi S: ionizing Radiation and Autoimmunity - lndxtiun cd Autoimmune Disease in Mice by HiRh Duse Fractfmated Total Lymphoid Irradiation ana Its Prevention by tnucdati~g &mal T Cdk. I lmmund 1994. 152:2586-2595. Sakaguchi S,‘Ermak TH, Todd M. Lter~ LI, Ho W, Destgroth BF, Peterson PA, SakaRuchi N, Davis MM: induction of Autubnmun Dike& in Mice by Ccmdin Alteration uf the T-Cell ReccDtor Gene Exoression / hmund 1994,152:1471-1384. Santamaria P, Lewis C, lessurun 1. Sutherland DER, tlatbosa II: skewed T-Cell Receptor Usage Junctional and tieterugenefty Among Isletiti~alpha Beta and Gamma Delta-T-Cdk in Human IDDM. Diaberes 1994, 43:599-606. Saoudl A, Kuhn I. Huygen K, Oekorak Y, Velu T, Goldman M. Druet p. Bellon B: TH2 Activated Cell Prevent Experimental Autuimnw Uveoretinitis, a THlDependent Autuimmum Disease. fur I lmmunol 1993, 23:3096-3103. Schattner A: Lymphddnes in Autotmnunity - a Critical Review. C/;n lmmonol /mmunoparhol 1994. 70:177-l 89. Schmied M, Breicxhqwf H, Gold R, Zischler H, Rothe C, . Wekerle H. Lassmann H: Apuptosis of T Lymphocyles in Experimmal Autoimmune Encepbalumyelitir: Evidence for Prugrammed Cell Death as a Mechaism to Cuntrd tntlmumtion in the Brain. Am I Parhol 1993, 143:44&452. Scofield RH, Warren WL, Koelsch G, Harley 16: A Hyputbesis for the HtA-B27 hnmun Dysregdation in Spmdyluarthmpathy - Cuntibutims from Enteric O&in&s, B27 Sins&e, Peptfdes Bound by B27, and Cmvenent Evdution. Pmc Nafl Acad Sci IJ 5 A 1993,90:93&-9334. S&z M, Luetscher P, Dewald 6, Tcwbin l-l, Ceska M, Bareiolini M: Pruductiun d tntaleukin-1 Recentor Prost&ndin E by Rh&atuid and Osteoartbritic Synuviocytes _ Regulation by IFN-gamma md IL-4. / lmmund 1994, 152:206&2065. Sette A, Alexander I, Ruppert I, Snake K, Franc0 A, lshioka ?? G, Grey HM: Antigen AnalugsiMHC Cumplexes ;LI Specific T Cell Receptor Antagcmkk. Annu Rev /mmuno/ 1994, 12:413-431. Sew A, Sidney 1, Gaeta FCA, Appella E, Colon SM. Delguercio MF, Guery JC, Adorini L: MHC Class-II Mdeculu Bind t~rimfnately 5elf and Nun-Self Peptfde Homdugs -Effect on the tmmunugenicity of Nun-5df PC&ides. /nf lmmund 1993.5:631-638. Smgh 8. Dillion ?, Lauzon 1, Fraga E, R&II AS: Tolerance to the Ht.A-627 and Klebsfella Pnesmmfae Croweactive Epitop in Mice Tmmgenic for HLA-B2705 and Human Betd2)-Microgldwlin. / Rheumafoll994, 21:67&674. Smgh R, Mullinax PF, Moxley C: Systemic Lupus Erythmsatusus is nut Aswciated with Allotypic Markers d tmrmnuglobdin loppl in Caucafano. / Rhwmafoll994, 21:839-842. Slatterv RM. Miller IFAF. Heath WR. Charlton 8: Failure .” of P Prokctive .’ Major Histocm@bflity Complex Class-11 Mdecde to Delete Autoreactive T-Cclk in Autubmmme Diabetes. Proc Nat/ Acad SC/ U S A 1993,90:10808-10810. Smdek DE, Wraith DC, HodRkinson 5, Dwivedv S, Steinman L, McDevitt t%: A 5bsgk An& Acid Change in a myelin Basic Protein Peptide Confers the Cana& to Prevmt Rather Than hsduce Extwbnental SA 1991, M): 963’3-9637: Smith LR. Kona DH. Asthana D. Balderas RS. Lindstrom 1, Tl&&poulb AN, Fujii’t T Cell R&eptor V Beta 15 Dominates the Antiacetykbdim Receptor Responw in Lewis Rat T Cell lbus. / /mmuno/ 1994. 152:2596-2600. Scos IM, Schiffenbauet I, Johnson HM: Treatment of FL/J Mice with the Supwanti~, 5taphylucuccal Enterutuxin B, Prevenk &‘&+mt of Experfmental Atkrgic Encephdamyelitk. / Neuroimmund 1993, 423943. 5otrlni A, lmberti L, Bettinardl A, Maua C. Coda R. PrImi D: 5etectiun of T-Lvmohuwt es in 2 Rheunatuid Mhritb Pat&k &f&s l&rent TCdl Rcccpta V Beta Repertoires in CM+ and CD8+ TCell5ubsets. / Au,om~mun 1993, 6:621637.

971

972

Autoimmunity Autoimmunity

and apoptosis in MRL-@r&r

St~egktz H, Lipsky P: Association Between Reactive Arthritis and Antecedent Infection with ShigcllaFlexneri Carrying a Z-Md Plasmid and Encoding a” HLA-627 Mimetic Epitope. Arthrifis Rheum 1993, 36:1387-1391. Takahashi K, htoh I, Seine H, Zhu XP, Sagara M, Masud.1 T, Toyota T: Prevention of Type-t Diabetes with Lymphotoxin in BE-Rats. C/m lmmunol lmmunoparhol 1993,69331&323. Takeuchi F, Nakano K, Yamada H, Hong GH, Nabeta H. Yoshida A, Mats& K, Eannai M, TokunaRa K, Ito K: Associition of HLA-DR with Prog&sive Systemic Sclerosis in Japanese. / Rheumatol1994. 21:857-863. Ta”e/a: HLA-Linked Susceptibility to Rheumatoid Arthritis - a St& of Fortv-One Multicase Families from Northern I&a (Vd’36, Pg 1380, 1993). Arthrrrrs Rheum 1994, 37:299. Taneja V, Mehra NK. Anand C, Malaviya AN: HLA-Linked Susceptibility to Rheumatoid Arthritis - a Study of 41 ~ulticase Families from Northern India. Anhrrrrs Rheum 1993, 36:138L-1386. Than BA, Bakker NPM, jonker M, Bontrop RE: Resistance to Collagen-In&ad Arthritis in Rats and Rhesus Monkevs after Immunization with Attenuated Tvwtt c&gen. Fur / /mmuno/ 1993,23:158&l 594.’ Tirch R, Mcdevitt HO: Antigen-Specifs Immtmotherapy _ is it a Real Possibility to Combat T-Cell-Mediated Autoimnunity. Proc Nat/ Acad ki U 5 A 1994, 91z437-438. Tsuchida M, Matwmoto Y, Hirahara H, Hanawa Ii, Tomiyama K, Abe T: Preferential Diitribution of V tieta 8.2-Positive T-Celk in the Central Nervow System of Rats with My&n Basic Protein-Induced Autoirnmune Enccphlamyelitk. Fur/ lmmunol1993. 23:2399-2406. Uitdehaag BMJ, Degmot CIA, Kreike A, Vandermeide PH. Polman CH, Dijkstra CD: The Sigrdficancc of lraitu la Antigen Expression in the Pathogen& of Autoimnune Central Nervous System Dtkease. I Autoimmun 1993,6:323-335. Utz U, Biddaon WE, McFarland HF. McFarlin DE, FledaRe M, Martin R: Skewed T-Cell Receptor Repertoire in Genctiollv ldentiul Twinr Correlates with Multiple Sclnak. ~at”n? 1993, 364~243-246. Utz U, Brooks IA, Mcfarland HF, Martin R, Biddison WE: T-call Rece~~lor Alpha-chain Compf&nt&ity-dctcini~ Rag&t 3 in Myelin Basii F’mtet~necific T Cdk Increases with Sweritv of Mtdtipk S&oats. Pmc Nat/ Acad 5ci IJ 5 A 199h. 91:5567-5571. Vanendert PM, Liblau RS, Pate1 SD, Fueser L, Lawr T, Pociot F, Nerup j, Mcdevitt HOz.-?&jor Cam&a-Encoded Anticen F+mces& Gene &ym&phkm in IDDM.“Diaberes 1994,43:110-117. WataMtxohnirhi R, Aelion 1, Legros L, Tomai MA, 5okurenko EV, Newton D, Tabhara I, IriM S, Rashed S, Kotb M: Characterization of Unique Hunin TCR V Beta Swcifwities fa a Fanily of Streptococol Sup&ntigms Repvesmled’by Rheumatogmic Sewtypes of M Protein. I fmmunol 1%94,152:206E+2073. Waube” MHM, loosten I, Schlief A, Vanderzee R, Boog CIP. Van&n w: lnhibitbm d ErrA&mmtme Enceptnlomyelitk gy MHC Class II BitldhIg cmlpetita Peptides Depends on the Relative MHC flindbtg mnity of the Dkeaubaduciq Pep&k. / /mrnund 1994,152:4211-4220. Wauben MHM, Kozhich A, loosten I, Schlief A, Boog CIP, Vaneden W: d Entire Myelii Basic Protein. induced Expubwntd Mdmmuw Etuephdomyelitir in Lewk Rats by Majaw Hktocrmpaibility Complex Class II-binding Cmpctftor Pcptides. Eur / lmmund 1994, 24:1053-1060. Wembera AD. Wallin II. laws RE. Sullivan TI. Bourdette DN,-Var&barl; ti, 0ffne~l-t: Target &+Ispceitk UpRqquhlbn d the MRC Ox-40 Matiter andSekctivehaMiondlhlL~Mma by Encqhalitqenic T lie+ Celf; l&fated fmm the SpilvlCaddRatswithExpubnmtdMdmmune Enceph&mtyJitk. I /mmurw/1994,1.52:4712-4721. WeinJB, Granger DL, Pisetsky OS, 5ektin MF, Misukonis MA, Mason SN, Pippa” AM, Ruiz P, Wcad ER. Cilkeson CS: The Rde d Nit& OxideintkPadmpehd~~ne MdnnrrrDirca+-kmacdNilric<)ridc Pm&ctbnnlNl&kOxideS~hpnrionin MR1-Lpr/Lpr Mice, snd Rehctkm d N

tictcnnmcity of

klii_tiMli

lnhihtion

GbnvnJorcpkrllb~~~oRwy A&&&aed t’%-h@W”I+f-l-~. 1 Exp Med 1994,179:651-660. Weiner HL, Friedman A. Miller A, Khoury 51, Al-Sabbagh . A, Santa 1, SaHnh M. Nussmblatt RB, Trentham DE,

mice

Autoant&“% Annu Rev lmmunol1994. 12: 809-837. 129’1. weyand CM, Hunder NNH, Hicok KC, Hunder CC, Coronzy II: HLA-Drbl Alleles in Pdymyalgia Rheumatica, Giant Cell A&&is, aml Rheumatoid Arthritis. Arihrilis Rheum 1994, 37:514-520. Wrlhams RO, Mason LI, Feldman” M, Maini RN: Synergy Betwcn AntiCD4 and Anti-Tumor Nccrosir Factor in the Amelioration of Established CollagenInduced Arthritis. Proc Nar/ Acad SC; U 5 A 1994, 91:2762-2766. Wolflevin R, Azunu T, Aoki K, YaRami Y, Okada H: SpecifK IgG At&antibodies ire Potent Inhibitors of Autoreactive T-fell Resoonse to PbvtohemacdutininActivated T-Cells. / Imn&/ 1993. ‘151:586r5877. Wu IC, Zhw T, He 1, Mountz ID: Autoimmune Disease in Mice Due to Integration of an Endogenous Retrovirur 1993, 178:461468. in an Apoptosk Gene. / Yamamofo K, Sakcda H, Nakalima T, Kate T, Okubo . M, Dohi M, Mirushima Y, llo K, Nishioka K: Accundation of Mdtide T Cell Clonotvwr in the Synovial Lesion of Pat& with Rheun&aid Arthritis Rcveakd by a Novel Clwlity Analysis. /nr lmmunol 1992, 4:1219-1223. 1471. Yap HK, NR SC, Lee BW, Seah CC, Tan MAJA, Choy MY, lorda” SC: Mcddation of MHC Expression on Hunan End&dial Celk by Sera from Patients with Systemic Lupus Erylhematosus. C/in lmmunol /mmunopatho/ 1993, 68:321-326. Yelamos j, Garcialozano JR, Moreno I, Aguilera I, Gonzalez MF, Garcia A, Nunerroldan A, Sanchez B: Associattion of HLA-DR4-Dw15 (DRBl-Aslcrirk-0405) and DRlO with Rheumatoid Arthritis in a Spanish Population. Arthriris Rheum 1993, 36:811-814. Zhane I. Mark&c-Plese 5. Lacet B. Raus I. Weiner HL. l%fler DA: Increased Frequency of I&rleukin. 2-respomive T Cclk Spe&c f& Myelin Basic Protein and Rotedipid Protein in Peripheral Blood and Cerebrospinal Fluid of Patients with Multiple Sclerosis. / Exp Mad 1994, 179:973-984. I251. Zhou T, Weaver C, Linsley PS, Mcuntz ID: T Celk of Staphylococcal Enterotoxin B-tderired Autoimmune MRL-lprflpr Mice Rcguin Co-stirrndation Through the B7CDZB/CTLA-4 Pathwav for Activation and can be Re&gized in Viva b; Stimulrtia, d the T Cell Receptor in the Abmce of Thk Coatirmlatory Signal. Eur I lmmunoll994, 24:1019-1025.

fxpMed

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Autoimmunity and apoptosis in MRL-/pr//pr mice Related review: Apoptosis, FAS and systemic autoimmunity: the MRL-/pr//lpr model (pp 913-920)

Aberrant

Apoptosis

Auhm&iy &ek

Fateneiad S, Brooks W, Schwartz A, Craft I: Pattam of

. . . t4ucIWRibaKkoproccn,AnbbGdm

MRuMda/brMiceSuac&athatthaIn(lclU1 SnRNP Pa&k k Tbeb /mmu”o/ 1994, 152:5523-5531.

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ExpMed

Adachi M, Wata”abe-Fukunaga R, Nqata 5: T~nocription Cased by the lmertion of an Early Transp&blc Element iA a” lntron of the Fa Antim Gene of la Mice. Pmc Narl Acad Sci USA 199% 9&l 756-l 7.60. [SO]. B&e P, Benihoud K, Kiger N: Allogenic MHC ClassII DetetinntfS) in MRL/lp Autoimmune DkeacRom Mice - U-l Expression of an Ll Traqrsable Element Creates Mdecdar Mimicry. I lmmunoll993, 151:2813-2819. Borru P, 5inRer CC, Andes P, Ettinger R, Marshak. Rothstein A, Abbs Al(: Mature CD4 + T Lymphocytes from MRL/lpr Mice arc Resistant to ReceptwMediated Tderance and Apoptak. / fmmund 1993, 151:7233-7239.1411. Cheng I, Zhou T, Liu C, Shapiro IF’, Brauer Mj, Krefer MC, ?? * Barr PI, Mwntz ID: Rote&~” fmn F&Mediated by a Sduble Form of the F.w Mdecde. S&we 1954, 263:1759-l 762. 1651. Chu I-L. Drama I, Parnassa A. Elkon KB: The Defect in . &MRti E&aaion in MRLlrpl Mice is Associitcd with lmerifcm cd the Retrotrarapaon, FTn. I Fxp Med 1993, 171):723-730. [Sl]. Cohen PL, Creech E. Nakulaquaronne D, Mcdaniel R, Ack!-er 5, Rapoport RG. Sdxl ES, Eirenberg ~:Antigm&mspecificEffectd~ Hktoc~dbilitv cmlder HadotwK on in &tan& Lt&n Erydwmatorus Prone Lpr Mice. I C/in Invest 1993, 91:2761-2768. Drappa 1, Bfot N, Elkon KB: The Fas Protein is Exprmed at Hi Levefs M CDI+CDB+ Thymacytes and A&& kwIc Lymphacyles in Normal Mice But not in the Lup&Raw Strain,MRL Lpdlpr. Pmc Narl Acadki USA 1993.90:1034@-10344.

