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Basic Science Research
Basic Science Research Dennis A. Ausielio, MD, and Shaul Massry, MD
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HREE AREAS of basic science initiatives were considered of high priority and immediate relevance to end-stage renal disease (ESRD). These areas include (1) leukocyte biology, (2) lipid metabolism, and (3) hormonal action. The biology of leukocyte adhesion, cell signaling, and gene transcription of, for example, cytokine induction are relevant to inflammation, injury, and the immune response in uremia. Evaluation of those aspects that are generic to chronic disease versus those that are unique to uremia was felt to be important, with particular emphasis on the sequential quantitative and From a Workshop held in Miami, FL, February 27 to March 1, 1992. Received May 4, 1992; accepted in revised form July 31, 1992. Address reprint requests to Dennis A. Ausiel/o, MD, Renal Unit, Massachusetts General Hospital, Charlestown, MA 02129. © 1993 by the National Kidney Foundation, Inc. 0272-6386/93/2101-0028$3.00/0
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qualitative pattern of response in infection, wound healing, and atherosclerosis. Fatty acid metabolism was felt to be particularly relevant to the uremic state, as a target for dietary manipulation and as an important modifier of the pathology of signal transduction and growth, Fatty acyl modification of proteins is an important component of transducing proteins, enzymes, and proto-oncogenes, and is modified by alterations in the cholesterol biosynthetic pathway that is likely to occur in uremia. The oxidatiation of lipoproteins and its resultant pathology was also felt to be relevant to the patient with ESRD. The modification of hormonal responses in the uremic melieu was felt to be particularly receptive to study using the tools of cell and molecular biology, The ability to determine ligand-receptor interactions at the molecular level, as well as to determine and modify the subsequent signal transduction pathways, was felt to be a high priority for insulin resistance, abnormal response to parathyroid hormone, and modified or induced responses to growth factors in ESRD.
American Journal of Kidney Diseases, Vol 21, No 1 (January), 1993: p 120
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HREE AREAS of basic science initiatives were considered of high priority and immediate relevance to end-stage renal disease (ESRD). These areas include (1) leukocyte biology, (2) lipid metabolism, and (3) hormonal action. The biology of leukocyte adhesion, cell signaling, and gene transcription of, for example, cytokine induction are relevant to inflammation, injury, and the immune response in uremia. Evaluation of those aspects that are generic to chronic disease versus those that are unique to uremia was felt to be important, with particular emphasis on the sequential quantitative and From a Workshop held in Miami, FL, February 27 to March 1, 1992. Received May 4, 1992; accepted in revised form July 31, 1992. Address reprint requests to Dennis A. Ausiel/o, MD, Renal Unit, Massachusetts General Hospital, Charlestown, MA 02129. © 1993 by the National Kidney Foundation, Inc. 0272-6386/93/2101-0028$3.00/0
120
qualitative pattern of response in infection, wound healing, and atherosclerosis. Fatty acid metabolism was felt to be particularly relevant to the uremic state, as a target for dietary manipulation and as an important modifier of the pathology of signal transduction and growth, Fatty acyl modification of proteins is an important component of transducing proteins, enzymes, and proto-oncogenes, and is modified by alterations in the cholesterol biosynthetic pathway that is likely to occur in uremia. The oxidatiation of lipoproteins and its resultant pathology was also felt to be relevant to the patient with ESRD. The modification of hormonal responses in the uremic melieu was felt to be particularly receptive to study using the tools of cell and molecular biology, The ability to determine ligand-receptor interactions at the molecular level, as well as to determine and modify the subsequent signal transduction pathways, was felt to be a high priority for insulin resistance, abnormal response to parathyroid hormone, and modified or induced responses to growth factors in ESRD.
American Journal of Kidney Diseases, Vol 21, No 1 (January), 1993: p 120