- Email: [email protected]
Autoimmunity as the Consequence of a Spontaneous Mutation in Rasgrp1
Immunity
Retraction Autoimmunity as the Consequence of a Spontaneous Mutation in Rasgrp1
Katrin Layer, Guosheng Lin, Alessio Nencion, Wei Hu, Adam Schmucker, Andrey N. Antov, Xiaoyu Li, Satoshi Takamatsu, Timothy Chevassut, Nancy A. Dower, Stacey L. Stang, David Beier, Janet Buhlmann, Roderick T. Bronson, Keith B. Elkon, James C. Stone, Luk Van Parijs,* and Bing Lim* *Correspondence: [email protected] (L.V.P.), [email protected] (B.L.) DOI 10.1016/j.immuni.2012.05.007
(Immunity 19, 243–255; August 2003) The authors have agreed to retract the paper because of the falsification of the Western blot in Figure 6A. The figure shows a defect in Ras activation, labeled as RasGTP, following TCR engagement, in thymocytes isolated from a RasGRP1 lag mutant mouse strain. This data set is one of several that show signaling and functional deficiencies identified for cells with lost of function of RasGRP. The authors stand by the validity of the other figures, results, and interpretation in this paper. This matter was investigated by the Massachusetts Institute of Technology and the Office of Research Integrity at the United States Department of Health & Human Services, which found that the figure was falsified by Luk Van Parijs, who is solely responsible. The authors deeply regret any inconvenience resulting from the publication of this data.
886 Immunity 36, 886, May 25, 2012 ª2012 Elsevier Inc.
Retraction Autoimmunity as the Consequence of a Spontaneous Mutation in Rasgrp1
Katrin Layer, Guosheng Lin, Alessio Nencion, Wei Hu, Adam Schmucker, Andrey N. Antov, Xiaoyu Li, Satoshi Takamatsu, Timothy Chevassut, Nancy A. Dower, Stacey L. Stang, David Beier, Janet Buhlmann, Roderick T. Bronson, Keith B. Elkon, James C. Stone, Luk Van Parijs,* and Bing Lim* *Correspondence: [email protected] (L.V.P.), [email protected] (B.L.) DOI 10.1016/j.immuni.2012.05.007
(Immunity 19, 243–255; August 2003) The authors have agreed to retract the paper because of the falsification of the Western blot in Figure 6A. The figure shows a defect in Ras activation, labeled as RasGTP, following TCR engagement, in thymocytes isolated from a RasGRP1 lag mutant mouse strain. This data set is one of several that show signaling and functional deficiencies identified for cells with lost of function of RasGRP. The authors stand by the validity of the other figures, results, and interpretation in this paper. This matter was investigated by the Massachusetts Institute of Technology and the Office of Research Integrity at the United States Department of Health & Human Services, which found that the figure was falsified by Luk Van Parijs, who is solely responsible. The authors deeply regret any inconvenience resulting from the publication of this data.
886 Immunity 36, 886, May 25, 2012 ª2012 Elsevier Inc.