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Faulds GB, lsenberg DA, Latchman D5: The Tinuc 5oecifK Elevation in Svnthesis of the 90 KDa Heat Shock Protein Rec& the Omet of Disease in Lupus Prone MRL/Lp Mice. / Rheumard 1994, 21:234-238. Fossati L. Takahashi 5, Merino R, lwamoto M, A&y IP, Nose M. SDach C. Mona R. lzui S: A” MRVMelIpr/lpr Sudtnin with a Limited Expansion of ipr Do&k-Negative TCdk and a Reduced Autoimmw Svndrome. Inr /mmunol1993.5:525-532. Fost&‘MH. Sabbaga I, Line SRP, Thornps~~ KS, Barrett KJ, Mad&o MP: Mdecular Andy& of Spontaneous Ncphrotropic Anti-Laminin Antibodies in II Autobnmune MRL-lw/ltw Mouse. I fmmurrd 1993, 151:814-824. . ’ Crese T, Davidson WF: Chronic Treatment d C3H-Lpr/Lpr and C3H-Cld/Cld Mice with Anti-CDB Mcmoclonal Antibody P&z~~ts the Accumulation of Double Praductiin. Negativ; T Celk But not At&antibody I Immund 1994. 152:200&2010. C&&fquson I, Sidma” CL: A Specific Intercellular Pathway of Afwptotic Cell Death k Defective in lpr the Mature Peripheral T Celk d Autoiand Cld Mice. Fur/ /mmuno/1994,24:1181-1185 Gillette-Ferwrcn I, Sidman CL: A Specific Intercelbdar Pathwiy of Apoptotic Cell De&h k Defective in the Maturc Ptridwnl T Celk d Autobmnme ltwandndrld Mice. EM/ ~WMJ/ 1994,24:1181-1185. i42]. Conzalo IA, Tarazona R, Schuurman HI, Uytdehaag F, Wick G. Martmez C. Kmenw G: A Sinde lniection of Stap);ylococcw Aumn Enterotoxin i R&m Autoimmunity in MRL/Lp Mice. C/in /mmurw/ tmmunoparholl994, 71:17&182. Hamano l-l, Saito I, Haneii N, Mitsuharhi Y, Miyasaka N. Hayasho y: Expresai& of Cyloldnc Gencr .ihui”g Development of Autoimrmme Sbdadenitir in MRL/lpr Mice. Eur I lmmuno/l993, 23:2387-2391. Herro” LR, Eisenberg RA, Roper E, Kakkanaiah VN, . Cohen PL. Kotzin BL: Selection of the T Cell in Ipr Mice. / /mmuno/ 1993, Rcccpto&pertotre 151:34503459. 1561. Heyman B, Gustavsron 5, Kusakari C, Nose M, Kinoshita T, Klareskog 1, Tarkowski A: Antibody Feedback Regulation in MRL/lp Mice. / Auroimmun 1993, 6z437-448. lshida T, lnaba M, Hirha H, Sugiura K, Adachi Y, Nagata N, Ogawa R, Good RA, lkehara s: Rquim”t of Dona-Derived Stanal Ceik in the Bone Manow for Successful AlloRenaic Born Marrow Tnnrplntatbn - Canpktc F’reventio” of Recwrenc ??of Autdmmune Diseases in MR4MP-Lpr/Lp Mice by Tnmpfantation of Bon Marrow Pbn Bones (Strand Celk) fmkn the SaneDomr.//mmund1994,152:3119-3127. levnikar AM, Grusby Ml, Glimcher LH: Prevention of Ncptwitk in Major Hiatocompalibility Complex Clas+ll-Deficimt MRL-lp Mice. / 1994, 179x1137-1143. levnikar AM. GrusbY Ml, Glimcher LH: Prevention of Nephritk in M&I Histocompalibility Complex Class II-Deftcknt MRL-fnr Mice. I EXD Med 1994, 179:1137-1143.1461.

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lu 5-T. Cui HL, P&a DI, Ettinger R, Marshak-Rothstein . A: ParticiDation of Target Fa Protein in Apoptosb Pathway inbccd byc-b4+ T,l a”d cod+. Cylotoxic T Celk. Proc Nad Acad SC; U S A 1994 91:4185-t189. 1231. Kojima H, Shinohara N, Han&a 5, Someya-Shirota Y, . Takagaki Y, Ohno H, Saito T, Katayama T, Yagita H, Okumura K, er Al.: Two Distinct Pathways of SpKitic Killing Revealed by Perforbt Mutant Cyiotoric T Llnphocyln. fmmunity 1994, in F’rcss:.

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Levme IS, PuRh Bl, Hanwell D, Fitzpatrick IM, Marshakrothstein A, Belier DI: interfcukin-1 Dysregtdation is a” Intrinsic Defect in Macrophases mmnc-Pmnc Mice. Fur I lmmunol flW”MRLAUtOi 1993, 23:2951-2958. Lvnch DH. Watson ML. Alderson MR. Baum PR. Miller RE Tough T, Gibson A, Davis-Smith’T, Smith CA, Hunter K, et A/.: Tha Mowa Fa-Liynd Cmc ir Mutated in gfd Mice and is Rrt of a TNF Fmily CW Cluster. immunity 1994,1:131-136. IS41. Merino R, 1wam010 M, Fossati L, lzui 5: Pdplorul B-Cell Activatfo” A&es from Diffumt Mechanisma in Lupus-Prone (NZB X NZW)Fl a”d MRL/MpJ-lpr/lpr Mice. I lmmrmdl993, 151:6509-6516. Meryhew NL, h4ess”ei RP: Murinc Complmwnt-Mediated Irmnme Ck!&lnce D@un&m is Asaociited with the Lympboprdifer&W (lpv) cm. c/in lmmu”o/ /mmunoparho/ 1993,69:324-332. Moray T, Grzeschiczek A, Petzold S, Hartmann KU: Expmaim da Pbn-1 Tramgene Accelerates ~ynrphopdifcntionadbddbitsApoptoskin Lpr/lpr Mice. F’mc Nar/ Acad SC; U S A 1993, 90fl0734-10738. Mount ID, Zhcu T, Long RE, Blwthmann H. Koopma” wj, Edwards CK: T Cell tnflumce on Supemntigen-

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Autoimmunity Rheumatological diseases Inbred Arthritis in MRL-Lpr/Lpr Mice. Anhr&s Rheum 1994,31:113-124. My&r E, Bini P, Drappa I, Rama P, Friedman SM. Krammer PH. Elkon KE: The Apoptosio-1 Fa Protein in Human Systemic &us Erythematosus. / C/in Invest 1994,93:1029-1034. Noyori K, Koshino T, Takagi T, Okamoto R, lain HE: Binding Characteffsttin of Antitype II Collagen Antibody to the Surface of Diseased Human Cartilage 1) a plobc far Tissue Danage. / Rheumatol 1994, 21:293-2%. Ratkay LC, Zhang LW, Tonzetich 1, Wateriield ID: Complete Freund Ad@at Induces an Earlier and More Severe Mhritis in MRL-lpr Mice. / lmmunol 1993, 151:5OBl-5087. Russell JH, Rush B, Weaver C, Wang R: Mature T Cells of ?? Autoimmune @r/b Mice l&we-a Defect in AntigenStimulated 5&i&. pmc Nat/ Acad Sci USA 1993. 90:44094413. [lo]. Singer CC, Abbas AKz The Fa Antigen is tnvdved in . Peripheral But not Thymic Dektion of T lymphocytes in T Cell Receptor Tramg&c Mice. fmmunity 1994, in Prnr:. (571. Smith CA, Fanah T, Goodwin RC: The TNF Receptor ?? . Supetfamily of Cclbdar and Viral Proteins: Activation, Cortirm*tion. and Death. Cell 1994. 76959-962

1181. Sobel ES, Kakbnaiah VN, Cohen PL, Eirenberg RA: cwrection of ad Autdmmunity by Co-ltion ofNomulBoneMarmw5ucseststhatGldka Mutation Fa Ligand &e. Inr lmmunoll993, 5:1275-1278. Suds T, Takahashi T, G&stein P, Nag& S: Mdecular ?? * Clonbvg ud Expwmion of the Fa Liind, a Novel Member d the Tuna Neck Factor Family. Cell 1993, 75:1169-1178. [ZO]. Suzuki H, Yasukawa K, Saito T, Narazaki M, Hasegawa A, Taga T, Kishimoto T: Serum soluble Intcrleukin6 Ret-eptor in MRVlpr Mire is Ekvated with Age and Mcdiatu the Inlerkuki~6 Siuul. Eur I lmmunol 1993,23:107&1082. Takaharhi T, Tanaka M, Brannan Cl, Jenkins NA, ?? * Cowland NC. Suds T. Nacata s: Ceneraliied Ly&hopmlif&ative L&&z in Mice, Cased by a pdnt Mutation in the Faa Liind. Cell 1994, 76:969-976. 1531. Tan EM: Maimmunity and Apoptosis. / FX/I Med 1994, 179:1083-1086. Weinberg IB, Granger DL, Pisetsky DS, Seldm MF, Misukonis Mh Mason SN, Pippen AM, Ruiz P, Wood ER, Gilkmn GS: The Role d Nitric Oxide in thr w of 5fmntmas Muine Mdmnwne Diseae - lncreaaed Nitric Oxide Roduai and Nit& Oxide Synthae Exprcaion in MRL-l.pr/Lp Mice, and Reduction of 5pwwwws Gl~ and A&with by orally A&d&Wed N-G-Monomethyl-L-qnb~~. / Fxp Med 1994,179:651+60. Wu 1, Zhcu T, Zhang I, He 1, Cause WC, Mwntz ID: ?? * Cowwtbn dAccelented Autdnwnune Diseae bv EwlyReplacemmtdtheMutated~Cenewitb’ theNom&FrApoptc&CeneintbeTCelbof Traqenic MRL-b/@r Mke. plot Nat/ Acad SC/ U 5 A 1994, 91:23U-2348. [SZ]. Wu IG, Zhw T, Zhang II, He 1, Gause WC, h4ountz ID:

ofthe

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~th&N&nulFaApq#oskCmin’theTCelk of Traqenk MRL-Lpr/Lpr Mice. Pmc Nad Acad SC; U 5 A 1994,91:2344-2340. Zhou T, Weaver C, Linrlw PS. Mountz ID: T Cefk of 5tqlbykcacaI Ente&xin B-tdtlired Au&immum MRL-lpv/lp Mice Re@e Co-&nd&m Through the B7-CDZB/CTLA-4 Pathwav for Activation and canbeRmeqjzedb1Vivobj5tbm&thmoftbeT Cell Receplw in the Ab9encc d Tbb Co-stin*lktwy Sit@. Fur//mmuno/ 1994, 24:1019-1025.

Fluid of Rhaanatoid Arthritis Patients tnduces Unorthodox Au&antibodies (I@ Rheumatoid Factor) in NZB, Nzw and (NZB X Nzw)Fl Mice. Evr / /mmu~/1994,21:6&(-691_ Ablnum M, Cant Al: Toxic Shocit Syndrome Toxirr Secreting Staphylococcus Aureus in Kawasaki Syndrome [Letter]. 1ancet 1994, 343299. Adebajo AO, Cawston TE, Hazleman BL: Rheumatoid Factors in Associittion with Rheumatoid Arthritis and Infectious Diseases in West African [Letter]. / Rheumafol 1994, 21368-969. Aderka D. Wyrenbeek A, Engelmann t-l, Cope AP, Brennan F. M&d Y. Homik V. Levo Y. Maim RN. Feldmann M, Walk& D: Co&k&n Liehveen 5&m Levels of Soluble Tumor Nccrmk Facta Receptor and Disease Activity in Systemic Lupus Erythematosus. Arfhrifis Rheum 1993, 36:1111-1120. Aho K, Vonessen R, Kurki P, Palosuo T, Heliovaara M: Antikeratin Antibody and Antiperhwcleu Factor as Marken for Subciinical Rheumatoid Disease Pmcess. / Rheumato/1993,20:12761281, Akahoshi T, Wada C, Endo H, Hirtia K, Hosaka S, Takavishi K. Kondo H. Kashiwazaki 5. Matsushima K: E&e&on of Mom&e Chem&tii and Acti&% Factor in Rh&natoid Mhritk - Regulation of Its Pmductii in Symvial Cdk by tnterleukin-1 and Tumor Necmsk Factor. Anhriris Rheum 1993. 36:762-771. Alarconsegovia D, Reyes E, Sanchezgwnero I: Antidtosdwlidd Antibodies and Intestinal Path&xv “’ 242170. -Rcpiy [t.etter~. I Rheumafoll993, Aljanadi M, Alballa S, Aldalaan A, Raziuddin S: Cytddne Production by Helper T-Cell Popdationr hom the Synoviai Fluid and Blood in Patimk with Rhewnatoid Arthritis. / Rheumaro/l993,20:1647-1653. Aljanadi M, Alwabel A, Raziuddin S: Soluble Cd23 and Interleukirr4 Levek in Moimmm Chronic Active Hepatitis and Systemic Lqw Eqlbematosus. C/in lmmunol lmmunmafhol1994. 71:33-37. Al-Janadi M, Raziuddii 5: B Cell Hyperactivity is a Function of T Cell Derived Cylokim in SLE. / Rheumaroll993, 20:1885-l 891. Aljarallah KF, Buchanan WW, Sastry A, Singal DP: Seroqative Rheumatoid Arthritis and HLA-Dr4. / Rheumato/l994,21:190-193. Allen 16, Wang HL, Costa CL, Bienkowski MI, Wahl 5~: Suppnrai~n of Monocyle Function and Diffmntial Re@ation of IL-1 and IL-ln by IL-4 Contribute to Radution of ExperinrmlJ Arthritis. I fmmund 1993, 151:4344-4351. Alsalameh S, Molknhawr 1, Scheuplein F, Stosr H, Kalden JR, Burkhardt H, Burmester CR: F’mferential Cdlular and Humoral tmmune Reactivitii to Native and Denatured Cdlqen Type-IX and Type Pdychondritir. / XI in a Patient with F&d Rdapiq Rheu~toll993,211419-1424. Anderton SM. Vanderree R, Noordzii A, Vaneden W: Differential Mycobxterial 65&a Heat 5bock Pmtein T Cell Enitooe Recowdtian af&er A&want Arthritblnducih & Pm&n lmnniz&n Rotocob. I /m&mo/ 1994,152:365M664. Andrewr PA, Framdon G. Cameron IS: Antinhosnbdioid 5yndronK sy&llc Lqmm &il. Lalcu 1993, 342r9B&989. Archer JR, Whelan MA: HLA-127 and Effector T-Cells _ Ardwitgcnic Peptkk or A&it& Antitten [~at~l.~~d~ec i993,342:1307. Arnaudova P. Rashkov R. Tsanw R: Aodiotion d tnte&m+mma Cawniq Ci’fw Local Treatment of 5ldn Ukers in Autdmmune vascditido and 5kin Changes in Pqresiw Systemk 5clemsk [letter]. I Rheumafo/1993,20:1445-1446. Asch ES, Bujak DI, Weiss M, Peter$oonMGE, Weinstein A:LymeDkease-anlnfcctiasandPmtinfcctious SyaanC. I Rheumatd 1994,21:454461. Asherson RA: SLE and the AP5 [letter]. / Rheumafo/ 1993, 2ClBOl. Ayer LM, Rubin RL, Dixon GH, Fritzler MJ: Antibodies HMG Pmtebn bt F+atimb with Dn@nbccd Autdnmnity. Atdwitis Rheum 1994, +98-l 03. Baker DC, Schumacher HR: Current Concepts - Acute

anti

i&tor;r

to

Rheumatolqical diseases Related reviews: How unique are pathogenic anti-DNA autoantibody V regions? (pp 921-925); Autoantibcdies in scleroderma and tightskin mice (pp 931-937t1 Abdelnour A, Bremell T, Holmdahl R. Tarkowski A:

syn&‘mw Tcukclqmduci~ 5hpby%xocci. Fur I lmmwd 1994,2&1161-1166. AbedivakIgerdi M. Rii A, Lettesjo H, Strom H, hioIler E: R0cein.G Binding Materid from Synoviai

NFngflMedl993, 31931013-1020. Monorhritk Bakimw R. Guilburd B, Zurgil N, Shoe&Id y: the Effect dlnbmmu ciamu-cbbdinontbehNkKlhm d Erpt*ncnhl w ~y&ome. c/in lmmund hnmunqathd 1993,69:97-102. Bandara G. Mueller GM, Galcalauri 1, Tirdal MH, Geage~~u HI, Suchanek MK, Huq CL, Gkwiosa JC, R&bins PO, Evans Cn: l&atkdu Expmriond BiilyActiveI~ 1 Rece@r-e Protein bv Fxviva Cme Trrdn. Pm Nad Acad SC; IJ 5 A t9;J3,9oz10764-10768. Barile L, bra LJ, Graef A, Lavalk c: Sen Hamxmes and CNldhood 5LE [LetleVI. I Rheumato/ 1994, 21:966. Barinaga M: Autd&mc &eau -Tratin# &thrftk with Tderace. Science 1993,261:166+1670.

Barker RN, Oiiveira CCD, Elson CJ, Lydyard PM: in the NZB Mwre Pathogenic Auto&ibodii are Spcift for Erylbmcyie Ban&3 Plwein. Fur / /mmund 1993,23:1723-l 726. Barrera P, Boerbooms AMT. lamsen EM, Sawnvein RW, Callati H. Mukfer I, Deboo T, Demacker PNM. Vandeputte LBA, Vandermeer JWM: Circulating Sdtible Tuner Nwrorir Frtor Rc~eptors, tntedeukin. 2 Receptm, Tuner Necrosis Facta-Jpha, and tntetfeukin-6 Levels in Rhamatdd Arthritis Lcqitudinal Eva&&on Ihatfq~ A&ids Rheum 1993, 3~1070-1079. Barrett TG, Et Al: Envi ronmental Trigger for AntiNeutmphil Cytopfxmk Antibmiks? [Letter]. Lancer 1993,342:369. Belmont HM, Buyon I, Ciorno R, Abramson S: Up Rqdatirm of Endothelid Cell Adhesia Mdwules Charxteriza Disease ActivRy in Systemic Lupus Etythematasus - the Shwvlmu n phmomenott Rwisited. Anhriris Rhwm 1994, 37:376-383. BensimMl C, Chastagner P, Zarali M: Human Lup15 Anti*. DNA Autoantfhodies Undergo Eswntially Rbnary V, Cm Reanaqement* FML?O/ 1994, 13:2951-2962.

ad AMhiopdnl’hcnpy.

