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Bioinorganic Chemistry of Copper
608
Book Reviews
Fluorocompounds play a role in antibiotics, antiviral and anticancer agents, cardiovascular drugs, fluoroamino acids and peptides, the fluoroarachidonic acid cascade, volatile anaesthetics, CNS drugs, beta lactams, fluorinated surfactants, and ~8-F in positron emission tomography. These topics together with a survey of fluoromedical compounds are presented in this book. Cell Surface and Extracellular Glycoconjugates; Structure and Function--Edited by D. R. Roberts and R. P. Mecham. 314 pp. 1993. Academic Press, San Diego. Glycoconjugates (G) such as the selectins have an important role as mediators in lymphocyte recirculation, activation and inflammatory responses. Alterations of G can affect the maligant behaviour of tumor cells. Some hormones and growth factors react with the G on the cell surface receptor. The monosaccharide on the cell surface can be linked to a second sugar to form up to eight positional and anomeric isomers each having distinct chemical and biological properties. This book deals with; the functions of N- and O-linked sugar chains of G; pericellular proteoglycans; glycosyl phosphatidylinositol linked membrane proteins; glysylation inhibitors; the use of mammalian cell mutants to study the functions of N- and O-linked lgycosylation; glycophingolipid receptors in inflammation and cancer; G in human choriogonadotropin; G in adhesive cell function. Protocols for Oligonucleotides and Analogs; Synthesis and Properties--Edited by S. Agrawal. 502 pp. 1993. Humana Press, New Jersey. PB.$59.50. The major applications of oligonucleotides (O) have been in the areas of DNA based diagnostics, antisense O therapeutics, and O as therapeutic agents. This book gives practical details of the different O synthesis methods: the phosphotriester approach; phosphoramide method;
H-phosponate; silyl-phosphoramidite; 2'-O-alkyl-oligoribonucleotides; methylphosphonate O; phospborothioates; phosphorodithioates; borane phosphonate; fluoridates; pchiral analogs; dimethylenesulfide, sulfoxide, and sulfone analogs; scale up synthesis of O; large scale O synthesis; solid phase supports for O synthesis. Oxygen Free Radicals and Scavengers in the Natural Sciences--Edited by G. Mozsik, I. Emerit, J. Feher, B. Matkovics and A. Vincze. 366 pp. 1993. Akademiai Kiado, Budapest. $55. This contains the papers presented at the congress on free radicals and scavengers (FR and S) at Budapest in February 1993. It deals with the chemistry, physiology and biochemistry, human clinical medicine, drug research, and nutrition aspects of FR and S. FR are associated with cell damage, ageing, biochemical defects, ischaemic damage, and many other pathological conditions. Increased attention and interest is given to scavengers such as MTDQ, spermine, Vitamin E, gluthathione, RG-107710 and retinoids. Bioinorganic Chemistry of Copper--Edited by K. D. Karlin and Z. Tyeklar. 506 pp. 1993. Chapman and Hall, London. £65. Copper plays a vital biochemical role in an essential metalloenzyme active-site cofactor involved in electron transfer, dioxygen transport, and the reduction of nitrogen oxides. This book deals with copper proteins; blue copper proteins and electron transfer; natural and synthetic regulation of gene expression; copper resistance; copper homeostasis; hemocyanin and copper monooxygenases; copper mediated redox/oxidative pathways; dioxygen binding and oxygenation reactions; copper-nitrogen oxide complexes; copper oxidase.
Book Reviews
Fluorocompounds play a role in antibiotics, antiviral and anticancer agents, cardiovascular drugs, fluoroamino acids and peptides, the fluoroarachidonic acid cascade, volatile anaesthetics, CNS drugs, beta lactams, fluorinated surfactants, and ~8-F in positron emission tomography. These topics together with a survey of fluoromedical compounds are presented in this book. Cell Surface and Extracellular Glycoconjugates; Structure and Function--Edited by D. R. Roberts and R. P. Mecham. 314 pp. 1993. Academic Press, San Diego. Glycoconjugates (G) such as the selectins have an important role as mediators in lymphocyte recirculation, activation and inflammatory responses. Alterations of G can affect the maligant behaviour of tumor cells. Some hormones and growth factors react with the G on the cell surface receptor. The monosaccharide on the cell surface can be linked to a second sugar to form up to eight positional and anomeric isomers each having distinct chemical and biological properties. This book deals with; the functions of N- and O-linked sugar chains of G; pericellular proteoglycans; glycosyl phosphatidylinositol linked membrane proteins; glysylation inhibitors; the use of mammalian cell mutants to study the functions of N- and O-linked lgycosylation; glycophingolipid receptors in inflammation and cancer; G in human choriogonadotropin; G in adhesive cell function. Protocols for Oligonucleotides and Analogs; Synthesis and Properties--Edited by S. Agrawal. 502 pp. 1993. Humana Press, New Jersey. PB.$59.50. The major applications of oligonucleotides (O) have been in the areas of DNA based diagnostics, antisense O therapeutics, and O as therapeutic agents. This book gives practical details of the different O synthesis methods: the phosphotriester approach; phosphoramide method;
H-phosponate; silyl-phosphoramidite; 2'-O-alkyl-oligoribonucleotides; methylphosphonate O; phospborothioates; phosphorodithioates; borane phosphonate; fluoridates; pchiral analogs; dimethylenesulfide, sulfoxide, and sulfone analogs; scale up synthesis of O; large scale O synthesis; solid phase supports for O synthesis. Oxygen Free Radicals and Scavengers in the Natural Sciences--Edited by G. Mozsik, I. Emerit, J. Feher, B. Matkovics and A. Vincze. 366 pp. 1993. Akademiai Kiado, Budapest. $55. This contains the papers presented at the congress on free radicals and scavengers (FR and S) at Budapest in February 1993. It deals with the chemistry, physiology and biochemistry, human clinical medicine, drug research, and nutrition aspects of FR and S. FR are associated with cell damage, ageing, biochemical defects, ischaemic damage, and many other pathological conditions. Increased attention and interest is given to scavengers such as MTDQ, spermine, Vitamin E, gluthathione, RG-107710 and retinoids. Bioinorganic Chemistry of Copper--Edited by K. D. Karlin and Z. Tyeklar. 506 pp. 1993. Chapman and Hall, London. £65. Copper plays a vital biochemical role in an essential metalloenzyme active-site cofactor involved in electron transfer, dioxygen transport, and the reduction of nitrogen oxides. This book deals with copper proteins; blue copper proteins and electron transfer; natural and synthetic regulation of gene expression; copper resistance; copper homeostasis; hemocyanin and copper monooxygenases; copper mediated redox/oxidative pathways; dioxygen binding and oxygenation reactions; copper-nitrogen oxide complexes; copper oxidase.