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Biochemical Pharmacology and Toxicology. Vol. I. Methodological Aspects of Drug Metabolizing Enzymes
Davis, Hadgraft, and Palin wrote the third chapter which is on medical and pharmaceutical applications of emulsions. There is little doubt the authors compiled a comprehensive survey on the application of emulsion systems to the delivery of drugs and nutrients. This is verified by the 277 references in the chapter’s bibliography. The chapter is light on theory, which is suitable given the intent of the volume and the breadth of applications covered. Even perfluorochemical emulsions as artificial blood substitutes are included. The fourth chapter, agricultural applications, was written by David Becker. Essentially, it discusses emulsions and their application to pesticides and growth regulators for plants. Much information is covered, but its organization lessens its effectiveness.Both Chapter 5 by Krog, Rusom, and Larsson and Chapter 6 by Jaynes cover applications in the food industry. The editor states that the topic requires two chapters since the first discusses preparation of a large area of food emulsions while the second restricts itself to emulsions stabilized by emulsions. Cosmetic emulsions are briefly covered by Breuer in the seventh chapter. The chapter includes discussions on ingredients, manufacture, rheology, and stability. Given the inherent problem of thermodynamic instability, the author should have devoted more than 2 112 pages to a discussion that illustrates problems in this critical area. The final chapter, compiled by the editor, does not really fit the category of applications since it is a bibliography of hydrophile-lipophile balance (HLB). Becker states that this bibliography is an update; the most recent previous bibliography of his appeared in 1974.It appears the purpose of this updated chapter is not simply to list those references published since 1974,but instead to recap those published in the 1950s and 60s. Overall, the volume is reasonably current and provides a broad overview of the application of emulsion technology. It will be a useful addition to the library of anyone who works with emulsions. This is particularly true for the pharmaceutical and food scientist. Galen Radebaugh McNeil Consumer Products Co. Research and Development Ft. Washington, PA 19034
Directed Drug Delivery: A Multldlscipilnary Approach. Edited by Ronald T. Borchardt, Arnold J. Repta, and Valentino J. Stella. The Humana Press Inc., Crescent Manor, P.O. Box 2148, Clifton, NJ 07015. 1985. CCCLXXXIV + 384. ISBN 0-89603-089-X. $59.50.
During the past decade, an increasing number of books and reviews have appeared on the general topic of drug delivery. As a consequence, there has been considerable overlap and repetition, which has negatively impacted on the overall value of these publications. Furthermore, the field of controlled drug delivery is expanding at such a rapid rate that the timeliness of symposia volumes and other publications have been questioned. This book is based on the proceedings of a symposium held in October 1984,which was dedicated to Dr. Takeru Higuchi. As a result, most of the speakers and subsequently many of the authors in this publication have, a t some point in time in their professional career, interacted with Dr. Higuchi and are presently well-known researchers and industrialists. In some respects, it is the assimilation of the inputs of these
reputed scientists that makes this volume different from the routine publications and gives this book a good opportunity to have a lasting value. The book is divided into five sections: (a)pharmacodynamic and pharmacokinetic factors influencing directed drug delivery; (b) physiological and biochemical factors influencing directed drug delivery; (c) physicochemical approaches to directed drug delivery; ( d )biological-chemical approaches to drug delivery, and (e) analytical aspects of drug delivery. The individual chapters are well written and represent all of the key physical, chemical, and biological aspects of drug delivery. Drug delivery development requires a multi-disciplinary approach; and, for those involved in the various aspects of the problem, this volume should serve as a valuable reference. However, it should be mentioned that the book is not intended to provide quick answers, and a full appreciation of this rapidly growing field will be obtained only by a thorough reading of the entire symposium volume. S. Kumar Chandrasekaran Sola-Syntex Ophthalmics Phoenix, AZ 85069-9600
Biochemical Pharmacology and Toxicology. Vol. 1. Methodological Aspects of Drug Metabolizing Enzymes. EditJohn Wiley ed by David Zakim and Donald A. Vessey. and Sons, Third Avenue, New York, NY 10158. 1985. 372 pp. ISBN 0-471-86793-4. $35.00.