Methotrrwte

1201. Berman L: Prinuy AP5 - Reply Ilettcrl. / Rheumarol 1993, M:lBO2. Bermcal A, Cotuzzo E, C&o A, Carrillo C, Cartaneda 0, Alarcon GS: Stemociavicdar Brucdlv Arthritis -a Report of Seven Cases nd a Review of the Literature. I Rheumafoll993. 2O:ll E&l 1%. Bhalia R, Ajmani HS, t&n WW, Swedler WI, Lazarwic MB, Skosey IL: Syrtemk Lupu6 and HcdRldns Lym#wmu j Rheu&o/ 1993, 20:1316-1320. to Sy&mic Birdi: Localized 5clcrodrmu Rqradn~ Dii - Case Report and R&i & tbe’literature tVd 36. PC 410. 19931. Arfhrifis Rheum 1993. 36:llBi. ” Blasini AM, Stekman IL, Gonzalez F, Tositti ML, Rodriguez MA: T-Lympbocytn fmm Patlenb with Systemic Lupa Erythmwtosus Show tncveaed Rqome to blterk&in-2 after cortbndation with oKT3 Mow~lond Antibody and Plwbd Eden C/in /mmuno/ /mmunoparho/ 1994,70:66-72. Blomberg 1, Nived 0, Pipkan R, Bengtsron A, Erlinge D, Studelt C: Increased Antiretrovbal Antibody Reactivitv in 5era front a Defbwd Pomdatkwt d with Systemk LumusE&matosus - Cowelation witk Autontib&a &d Clinical Manifestation& Anhrifis Rheum 1994, 37z57-66. Bocchieri MH, Christner PI, Hen&en PD. limenez SA CIwatuka d (Tight SkiJNZBJFl Hybrid Mke with Connectiw Ti*uc and Autobmwne Featum Rewmbliq HSyaemic klermb. / Auroimman 1993,6:337-351. Boehme MWI, Nawroth PP, Kling E, Lin 1, Amiral I, Riedesel I, Raeth U. Schetbaum WA: Serum Thmmbm&din-aNwelMr(mdDkeae Activity in Systemic Lupus Eryibemataus. Anhritis Rhwm 1994, 37:572-577. Boire G. Menad HA, Gendron M, Lursier A, Myhal D: Rheunatdd Arthritis - Anti-00 Antibcdlu Define a Nan-HLA-DR4 Arociated Clinkow&&al Clurtcr. j Rheumato/1993,20:1654-1660. Bonagura VR, Artandi SE, Davidson A, Randen I,

Erylhmatosus

P&k&

tmmundogicaI

tion

~gos1iK) N, Thompson K, Natvig IB, Morrison Eoitmw on 5L: -8~ S&d& Reved Udaw @C R&t&d by Rkeuwtdd &&i&rived Monock+td Rbeum&d Facta% I lmmund 1993, 151:3B40-3852. Borba EF, Cantos RD, Bonfa E, Vinagre CG, Pikggi FJC, Cossermelli W, Maranhao RC: Lipoprz&in(A) Levels in SMemic Lupus E+mutws. / Rheumardl994, 21:220-223. Bores P, Muryoi T, Spiera It, Bona C, Unkeksr jC: ?? Autoanti~Dilected~Diffmnlclom of Fqit are Fmmd in 5era & Autdnmwne Patienk. I lmmunol1993. 150:201b2029.153~1. Bores P, Odin IA, Cl& IV, Unkekss k 5p&itkity ndClamDkbibutioadFcGanmnR+ecKw ~blPaie&lrithMoinn*mDiiase. / /mmund 1994,152:302-306. Brand DD, Myers LK, Terato K, Whittington KB, Stuart IM, KanB AH, Rosloniec EF: chrterluaion d the T CeH~intbclnLvtbndAutobmmme Artbritb by Bovbw Alftba l(II&Cbll in H-2(Q) Mice. I /mmund 1994,152:3OBB-3097. Brand SR, Bernstein RM, Mathews MB: Autoreactive Edtcmcprdfksdthc hdwcnthn cell Nuckar A&&D&eTwoc*radA&ntibadks./ lmmund 1994,152:412&4128. Brezinsxhek HP, Gnachwitz M, Sgonc R, Moormann 5. Hemld M. Gershwin ME, Wick G: Effects d Cyiddne Appliotion am Clwocoriicoid 5ecretion in an Animal

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Rheumatological

diseases

Mcdd for Systemic Sclercdcmu. / Auroimmon 1993, 6:719-733. Br,~s D, Stephens C, Vaughan R, Welsh K, Black C: A Mdecubw and Serdogic AnaIy*I of the Major Histocompat&ility Complex and Complement CompowntC4 in Systemic Sclerosis. Arthritis Rheum 1993, 36:943-957. Brownell AKW: Intravenous Immune Globdin fOr Dmnatomvmith Iletterl. N Em!/ I Med 1994. 33or1392.’ R, Haga Hi: Measwemmt of Plasma Cafprotectin as an Indicator of Arthritis and ~&ease Activity in Patients with lnflrmutory Rheumatic Diseases. / Rheumard 1994, 21:733-738. Burhngame RW, Rubin RL, Rosenberg AM: Autoantibodies to Chmmatin CornDonents in luvenile ftheunatoid Arthritis. Arfhririr ihewn 199j, 36:83&841 Buyon JP, Slade SC, Reveille ID, Hamel K, Chan EKL: AutoantibodrRto the Native 5%kDa SSAlRo Protein in t&mutal Lupus Syndromes, Systemic Lupus Eqthmlat~ and S&l& syndrome:/ lmmund 1994,152:3675-3684. Buyon JP, Winchester RI, Sk& SC, Amen F, Cope1 I, Friedman D, Lockshin MD: ldmtitication of Mothers at Rkk for Congenital Heart Block and Other Neonatal Lumn Svndin Their Children Compa&on of En&w-ii&d 1-t Assay and immunablot f&r Measurement of Anti-%-A Ro and Anti-%-B la Antibodies. Anhrifis Rheum 1993. 36:1263-1273. Peptide, and the Calm A: HLA-627, the Mlwitogenic Effector T-Cell. Lancef 1993. 342:629. Campbell IK, Waring P, Novak u. Hamilton IA: Production of Leukemia Inhibitory Factor by Hunan Micubr and Cartilage in Rcrporac to Chm&c+es Interkukin-1 and Tuner Necrasis Factor-alpha. Anhrifis Rheum 1993, 36:790-794. . Cannon CW. Emkev RD. Dews A. Et Al: Pr-tive 5. Year Follmw~. of Recomh&t Interfero&nuna in RA. / Rhe&d 1993, 20:1867-1873. Carson CW, tleall LD, Hunder CC. lohnson CM, Newman w: Sol&c E-Selectin is Increased in lnfl-tory Symvfal Flu&J. I Rheumafoll994, 21:M)5-611. Casciolarosen LA, Anhalt C, Rosen A: Autoantigens Tsqeted in Sy&nnic Lupus ErythcMtosus are Clustered in Two Pop&ions d S&ace Stsuctun on Afsaptatic Kerathwcyles. I Exp Med 1994, 179z1317-1330. Cash JM, Klippel JH: Second-Line Drug Therapy for Rhetanatdd Arthritis. N End I Med 1994. 3303136&13X. Caswsanaisla Cl, Herreramaninez G, Vegamdina I: Erythema Nodaun and Takayasu Art&ii after lmmunfzation with plasma Derived Hepatitis-B Vaccine. j Rhewnald 1993,20:1417-1418. Caulier M. Dromer C. Andrieu V, Lewenne~ P, Four&! El: SulfaxJaaine Induced Lupu, injiheumatoid Arthritis. / Rhewnafoll994, 21:750-751. Chen C, Radic MZ, Erikson I, Camper SA, Litwin S, Hardy . RR, Weigen M: Defetion and Editia of B Cells that Express Antibodies to DNA. / lmmund 1994, 152:1970-1982. 1261. Chen E, Keyslone EC, Fish EN: Restricted Cylddne Expaiat in Rheumatoid Arthritis. Arthritis Rheum 1993,36:901-910. Cicuttini FM, Martin M, Boyd AW: Cylokine Induction of Adhesbn Molecules on Synovial Type B Cells. I Rheumato/1994,21:40Ml2. Cirino G, Cicala C, Sorrentino L, Maiello FM, Browning IL: Recanbinnt Secreted Ncqancrtatic Pfqshdii A(2) lndum a Synovitklik ldkmutkm in the Rat Air Pouch. / Rheumatd 1994,21:B24-329. Clarke F, Crook P, Mcdonagh J: Lyrnphmutofd crandonw* an ullutual clac of wkmlmatory A&sit& (Letter]. I Rheumafd 1994,21:774-775. Cohen B: ttParwvirw 619 tdection in Kawzuki LanceI 1994,344%. Dii. Cohen MG: Ant&o&s toChDNAinDnsgInduced [letter]. I Rheumato/ 1994, :z&r Cole BC, Griffith; MM: Trfgge#fng and Exacerbation Atth&bythtMyC+lllW z Arthritis Rheum 1993, 3L:994-1002. Cornillet P, Petmafwte IL, Philben F, Bouwois P, Kahn MF, Kazatchkine MD, Cohen IHM: C&pkment c4A-c&eDekuoninPatiwtstiths)%temicLupus Er*danaou in Fmwe Iktterl. I Rhewnatd 1993, 2&1633-1634. Cram DS. Fisicaro N, Mcneilage LJ, C-1 RL, Harrison ?? * LC:AaubodySpcifieitkrdThaiandkstnl*n kkrodcnru Sera Wfth Topobamac-I Recan&nant Fuia Proteins. I fmmuno/ 1993,151:6872-6&31_ [25t]. Crilly A, Madhok R: Ttw Effuls of B on Sdubk Is&de&in-l Receptor Lewh in ttheunatoid

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Arthritis - Comment [Letter]. Arthritis Rheum 1994, 37:597x598. Crotford LI, Sane H, Karalis K, Friedman TC, Epps HR. Remmers EF, M&hem P, Chrousos CP, Wiider RL: Corticotropin-Releasing Hormone in Synwial Fluids and Issues d Patients with Rheumatoid Arthritis and Osteoarthritis. I lmmund 1993, 151:1587-1596. Crotiord LJ, Wilder RL, Rislimaki AP, hno H, Remmers EF, Epps HR. Hla T: Cyclooxygenase-1 and -2 Expression in Rheumatoid Sync&l Tissues. Effects of Interleukin-1 Beta, f%wbd Ester, and Corticateroids. I C/in /west 1994, 93:1095-1101. Csepany T, Valikovics A, Fulesdi 6, Kiss E, Szegedi G. Csiba L: Cerebral Systemic Lupus Esythematcmts (vol 343, Pg 1103, 1994). Lancer 1994, 343:1512. Curtis N, Et Al: Toxic Shock Syndrome Toxin-Secreting Staphylococcw Awew in Kawaki Syndrome [letter]. Lancer 1994, 343:299. Gush II, Rothlein R, Lmdsley HE, Mainolii EA. Lipsky PE: increased Levek of Circulating Intercellular A&ion Moleculcl in the Sera of Patients with Rheumatoid Arthritis. Anhritis Rheum 1993, 36:1098-1102. Cut010 M, Accardo 5, Villqgio B, Clerico P, Bagnasco M. Coviello DA, Carruba G. Locasto M, Caslagnetla L: Presence of Estrogen-Binding Sites on MacrophageLike Synoviacyies asd CDB+, CD29+, CD45RO+ TLymphocytes in Normal and Rhcurutoid Synovium. ,&h&;s Rheum 1993, 36:1087-1097. Dalakas MC: Intravenous lmmum Globulin for Dermatomyositis _ Reply [Letter]. N En@ 1 Med 1994. 330:1392-l 393. Dang H, Ogawa N, Takei M, Lazaridis K, Talal N: Induction d Lupus-Associated At&antibodies by hnmudzatii with Native and Recombbunt Ig Pdypcptides Expressing a Cross-Reactive ldiotyp 484. I hnmund 1993,151:7260-7267. Dasgupta B: Serial Estbnation of Serwn Interkukin6 Durfw Treabnent with Recanbilunt Human Erylhrqditin in Patientr with the Anemia of Rlwwnatoid Arthritis - Reply [LetterI. I Rheumafol 1993, 20:1255. Dasilva JAP, Colvillenash P, Specfor TD, Scott DL, Willoughby DA: IntIatmnation-Induced Cartilage DetTradation in Female Rodents - Protective Role of SeiHomwnes. Arthritis Rheum 1993, 3(:1007-1013. Dasilva IAP. Larbre IP. Seed MP. Cutdo M. Vdlaw.io B. &oh DL, Gl&hby DA: Sex Differen& in lnflammatim I&&d &rtilage Drnage in Rodents _ the lnfkbmcc of Sex Steroids. I Rheumarol 1994. 21:330-337. Davey MP, Munkirs DD: Patterns d T-Cell Receptor Variabk Beta-Gene Exwession bv Svnovial Fluid and Perfpberal Blood T-Cells in Rhe&aioid Arthritis. C/in lmmund lmmunopathd 1993,68:79-87. Dawisha SM. Cmelig&yling F, Steinberg AD: A%essment of Clinical Pamten Associated with Increased Frequency of Mutant T Celk in Patients with S@emic Lupus Erythematosus. Arthrifis Rhwm 1994, 37:270-277. De&net I, Briolay I, Rissoan MC, Chomarat P, Calizzi IP, Banchereau 1, Miossec P: IL-l Inhibits Growth FwtorSthndated Rheututoid Synoviocyte Proliferation by Bhxkblg the Early Phases of the Cdl Cycle. I lmmund 1993, 151:49084917. Delany AM, Brinckerhoff CE: The Syntktic Retbwid (4. Hvdmxvd~~vl)Retinamiwnidc Decreases Cdlacen E&es& l&o and in the Tight-Skin MC&. Aihrifis Rhwm 1993, 36:983-9%). Dellestable F. Kures L. Mainard D. Pere p. Gaucher A: Fungal Arthritis Due to Pseudallescheria Boydii (Sccdaporiun Apiospe-). / Rheumaroll994, 213766-768. Delpapa N, Conforll G, Gambini D, Larosa L, Tincam A. Dcruz D, Khamashta M, Hughes GRV, Ealeswieri G, Meroni PL: End&dial St&cc Proteins Recoyized by Anti-End&dial . . Ant&&esinPrinwyandSecondaryM0immune Vaaaditii C/in h-nmunol lmmuMparho/ 1994, 70:211-216. Demaison C, Chastagnw P, Theze I, Zcuali M: Somatic Di in the Heaw Chafn Vari&k Reaion

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lqus-&&ted &phritogmk - Anti-DNA PmN~t/Acad5ciU5A1994.91:514-518.

ldiatyje.

