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Barriers to Human Papillomavirus (HPV) vaccine uptake in Asia: A pilot study
Abstracts from the 41st Annual Meeting / Journal of Dermatological Science 86 (2017) e1–e95
Category 6 (P06): Epidemiology/Health Service Research P06-01[O2-39] Evaluation of the clinical characteristics of pruritus in patients with psoriasis using the Japanese version of the 5-D itch scale Yozo Ishiuji 1,∗ , Yoshinori Umezawa 1 , Norie Aizawa 1 , Sanae Inokuchi 1 , Akihiko Asahina 1 , Koichi Yanaba 1 , Toshiya Ebata 2 , Hidemi Nakagawa 1 1
Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan 2 Department of Dermatology, Chitofuna Dermatology Clinic, Tokyo, Japan The prevalence of pruritus has ranged from 64% to 97%. Pruritus leads the patients with psoriasis to scratch and it may trigger new eruptions. Thus, the management of pruritus is important to avoid aggravation of psoriasis by scratching. It is needed to assess pruritus in the psoriatic patients for the choice of appropriate treatments. Currently, only a few resources are available to measure pruritus. However, these scales do not take into account the multidimensional aspects of pruritus. The 5-D itch scale is a new simple self-administered questionnaire. It consists of five sections that measure duration, degree, direction, disability and distribution of itching. To examine the clinical characteristics of pruritus in patients with psoriasis using the Japanese version of the 5-D itch scale. A total of 69 patients with psoriasis (44 men and 25 women), all between 23 and 80 years of age, participated in this study (mean ± SD; 54.6 ± 15.6). The Japanese version of the 5-D itch scale was administered to these patients. In addition, we evaluated the disease severity and quality of life (QOL) by the severity of psoriasis (psoriasis area and severity index [PASI]) and the dermatology life quality index (DLQI), respectively. The mean and standard deviation of 5-D score was 10.1 ± 4.3 with the scores ranging between 5 and 22. The mean PASI score was 6.4 ± 7.3 with the scores ranging between 0 and 28. Our data are currently under analysis and will be expected to give the characterization and correlation of pruritus, the disease severity and QOL in Japanese patients with psoriasis. The 5-D is a reliable, multidimensional measure of itching that has been validated in patients with psoriasis. The 5-D should be useful as a new tool for the evaluation of psoriatic pruritus. http://dx.doi.org/10.1016/j.jdermsci.2017.02.143 P06-02[O2-40] Quality of life in adult patients with atopic dermatitis at dermatology hospital of Ho Chi Minh City Trinh Ngo Binh The Department of Dermatology Hospital at Ho Chi Minh City, Japan Background: Atopic dermatitis is a common skin disease, accounting for 15–20% of children and 1–10% of adults in developed countries. Atopic dermatitis is a chronic, relapsing disease. This disease may cause physically and mentally enormous loss, therefore, affects on patients’ quality of life. Objectives: Assessing the impact of atopic dermatitis on the quality of life of patients. Methods: A case series report was conducted in over 16 years old patients with atopic dermatitis, who was diagnosed by Hanifin and Rajka criteria. The severity of disease was calculated by SCORAD. These patients were interviewed by questionnaire of quality of life index (DLQI) to assess the quality of life.
e49
Results: We observed 116 patients with atopic dermatitis. The mean age was 35.43 ± 13.48. Moderate atopic dermatitis accounted for 43.2% according to SCORAD. Quality of life index (DLQI) showed 40.5% of patients have a large effect on their quality of life. Moreover, quality of life and severity of atopic dermatitis were correlated (r = 0.65). Conclusion: In this study, 40.5% patients were affected on their quality of life. This effect was correlated with severity of the disease. Keywords: Quality of life, atopic dermatitis http://dx.doi.org/10.1016/j.jdermsci.2017.02.144 P06-03[O2-41] Barriers to Human Papillomavirus (HPV) vaccine uptake in Asia: A pilot study Mingjuan Tan ∗ , T. Thirumoorthy Duke-NUS Medical School, Singapore Background: Approximately half of cervical cancer cases globally are in Asia, yet uptake is low in many Asian countries including Japan, where perceptions about adverse effects have affected uptake. This study explores barriers to Human Papillomavirus (HPV) vaccine uptake in Singapore, where it is recommended and funded, but not enforced, by the government for girls aged 9–26. Methods: For this qualitative pilot study, an online survey was sent to a select sample of head and/or senior clinicians in Dermatology and Obstetrics and Gynecology at Singapore major public hospitals. This group was chosen as they are field experts and opinion leaders who drive health and hospital policies. 6 of 11 clinicians completed the survey. Results: Respondents largely agreed that the HPV vaccine prevents associated disease (i.e. cancer, genital warts). Most agreed that government coverage of the vaccine should extend to both sexes. Most would not proactively suggest the vaccine to male patients, but would recommend it if asked. Reasons given were possible sexual compensation and fear of embarrassing patients. Respondents were also asked about reasons given by parents and patients for declining the vaccine. Some parents felt their daughters would not benefit or were concerned about sexual compensation. Reasons given by female patients included fear of adverse side effects, cost, the need for three doses, and the perception that they would not get HPV-associated diseases. Conclusion: Barriers to HPV vaccine uptake still exist on the part of clinicians, patients and parents. This is despite evidence for its efficacy, low rate of adverse effects (Ushida, 2016) and lack of associated sexual compensation. Measures to address these barriers include improving clinician and public education. http://dx.doi.org/10.1016/j.jdermsci.2017.02.145