The objective of this volume is to provide basic information on the methodology for characterization of several of the complex enzymes involved in metabolism of drugs and other xenobiotics. The editors have selected enzymes for review which they deem the most complex in multiplicity, substrate specificity, regulation, and kinetics. These enzymes include epoxide hydrolases, sulfotransferases, UDP-glucuronyltransferases, monoamine oxidases, cytochromes P-450,and glutathione S-transferases. While the chapters vary in the depth of information provided on purification and characterization of each enzyme, the major unifying strength of each chapter is an emphasis on detailed assay methodology. Special attention is given to the appropriate use of various enzyme assays and the limitations, or problems in interpretation, which might arise with their use. Each chapter contains an extensive table of contents which can quickly lead the reader to appropriate sections for specific purification, characterization, and assay procedures. Indeed, these extensive outlines a t the beginning of each chapter are generally more useful than the subject index for the entire volume. The references cited in each chapter are complete through 1983,with a few references to work published in 1984,or in press for 1985. In summary, this volume meets the goal of the editors of providing basic biochemical information on selected drug metabolizing enzymes to researchers in pharmacology, toxicology, and related disciplines. Therefore, it provides both an introduction to research literature on several drug metabolizing enzymes and experimental details on assay and characterization of these enzymes. Michael W. Duffel Division of Medicinal Chemistry and Natural Products College of Pharmacy University of Iowa Iowa City, Iowa 52242 Journal of Pharmaceutical Sciences / 727 Vol. 75,No. 7,July 1986
Directed Drug Delivery: A Multldlscipilnary Approach. Edited by Ronald T. Borchardt, Arnold J. Repta, and Valentino J. Stella. The Humana Press Inc., Crescent Manor, P.O. Box 2148, Clifton, NJ 07015. 1985. CCCLXXXIV + 384. ISBN 0-89603-089-X. $59.50.
During the past decade, an increasing number of books and reviews have appeared on the general topic of drug delivery. As a consequence, there has been considerable overlap and repetition, which has negatively impacted on the overall value of these publications. Furthermore, the field of controlled drug delivery is expanding at such a rapid rate that the timeliness of symposia volumes and other publications have been questioned. This book is based on the proceedings of a symposium held in October 1984,which was dedicated to Dr. Takeru Higuchi. As a result, most of the speakers and subsequently many of the authors in this publication have, a t some point in time in their professional career, interacted with Dr. Higuchi and are presently well-known researchers and industrialists. In some respects, it is the assimilation of the inputs of these
reputed scientists that makes this volume different from the routine publications and gives this book a good opportunity to have a lasting value. The book is divided into five sections: (a)pharmacodynamic and pharmacokinetic factors influencing directed drug delivery; (b) physiological and biochemical factors influencing directed drug delivery; (c) physicochemical approaches to directed drug delivery; ( d )biological-chemical approaches to drug delivery, and (e) analytical aspects of drug delivery. The individual chapters are well written and represent all of the key physical, chemical, and biological aspects of drug delivery. Drug delivery development requires a multi-disciplinary approach; and, for those involved in the various aspects of the problem, this volume should serve as a valuable reference. However, it should be mentioned that the book is not intended to provide quick answers, and a full appreciation of this rapidly growing field will be obtained only by a thorough reading of the entire symposium volume. S. Kumar Chandrasekaran Sola-Syntex Ophthalmics Phoenix, AZ 85069-9600
Biochemical Pharmacology and Toxicology. Vol. 1. Methodological Aspects of Drug Metabolizing Enzymes. EditJohn Wiley ed by David Zakim and Donald A. Vessey. and Sons, Third Avenue, New York, NY 10158. 1985. 372 pp. ISBN 0-471-86793-4. $35.00.
The objective of this volume is to provide basic information on the methodology for characterization of several of the complex enzymes involved in metabolism of drugs and other xenobiotics. The editors have selected enzymes for review which they deem the most complex in multiplicity, substrate specificity, regulation, and kinetics. These enzymes include epoxide hydrolases, sulfotransferases, UDP-glucuronyltransferases, monoamine oxidases, cytochromes P-450,and glutathione S-transferases. While the chapters vary in the depth of information provided on purification and characterization of each enzyme, the major unifying strength of each chapter is an emphasis on detailed assay methodology. Special attention is given to the appropriate use of various enzyme assays and the limitations, or problems in interpretation, which might arise with their use. Each chapter contains an extensive table of contents which can quickly lead the reader to appropriate sections for specific purification, characterization, and assay procedures. Indeed, these extensive outlines a t the beginning of each chapter are generally more useful than the subject index for the entire volume. The references cited in each chapter are complete through 1983,with a few references to work published in 1984,or in press for 1985. In summary, this volume meets the goal of the editors of providing basic biochemical information on selected drug metabolizing enzymes to researchers in pharmacology, toxicology, and related disciplines. Therefore, it provides both an introduction to research literature on several drug metabolizing enzymes and experimental details on assay and characterization of these enzymes. Michael W. Duffel Division of Medicinal Chemistry and Natural Products College of Pharmacy University of Iowa Iowa City, Iowa 52242 Journal of Pharmaceutical Sciences / 727 Vol. 75,No. 7,July 1986