Denburg SD, Behmann SA, C&x& RM, Denbq !A: Lwphoo4~ Antkens in NNopychiatrfc Systemic Lisp&E$kntat&s d Lympihocyle Ant&t& Smxificities to Clinical Dfsease. Arthritis Rheum 1994,37:369-375. Des& DD, Krirhnan MR. Swindle IT, Marion TN: Anti&wSpecif& tn&+s d As&o&es Against Mnmkn DNA M Nauuloimmtme Mice. I fmmund 1993, 151:16lC1626. Digiovine F, Bailly 5, Bootman I, Almond N, Duff CW: Absence of Lentiviral and Human T Cell Leukemia

Refr&&Wp

Viral Sequences in Patients with Rheumatoid Arthritis. Arthrifis Rheum 1994, 37:349-358. Dweskeneli H, Dcruz D, Khamashta MA, Hughes GRV: Autoantibodies Agairnt Endothelfal Celli, Wracelhdar Matrix, and Human Collagen Type IV in Patients with Svstemic Vasculitis. C/in Jmmunol Immunorwhol 1494, 70:206-210. Dolman KM, Cans ROB, Vewaat TI, Zevenbergen G, Mainuv D. Nikkels RE. Danker AIM. Borne AEGKV. Gdd&&ding R: Vas&itis and &eutrophil Cytoplasmic Autoantibodi~ Associated with P&ylthicuracil Therapy. lancer 1993, 342:651-652. Do&v MA. Gush IL Lioskv PE. Dawson DV. Pisetskv D!.: Th; Effecbof ‘N&D iberapy in E&ly RA on Serum Levek of Sdubtc IL-2 Receptor, CD4 and CD& / Rheumatoll993,20:1857-1862. Dore S. Pelletier IP. Dbattista IA. T&if G. Brazeau P. Martelpellelie; I: H&eoarth&ic Chond&yta Powss an Increased Nunkr d Insulin-like Growth Factor 1 Bindi% Sites But are Unresponsive to Its Stimulation -Possibk Rde of ICF-1-BindinR Rot&s. ” Alrhriris Rhwm 1994, 37:253-263. Drake CC, Babcock SK, Palmer E, K&zin BL: Genetic Analysis of the NZB Contribution to Lupus-Like Autoimmunc Disease in (NZB X NrwIF-1 Mice. Proc Nad Acad SC; U 5 A 1994,91:4062-4066. Duclos TW, Zlock LT. Hicks PS, Mold C: Decreased Autoantibody Levek and Enhanced Swvival of (NZB X NZW F(1) Mice Treated with C-Reactive Protein. C/in lmmunol lmmunoparholl994, 70:22-27. Durand IM, Kaplanski G, T&lle H, Soubeyrand 1, Pa& F: Bemficiaf Effects d tnterfwon-alohaf2b) in Behcet’s Disease. Arrhriris Rheum 1993,3&1025-1026. Durie FH, Fava RA, Fey TM, Aruffo A, Ledbetter )A, Noelle RI: Rcvention of Collagen-Induced Arthritis with an Antibody to Gp39, the Ugand far CMO. 5cience 1993, 261:13261330. Dybwad A, Fcxre 0, Kjeldsenkragh I, Nawig IB, Siwd M: IdentiLation of New B-CeH Edtows in the Sen of Rheumatoid Arthritis Patients ‘U&g a Random Nanopeptide F%age Library. Eur / fmmund 1993, 23:3189-3193. Eberhardt K, G&b R, Johnson U, Pettersson H: HLA-OR Antigens, Cm ~llotypes and Antiallotypes in Early RA -Their Relation to Disease Pqression. I Rheumaml 1993, 20~1825-1829. Edwards T, Thomas RD. Mchugh NJ: Antiurdidipin Antibodies in lschaemic Heart Disease [Letter]. Lancer 1993, 342:989. Ehrenstein MR, Longhurst CM, Latchman DS, lsenbeq DA: Serdogical ad Genetic Characterization of a l&man htonoclonal lmnunodobdin G Anti-DNA Idiotwe. I ,* c/in Invest 1994,93:i787-1797. Ehces Ml, Tsai V, Swahl D, Gael AS, Tdlefson V, Arrhenius T, Wayner EA. Caeta FCA, Fikes ID, Firestein Gs: Expression and Functional Significance d Alternatively Spliced Ctl Fihronectin in Rheumatoid Arthritis Microvasculatwe. I C/in lrwesf 1994, 93:405-416. Elhott Mj, Maini RN, Feldmxm M, LonRfox A, Charles P, Kalsikis P, Erennan FM, Walker 1, &I Ii, Ghrayeb I, Woodv IN: Treatment of Rkumatoid Arthritis with Chimtiii Monorbnal Antibodies to Tumor Necrosis Factor-alpha Arthritis Rheum 1993,36:1681-1690. Emlen W, Niebur 1, K&m R: Accekrated in Vitro Afx+nis of Lymphocyte fmm F’atimb with I lmmundl994, Systemic Lupa ErylW 152:3685-3692. Erlksson P, Almrah G, Denneberg T, Lindstrom FD: lgC2 Defiiiency in Prhnary Sjogrens Syndrome and HypeavmudohJinemic F’wp~ra. C/in lmmunol rmmuqadlo/ 1994,7Bz6065. Esser RE, Angelo RA, Murphey MD, Watts LM, Thornburg LP, Palmer IT, Talhwk IW, Smith RE: Cysteim plot&we lnhibiton Decrease Micdar Cartilage and Bone Destruction in Chronic Idkmnatory Arthritis. Anhriris Rheum 1994, 37236-247. Esser RE, Watts LM, Aqelo RA, Thornbur~ LP. Prior II, Palmer IT: The E%cts d FluommihylKetone Inhibiton d Cathemfn-B on Adiwant Induced Arthrftk. / Rheun& 1993,zo:i 176-l 183. d Sam tnterkukin-6 Dwing Trtabnmt with Reco&inu* HLrythropo*tin inPatientswfththeAnen&dRkunatddAtihritir

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- Reply [Ldtnl. I Rheumaro/l993,20:1254-1255. ldng Q. Kanwapell CC, Gaskin F, Sdan~n A, Koopman WI, Fu SM: Htmlat~ m Factors with Restrfctive Spedtkity for Rabhft Inanw@bulin c - Auto. ud Mdti-Reacwty, Dfver¶e v-n CmScgncnt~andPr&evlutJsageof Vf*mbc*)liii I 1994, 17931445-1456. Fader J, Than A, Tsikas 0, Vondedwch ii, Frolich JC: Enhanced Sydhesk d Cydebvyi kukob’im in fwenik Rbnanatofd Arthritis. Arthritis Rheum 1994. 37:93-97.

ExpMed

Autoimmunity

F&on D, Anderson I, Boerr M, Bombardier C, Furst D, Goldsmith C, Lightfoot R, Paulur H, Tugwell P, Weinblatt M, Katz L, Williams HI, Wolfe F: Reduced loint Cwntr in Rhcunatoid Arthritis Clinical Trials. Arthritis Rhwm 1994,37:463-464. Fbeld M, Clinton L: Expression of CMCSF Receptor in Rheumatoid Arthritis [letter]. Lancer 1993, 342:1244. Finkel TH, Torok TI, Fequson PI, Durigon EL, Zaki SR, Leun~ DYM, Harbeck RI, Gel/and EW, Saulrbq FT, Hollirter JR, Anderson LJ: Chronic Parvovirur 619 Infection and Systendc Necrotising Vaculitis: Oomuhmistic Infection or Aetidocical ARent? Lance1 1554, 343:1255-1258. Fishwld DM, Strand V: Mminktratio” of a” Anti-Cd5 tmmunoconjugate to Patients with Rhewwtoid Arthritis -Effect on Peripheral Blood Mononuclear Cells and in Vitro tmnwne Function. I Rheurn~fol 1994, 21:596&x ford DK: Synovisl Lymphocytes can Indicate Specific Microbiologic Cwacr of Rheumatoid Arthritis. Arthritis Rhwm 1993, 36:1350-1352. Fox RI, KanR HI, Ando D, Abrams 1, Piss E: Cyiokine MRNA Expresston in Salivary Gland Biopsies of Siogren’s Syndrome. I /mmuno/1994, 152:5532-5539. Franch A, Castellote C, Vila IL, V~laro 5, Caste11M: AnticvtosJteletal Autoantibodv Devclormcnt in Ad&ant Mhritis. / Rheurn&/1994,‘21:489~97. Frank MB, Mattei MC: Mappiq of the H-n 6OBOO M(R) Ro/SSA Locus _ the Ccmr for Three Ro/SSA Autoantigens we Located on Separate Chromosomes. lmmonofienerics 1994, 3942843 Fraser DD, S&iano GP, Butler TW, Treadwell EL: Neutrwenia of Feltw Svndrcmw Successhdlv Treated with C&ulocyte &l&y Stimulating Facto; [Lettcrl. / Rheumaro/l993,20:1447-1448. Fredriksen K, Osei A, Sundsfjord A, Traavik T, Rekvig OP: On the Btdaiul Ortcin of Anti.Double-Stranded (DS)DNA An&&es -Syst&c lupus ErythentatowsRelated AntidsDNA Antibodies we l&cd by Polvornavirus Bk in Lucus-Prom (Nzbxnzw) F1 liybrids, But not in &NI Mice. Eur / fmmunol 1994, 24:6a70. Fries IF, Hochberg MC, MedsRer TA, Hunder CC, Bombardier C. Altman RD. Arnett FC, Cassidv IT, Cladman DD, Lightfoot RW, Schwartz 61% White 8: Criteria for Rheunatic Disease -Different Types and Different Functions. Arthritis Rheum 1994, 37:454-462. Fuchs HA, Pincus T: Reduced Joint Counts in Controlled Clinical Trials in Rheumatoid Arthritis. Arthritis Rhwm 1994,37:470-475. Gabrielli A, Diloreto C, Taborro R, Candela M, Samba P, Nitti C, Danieli MC, Delustro F. Dasch IR. Danieli G: Irmwnohisttoehrmical Localiition cd Intracellular and Extracelkdar Associated TCF-beta in the Ski” of Patients with Svstmtic Sclerosis (Sclcmderma) and Primary Raynatd Phmommm Cl/n /mmuno/ /rnmunopaiiw/ i993,6&340-349. Caneemi RMR. Sinclh AK. Barrett KI: lndeoendmtlv Derived I& &Ii-DNA Mo&bodib from iwo Lupus-Pmne Mouse Strains Exprw a VH Gene that is not Present in Most Mwine Straina / /mmuno/l993, 151:466C4671. Cay D, Saunders T, Camper 5, WeiRert MC: Receptor ?? . Editi* a” Approach by M&active B Ccl); to Escaw Tderance. I FXD Med 1993,177:999-1008. 1231: Gherardi R, B&c L, Mhiri C, Gray F, Lescs MC, 5&l A. Cuillevin L, Wechsler I: The Spectrum of V&culitis in Human kwmwddiiiency Virw-Infected Patients - a Clinicqutwc Evahution. Arthritis Rheum 1993, 3&1164-1174. Gilliam AC, Ueitz JA: Rwe Sckmdemu Autoantibodies to the Ul 1 snvll Nuclear Ribwuckapmtein and to the Trinwthy@“aim Gp of U-RNA Small Nuclear RNA. Prcx Nat/ Acad SC; U S A 1993,90:67814785. Gladman DD: Tow& Umaveling the Mystery of Psoriatic Ar%tii Arthriris Rhwrn 1993, 36:881-884. Ghckstein SL: Lu~lib f’rewntitian d tiParvcwi~ El9 hdectio” [letter]. / Rheurnafol 1993. 20:1253. Gorski A, PiekarczYk I, Skurzak H, Nowacryk M, Dybowska B, &pienropniewsb 8, Ko&akkowalska G. Pazdur I. Filioowiczsosncwska A: Abnwnufities in’T-Cdl l~e&tiuw with the Extracell&& Matrix Proteins in = Rticnc with Wqe”ers Cnmdarutosis. C/in /mmuno/ /mmuncpafho/ i993,69:149-154. Grlffiths AD. Williams SC. Hartlev 0. Tomlinson IA. Waterhouse P, Cm& WL, K&t&ma”” RE, Jones PT, LOW NM, Allison~TJ et A/.: kddiat d Hi@ Af%itv liurrn At&“&s Directlvfmm Sv”th&c Rqert’oim. FM801 1994, 13:3~4’~326&‘j211. Grober IS, Bowen EL, Ebling ii, Athey 8, Thompson CB. Fox DA, Stoolman LM: MmocyicEndothcl&t ”

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Adhesion in Chronic Rheumatoid Arthritis _ lnsitu Detection of Selectin ad IntegrirrDependent tnteracticms. I C/in Invest 1993. 91:2609-2619 Cram AA, Thorn&on SD, Luyrink L; Passe M, Choi E, Glass DN: Dani”xd T-Cell-Receptor-beta Chain Variable Region V Beta 14+ Cloncr in Juvenile Rheumatoid Arthritis. f’rcx Nat/ Acad SC; U S A 1993. 90:11104-11108. Guollevin L, Virser Ii, Noel LH, Pourrat I, Vernier I, Gayraud M, Oksman F, Lesavre P: Antineutrophil Cytoplasm Antibodies in Systemic PdyarterilisN.&k& with and With&Hepatitis-B-Virus infection and Chum-Strauss Svndmnw - 62 Patients. / Rheumafol1993, 2&l 345-l 3h9. Culko PS, Revedle ID, Koopman WI, Burgard SL, Bartolucci AA, Alarcon GS: Anticardidipin Antibodii in Systemic Lupus Erythmutoru _ Clinical Correlates, HLA Asswiatiws, and Impact on Survival. / Rheumaroll993, 2031684-1693. Culko PS. Reveille ID. Koooman WI. Bumard SL. Ban&i AA,~Aixon’ GS: S&&l ‘impact of Autoantibodia in Systemic Lupus Erylhatosus. / Rheumafoll994. 21:224-228. Cws 5E. Villa NC, Cocco IAM, Barcelo HA, Schemes El, Catopgio LJ, Moreno C, RavaRlia C, Palioni I: S&ens Synd&e in Srmnegattw S&loarthropathi& Unuwal Finding Iletter]. / Rhwmafol 1994, 21~771-772. Hack CE, Abbink II, Kamp AM, Nuijens IH, Swaak TIC: Mechankms of Alolu0)_Antitrvnsin tnactivation in Arthritic Joints iply [Letter]: ;\rfhrifis Rheum 1994, 371151-152. Wakala M, Karttunen R, llonen I: Elevated Soluble lnterleukin-2 Receptors are Associated with ArtJhitk IM am not Helpful in Making a Specifx Diagnoris [Letter]. / Rheumafol t993,20:144al449. Hakcda M, lshimoto T, Hayashimoto S, lnoue K, Taniguchi A, Kamatani N, Kashiwazaki 5: Selective tntiltraticm of ECclk Cmmitted to the Production of Mowreactive Rheumatoid Factor in Synovial Tissue of Patienti with Rheumatoid Arthritis. C/in lmmunol /mmurwpafho/ 1993,69:1a22. Halpern MD; Craven SY, Cohen PL, Eisenberg RA: Rerulation of Anti&n Autoantibodies bv the l~lotadi” Heavy CWn Locus. I ;mmuno/ 1993,151:7268-7272. Hamilton IA: Rheunatoid Arthritis Opposing Actions of Haenwpdetic Growth Factors and Slow-actb?g Antirhwniatotd drugs. ~ancef 1993,342:53a539. Hamilton IA, Butler DM, Stanton H: Cyiokinc Interactions Pmmotin# DNA Synthesis in Hunun Synovial Fib&last% / Rheumafoll994, 21:797-803. Hariaai M, Ham M, Yorhimura T, Leonard El, Incue ‘ic, Kashiwazaki S: Monocyle Chenwxttractant Protein-l (MCP-1) in Infkwmuton l&t Diseases and Its lnvdvmrnt in the Cyl”&Network of Rheumatoid Symviun. C/in lmmunol lmmunoparhol 1993,69:83-91. Harth M: Effects of Gdd on Interkddn-2 and Interleukin2 Receptor _ Comment [Letter]. Anhrifis Rheum 1994, 37:147. He XW, Goronzy II, Weyand CM: The Repertoire of Rhetmutoid Facta’F’roduciq R-Cc& in Nornxd S&i&s nd Patients with Rheumatoid Arthritis. Art/& Rhwm 1993, 36:106-1069 H&bar M, lanin A, Huglo D, Capin MC, Lalyatir R, Devulder B. Marchandise X. Corset D: Xerostomia in Systemic Sckmsk - S&n& Evakution by Sal&y Scintigraphy a”d lip Biqsy in Thirty-iour Patitimb Ilettcrl. Arthr/t/s Rheum 1994. 37:439-441. Henrhaw TI. &I&I; CC, Gabay IE, Williar&RC: Elevatitms of Neutrophil F’rotebuse 3 in Serum of Wenb with Wege”en Grwulonutosis and Pdva&ritii No&a. Arthriris Rheum 1994, 37:iO4-112. Hentati B, hto MN, Payellebqard 8, Avrameas 5. Ternvnck T: Ben&id EtFect of Pdvcional I”m&&b&m fnmt Mdaria-b&&d BALB/C Mice on the Lupa-Like Sy&onw cd (NZB X N&F1 Mice. EuurI fmrrwno/ 1994,zI:ai 5. Hermann E, Yu DTY, Zumbvxh~&l& KHM, Fleircher B: HLA-B27-Restrktzd CD6 T-Cetk LIwivtd from Svnwid Fluids of Patients with Rextivr Arthritis and A&i&~ @nd@tk. Lancei 1993,342:646650. Herranz MT, Rivier C, Khamashta MA, Blase, KU, HuRhea GRv:Aw&tiwlktweenAntiphc+dii A”hb&tsndEpikpsyi”P&mtswitbSystrmic $I&F.E A&iris Rheum 1994,

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Hess AD: Mcchniura d Actii d Cycbsporinc ConridcntiorafortbrT~ofAutoimrmne Diseases. C/in frnmunol /mmunoparholt993, 6&220-228. Heytman M, Ahern Ml, Smith MD, Rcbertsthomwn PI: The lwgtm Effect of Puked Cwticosteroids cm the

