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Better Syrup of Orange
REFRIGERATION GIVES
by W. H. GLOVER, L. M. OHMART, and M. J. STOKLOSA MASSACHUSETTS COLLEGE OF PHARMACY
A
LTHOUGH prescription surveys reveal that Syrup of Orange, U. S. P., is one of the most frequently used of the syrup vehicles, it is the opinion of the authors that the syrup of orange commonly dispensed does not fully represent the possibilities of the official preparation. When first prepared, Syrup of Orange is a brilliant, golden-yellow syrup with the delicate and refreshing fragrance and taste of fresh, ripe oranges. Under the conditions of storage recommended by the Pharmacopceia and followed in most prescription departments, the appearance, taste and odor of the syrup change rapidly. Within a period of a few days, at most, the syrup begins to lose some of its brilliancy and the taste and odor have undergone such marked changes that they are only faintly reminiscent of fresh oranges. While these changes are probably too subtle to be demonstrated chemically, they are perfectly apparent to the senses and detract seriously from the usefulness of Syrup of Orange as a prescription vehicle.
room temperature during the observation period of four months. Series 2.-Three 500-cc. samples were prepared by the official method. Immediately following their completion, they were placed in a mechanical refrigerator at a temperature of 2° C. and were maintained at approximately that temperature during the observation period. Series 3.-Three 500-cc. samples were pre-
Acting on the theory that the undesirable changes which take place in Syrup of Orange are due to the conditions under which the preparation is usually stored, a study was undertaken to determine if storage at a low temperature would retard these changes.
Experimental Four series of samples of Syrup of Orange were prepared. Series i.-Three 500-cc. samples were prepared by the official method and were stored at
309
by W. H. GLOVER, L. M. OHMART, and M. J. STOKLOSA MASSACHUSETTS COLLEGE OF PHARMACY
A
LTHOUGH prescription surveys reveal that Syrup of Orange, U. S. P., is one of the most frequently used of the syrup vehicles, it is the opinion of the authors that the syrup of orange commonly dispensed does not fully represent the possibilities of the official preparation. When first prepared, Syrup of Orange is a brilliant, golden-yellow syrup with the delicate and refreshing fragrance and taste of fresh, ripe oranges. Under the conditions of storage recommended by the Pharmacopceia and followed in most prescription departments, the appearance, taste and odor of the syrup change rapidly. Within a period of a few days, at most, the syrup begins to lose some of its brilliancy and the taste and odor have undergone such marked changes that they are only faintly reminiscent of fresh oranges. While these changes are probably too subtle to be demonstrated chemically, they are perfectly apparent to the senses and detract seriously from the usefulness of Syrup of Orange as a prescription vehicle.
room temperature during the observation period of four months. Series 2.-Three 500-cc. samples were prepared by the official method. Immediately following their completion, they were placed in a mechanical refrigerator at a temperature of 2° C. and were maintained at approximately that temperature during the observation period. Series 3.-Three 500-cc. samples were pre-
Acting on the theory that the undesirable changes which take place in Syrup of Orange are due to the conditions under which the preparation is usually stored, a study was undertaken to determine if storage at a low temperature would retard these changes.
Experimental Four series of samples of Syrup of Orange were prepared. Series i.-Three 500-cc. samples were prepared by the official method and were stored at
309