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B34 An interstitial deletion of chromosome 11q in a pineoblastoma
Abstracts
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*B33HEPATOBLASTOMA CHARACTERIZED BY T R I S O M Y 20 AND D O U B L E MINUTES. J. T. M a s c a r e l l o I and H. F. K r o u s 2. D e p a r t m e n t s of G e n e t i c s l and P a t h o l o g y 2, C h i l d r e n ' s H o s p i t a l - San Diego, 8001 Frost St., San Diego, CA 92123. Hepatoblastoma is a rare p e d i a t r i c liver tumor for w h i c h v e r y l i t t l e c y t o g e n e t i c i n f o r m a t i o n is a v a i l a b l e . Prior to i n i t i a t i o n of c h e m o t h e r a p y for an i n o p e r a b l e liver tumor in a twelve month-old m a l e patient, we o b t a i n e d tumor b i o p s i e s for c y t o g e n e t i c and histologic analysis ............... staining revealed a fetal-type hepatoblastoma that s t a i n e d p o s i t i v e for a l p h a - f e t o p r o t e i n but n e g a t i v e for a l p h a - l - a n t i t r y p s i n as well as s u r f a c e and core a n t i g e n s of h e p a t i t i s B. The k a r y o t y p e of t u m o r cells was c h a r a c t e r i z e d by t r i s o m y 20 and by a small but v a r i a b l e n u m b e r of d o u b l e m i n u t e c h r o m o s o m e s . The p a t i e n t ' s p h e n o t y p e and c o n s t i t u t i o n a l k a r y o t y p e w e r e b o t h normal. T r i s o m y for an F g r o u p c h r o m o s o m e has been p r e v i o u s l y r e p o r t e d in an u n b a n d e d study of a cell line d e r i v e d from a h e p a t o b l a s t o m a . A f t e r three m o n t h s of therapy, o n l y p a r t i a l r e s p o n s e has been noted.
*B34 An I n t e r s t i t i a l Pineoblastoma.
Deletion
o f Chromosome l l q
in a
Sreekantaiah C I, Jockin H 2, Brecher ML 3, Sandberg AA I 1) Southwest Biomedical Research Institute, Scottsdale, AZ. 2) Children's Hospital, Buffalo, New York. 3) Roswell Park Memorial Institute, Buffalo, New York. A case of pineoblastoma with an interesting cytogenetic abnormality is reported. Chromosomal analysis of cultured cells from the tumor of a I0 week old white male revealed an interstitial deletion of the long arm of chromosome 11, del(11)(q13.1q13.5). Tumors of the pineal region are relatively rare and this is the first report of a pineoblastoma with a del(llq). This research was funded by a grant from the Association for the Research of Childhood Cancer (AROCC) and the Mae Stone Goode Foundation, Buffalo, New York.
28 5
*B33HEPATOBLASTOMA CHARACTERIZED BY T R I S O M Y 20 AND D O U B L E MINUTES. J. T. M a s c a r e l l o I and H. F. K r o u s 2. D e p a r t m e n t s of G e n e t i c s l and P a t h o l o g y 2, C h i l d r e n ' s H o s p i t a l - San Diego, 8001 Frost St., San Diego, CA 92123. Hepatoblastoma is a rare p e d i a t r i c liver tumor for w h i c h v e r y l i t t l e c y t o g e n e t i c i n f o r m a t i o n is a v a i l a b l e . Prior to i n i t i a t i o n of c h e m o t h e r a p y for an i n o p e r a b l e liver tumor in a twelve month-old m a l e patient, we o b t a i n e d tumor b i o p s i e s for c y t o g e n e t i c and histologic analysis ............... staining revealed a fetal-type hepatoblastoma that s t a i n e d p o s i t i v e for a l p h a - f e t o p r o t e i n but n e g a t i v e for a l p h a - l - a n t i t r y p s i n as well as s u r f a c e and core a n t i g e n s of h e p a t i t i s B. The k a r y o t y p e of t u m o r cells was c h a r a c t e r i z e d by t r i s o m y 20 and by a small but v a r i a b l e n u m b e r of d o u b l e m i n u t e c h r o m o s o m e s . The p a t i e n t ' s p h e n o t y p e and c o n s t i t u t i o n a l k a r y o t y p e w e r e b o t h normal. T r i s o m y for an F g r o u p c h r o m o s o m e has been p r e v i o u s l y r e p o r t e d in an u n b a n d e d study of a cell line d e r i v e d from a h e p a t o b l a s t o m a . A f t e r three m o n t h s of therapy, o n l y p a r t i a l r e s p o n s e has been noted.
*B34 An I n t e r s t i t i a l Pineoblastoma.
Deletion
o f Chromosome l l q
in a
Sreekantaiah C I, Jockin H 2, Brecher ML 3, Sandberg AA I 1) Southwest Biomedical Research Institute, Scottsdale, AZ. 2) Children's Hospital, Buffalo, New York. 3) Roswell Park Memorial Institute, Buffalo, New York. A case of pineoblastoma with an interesting cytogenetic abnormality is reported. Chromosomal analysis of cultured cells from the tumor of a I0 week old white male revealed an interstitial deletion of the long arm of chromosome 11, del(11)(q13.1q13.5). Tumors of the pineal region are relatively rare and this is the first report of a pineoblastoma with a del(llq). This research was funded by a grant from the Association for the Research of Childhood Cancer (AROCC) and the Mae Stone Goode Foundation, Buffalo, New York.