Rheumatological

diseases

Efficacy and Toxicity of Chrywlhcnpy in Rheumatoid Arthritis. I Rheumarol 1994, 21:435441. Hqh WB, Bugelski PI, Nichols ME, Swift BA, Solleveld HA, t?a$er AM: Effects of 1 Novel Azqirane (Sk&f 105685) on Arthritic Lesions in the Adjjvant Lewis Rat - Attcnuatim d the Intla”mwory Pmcm and Pmservation of Skeletal Integrity. I Rheumafol 21:476-483. HiRley H, Persichitte K, Chu S, Waegell W, Vancheeswaran R. Black c: rmnmocvtocheminl Localization and Serologic Detection o( Tramforming Growth Factor Beti 1 -Assaciition with Type Procdlagen and Infla”mn&ry Cell Markers in Diffuse a”d Limited Systmric Sckrosi~ Morphea, and Raynauds Phenomenon. Arfhriris Rhewn 1994, 37278-288. Hwakata M, Okarw Y, Pati U, Suwa A, MedsRer TA, Hardin IA, Craft I: ldentifiation of Autoa”tibadies to RNA Pdynwrase-II _ Occurre”c ??in Systemic Sclerosis and Association with Autoa”tibodies to RNA F’dy”wase-I and Pdymrase-Ill. 1 C/in /west 1993,91:2665-2672. Hlrohata 5, Kosaka M: Assoctttion of Anti&n Antibodies with Organic Brain Syndrome Secondary to Systemic Lupus Erythmratosus [Letter]. Lancef 1994, 343:796. H~rose 5, Wakiya M, Kawano-Nishi Y, Yi 1, Sanokawa . R, Taki 5, Shimamura T, Kishimoto T, Tsurui H, Nishimura H, Shirai T: Somatic Divcrsifiiation and Affiity Maturation of IgM rrd IgG Anti-DNA Antibodies in Murine Lupus. fur I /mmuno/l993, 23:2813-2820. 191. Hoffman BR, Kandel RA, Cruz TF: Effect of Pborbd Ester on the tnhibition of Prateaglyun Synthests Induced by Interleukin-1 a”d AntiinflmMtory Dogs. / RheumafoJ1993,20:1741-1746. Hoffman RW, Cassidy IT, Takeda Y, Smithjones El, Wang GS, Sharp CC: Ul-70-kD Maantibody-Positive Mixed Connective Tissue Disease in Children - a Longitudilul Clinical and Serdogtc Andy&. Arfhrifis Rheum 1993, 36:1599-1602. Hoffman RW, Takeda Y, Sharp CC, Lee DR. Hill DL, Kane& H, Caldwell Cw: Hunu” T-Cell Clam, Reactive Agairat U-Snull Nuclear Ribwwcleoprotein Autcuntigeens from Connective Tissue Disease Patitimts and Healthy Indivir&ds. I /mmuno/ 1993, 151:6460-&469. Holman BL: Functional Icing in Syrtcmic Lupus EryIhe”utosus - .111Accurate Indicator of Central Nervous Systm, lnvdvmnt. Arfhrifis Rheum 1993, 36:1193-1195. Homandberg GA, Meyers R, Williams JM: Intrurtkular Injection of Fibronectin F-U Causes Severe Depletion of Crrtbge Pro(>yunr Invivo. / Rheumafo/l993,20:137a1382. Hong GH. Kim HY, Takeuchi F, Nakano K. Yamada H, Matsuta K, Han H, T&ma@ K, 110K, Park KS: Aswciation of Ccunplcment C4 a”d HLA-h Alleles with Systendc Lupus Erythenutmus in Wore=. / Rheumaro/1994,21:442-t47. Hoshina Y, Moriuchi I, Nakamura Y, Arimori S, lchikawa Y: Cd4+ T Cdl-h&d&d Leulmpmia of Fefty~ Syndrome Successfdly Treated wtth CrandocyteColony-Stirmlati”g Factor a”d Meth”trerate. Arfhnfls Rhwm 1994,37:29a299. Horhino I, Beckmann C, Huser I, Kroger H: lderleukin 1 lktaE”ha”cestheReqonscofR&bit Synwial Fibmbfask in Vitro to Dcumcthmnc Injury - t*im for the Role of Increased Nuclear Hrprmaitive sites a”d the Nw”ber of Dexmthmnc Receptws. I Rheumafoll994, 21:616-622. Hrvcaj P, Sobieska M. Mackiewicz 5, Muller W: Micmhekrogenetty of Alpha(l )-Acid Clycopotein in Ewfy and Est&lkhed Rheumatoid Arthritis. / Rheumafo/l993,20:202a2024. Huet G, Flipo RM, Cdin C, bnin A, Hemon 8. Collyndhoqhe M, Lafyatis R, Duquesnoy B, Degand P: Stkndation d the Secretion of latent C&&e Rot&use Activity by Tunwr Necmsis F&-alpha wd Intcrieukin-1. Arfhriris Rheum 1993, 36:772-780. HuRedxrg ST, Brandt KD, Cole u\: Effect of SodiM Sdiie, Aspbin, and lbqwofe” “” Enzymes Required by the Chondmqte far Synthesis of Chandmiti” su(fate. / Rheumard 1993, 20:212E2133. Hughes CRV: The Antiphqhdipid Syndrome: Ten Years On. Lancef 1993, 342:341-344. Hultman f’, Bell Ll, Enestrom 5. Pollard KM: h&wine Swccdibitity 2. Moantibody Deposits in H’wd, Pmtilka”d‘Re”d t”t”& t3ackcross, nd H-2d Cmgenk Mice. C/in lmmunol lmmunopatho/1993,6&~20. Humbria A, Diaqonzalez F, Campanero MR. Arroyo AC. Laffon A. Conzalezamaro R. Sanchezmadrid F: Ex&sto” d &kcti”, Cd43, nd Cd44 in Synovial Fluid Neutrophih from Paticnb with lnfl-tory

I994,

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joint Disc- Evidence for a Soluble Form of L-Selecti” in Synwial Fluid. Anhritis Rheurn 1994, 37342-348. Humphreysbeher MC, Brinkley 1, Purushotham KR, Wang PL, Nakagawa Y, Dusek D, Kerr M, Chegini N, Chan EKL: Characterization of Antbwckar Autoantibodies Present in the Serum from Nambese Diabetic (NOD) Mice. C/in lmmud hnmunopatholl993, 6&35&356. Hunder CC, Lie IT, Coronzy II, Weyand CM: Current Conmwnt - Pathngenesis of Giant Cell Meritir. Arthritis Rheum 1993,36x757-761. Hundt M, Zielinskaskowronek M, Schmldl RE: Fc-gannna Receptor Activation d Neutrophils in CrynglobulinInduced Leubucyioclastic Vasculitir. Althriris Rheum 1993,36:974-982. Hunt DWC. Corron L. Barker HO. Levv IG. Pertv Rt: Relati&bip Ret&” Cdl&“-In&cd anb Adjuvant Artbrith in the Lewis Rat. I Auroimmun 1993,6:691-700. Hunter T: The ho~nosis of E&r/y Rheumatoid Arthritis How F.&y is -My. / Rhewkoll993, 20:1999-2000. lmai F. Suzuki T. lshibashi T. Tanaka M. Akivama Y. Doht on B Cell Hy&ac&ity y: Et%ct nf’Sdfatalaz& in Patknb with Rbeuntatoid Arthritis. I Rheomard 1994, 21:612-615. lsacovics 6, Silverman ED: Limitim Dilution Analysis of Epstein-Rarv Vi lnfectaMe &Cells Secreting Anti-Ro/SSA and Anti-la/SW Antibodies in Nermdd Lupus Erythematosus and Systemic Lupus Erythmutosus. / Autoimmun 1993, 6:481494. lsenberg DA, Ehrenstein MR, Longhurst C. K&i JK: The Ori@, Sqence, Stmctwe, and Consequences of Dewfopbtg Anti-DNA Antibodies - a Htanan Perwectivc. Arthriris Rheum 1994, 37169-l 80. Irhoda ti,‘Muchanwel T, Sakaguchi S, Andrade 5, Menon 5. Howard M: ContiAdndnktration of Anti-lr&eukin 10 Antibodies Delay Onsrt of Autnirmnurdty in NZBIW F-l Mice. / Exp Med 1994, 179:305-310. lacobs JC, lmundn LF: Silicone Implants and Autnbmnunc Diiale [Letterl. Lancer 1994, 343:35&355. laccbson EA. Sharon I, Shari H, Shlonwhik M, Weiaert MC, Marshakrothrtein A: A” Isotype Switched’ and Sanutiullv Mutated Rhewnatnid Factor Clone lsdated’bnm a MRL-Lpr/Lp Mouse Exhibits Limited lntmlonal Affinity Maturation. / /rnrnuno/ 1994,152:44894499. lansson 1, Holmdahl R: The Y chmmmnnw-liked ‘autdmnwn Accelerating” Yaa Gene Sqpwsn Cdlagen-induced Arthritis. Fur / lmmund 1994, 24:1213-1217. longenlavrencic M, 5waak A/C, Vreugdenhil C: Serial Estimation of Serwn lnterieukin-6 During Treatment with Recombinant Human Erytlwopuietin in Patients with the Anemia of Rheunatdd Arlbrkb [LetterI. I Rheumad 1993,20:1253-1254. lulkunen H, Kurki P, Kaaja R, Heikkila R, lmmonen I, Chan EKL, Wallgren E, Friman C: tsdated Cnngmital Heart Block - Lrqf-Tmn Outcnnw of Mothcn and Chnctcriulkm d the tnnnune Rapaa+ to SS-AIR” and to %-R/La. Anhriris Rhwm 1993, x1588-1 598. Kageyama Y, Koide Y, Miyamoto 5, Inoue T, Yoshida TO: lbeRfasedVGwmuCeneUsageintbeSynnvial Fluid d Patknts with Rheumatoid Arthritis. Fur I hnrnuno/ 1994,24:1122-1129. Kalirh RA, Knopf AN, Canoso II, Gary W: Lupus-like &senhtion of Human Pvvovina 619 Infectinn Reply [Letter]. / Rheumatd 1993, 20:1253. Kaplan 5, Hyman K. Brooks R. Wakai M, Hashimoto 5, Furie R, Chiorazzi N: Monociond IgM, IgG, and IgA HRbetmutnid Factam Pm&cd by Synovid &Cdl iii (Vd Tiuc-De&d, ERV-Traafnmwd 66, Fg 18,1993). c/in lr”muno/ /mmu”opadlo/ 1993. 60:93. Kasaian MT, lkematw H. Balow IE, Carali P: Structure . oftiteVHandVtSeRmcnbdMnnweactiwand Pdyrwtiw I@ Autoantibodies to DNA in Mients / frnrnurro/ 1994, with Syskmfc Lupg Eryihematnw. 152:3137-3151. 117). Kate T, Yamamoto K. Takeuchi t-l. Ok&o M, Hara E. Nakxla S, Qda KI, ho K. Nirhioka K: Idmtbicatinn d a Univmal R-Cdl Epftopc on DNA Topobanwrac-I, an Automt+ Assoc&d with Sclcmdcnru. Arthritis Rheum 1993,36:1580-1587. Katsikir PD. Chu CQ, Brennan FM, Maini RN, Fe/dmann M:wIdCdlntnWinlO inRhwmtaidArUwfds.!ExpMed1994, lr):1517-1527. Keech CL, Go&n TF’, Reynolds P, McCluskey I: Erqwession andFtmct&&CmwntiandthtH-la&S R)HdsrAwudgeninMuincCdLirn./ Aumirnrnun 1993,6:543-555. K&tar A, bitta MR. Keene ID: Mdccu*r Conpo*tion

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Kerr C, Hoifman CS: Relationship Between Antineutrophil Cytoplasndc Antibody Levels and Disease Activity in Wegenerr Granulanatusis . Reply [Letter]. Arthritis Rhewn 1994, 37:596-597. Klemau 5, Klareskq L: Oil-induced Arthritis in DA Rats Passive Transfer by T-Cells But not with Serum. / Autoimmun 1993, 6:449-+58. Klinman DM, Shirai A, Conover I, Steinberg AD: CrnssReactivity of i8G Anti-DNA-Secreting Et Cells in Patients with S~tendc Lupus Erythematnsus. Fur / lmmuno/l994,24:53-58. Knlfiht GE, A+lo V, Bonagura V, Earner IL, Panka DI, ZhanR QX: Human Rheunutnid Factnr Cm&s. Idiot& 4. Studies on WA Xld-Pnsitive IgM Without Rhemnatoid Factor Aclivitv Provide Evidence that the WA Xld is not Unique to &urnatoid Facturs and is Distinct fran the 17.109 and C6 Xids. I Exp Med 1993, 17tI:1903-1911. Knott I, Dieu M, Burton M, Houbio” A, Remacle I, Raes M: Inductii d Cyclnnxywmse by lnterkukin 1 Cnmparative Study Beh& Hun& Synovial Cells and Chnndrncvtes. I Rheuma@~/ 1994. 21:462-466. Knupp Cl, Uner AG, K&thar C, Gavalchin I: Characterization of Id(LN)F(l )-Specific T-Cell Clones from the (NZB XSWRr)F(l ) &twine Model for Systanic lupus Erylbmutnsus. C/in lmmonol /mmunopdrho/ 1993,68:273-282. Kobayashi R, Rasrenti LZ, Meisenholder C, Carson DA. Kipps TI: Autnantign Inhibits Apnptwir of a Human B-Cell Leukemia that Ruduces Pathogenic Rheunatoid Factor. / lmmund 1993, 151:7273-7283. Koch AE. Harlow LA, Hainer GK. Amen10 EP. Unemori EN, Wang WL, Pope RM, Ferrara N: Vascular Endothclial Cytokine Modulating End&dial Crnwih Factor Function in Rheumatoid Arthritis. I frnmund 1994, 152:4149-4156. Koch AE, Kunkel SL, Harlow LA, Mazarakis DD, Haines GK. Burdick MD. Pow RM. Stricter RM: Macmohaxe Inf*mmatnry Rot&l Alpha _ a Novel Chm&ta&c Cytokin for Macrophages in Rheunmtnid Arthritis. I C/in lnvesl 1994, 93:921-928. Koch AE, Shah MR. Harlow LA, Levis RM, Pope RM: Soluble Intercellular Adhesion Molecule-i in Arthritis. C/in lmmunol Immunopathol 1994, 71:2oa215. Koch AE, Turkwwicz W, Harlcw LA, Pope RM: Sdublc E-Selecti” in Arthritis. C/in lmmunol lmmunwarhol 1993, 6929-35. Kraus A, Cifuenter M. Villa AR, lakez I, Reyes E, Alarconwovia D: Mvusitis in Rinwv Siolrens Syndwrne”- Report d 3 Case% / Rh&n.d 1994, 21:649-653. Kretidstem 5H. Lytwyn A, Keyslone EC: Takayasu Arteritir with Acute Interstitial Pneuntnnia and Coronary Vasculitis . Expanding the Spectrum. Arthriris Rheum 1993, 36:1175-1178. Kuwana M, Kaburaki I, Minwri T, To/o T, Homma M: ,t”tOdi@C Epitopcr on DNA Tnp&merare-I _ Clinical and Irmwnownetic Aswciatiom in SvJtemic S&r&. Arthriris Rhkn 1993, 3b:140&14lj. Kuwana M, Kaburaki 1, Qkano Y, lnoko H, Tsuji K: The HLA-DR and DQ Genes Control the Autoimmune Response to DNA Tcrpnbmenrc-I in Systemic Scierab &I emdemul. I C/in /west 1993. 921296i3ot. Lahlta RG, Rivkin E, Cavanagh I, Romano P: Luw Levels of Tutal Chnksterd, Hiih-L&&y Lipqwotein, and Apdipoprotrbr Al in Assnciatinn with Anticardidipin Andbodies in Wmb with Systendc Lupus Eqtbenntosus. Arihriris Rhwm 1993, 36:1566-1574. Lazarovits Al. Karrh I: Differential Expmssion in RheunatddSyncwiw and Synnvial Fluid d Alpha 4 Beta 7 lntegrin - a Nwel &rxptw fur Fib&ectin and VanJr Cell Adb&m htdecde-1 . I lmmunol 1993, 151:6482&i89. Lee SK. Bridges SL, Kirkham PM, Kcqma” WJ, Schroeder HW: Evidence d Antken Recentw-lnflucnced OfisodonJ B L&e Expbsion in the Syrwviun da Patient with Lo@andiq Rheumatoid Arthritis. / C/in lnvesf 1994, 931361-370. Leprar F, Martin T, Knapp AM, Pasquali JL: Infiltratiq T CdbfranPatkntsrrithPrbnwSiowcnsSyndmnw Expnr IkSbiCtcd or lhwatrict;d-T-Cdl R&tnr V RetaReRfomCbmdfnaonthcstaeeoftheDisease. Furl Im;n”“d&4,2~181-185. _ Lewalorepo M. Tunmen U, kenman 5, He&us P, Seppala K: Hi#r Fm d Siknt lnflnmanry Bawd Disease in Spwdyl&bqwby. Anhriris Rheum 1994, 37:23-31.

