- Email: [email protected]
Bariatric surgery, diabetes mellitus, and epicardial adipose tissue
Accepted Manuscript Bariatric Surgery, Diabetes Mellitus, and Epicardial Adipose Tissue Zeynep Cerit, MD PII:
S0939-4753(17)30063-7
DOI:
10.1016/j.numecd.2017.03.007
Reference:
NUMECD 1711
To appear in:
Nutrition, Metabolism and Cardiovascular Diseases
Received Date: 17 March 2017 Revised Date:
30 March 2017
Accepted Date: 31 March 2017
Please cite this article as: Cerit Z, Bariatric Surgery, Diabetes Mellitus, and Epicardial Adipose Tissue, Nutrition, Metabolism and Cardiovascular Diseases (2017), doi: 10.1016/j.numecd.2017.03.007. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT
Bariatric Surgery, Diabetes Mellitus, and Epicardial Adipose Tissue
Zeynep Cerit, MD (corresponding author)
RI PT
Zeynep Cerit
SC
Near East University Hospital, Department of Pediatric Cardiology, Nicosia, Cyprus
Conflict of interest: None
AC C
EP
TE D
Funding statement: None
M AN U
Tel: 00903926751000, Fax: 00903926751000, Email: [email protected]
ACCEPTED MANUSCRIPT Dear Editor, Bonaventura et al. (1) reported that bariatric surgery (BS) improved both metabolic and inflammatory biomarkers at 1- and 3-year follow-up. Pre-surgery high C-reactive protein
RI PT
(CRP) levels predicted 3-year type 2 diabetes mellitus (T2DM) partial remission, indicating a promising target population to be especially treated with biliopancreatic diversion..
Epicardial adipose tissue (EAT) is clinically related to metabolic syndrome, fasting
SC
insulin, adiponectin, and low-density lipoprotein cholesterol. EAT is rich in saturated fatty acids, such as the palmitate and stearic acid (2). Palmitate has been shown to down-regulate
M AN U
leptin secretion (3). Leptin is an adipokine well known for its role in the regulation of food intake and energy expenditure. Leptin suppresses insulin synthesis and secretion and increases insulin sensitivity, but also contributes to regulate liver and skeletal muscle lipid oxidation and glucose metabolism (4). BS induced a efficient reduction in inflammatory and insulin
TE D
resistance parameters. Lai et al. (5) reported that EAT was independently associated with systemic inflammation in terms of elevated hsCRP after adjustment for traditional body fat measure.
EP
In this context, beneficial effects of BS in patients with T2DM were evaluated in this
AC C
study (1), correlation of this study’s results with EAT might be beneficial due to close association among EAT, leptin, and CRP.
ACCEPTED MANUSCRIPT References 1. Bonaventura A, Liberale L, Carbone F, Scopinaro N, Camerini G, Papadia FS, et al. High baseline C-reactive protein levels predict partial type 2 diabetes mellitus
10.1016/j.numecd.2017.01.007. [Epub ahead of print]
RI PT
remission after biliopancreatic diversion. Nutr Metab Cardiovasc Dis. 2017. doi:
2. Pezeshkian M, Noori M, Najjarpour-Jabbari H, Abolfathi A, Darabi M, Darabi M, et
Metab Syndr Relat Disord. 2009;7:125-31.
SC
al. Fatty acid composition of epicardial and subcutaneous human adipose tissue.
M AN U
3. Schaab M, Kausch H, Klammt J, Nowicki M, Anderegg U, Gebhardt R, et al. Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action. PLoS One 2012;7:34787.
4. Amitani M, Asakawa A, Amitani H, Inui A. The role of leptin in the control of insulinglucose axis. Front Neurosci 2013;7:51.
TE D
5. Lai YH, Yun CH, Yang FS, Liu CC, Wu YJ, Kuo JY, et al. Epicardial adipose tissue relating to anthropometrics, metabolic derangements and fatty liver disease
EP
independently contributes to serum high-sensitivity C-reactive protein beyond body fat composition: a study validated with computed tomography. J Am Soc Echocardiogr.