Category 6 (P06): Epidemiology/Health Service Research P06-01[O2-39] Evaluation of the clinical characteristics of pruritus in patients with psoriasis using the Japanese version of the 5-D itch scale Yozo Ishiuji 1,∗ , Yoshinori Umezawa 1 , Norie Aizawa 1 , Sanae Inokuchi 1 , Akihiko Asahina 1 , Koichi Yanaba 1 , Toshiya Ebata 2 , Hidemi Nakagawa 1 1
Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan 2 Department of Dermatology, Chitofuna Dermatology Clinic, Tokyo, Japan The prevalence of pruritus has ranged from 64% to 97%. Pruritus leads the patients with psoriasis to scratch and it may trigger new eruptions. Thus, the management of pruritus is important to avoid aggravation of psoriasis by scratching. It is needed to assess pruritus in the psoriatic patients for the choice of appropriate treatments. Currently, only a few resources are available to measure pruritus. However, these scales do not take into account the multidimensional aspects of pruritus. The 5-D itch scale is a new simple self-administered questionnaire. It consists of five sections that measure duration, degree, direction, disability and distribution of itching. To examine the clinical characteristics of pruritus in patients with psoriasis using the Japanese version of the 5-D itch scale. A total of 69 patients with psoriasis (44 men and 25 women), all between 23 and 80 years of age, participated in this study (mean ± SD; 54.6 ± 15.6). The Japanese version of the 5-D itch scale was administered to these patients. In addition, we evaluated the disease severity and quality of life (QOL) by the severity of psoriasis (psoriasis area and severity index [PASI]) and the dermatology life quality index (DLQI), respectively. The mean and standard deviation of 5-D score was 10.1 ± 4.3 with the scores ranging between 5 and 22. The mean PASI score was 6.4 ± 7.3 with the scores ranging between 0 and 28. Our data are currently under analysis and will be expected to give the characterization and correlation of pruritus, the disease severity and QOL in Japanese patients with psoriasis. The 5-D is a reliable, multidimensional measure of itching that has been validated in patients with psoriasis. The 5-D should be useful as a new tool for the evaluation of psoriatic pruritus. http://dx.doi.org/10.1016/j.jdermsci.2017.02.143 P06-02[O2-40] Quality of life in adult patients with atopic dermatitis at dermatology hospital of Ho Chi Minh City Trinh Ngo Binh The Department of Dermatology Hospital at Ho Chi Minh City, Japan Background: Atopic dermatitis is a common skin disease, accounting for 15–20% of children and 1–10% of adults in developed countries. Atopic dermatitis is a chronic, relapsing disease. This disease may cause physically and mentally enormous loss, therefore, affects on patients’ quality of life. Objectives: Assessing the impact of atopic dermatitis on the quality of life of patients. Methods: A case series report was conducted in over 16 years old patients with atopic dermatitis, who was diagnosed by Hanifin and Rajka criteria. The severity of disease was calculated by SCORAD. These patients were interviewed by questionnaire of quality of life index (DLQI) to assess the quality of life.
e49
Results: We observed 116 patients with atopic dermatitis. The mean age was 35.43 ± 13.48. Moderate atopic dermatitis accounted for 43.2% according to SCORAD. Quality of life index (DLQI) showed 40.5% of patients have a large effect on their quality of life. Moreover, quality of life and severity of atopic dermatitis were correlated (r = 0.65). Conclusion: In this study, 40.5% patients were affected on their quality of life. This effect was correlated with severity of the disease. Keywords: Quality of life, atopic dermatitis http://dx.doi.org/10.1016/j.jdermsci.2017.02.144 P06-03[O2-41] Barriers to Human Papillomavirus (HPV) vaccine uptake in Asia: A pilot study Mingjuan Tan ∗ , T. Thirumoorthy Duke-NUS Medical School, Singapore Background: Approximately half of cervical cancer cases globally are in Asia, yet uptake is low in many Asian countries including Japan, where perceptions about adverse effects have affected uptake. This study explores barriers to Human Papillomavirus (HPV) vaccine uptake in Singapore, where it is recommended and funded, but not enforced, by the government for girls aged 9–26. Methods: For this qualitative pilot study, an online survey was sent to a select sample of head and/or senior clinicians in Dermatology and Obstetrics and Gynecology at Singapore major public hospitals. This group was chosen as they are field experts and opinion leaders who drive health and hospital policies. 6 of 11 clinicians completed the survey. Results: Respondents largely agreed that the HPV vaccine prevents associated disease (i.e. cancer, genital warts). Most agreed that government coverage of the vaccine should extend to both sexes. Most would not proactively suggest the vaccine to male patients, but would recommend it if asked. Reasons given were possible sexual compensation and fear of embarrassing patients. Respondents were also asked about reasons given by parents and patients for declining the vaccine. Some parents felt their daughters would not benefit or were concerned about sexual compensation. Reasons given by female patients included fear of adverse side effects, cost, the need for three doses, and the perception that they would not get HPV-associated diseases. Conclusion: Barriers to HPV vaccine uptake still exist on the part of clinicians, patients and parents. This is despite evidence for its efficacy, low rate of adverse effects (Ushida, 2016) and lack of associated sexual compensation. Measures to address these barriers include improving clinician and public education. http://dx.doi.org/10.1016/j.jdermsci.2017.02.145