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DYM, hteissner HC, F&on DR, Munay DL, Kotzin BL, Schliewn PM: Toxic Sbncb Syndmnr in Kawasaki ToDL~SCC~ Shdwioc--wets S+O”U. La&i &3, 342:138S-1388. Lewthwaite I. Blake SM. Hardingham TE, Warden PI, &“dersnn8:TbeEffectd~Hwnan lntertewin 1 Receptor AntaRn& on the Induction

Phase of Antigen Induced Arthritis in the Rabbit. / Rheumarol 1994. 21:467-t72. Lw IT: Vaculitk in the Antiplwphdipid Syndrome Culprit ur Consort. / Rheumaro/l994,21:397-399. P. Hassell A. Williams K. Youne 5. Bacon P. Southwood’T, Gaston ISH: R&&es to &“I Nq@ve Enteric Bacterial Antigens by Synovial TCells fmn~ Patients with juvenile Chronic Arthritis Recognition of Heat Shnck Pmtein HSP60. / Rheumardl993, 20:1388-l 396. Lima GCD, Zyad A, Decreusefond C, Mevel JC, Stiffel C, Mouton 0, Couderc I: T-Cell Cu”tpart”w”t tnvdvernent in Two High Antibody Responder Lines of Mice (HI and lilt Biozzi Mice) Respectively !GusceptiMc and Resistant to Cd++Induced Arthritis. / Auloimmun 1993, 6:38%04. Lmkerisraeli M, Hyun S, Ozerichen T, Wallace D/, Banks K, Klinenberg JR: Elevated in Viva and in Vitro Secretion of CDB-alpha Mdecules in Patients with Systemic Lupus Erythernatows. I lmmunoll994, 152:315a3167. tlpnick RN, Sfikakis PP. Klipple CL, Tsokos CC: Elevated Sdubk CD8 Antigen and Soluble Interkukin-2 Receptors in the Sera nf Patients with Juvenile Rheumatoid Arthritis. C/m lmmund lmmunoparhol 1993, 6Bz64-67. Llvneh A, or G, Many A, Gazit E, Diamond B: Anti-DNA Antibodies Secreted by Peripheral B-Cells of Lupus Patients have Both Normal and Lupus-Specific Features. C/in lmmund lmmunoparhol 1993. 68:68-73. Loeser RF: Intcgrin-Mediited Attachment of Articular Chondrocytes to Extracellubr Matrix Proteins. Arthriris Rheum 1993, 36:1103-1110. Lohmander LS, Neame PI, Sandy ID: The Structure of Aggrecan Fragntents in Hunxm Synnvial Fluid - Evidence that Avanase Mediates Cartilage Degradation in Inflammatwy Joint Disease, joint Injury, and Osteoarthritis. Arrhriris Rheum 1993, 36:121&1222. Losman Ml, Fasy TM, Novick KE, Monesrier M: Relationships Aman# Antinuclear Antibodies from Autoinwnunc MRL Mice Reacting with Histone H2A-H2B Dimn and DNA. Inf /mmuno/ 1993, 5:513-523. Lwthrenoo W: Salmonella Septic Arthritis in Patients with Huntan Imnnmnddiiiency Virus Infection Iletter]. I Rhwmaroll993, 20:1454-1455. Lu EW, Dehos M. Olee T, Huang DF, Sotqil RW, Carron DA, Chen PP: Generation and Molecular Analyws of Two Rtitoid Sync& Fluid Derived IgG Rhewnatuid Factors. Arthrilis Rhwm 1993, 36:927-937. Machdd KP, Kiener HP, Graninger W, Graninger WE: Sdubk Intercellular Adbesii Mdecule-1 (sICAht1) in Patients with Rbeunutdd Arthritis and Syttrmic Lupus Erythmutosus. C/in lmmunol lmmunoparhol 1993.68:74-78. Mader R, Narendra” A, Lewtas 1, Bvkerk V, Goodman RCI, Dickson /R, Keystone EC: .Sfiendc Vasculitis Fdlowim Influenza Vaccination - Renwt of 3 Gates &d Literature Review. I Rhekd 1993, 20:1429-1431. Maeda T, Saikawa I, Hotokebuchi T, Sugioka Y, Elo M, Murakami Y, Nomoto K: Exacerbation d Established CdlaRe+lnbced Arthritis in Mice Treated with an Anti-T Cell Reccpta Antibody. Arthrilis Rheum 1994, 37z406-413. Maw R, Ganu V, Lotz M: lnterfeukin-11, an lnduciMc C&bin in Hwnan A&&r Chnndrncvtn and Stimulates the Robction of the Tii Inhibitor d Metalloproteinases. / Bid Chem 1993, =21527-21532. Makker SP: Analysis of Glonwuli-fluted Cp330 At&antibodies and of Gp330 Antigen of Heymann Nephritis. / lmmund 1993,151:650&6508. Malfart AM, Verbruggen G, Veyr EM, Lambert 1, Deridder L, Cornelissen M: Canparatfve and Combined Effects uf Interkukin 6, lnterieukin 1 Beta, and Tumor Necmsfs Factor Alpha on Roteoglycan Metabdism of Human Micdar Chomlmwt~ C&wed in ARarnse. / Rheumato/l994,21:314-3iO. Malvak M. 5wanw RE. Arend Wp: Levels d Svnovial Fluid ‘lotc&ki~l Reccp(or Anta@st in Rh&atnid Arthritis and Other Arihropathfes - Potendal Cnnt&ut& from Symvial Fkdd Neutrophik. Arrhdis Rheum 1993, 3(:781-789. Mamula MI, Fatenejad S, Craft I: R-Cdb F’mceor and lvesmi Lupw woarltigemthat initiate Autnfmrnune T&R Rcrpaan. / /mmum/ 1994, 1521453-1461. Manmwni L, Wilder RL, Casali P: HulM Rbewnatnid-Bla (CD5+ B) Cells Mabc -1~ H~p-utatd High Affbtity tght Rbewnatnid Facton. / lmmunol 1993, 151:473488. Mao CC, Osman GE, Adams 5, Dana SK: TCdl Receptor AlohaChain Reuertaire of Pathownic Autoantibodv-

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Autoimmunity Rheumatological diseases In&&g TIdk in Lupus Mice. I Immunol 1994. 15211462-1470. Mxan R, Dueymes M, Pennec YL, Casburnbudd R, Shoenleld Y, Youinou P: Predominance of IgGl Subclass d Anti-Ro/SSA, But not Anti-La/SSB Antibodies in Primary *en’s Syndrome. I Aufoimmun 1993, L:379-387. Marsal 5, Hall MA, Panayi CS, Lanchbury IS: Association of Tap2 Pdymwphhm with Rheumatoid Arthritis is Secondary to Alldi Association with HLA-Drbl. Anhrifis Rheum 1994, 37:504-513. Marshall KW. Theriault E. Hcmonko DA: Distribution of Subs&e P-and Caicitonin Gene Related Peptide Inmwnoreactivity in the Normal Feline Knee: I Rheumaroll994, 21 :BB3-889. Maruyama T, hito I, Miyake S, Hashimoto H. Sate K YaRita Ii, Okumura K, Miyasaka N: A Possible Rde of Two Hydrophobic Amino Acids in Antigen Recognition by Synavial T-Cells in Rheumatoid Arthritk. Eur / /mmurd 1993, 23:2059-2065. Masra M. De Benedetti F. Robbioni P. Ramerwhi Lt. Alban! 5, Martini A: Association of MTX Treat&nt with a Decrease of Double Negative (CDQ-CDB-) and Gamma/delta T Ceil Levels in Patients with IRA. Rheun&/ 1993, 20:1944 Mcarthur CP, Fox NW, Kragel P: Monoclonal Antibody Detection of Lwtinin in Minor Salivarv Glands of Patients with Sjogrcn’s Syndnwne. / Auformmun 1993,6:649-661. Mccartneyfrancir N, Allen IB, Mrzel DE, Albma JE, Xre QW, Nathan CF, Wahl SM: Suppwssion of Arthritis by an Inhibitor of Nitric Oxide Syntharc. I Fxp Med 1993, 178:749-754. MccaRy GA, Harley /B, Reichlin M: A Distinctive Autoantibodv Rufile in Black Female Patients with Lqws-Nephritis. AR/v/f/s Rheum 1993, 36:156&l 565. McHugh NJ. whyte I, Artlen C, Briggs DC, Stephens ?? CO, Olsen NJ. Cusseva NC, Maddiron PI, Black CM, Welsh K: Anti-cmtromere Antibodies (ACA) in Systendc S&n& Patients and Their Rdatives: a Serological and HLA Study. C/in Exp lmmudl994, 96:267-274. flZt1. Mcmurray RW, Allen SH, Braun AL, Rodriguez F, Walker SE: Hyperprdactincmia Ass&ted with Sntnnk Luaus Ewthenutaur: Pnssibk Homwnal Siiwlation’of a” ;*ltdmrmnt Disease. I Rheumafol 1994, 21:&03-850. Medina-Rodrieuez F, Curman C, lam LI, Et Al: Rhewnatic Manife&ionr in HIV Positive and Negative lndividualsz a Study of 2 Popdationr with Similar Risk Factors. / Rheumafd 1993,2o:lBBO-lBB4. Mellbye 01, Mollnes TE, Steen Ls: IgC Sub&w Distributton and Contpfenvmt Activation Ability of Autwmtibodia to Neutraphil Cyloplasndc Anticens (ANCAL C/in lmmunol lmmunowfholl994. 70:3x39: Mielants H, Veys EM, Cuvelier C, Dews M, Coemaere 5, Maerlens M, loos R: Gut Idlanwution in Children with Late Omt Pauciarticular Juvenile Chronic Arthritis and Evdutinn to Adult Spondyioarthropathy Rheumafoll993, 203156;-1572. M~elaRs H. Veys EM, Goemaere 5. Cuvelier C. Dews M: A Pwpecttw Study of Patients with Spondylonthmp;tby titb +&al Reference to HLA-827 and to Gti Hktdogy. / Rheurnatoll993, 20:1353-1358. Mikolich DJ, Schlaeffer F, Ryter RI: Pdymicrobiil Pdyrtku*r Mhritk [Letter]. / Rheumafol 1994, 21:971-972. Mills LA: Medical progre% Systemic Lupus Eryihematosus [twiewj. NEng//Med1994,330:1871-1879. Mlsaki Y, Pwjn GJM, Vanderkemp AWCM, Vanvenrooq WI: The 56K Monb;(lm k Identicd Human Amxin Xl. /B/d Chem 1994, 2694240-4246. Mlsra R, Et Al: Raised Anaiunliortpin in Takayasu’s Aft&k [Letter]. Lancet 1994, 343:1644. Mwhell I, Webb M, Hughes R, Maisey M, Cameron 15: cerebral Lupus. Lancer 1994,343:579-582. Mivahara H. Hotokebuchi T. Saibwa I. Arita C. ’ Takagirhi K, Suttiia t.The Effects d ltceatnbinant Hu& Gra&qie Colony-Stlmdating Factor onf’assinC~ln&cedAttlwitisTra”sfwed with Anti-Typrl~Cd&gei~ Antii. C/in lmmunol /mmunopathd 1993,69:69-76. Mlzutani H, Engelnwn RW, Kinjoh K, Kurata Y, lkehara 5, Matsuzawa Y, Good RA Cd&e Rtstiiction Prew”tstheoccfu!dvecomrvyvaculvDii~ of Autokwainc (NZW X RXSEl)F-1 Mice. Proc Nat/ Acad SC; U 5 A 1994,91:4402~406. Mall JWB, Markwe HM, Henzen~mans SC, Vecht Cl: Anti-neumnd Ant&&es in S&m~‘s Syndrome and in B Newdogicd Diiase Iletter]. Lancer 1994,34):1299. Morand EF, jefferiss CM, Dixey J, Mitra D, Coulding NI: Impaired Clucocorticaid Induction of Monowclear

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Leukocyte Upocortirrl in Rheumatoid Arthritis. Anhrilis Rheum 1994, 37:207-211. Moulds IM, Warner NB, Arnett FC: Complement C4 Levels in SLE in Ret&on to Nuti Allele Status -Reply [Letter]. / Rheumatol 1994, 21:578. Mulder AHL, Horst G, Vanleeuwen MA, Limburg PC, Kallenberg CGM: Antineutrophil Cyloptarmic Characterization Antibodies in Rheunutoid Arthritis and Clinical Correlations. Arthritis Rheum 1993, 36:1054-1060. Mullerberar N, Mincwada I, Tsujitakayama K, Drexler H, Lanofte M, Wieslander I, Wiik A: The Phylogeny of Proteinase-3 Myeloblastin, the Autoantigen in Wegeners Crandonutosk, and Mydnperoxidase as Shown by lmmunohistochemiial Studies on Hurnan Leukendc Cell Lines. C/in lmmund lmmunopatho/ 1994, 70:51-59. Munozfernandez S, Barbado Fl, Mola EM, Gijonbanos I, Zap~co RM, Quevedo t, Arrrbar JR, Awlada IG, Va~zquezII: E&ence of Hepatitis C V&s Antibodies in the Cryqwecipitate of Patients with Mixed Cryogiobulinemia. I Rheumard 1994, 21:229-233. Murphy EA. Morris Al, Walker E, Lee FD, Sturrock RD: Cyclospwine-A Induced Cditir and Acquired Selective IgA Deficiency in a Patient with fuvenile Chronic Arthritis. I Rheumafd 1993,20:1397-1398. Myers LK. Seyer IM, Stuarl IM, Terato K, David CS, Kang AH: T-Cell Epitopes d Type-II Cdlagen that Regulate Murine Cdlage”&dwed Arthritis. / lmmunol 1993, 151:500-505. Mysler E, Bini P, Drappa J, Ramos P, Friedman SM. Krammer PH. Elkon KB: The Apoptosio-1 Far Protein in Human Svstendc Lupn Ewthentatosus. I C/m lnvesr 1994,93:1029-1034. Nadelman RD, Et Al: Can Lyme ltwnlioo be Prevented after Tick Bite? [Letter]. Lancef 1993, 323:1052. Nagafuchi H, Suzuki N, Mirushima Y, Sakane T: Constitutive Expression of IL-6 Receptors and Their Rde in the Exe&e B-Cell Fwtion in Patients with Systemic Lupw Etylhematorur. / lmmunoll993, 151:6525-6534. Nakamura T, Ebihara I, Shirato I, Fukui M, Tomino Y, Koide H: Endothelin-1 Messenger RNA Expression by Peripheral Blood Monocytes in IgA Nephropathy. Lancer 1993, 342:1147-l 148. Nakao T, Kon K, Ando 5, Miyatake T, Yuki N, Li YT, Furuya 5, Hirabayarhi Y: Novel &to-Canglio Type Canglhnides with C(MZ)-Epitope in Bovine Brain Which React with IgM fra a Patient of the Amyotmphic Lateral Sclcro&Uke Disc&r. / Bid Chem 1993, 26&2102a21034. Nelson IL Ef Al: Mater8uf-Fet.d Disparity in HLA Class II Alloantigem and the f&g”+-Induced Amelioration of Rheumatoid Arthritis. N Enp/ / Med 1993, 329z466-471. Nqro C. Zerbini M, Krzysrtofiak A, Genlilomi G. Porcaro MA, ManRo T, Musiani M: Active 01 Recent Parvovirus B19 l&tion in Children with Kawasaki Disease. Lancer 1994. 343:1260-l 261, Nlshlmura M. Toki I, Sugiura K, Hashimoto F, Tomita T, Fujirhima H, Hiram&u Y, Nishioka N, NaRala N. Takahashi Y, Ikehara 51 Foul Secnwntal Clanendar Sclnosis, a Type of b&&table Chronic Glmnendonephritis, is a Strm Cell Disorder. / Exp Med 1994, 179:1053-1058. Nlshiyori A, Et Al: Toxic Shnck Syndrome ToxirrSecreting Staphylanwus Awe118 in Kawaki Syndronw [Letter]. Lancef 1994. 343:299. Nonab 5, Yasuda M, Nabunaga M: In Vitro lght Rheunutoid Factw Rc&ctio” by Pwidwal Blood Monnm~ckr Cdls fmn P&e& with Semnegative Rheumatoid Arthritis. I Rheumafol 1993. 2o:i47ai484.

