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Bacterial Outer Membrane Vesicles Alter Mediators of Inflammation and Coagulation
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ASSOCIATION FOR ACADEMIC SURGERY AND SOCIETY OF UNIVERSITY SURGEONS—ABSTRACTS Petrone,1,2 R. Lee,1 R. S. Chamberlain2,3,4; 1Saint Barnabas Medical Center - Dept. Of Surgery, Division Of Burn Surgery, Livingston, NJ, USA; 2Saint Barnabas Medical Center - Dept Of Surgery, Livingston, NJ, USA; 3St. George’s University School Of Medicine, St. George’s, Grenada; 4University Of Medicine And Dentistry Of New Jersey, Newark, NJ, USA
66.19. The Impact of Leukoreduced Red Blood Cell Transfusion on Mortality of Neonates Undergoing Extra Corporeal Memebrane Oxygenation (ECMO). H. T. Jackson,1 T. A. Oyetunji,1 A. E. Thomas,1 M. C. Hamrick,1 E. P. Nadler,1 E. Wong,1 F. G. Qureshi1; 1Children’s National Medical Center - Surgery, Washington, DC, USA
66.20. Penetrating Injuries In Older Adults: An Urban Trauma Center’s Experience. D. Scantling,2 D. Holena,1 J. Pascual,1 P. Kim,1 C. Schwab,1 P. Reilly,1 S. Allen1; 1University Of Pennsylvania - Division Of Traumatology, Surgical Critical Care And Emergency Surgery, Philadelphia, PA, USA; 2 Philadelphia College Of Osteopathic Medicine - College Of Medicine, Phildelphia, PA, USA
TRAUMA/CRITICAL CARE 1: WOUND HEALING AND IMMUNITY 67.1. Bacterial Outer Membrane Vesicles Alter Mediators of Inflammation and Coagulation. M. C. Soult,1 K. H. Wahab,2 Y. Dobrydeneva,2 L. D. Britt,1 C. J. Sullivan1; 1 Eastern Virginia Medical School - Surgery, Norfolk, VA, USA; 2Eastern Virginia Medical School - Physiological Sciences, Norfolk, VA, USA
67.2. Epidermal Growth Factor Mediated Wound Repair In Human Embryonic Stem Cell-Derived Epithelial Cells. L. Palencia,3 A. Das,2 S. Palecek,2 S. Thibeault,1 C. Leydon1; 1 University Of Wisconsin - Department Of Surgery-Division Of Otolaryngology, Madison, WI, USA; 2University Of Wisconsin - Department Of Chemical And Biological Engineering, Madison, WI, USA; 3University Of Wisconsin School Of Medicine And Public Health, Madison, WI, USA
67.3. Disruption of Nuclear Factor–kappa-B Signaling in the Fibroblast-Populated Collagen Matrix. T. M. Guenther,1 J. Chao,1 D. Heimann,1,2 C. Hansen,1,2 M. A. Carlson1,2; 1 University Of Nebraska College Of Medicine, Omaha, NE, USA; 2VA Nebraska Western Iowa Health Care System, Omaha, NE, USA
67.4. HIF1a is Induced by the Pro-Inflammatory IL-23 in Dendritic Cells but Not Macrophages. A. Spadaro,1 J. R. Klune,1 C. Bartels,1 Q. Du,1 R. Rothman,1 D. A. Geller1; 1 University Of Pittsburgh Medical Center - Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, USA
67.5. Apigenin Inhibits the Pro-Inflammatory and Pro-Fibrogenic Responses in Both Acinar Cells and Pancreatic Stellate Cells in Experimentally Induced Pancreatitis. A. A. Mrazek,1 M. Falzon,1 H. Chen,1 J. Zhou,1 F. J. Bohanon,1
L. Porro,1 V. Bhatia,1 X. Wang,1 M. R. Hellmich,1 C. Chao1; 1 University Of Texas Medical Branch, Galveston, TX, USA
67.6. Antibacterial Activity of the Natural Surfactant Glycerol Monolaurate in Preventing Development of Staphylococcus aureus Biofilms. D. J. Hess,1 M. J. Henry-Stanley,2 C. L. Wells1,2; 1University Of Minnesota - Department Of Surgery, Minneapolis, MN, USA; 2University Of Minnesota Department Of Laboratory Medicine And Pathology, Minneapolis, MN, USA
67.7. The Novel Mechanism for WISP1 Synergizes with TLR Agonist in Macrophage Activation. Z. Chen,1,2 Q. Li,2 T. Billiar1; 1University Of Pittsburg - Surgery, Piitsburgh, PA, USA; 2Tongji University School Of Medicine - Anesthesiology, Shanghai, SHANGHAI, China