AC C
2012;25:234-41. doi: 10.1016/j.echo.2011.09.018.
S0939-4753(17)30063-7
DOI:
10.1016/j.numecd.2017.03.007
Reference:
NUMECD 1711
To appear in:
Nutrition, Metabolism and Cardiovascular Diseases
Received Date: 17 March 2017 Revised Date:
30 March 2017
Accepted Date: 31 March 2017
Please cite this article as: Cerit Z, Bariatric Surgery, Diabetes Mellitus, and Epicardial Adipose Tissue, Nutrition, Metabolism and Cardiovascular Diseases (2017), doi: 10.1016/j.numecd.2017.03.007. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT
Bariatric Surgery, Diabetes Mellitus, and Epicardial Adipose Tissue
Zeynep Cerit, MD (corresponding author)
RI PT
Zeynep Cerit
SC
Near East University Hospital, Department of Pediatric Cardiology, Nicosia, Cyprus
Conflict of interest: None
AC C
EP
TE D
Funding statement: None
M AN U
Tel: 00903926751000, Fax: 00903926751000, Email: [email protected]
ACCEPTED MANUSCRIPT Dear Editor, Bonaventura et al. (1) reported that bariatric surgery (BS) improved both metabolic and inflammatory biomarkers at 1- and 3-year follow-up. Pre-surgery high C-reactive protein
RI PT
(CRP) levels predicted 3-year type 2 diabetes mellitus (T2DM) partial remission, indicating a promising target population to be especially treated with biliopancreatic diversion..
Epicardial adipose tissue (EAT) is clinically related to metabolic syndrome, fasting
SC
insulin, adiponectin, and low-density lipoprotein cholesterol. EAT is rich in saturated fatty acids, such as the palmitate and stearic acid (2). Palmitate has been shown to down-regulate
M AN U
leptin secretion (3). Leptin is an adipokine well known for its role in the regulation of food intake and energy expenditure. Leptin suppresses insulin synthesis and secretion and increases insulin sensitivity, but also contributes to regulate liver and skeletal muscle lipid oxidation and glucose metabolism (4). BS induced a efficient reduction in inflammatory and insulin
TE D
resistance parameters. Lai et al. (5) reported that EAT was independently associated with systemic inflammation in terms of elevated hsCRP after adjustment for traditional body fat measure.
EP
In this context, beneficial effects of BS in patients with T2DM were evaluated in this
AC C
study (1), correlation of this study’s results with EAT might be beneficial due to close association among EAT, leptin, and CRP.
ACCEPTED MANUSCRIPT References 1. Bonaventura A, Liberale L, Carbone F, Scopinaro N, Camerini G, Papadia FS, et al. High baseline C-reactive protein levels predict partial type 2 diabetes mellitus
10.1016/j.numecd.2017.01.007. [Epub ahead of print]
RI PT
remission after biliopancreatic diversion. Nutr Metab Cardiovasc Dis. 2017. doi:
2. Pezeshkian M, Noori M, Najjarpour-Jabbari H, Abolfathi A, Darabi M, Darabi M, et
Metab Syndr Relat Disord. 2009;7:125-31.
SC
al. Fatty acid composition of epicardial and subcutaneous human adipose tissue.
M AN U
3. Schaab M, Kausch H, Klammt J, Nowicki M, Anderegg U, Gebhardt R, et al. Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action. PLoS One 2012;7:34787.
4. Amitani M, Asakawa A, Amitani H, Inui A. The role of leptin in the control of insulinglucose axis. Front Neurosci 2013;7:51.
TE D
5. Lai YH, Yun CH, Yang FS, Liu CC, Wu YJ, Kuo JY, et al. Epicardial adipose tissue relating to anthropometrics, metabolic derangements and fatty liver disease
EP
independently contributes to serum high-sensitivity C-reactive protein beyond body fat composition: a study validated with computed tomography. J Am Soc Echocardiogr.
AC C
2012;25:234-41. doi: 10.1016/j.echo.2011.09.018.