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Noyori K. Okamoro R, Takagi T, Hyodo A, Suzuki K, Koshino T: Exm Induction of Arthritis inRats nmwnired with hchwichia Cdi 0~14 Lifwdy%acch;rridc. / Rheumafo/l994,21:484-%38. Offner H. BueMfe AC, Vain&e M. Celnik B. Weinbem AD,.Gdd DP, &him G, Vandenbark A: Where; Whe”,a”dHowtoDetectBiwd~pmsion of Dkease-Relevant V-beta-Genes in Rats with Inimurwll993, 151:506-517. Okano Y. Stein VD. Medseer TA: Autoantibodv Reactive with RNA Pdynwrate Ill in Systendc klemsis. Ann lrlfem Med 1993,119:lou5-1613. [46*]. Ortlzbravo E, Sieck MS, Schumacher HR: Clwxges in the Pwteins Coating Moans&an t/rate Crystals During ActiwandSub&RngIn&nmu&-Inmnunogdd Sh#dksdSmwidFfuidfanFwientswithCoutand ”

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Pouch Ma&t. Arthrifis &,,,,I 1993, 3631274-1285. Ortman RA, Hdderbaum 0. Ou XM. Bane&e S. Haaa~ TM: II&/W (H-Z(Q)) is ; TCR’D&i& t.4ut.i Mouse Strain (TCR V Beta(A), l(j16(-)) that k Suwepttbk to Type It Cd&n&&wd Mluitis. 1994, 151:41754182.

inmum/

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Outer~~PmteinrTrge(dAn&diesin Patkntswftb RkmuticDbcramdHIVldectiom / Atioimmun 1994,7z67-91. M. Loetscher P, Dew&l B, Towbin l-l, Cesb M, Baestiolini M: Robctim d I”tede&irrl Receotor

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in the Devclqmwnt of Nephritis in Patientr with Systemic Lupa Erythemat&s. / lmmund 1993, 151:112B-1136. Suzuki 5, Nakatcmi Y, Sate Ii, Tsukada H, Arakawa M: tiaem+tkn Pwaidluenuc Antigen and A”tibody in Renal Biopsy srnples and Sewn of Patients with tgA Nepbqatby. Lancet 1994,343:12-l 5. Swanson PC, Cooper BC, Click CD: High Resolution Epitop Mapping of an Anti-DNA Automtibody Using Model DNA Ligamk. / lmmund 1994, 152:2601-2612. Szekanecz Z, Haines CK, Lin TR, Hadow LA, Cwrdt S, Rayan C, Koch AE: Differential Distribution of Intercellular Adbesio” Mdecda (KAM-1, ICAM2, and ICAM-3) and the MS1 Antige” in Normal ad Diseawd Huma” Synovia _ Their Possible Pathogmetic and Clinical Sigrtificmce in Rheumatoid Arthritis. Arthritis Rheum 1994, 37:221-231. Takeuchi F, Nakrma K, Yamada H, Hone, CH, Nabeta H, Yoshida A, Matsuta K, Bannai M, Tokunaga K, Ito K: Associitim of HLA-DR with Progressive Systemtc Sclerosis in Japanese. / Rheumard 1994, 21:857-863. lakeuchi T, Amano K, Sekine H, Koide 1, Abe T: Upregulated Expression and Function of I&grin Adbesiw Receptor in Systemic Lupus Erylhematosus Patients with Vascditis. I C/i” lnwsr 1993, 92:3ooa3016. Tanabe M, Ochi T, Tomita T, Suzuki R, Sakata T, Shimaoka Y, Nakagawa S, Ono K: Remarkable Elevation of lnterleukin 6 and lnterleukin B Levels in the Bme Marrow SCM of Patienk with Rheumatoid Arthritis. / Rheumard 1994, 21:83O-B35. Tan+: HLA-Linked Susceptibility to Rheumatoid Arthritis _ a Study of Forty-One &iulticaw Families Arthritis from Norlkrn I”dta (Vol 36, Pg 1380.1993). Rheum 1994,37:299. Teh LS, lsenberg DA: Antiriboswnal P Protein Antibodies in Systemic Lupus Erythematosus - P Reapprabal. Arthritis Rheum 1994, 37:307-315. Terao Y, Sakai K, Kate 5, Tanabe H, lrhida K, Tsukamoto i: Anthaeunnui Antibody in Sjrens Syndrome Masqwradiq as Paraneapbstic Cenbellar Degeneration [letter]. Lancet 1994, 343:790. Tervaen IWC, Stegema” CA, Huitema MC, Kallenberg CGM: Rdatiombip Between Antineubophil Cytoplasmic Antibody Leveh and D&ease Activity in Wegenen Cranubmato& -Comment [Letter]. Arthritis Rhwm 1994, 37:596. Tersier P, Audette M, Cattaruzzi P, Mccoll SR: Up ReRdatio” by Tuner Necrosis Factwalph of Int;rcellular ‘Adbesio” Mdecuk-1 E+sion and Function in Synovial Fibroblask and lb Inhibition by Glucaorticafds. Arthritis Rheum 1993, 36:152&l 539. Teuber SS, Rowley Ml, Yoshida SH, Ansari AA, Gershwin ME: Anti-CdlaRen Autourtibodia are Found in Women with &me Ertast Implank. / Autoimmun 1993.6:367-377. Than BA;Bakker NPM, /Fker M, Bontrop RE: Resistance to Cdlagecrrlnduced Arthritis in Rak and Rhesus Monkeys after lmmwtization with Attenuated TypeII Cdla~e”. Eur/ /mmuno/lVV3, 23:1588-l 594. Thomas R, &roll Cl: Reduction d Leukocyle and lntcrkddrr1 Beta Cmcentration in tbe Syovial Fluid of Rkumatoid Arthritis Paticnk Treated with Metbotrexate. Arthritis Rheum 1993, 36:1244-1252. Thomas R. Davis LS. Lioskv PE: Rlwumatdd Svmvium is En&ed in Mature AMiprt-Fwsenting Den&tic Cells. / fmmurw/l994,152:2613-2623. Tqr SL, Russell DM, Nemazee D: Receptor Editing in ?? * Selfreactive Bane Marrow B Celb. / Fxp Med 1994. 177:100%1020. [25]. Tlncana A, Bozzetti F, Tardanico R, Cerri G. Ealestrieri G, Larrari F, Morassi L, Bergonzini R, Cattaneo R, Radaeli E: Antipbcspbdpid Antibodies md Intestind Pathology [LetlevI. / Rkumatd 1993, 20x2169-21 70. Iowanen F’, Toivanen A: First Case d Lyme Arthritis [~etterl. Arthritis Rheum 1994, 37439. Tokuda M, Kurata N, Mizoguchi A, tnoh M, Seto K. Kinashi M. Takahara I: Effect d Low-h

, ,

D’&& Activity. A&iris R&m l&4, 37:551-558. Trentham DE, Dynesiustrentham RA, Orav El, Combitchi D, Lorenzo C, Sewell Kl, Hafler DA, Weiner I-IL: Effects of Chal *nblntiam d Type-11 Cdlage” on Rbewnatoid A&it&. Science 1993,261:1727-l 730. Tsuchiya N, Endo T, Mats& K, Yoshinoya S, Takeuchi F, NaKano Y, ShiUa hi, Furukawa K, Koch&e N, 110K, K&a A: Detection d Clycosylatio” Abmmulity in Rbemutotd Iffi Udm N-AcetvlducosambveSpecific F+satby&a-V&in. Let&T/ lmmunof 1993, 1.51:1137-1146. Tsuchiya N, Endo T, Shiota M, Kochbe N, lto K, Kobata A: Distributim d Glycosylatio~~ Abrwmulity Among Serum tgG Subctasses fra Patienk with

Autoimmunitv Autoimmune Rheumatoid Arthritis. C/in lmmunol Immunopathol 1994, 70:47-50. Tsuraka K, Fujli 1. Akizuki M, Mmwx~ 1, Tojo T, Fuj,~ H. Tsukaani Y, Kubo A, Homma M: Clinical Significance of Antibodies to Native or Denatured 60-kD or 52. kD Ro/SS-A Proteins in Siogrens Syndrome. Anhrrrrs Rheum 1994,37:8&92. Twomey BM, Dhillon VB. Mccallum S, lsenberg DA, Latchman DS: Elevated Levels of the 9&kD Heat Shock Protein in Patients with Systemic Lupus Ervthematowt are Dcpcndcnt Uwn Enhanced T&scription of the t&W-beta ‘Gene. / Aumimmun 1993, 6:495-506. Tyndall A, Et Al: Panovirus El9 and Erosive Pdprthritis [Letter]. Lancer 1994, 343:4BO. Trtoulas AC, Bwmba VA, Sderiadis K, Tsolas 0, Marlsopa~los HM: Autoantibodies to HMG-17 Nucleosomal Protein in Autoimmune Rheumatic Dixases - Con&ion with Systemic Lupus Erythematosw Clinical Activity and with Antibodies to Do&r-Stranded DNA. Arthrrfis Rhevm 1993. 36:955-961 Urowitz MB, Cladman DD, Farewell VT, Swwart I, Mcdonald I: Lupus and Pregnancy Studies. Arrhrrrrs Rheum 1993,36:1392-1397. \‘andam AP, Kuiper H, Spanjaard L, Danken 1: Lyme Borrcliosia [Letter]. Lancer 1994, 343:1567. Vandenbrink HR. Vanwijk MlG, Geertzen RGM, Bojlsma JWJ: lntluence d Cotticostemid Puke Therapy on the Serum Levels of Soluble lnterleddn 2 Receptor, Interkukin 6 and tnterleukin 8 in Patients with Rheumatoid Arthritis. I Rheumafol 1994, 21:43&434. Vanderlubbe PA, Reiter C, Breedveld FC, Kruger K, Schaltenkirchner M, Sanders ME, Rielhmuller G: Chimeric CD4 Monoclonal Antibody CM-T412 as a Therapeutic Approach to Rheumatoid Arthritis. Arthrifis Rheurn 1993, 36:1375-1379. Vanlent PLEM, Vandenhoek AEM. Vandenbersselaar AM, Vandeloo FAI, Eykholt HE, Brcuwer WFM, Vandeprtte LEA, Vandenberg WB: Early Cartilage Degradation in Cationic lmrmme Complex Arthritis in Mice _ Relative Role of lntedeukin 1, the Polymorphonuclear Cell (PMN) and PMN Elastar. I Rheurnatoll994, 21:321-329. Vanschooten WCA, Devereux D, HO CH, Quan 1, Aguilar BA, Rust CJI: Joint-Derived T Cclk in Rheumatoid Arthritis React with Self-lmmunoglohulin Heav Chains 01 Immunodohuli~Bindinc Rot&s that &purify with Imn&oglotndin. fzr / lmmund 1994, 2493-98. Vazquez-Abad D, Pasqual V, Zanetti M, Rolhfield NF: ?? Andy& of Human AntitopoiwnmacI Idiotvper. I ‘. C/in~nvr?sf 1993, 92:130211313. [29t]. Veale D, Yanni C, Rogers S, Barnes L, Bresmhan Lt. Fitzgerald 0: Reduced Synovial Membrane Macrophagc Numhem, ELAM-1 Expression, and Linirn: Lavcr Hvwmlasia in Psoriatic Arthritis as Corn&&l wftt;‘Rh&atoid Arthritis. Arthritis Rheum 1993, 36:893-900. Vehe RK. Nepom CT, Wilske KR, Stage D. Begovich AB, Nepom BS: Era&e Rheumatoid Factor Negative and Positive Rhetmutoid Arthritis are Irnmu~enetically Similar. I Rheumard 1994. 21:194-196. Venn G, Nietfeld II, Duitr Al, Brennan FM, Arner E. Covington M, Billingham MEJ, Hardingham TE: Elevated Svnovid Fluid levels of Intedeukin-6 and Tw& Necrosis Factor Awxiited with Early Expcritttet~td Canine Osteoarthritis. Arfhn’fis Rheum 1993, X819-826. Verschure PI, Vanderkraan PM, Wtters EL, Vandentxr~ WB: Stinudation of Roteoglyun Synthesis by Trimcindone Acetonide and Insulin-like Growth Factor 1 in Normal and Arthritic M&n Micular Cartike. I Rheumatof 1994, 21:920-926. VIM CS. T&OS CC. Bermas B. Clerici M. Shearer GM: T-Cdl-Antig&Resw& Cell l&actions in HSystemic Lupus Erythematosus - Evidence for Hetv Expresskm of Multiple Defects. / /mmuno/ 1993, 151:3914-3922. Vldal S, Gelpi C. Rodriguezsanchez It: (Swr X Sjl)F1 Mice - a New Model of Lupus-like Disease. / 1994, 17931429-143s. Waisman A, Mendlovic S, Ruiz PI, ZinRer H, Meshorer A, Mazes E: The Role of the 16/6 &type Netwwk in the induction and ManifestatimM of svstemic Llmus E@ematasm. Inf /mrnuno/ 1993, 5:~293-1300.r Wallace DJ, Linkerisraeli M, Hyun 5, Kline&erg IR, S&her v: The Effect of Hydmxychbm&ne Therapy OllSmmLmkdI mrunonyktwy Mdecuks in Patimb with Systemic Lupa E+mutosxa [letter]. / Rheumaroll994, 21:375-376. LVar~ng PM, Carroll Cl. Kandiah DA, Buirskr G, Mekalt D: Incr’eased Leveb of Leukemia Inhibitory Factor in Synovial Fluid from with Rhetmutoid Arthritis and Other l-tory Ardwitides. Anhrmr Rheum 1993,36:911-915.

txp

fad

Patients

Warner LM, Ad.~mr LM, SehKal SN: Rapamycin Prdongs Survival and Arrests Pathaphysiolqic Changes in Murinc Sy&‘mic Lupus Erythematosm. Anhrrris Rheum 1994,37:289-297. W.lranabeohnishi R. Aellon I, Lqros L, Toma MA, Sokurenko EV, Newton D, fakahara I, lnno S. Rashed 5. Kotb M: Characterization of Uniwe Human TCR V Beta Specifiiities for P Family of Streptococcal Superantigens Represented by Rheun&genic S&types if hi P&in. / lmr&no/ 1994, 1522066-2073. Wauben MHM, Vanderree R, loosten I, BOOR CIP, Vandijk AMC, Holewijn MC, M&en RH, Vaneden w: A Peptide Variant of an Arthritis-Related T-Cell Epitope Induces T-C& that Recognize This Epitope as a Synthetic Peptide But not in Its Naturally Proceswl Fam. j lmmund 1993, 150:5722-i730. I,To&r F. Mccluskev I. Cordon T: Werw YM. Mcrwlare identification if a t&tan-Specific Epitope in a Conserved Region of the LJSS-B Autoantigen. / C/in /maI 1993,92:1104-1108. Weyand CM, Schonbeqter I, Oppttz U, Hunder NNH, Hlcok KC, Coronzy II: Distimt Vascular Lesions in Giant Cell Arteritis Share kkntical T Cell Clonotypes. I Exp Med 1994, 179:951-960. \Vhyte A, Binns RM: RANTES and Chemokines in Rheumatoid Arthritis [LetterI. Lance+ 1994, 343:1291-1292. Wwnecke R Et Al: Cross Immunity ArnonR Types of Borrelia Burgdorferi [Lettn].‘Lanceti9!%, 342:435. Willoams RC, Malone CC, Harley IB: Rheumatoid Factors from Patients with Rheumatoid Arthritis React with TryptopharrCO and Tryptophan-95, Lysin-56, and Arginim-97, on Hwnan Bela-2-Microglohdin. Arthrhir Rheum 1993, 36:916-926. Williams RC, Staud R, Malone CC, Payabyab I, Byres L, Underwood D: Epitopes cm Rotcinaw-3 Recognized by Antibodies firm Patknts with Wegerrs Granu~tosir. I lmmunoll994, 152~47224737. Williams RO, Mason Lj, Feldmann M. Maini RN: Synergy Between Anti-CD4 and Anti-Tumor Necrosis Factor in the Ameliontion of Established Collagen. Induced Arthritis. Proc Nat/ Acad ki U 5 A 1994 91:2762-2766. Wilson AC. Gordon C, Digiovine FS, Denies N, Vandewtte LBA. Emerv P. Duff GW: A Genetic Ass&&m Between S’&rnic Lupus Erythematorus and Tuner Necrosis Factor Alpha. Fur / /mmuno/ 1994,24:191-195. Wilson IBH, Platt FM, Ire&erg DA, Rademacher TW: Aberrant Control of Calactayltramfcrase in Periplwal B-lymphocytes and Epstein-Ban Virus Tramformed B-Lymphoblasb from Patienk with Rheunataid Arthritis. I Rheumaroll993, 20:1282-l 287. Wlsniewrki HG, Maier R, Lotz M, Lee S, Klampler L, Lee TH, Vilcek I: TSC-6 . a TNF-, IL-l-, and LPS-Inducible Secreted Clycopmtein Associated with Arthritis. / /mmuno/ 1993, 151:6593-5601_ WI@ T, Dumoulin FL, Gessner IE, Schubert I, Gaze 0. Neumann C, Todd RF, Deicher H. Schmrdf RE: Defect of a Complement Receptor-3 Epitope in a Patient with Systemic Lupus Erythematosus. / C/in lnwst 1993, 92:11Bl-1187. Wittenberg RH, Willbtqer RE, Kleemeyer KS, Peskar BA: Invitro Release of &aaglandim &d Leukotricnes from Svnovial Tissue, Cartilae. and Bone in Dege&ative loint Diseases.%rhrilis Rheum 1993, 36:1444-l 450. Wolte F, Mitchell DM, Sibley IT, Fnes IF, Bloch DA, Williams CA, Spitz PW, HaRa M, Kleinheksel SM. Calhey MA: Th; Mortality br Rheunatoid Arthritis. Anhriris Rheum 1994. 37:4Bl-l94. Woke CC, Macnaul KL, Buechel FF, Mcdonnell 1, Hoerrner LA, Lark MW, Moore VL. Hutchmson NI: Differential in Viva Expression of Coilagenase Messenger RNA in Synovium ad Cat&age - Quantitative Comparkon with Stmmelysin Messenger RNA Levels in Hunan Rheumatoid Arthritis and Osteoarthritis Pat&k ad in 2 Animal Make d Acute Intlamnwtory Arthritis. Arthritis Rheum 1993, 36:1540-l 547. Wollheim FA, Telhag H, Henricrron A, Ceborek P: Prevention of Idnt Dcrtmction in Antinn-Induced irnmunol/mmumpafho/ 7994, 70:19-21. Wolos IA, Frondorf KA. Esser RE: lmmumsup~ession Mediated hy an Inhibitor d S-Adenosvl-Lhomocystei& Hydrdase _ Prevention’and Treabnent of Cd*cm-Induced Arthritis. I /mmuno/ 1993 151:52c534. Woodruff T, Cook A, Rowley M. Mackay I: Antibodin to Type II Cd&en in Human Serum - Stomp Effects and Rdc of IgM Antiidiolype in Regulation. I Rheumafol 1994, 21:197-202. i’vwley PH. Dufcher 1, Widrner MB, Gtlbs 5: Influence of a Recombinant Human Soluble Tumor Necrosis