67.8. Benzyl Alcohol Attenuates Acetaminophen-Induced Acute Liver Injury in a Toll-Like Receptor-4 Dependent Pattern in Mice. J. A. Luciano,1 C. Cai,1 B. Kautza,1 S. Whelan,1 S. Stratimirovic,1 T. R. Billiar,1 B. S. Zuckerbraun1; 1 University Of Pittsburg - Surgery, Piitsburgh, PA, USA
67.9. Not All Fat is the Same: A Comparison of the Functionality and Transcriptional Profiles of Adipose-Derived Stem Cells From the Subcutaneous and Visceral Compartments. D. Duscher,1 R. C. Rennert,1 M. G. Perez,1 M. Sorkin,1 Z. Maan,1 M. Januszyk,1 M. Rodrigues,1 H. Baker,1 R. Kosaraju,1 G. C. Gurtner1; 1Stanford University - Division Of Plastic Surgery, Palo Alto, CA, USA
67.10. Doxycycline Impacts Hernia Repair Strength and Collagen Deposition. J. C. Tharappel,1 C. E. Bower,1 J. Whittington Harris,1 S. K. Ramineni,2 D. A. Puleo,2 S. J. Roth1; 1University Of Kentucky - G. Surgery/Surgery/College Of Medicine, Lexington, KY, USA; 2University Of Kentucky - Center for Biomedical Engineering/College Of Engineering, Lexington, KY, USA
67.11. Heme oxygenase-1/CO Protect Against Delayed Onset Immunosuppression In A Murine Multiple Trauma Model. Y. Wang,1 S. Darwiche,1 J. Brumfield,1 C. Cai,1 B. Kautza,1 D. Escobar,1 A. Quintero,1 K. Vreeland,1 S. Stratimirovic,1 J. Luciano,1 S. M. Laverde,1 B. S. Zuckerbraun1; 1University Of Pittsburgh - Department Of Surgery, Pittsburgh, PA, USA
67.12. Modulation of the a7 Nicotinic Acetylcholine Receptor Pathway in Adipocytes: Implications for Obesity Related Morbidity in the Trauma/Critically Ill Patient. S. L. Tarras,1 D. M. Liberati,1 D. A. Edelman,1 J. D. Webber,1 L. N. Diebel1; 1Wayne State University Department Of Surgery, Detroit, MI, USA
67.13. Development of an In Vitro Organotypic Wound Model and Application of this Model to Study the Effect of
ASSOCIATION FOR ACADEMIC SURGERY AND SOCIETY OF UNIVERSITY SURGEONS—ABSTRACTS Petrone,1,2 R. Lee,1 R. S. Chamberlain2,3,4; 1Saint Barnabas Medical Center - Dept. Of Surgery, Division Of Burn Surgery, Livingston, NJ, USA; 2Saint Barnabas Medical Center - Dept Of Surgery, Livingston, NJ, USA; 3St. George’s University School Of Medicine, St. George’s, Grenada; 4University Of Medicine And Dentistry Of New Jersey, Newark, NJ, USA
66.19. The Impact of Leukoreduced Red Blood Cell Transfusion on Mortality of Neonates Undergoing Extra Corporeal Memebrane Oxygenation (ECMO). H. T. Jackson,1 T. A. Oyetunji,1 A. E. Thomas,1 M. C. Hamrick,1 E. P. Nadler,1 E. Wong,1 F. G. Qureshi1; 1Children’s National Medical Center - Surgery, Washington, DC, USA
66.20. Penetrating Injuries In Older Adults: An Urban Trauma Center’s Experience. D. Scantling,2 D. Holena,1 J. Pascual,1 P. Kim,1 C. Schwab,1 P. Reilly,1 S. Allen1; 1University Of Pennsylvania - Division Of Traumatology, Surgical Critical Care And Emergency Surgery, Philadelphia, PA, USA; 2 Philadelphia College Of Osteopathic Medicine - College Of Medicine, Phildelphia, PA, USA
TRAUMA/CRITICAL CARE 1: WOUND HEALING AND IMMUNITY 67.1. Bacterial Outer Membrane Vesicles Alter Mediators of Inflammation and Coagulation. M. C. Soult,1 K. H. Wahab,2 Y. Dobrydeneva,2 L. D. Britt,1 C. J. Sullivan1; 1 Eastern Virginia Medical School - Surgery, Norfolk, VA, USA; 2Eastern Virginia Medical School - Physiological Sciences, Norfolk, VA, USA