ArthritkC/in

hemolvtic

anemia

Factor Receptor FC Fusion Protein on Type-11 Collagen-Induced Arthritis in Mice. / lmmunol 1993, 151:66026607. Wooley PH. Whalen ID, Chapman DL, Eerger AE, Richard KA, Aspar DC, Staite ND: The Effect of an Interiwkin-1 Receptor Antllpnid Protein cm Type-II Collagen-induced Arlhritis and AntigenInduced Arthritis in Mice. Arthrilis Rheum 1993, 36:1305-1314. Xavw RM, Nakamura M, Tsunematsu T: Isolation and Characterization of a Human Nonspecific Suppressor Factor from Awitic Fluid of Systemic Lupus Etythmtatosus - Evidence for a Human Counterpart of the Momclonal Nonrpccific Suppressor Factor and Rclatiomhip to the T Cell Receptor Alpha-Chain. / lmmunoll994, 152:262&2632. Yamamao H, Sekiguchi T, ItaRaki K, 5aijo 5, lwakura Y: lnflanmatwy Pdyarthritis in Mice Transgenic for Human T-Cell Leukemia Virus Typ-1. Arthritis Rheum 1993, 36:1612-1620. Yap HK, NR SC, Lee SW, Seah CC, Tan MAJA, Choy MY, lordan SC: Modulation of MHC Expession on Human Endothdial Cells bv Sera from Patients with Svstemic Lupus Erythemat&. C/in lrnmunol fmmunqdarho/ 1993,68:321-326. Ydron I, Meyer FA, Weirman Y. Yaron M: Effect of 1,25Dihydroxyvitmin-DJ on Interleukin-1 Beta Actions and Cell Growth in Hunan Synovial Fibroblast Cultures. / Rheumaroll993, i&l 527-l 532. Yasuda M. Kihara T. Wada T. Shiokawa S. Furuta E Suer&u Y, Nonaka S, &bunaRa M,‘Yoshioka K, lsayama T: Granulocyte Colony-Stimulating FactorInduction of lm&oved L&kocytape& with lnflammatorv Flare in a Fehn Svrdrome Patient. Arthritis R/&m 1994, 37:14\-li6. Yoshikawa T, Suzuki H, Sugiyama E, Tunru IS, lkemoto M, Hori T, Matsui 5, Yamashita N, Kcbayashi M: Effects of Pmstadandin-E(1) on the Reduction of IeM and IgG Class-Anti-dsDNA Antihodin in NZBGF(l) 20:1701-1706. Mice. I Rheumatoll993, Yoto Y, El Al: Human Parvovina 819 Infection in Kawasaki Disease [Letter]. Lancell994,344:58. Youngblood K, Fruchter 1, Ding C, Lopez 1, Bonagura V, Davidson A: Rheumatoid Factors from the Peripheral Blood of Two Patienb with Rhewnatoid Arthritis an Genetically Heten+iwous and Somatically Mutated. I C/in /west 1994,93:852-861. Zeher M. Szegedi G, Csiki Z, Cseh A, Adany R: Fibindysk-Resistant Fibrin Deposits in Minor Labial Salivary Glands of htimb with S&ens Syndrome. C/in lrnmunol /mmunqMrho/ 1994, 71:149-l 55. Zhang Z, Stanworth DR. Asmar G, Blake DR, Winyard PC: Mechanisms of Alpha(l)-Antitrypsin Inactivation in Arthritic joints _ Comment [letter]. Arthritis Rheurn 1994, 37:150-151. Collagen Treatment in Rheumatoid Arthritis. lancer 1993, 342799. American College of Rhnnutology 57th Annual kimtifw Me&w, November 7-11.1993 San Antonio Convent&n Center, San A&do, Texas Arthritis Rheum 1993, 36(uppl):539-5279. Silicon Breast hmdants. Breast Feedine and Sclnodemla. La”&1994,343:229.1

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Abstracts.

Autoimmune hemolytic anemia Related review: AutDimmune

hemolytic

anemia (pp 926-930) Barker RN, De Sa Oliveira GG, Elson Cl, Lydyard PM: . Pathmmic Autoantihodii in the NZB Marc are S&iii for Erythmcyte Band 3 Protein. Fur / lmmund 1993, 23:1723-l 726. (31. ILLII 5, Merino R, Fossati L, lwamom M: The Role of the . Yaa Gene in Lupus Syndrome. lnrern Rev lmmunol 1994, 11:211-230. [39]. Leddy IP, Falany IL, Kissel GE, TinR Parsador 5, Rosenfeld Sk Erythmcyte Membrane Pmteim Reactive with Huttan (wr~mreactind Anti-red Cell Autoantibodies. I C/in /“vet 1993, 91::672-1680. [S]. Murakami M, Tsubata T, Shinkura R, Nisitani 5, Okamoto ?? * M, Yorhioka H, Usui T, Miyawaki 5, Honjo T: Oral Administration of Limwdv.rcturidrs Activates B. 1 Cdk in the Perit&& &ity and tat&u Pmpria of the cut and Induces Autoinmmme Symptoma in an Autoantibody Tnnsgenic h4ouse. / Exp Med 1994. ltwlll-121.1281. Nlsitani S, Tsubata T, Murabmi M, Okamoto M, Honjo ?? * T: The &l-2 Gene Product lnhihib Clonal Deletion of Self-reactive B Lymphocyles in the Periphery But not in the Bone Murow. / Fxn Med 1993. 178:1247-1255. [ZOI. Olweira GGS, Hutchings PR, Roitt IM, Lydyatd PM: . Production of Erythrocyte Autoantibodics in

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980

Autoimmunity Organ-specific

autoimmune

NZR Mice is Inhibited by CD4 Antibodies. C/m Exp lmmundl994, %:297-302. [151. Reap EA. S&l ES, Cohen PL, Ersenberg RA: Conventional . B Cells not 8-l Cells we Responsible for Producing Autoantibodies in lpr Mice. / Exp Med 1993, 177:69-78. 1251. Sthoeger 2, khoeger D, Green L, Geltner D: The Role of Anticxdidipi” Autoantibodks in the Pathogen& of Autoinmwn Hemolyiic Anemia in Systemic Lupus Erytbmtatosus. / Rhewnafoll993, 20:205a2061_ Tsubata T, Murakami M, Honjo T: Antigen-receptor Cross** liddng lnducn Peritoneal B-cell Apoptosis in Normal Rut no1 Mobmnunity-prone Mice. Gun t3iol 1994, 48-17. 1211. Williams CT, 5mrth CA: Molecular Regulation of . Awc&& Genetic Controls on Cell Death. Cell lb9j, 7+777-779. 1231.

Organ-specific autoimmune disorders Related review: Autoimmunity in the eye and its regulation (pp 938-945) Ansari AA, Neckelmann N, Wang YC, Gravanis MB, Sell KW. Herskowitz A: Immunologic Dialogue Betwm Cardiac Mvocvtes. Endotbelial Cells. and Monotwckar Cells. ‘C/d lr&unol Immu”opa;hol 1993,6&20b214. Antozzi C, EI All: Protein-A Imrmmoadsorption in Inwmmosuppression-Resistant Myasthenia Gravir [Letter]. lancer 1994, 343:124. Araga 5, Lebowf RD. Blalock IE: Prevention of Experbnental Autoimmune Myasthenia Cravir by hbnipdation of the Immune Network with 1 Canpknwntay Peptide for the Acctykhdine Receptor. Pmc Narl Acad 5X U 5 A 1993, 9w747-0751. Araga S, Letowf RD. Blalock IE: prevention of Exprimmtll Mdmnune Myastbenia Cravir by Madpdation of the lnmwne Network with a Canplenw”twy hptide for the Acc~lchdinc Receptor (Vd 90, pg 8747,1993). Proc Naf/ Acad 5citJSA1994,91:1598. Asher 0, Kues WA, Witzemann V, Tzanos SJ, Fuchs 5, Sourwjon MC: Iwe& Gene Expression of A~~tylchdine Receptor a”d Myogenic Factors in Pusivdy Tramferred Experbnentd Autoimnwne Myastbenia Cravk. / fmmund 1993,151:64426450. Beck RW: Cwticostemids, Optic Neuritis, and Multiple Sclerosis - Reply [Letter]. N Engl I Med 1994, 330:1239. Bwanani M. Dietrich G, Hurez V, Kaveri SV, Delrio M. Pau B, Kazatchkine MD: Age-Related Cbnges in Specificity d Hunun N&wal Montibodies to T-Ii”. / Aufoimmun 1993, 6:639-648. Braleyrwllen H, Sharp CC, Kyriakos M: Diirential Rquhmmt for Montibody-Reducing R-Cells for IMhlctio” of 1wndlocvtic vesws CR”dlJ”latous ExpclincnWA&in&& Thy&d&. 1 lmmunol 1994, 152:307-3 14. Broekhuyre RM, Kuhlmann ED, Winkens HI: Experimental ?? * Autotmmsme Atsterbr Uveitb (EMU). Ill. Induction by bmnmizatio” with Furif Uved ad Skin Mdanim. Exp Eye Res 1993, 5(:575-583.[22]. Caspi RR, Chan CC, Crubbr BC, Silver PB, Wigert 6, Parsa CF. Eahmanyar 5, Billiau A, Heremans H: E”dogemw Syttemic IFN-m Ha P Protective Rde &but Ocdu Autoimmmity in Mice. I fmmund 1994. 152:89m99. Chan CC, Hikita N, Dastgheib K, Whrtcup SM. ?? Cery I, Nussenblatt RE: Experimental Mclninprokin Induced UveRis in tbe Lewis Rat: Imtsw@ttologkJ Recesses. Ophhalmology 1994, 101:1275-1280. [231. Charteris DC, Lightman SL: In Viva Lympbokine ?? Roductkm in Expwime”tal Autdmnun Uvewetbtitii lmmtmdo~y 1993, 7&387-392.1331. Cunningham MW, Antone SM. Culizia IM, Mcmanus BA, Cauntt Cl: alpha-Helical coikd-Coil Mdecules - a RdeinA&dwm&ylbjnstthrHear~.C/i” lnvmmol lmmunopar/roll993,6&11&123. Dalakas MC, Et Al: A Corstmlkd Tti of H&&se lntmmaaLm*mClohrlinlnfudolra Dmcutanpdtk. ~E”gllMedl993. T-601 319:1993-2000. Dick AD, Cbmg YF, MEKinnon A, Liversidge I, Forrester . IV:NarlAdminirtntkmofReti~I&di~Suppress ttwI~ayRespawinExprin*ntllAlkrgic UwwUdth.Ap&nhwyReportdI”trarwxl lnawtbndTdcmrrwitbRc(kulAntiiBr/ +hfbafmd 1993, 77zl71-175.[621. Dwtrich C, Varela FJ, Hurez V, Bouanani hi, Kazatchkine MD:Sek&mdtbeExpwemedRCetlRgrt&eby lnfvdon d Namal hnmumt@din C in P Patient

disorders with Auloimnwne Thyroiditir. Fur / lmmunol 1993. 23:2945-2950. Egwuagu CE, Mahdi RM, Nussenblatt RB, Cery I, Casp~ ?? * RR: Evidewe for Selective Accumulation of Va 8 + T lvmphocvtes in Experimental Autoimnunc Uvewetinitis lrsduced with Two DitYerent Retinal Antigens. 1 lmmuno/l993,151:1627-1636. [27]. Flchorn M, Homeber M, Stredein JW, Lutjen-Drecoll E: ?? * Anterior Chvnbcr Associated lnnwne Deviation Elicited Via Priite Eyes. invest Ophrhal Vis SC; 1993. 34:2926-2930. [SS]. Fdn IL, Oesai RK, Seethararrwah CS, Dallas IS, Wagle NM. Prabhakar BS: Hetcroceneitv in Cellular and Antibodv Respomes Against Th;rotr&in Receptor in Patients with Gravesbiase &e&d Usind Synthetic Peotides. I Autormmun 1993. 6:799-808. Feron il. Roth&a A, Vanhagen PM, Baarsma GS. Suttorpschulten MSA: Interferon-alpha 2b for Refractory Ocular Behcet’s Disease [Letter]. Ldncef 1994, 3421428. r&y TP, Abbassi V, Copeland KC, Drarnm MB: Hypothymidkm Caused by Chronic Autoirm-nune Brief Report. N Thyroid& in Very Ymmg Infants &‘I I h&d 1994, 33Oz466-468. Fu LX, Magnusson Y, Bergh CH, Liljeqvist IA, Waagstem F, Hjalmarson A, Hoebeke I: Localization of 1 Functional Autoimrmne Epitope on the Muscarinic Acelylchdine Receptor-2 in P&nts with Idiopathic Dilated Cardiomyopathy. / C/in lrwesf 1993, 91:1%4-1968. Fuller BE, Okayasu I, Simon LL, Ciraldo AA, Kong YM: Chancterization of Resistance to Murine Expe&nmtd Autoimmune Thymiditis - Duration and Affermt Action of Thyroglobuliwlrtduced and TSHInduced Supprcorirm. C/in lmmunol Immunoparhol 1993, 69z60-68. Cery I, Chanaud NP Ill, Anglade E: Recoverin is Highly ?? * Uveitogerdc in Lewis Rats. /west Ophrhalrof vis Set 1994, 35:3342-3345.1101. Cilkeson GS, Ruiz e Howell D, Lefkowith JB, Plsetsky DS: Induction d Imnwnc-Mediated Glcnnerdonephritir in Nomul Mice Immunized with Bacterial DNA. C/in lmmunol lmmunoparholl993, 68:283-292. Crau IM, Herrero C, &ademont 1, Fernandezsola I, Urbanomarauez A: Cvcioswrine il as Firsl Choice Therapy for’Demutc&&ir [Letter]. / Rhwmarol 1994, 21:381-382. Greenwood j, Howes R, Lightman 5: The Blood-retinal ?? * Ranier in Experimental Autobnrmme Uvewetinitir. Leukocoeyte lntnwtiom and Functional Damage. lab f”wsll994,70:39-52. [311. Cregerson D5, tiitxh WF, Donoso LA: Oral Tolerance ?? * in Expwknental Autoinmwne Uveoretinith. Distinct Mecbankms d Resistincc are Induced by Low Dose Vs High Dooc Feeding Protocols. / fmmunoll993, 151:5751-5761. [64]. Cuzman I, Petty RE, Malleson PN: MonitorinR Disease Activity in’~uvmile Demsatomyositir - th; Role of Van Willebrand Factor and Musck Enmnes. Rheumamll994, 21:739-743. Hanawa H, Tsuchida M, Matsumoto Y, Watanabe H, Abe T, Sekikawa Ii, Kodama M, Zhang SS, lzumt T, Shabata A: Characterization of T-Cells Infiltrating the Heart in Rats with Experimental Moinmwn Myocarditis _ Their Similaritv to Ertntbvmic T-Cells in Mice and the Site of &lifer&& / lmmunof 1993, 150:5682-5695. Hart RC: Cwlicmteroids, Optic Neuritis, and Mdtipk klemsk [Letter]. N Engl I Med I994 33o:i 2361239. Hooks II, Percqo C, Wang Y, Detrick B: Reti”4 and Retbul @“e”t Epitbelial Cell Autoa”tibodia we Prothtced Dvin(( Murim Cortmavirus Retinopathy.

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hnmunoll993,151:3381-3389.

Hosenpud ID: The Effects d Interkukin-1 cm Myocardid Fsmction ad Metabdism. C/m lmmunol l&“tmojwfKlJ 1993,6&175-180. lsh@subo Y, lgarashi T, Ohno 5, Ueda A, Ok&o T, Klinman DM: Cross-Reaciivity d IRM&cretirtg and IgG-Smai”g R-Cells in Autdi&“e Mice. Anhn’ris Rheum 1993,36:1003-1006. Kalovidouris AE, Plotkin Z, Craesser D: lnterfercm+rm~ l”tdbib Pm&mtii, Diieresstiation, md Creatim Kinase Activity d Cultured Hurnan Muck Cells. 2. A F+ossibk Role in Mwsitis. I Rheumafoll993, 20:171a1723. Katzlevy Y, Kirshner SL, Sela M, Mazes E: lnhiitkm of T-Cdl lteactivitv to Mvasthcnonnic Eoitaors of the

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Proc Nad A&d Sci I/ S A 1‘993,9o:+JOC-7004. Kaufman LD. Keohxt GM. Seidman RI. Buhner D, Q&or& I, N&b&r L, Cleich Cl: The spchun d Eorinophitic Myositis - Cliti and kmunopPthoacnicShdiesdTlweeMknts, md Review d the Litentwe. Arthriris Rheum 1993, %:1014-1024.

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