67.2. Epidermal Growth Factor Mediated Wound Repair In Human Embryonic Stem Cell-Derived Epithelial Cells. L. Palencia,3 A. Das,2 S. Palecek,2 S. Thibeault,1 C. Leydon1; 1 University Of Wisconsin - Department Of Surgery-Division Of Otolaryngology, Madison, WI, USA; 2University Of Wisconsin - Department Of Chemical And Biological Engineering, Madison, WI, USA; 3University Of Wisconsin School Of Medicine And Public Health, Madison, WI, USA
67.3. Disruption of Nuclear Factor–kappa-B Signaling in the Fibroblast-Populated Collagen Matrix. T. M. Guenther,1 J. Chao,1 D. Heimann,1,2 C. Hansen,1,2 M. A. Carlson1,2; 1 University Of Nebraska College Of Medicine, Omaha, NE, USA; 2VA Nebraska Western Iowa Health Care System, Omaha, NE, USA
67.4. HIF1a is Induced by the Pro-Inflammatory IL-23 in Dendritic Cells but Not Macrophages. A. Spadaro,1 J. R. Klune,1 C. Bartels,1 Q. Du,1 R. Rothman,1 D. A. Geller1; 1 University Of Pittsburgh Medical Center - Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, USA
67.5. Apigenin Inhibits the Pro-Inflammatory and Pro-Fibrogenic Responses in Both Acinar Cells and Pancreatic Stellate Cells in Experimentally Induced Pancreatitis. A. A. Mrazek,1 M. Falzon,1 H. Chen,1 J. Zhou,1 F. J. Bohanon,1
L. Porro,1 V. Bhatia,1 X. Wang,1 M. R. Hellmich,1 C. Chao1; 1 University Of Texas Medical Branch, Galveston, TX, USA
67.6. Antibacterial Activity of the Natural Surfactant Glycerol Monolaurate in Preventing Development of Staphylococcus aureus Biofilms. D. J. Hess,1 M. J. Henry-Stanley,2 C. L. Wells1,2; 1University Of Minnesota - Department Of Surgery, Minneapolis, MN, USA; 2University Of Minnesota Department Of Laboratory Medicine And Pathology, Minneapolis, MN, USA
67.7. The Novel Mechanism for WISP1 Synergizes with TLR Agonist in Macrophage Activation. Z. Chen,1,2 Q. Li,2 T. Billiar1; 1University Of Pittsburg - Surgery, Piitsburgh, PA, USA; 2Tongji University School Of Medicine - Anesthesiology, Shanghai, SHANGHAI, China
67.8. Benzyl Alcohol Attenuates Acetaminophen-Induced Acute Liver Injury in a Toll-Like Receptor-4 Dependent Pattern in Mice. J. A. Luciano,1 C. Cai,1 B. Kautza,1 S. Whelan,1 S. Stratimirovic,1 T. R. Billiar,1 B. S. Zuckerbraun1; 1 University Of Pittsburg - Surgery, Piitsburgh, PA, USA
67.9. Not All Fat is the Same: A Comparison of the Functionality and Transcriptional Profiles of Adipose-Derived Stem Cells From the Subcutaneous and Visceral Compartments. D. Duscher,1 R. C. Rennert,1 M. G. Perez,1 M. Sorkin,1 Z. Maan,1 M. Januszyk,1 M. Rodrigues,1 H. Baker,1 R. Kosaraju,1 G. C. Gurtner1; 1Stanford University - Division Of Plastic Surgery, Palo Alto, CA, USA
67.10. Doxycycline Impacts Hernia Repair Strength and Collagen Deposition. J. C. Tharappel,1 C. E. Bower,1 J. Whittington Harris,1 S. K. Ramineni,2 D. A. Puleo,2 S. J. Roth1; 1University Of Kentucky - G. Surgery/Surgery/College Of Medicine, Lexington, KY, USA; 2University Of Kentucky - Center for Biomedical Engineering/College Of Engineering, Lexington, KY, USA
67.11. Heme oxygenase-1/CO Protect Against Delayed Onset Immunosuppression In A Murine Multiple Trauma Model. Y. Wang,1 S. Darwiche,1 J. Brumfield,1 C. Cai,1 B. Kautza,1 D. Escobar,1 A. Quintero,1 K. Vreeland,1 S. Stratimirovic,1 J. Luciano,1 S. M. Laverde,1 B. S. Zuckerbraun1; 1University Of Pittsburgh - Department Of Surgery, Pittsburgh, PA, USA
67.12. Modulation of the a7 Nicotinic Acetylcholine Receptor Pathway in Adipocytes: Implications for Obesity Related Morbidity in the Trauma/Critically Ill Patient. S. L. Tarras,1 D. M. Liberati,1 D. A. Edelman,1 J. D. Webber,1 L. N. Diebel1; 1Wayne State University Department Of Surgery, Detroit, MI, USA
67.13. Development of an In Vitro Organotypic Wound Model and Application of this Model to Study the Effect of