- Email: [email protected]
Biological approaches to the controlled delivery of drugs
Journal
of Membrane
Science,
Elsevier Science Publishers
45 (1989) 313-314 B.V.. Amsterdam - Printed
313
in The Netherlands
Book Reviews New Membrane Materials and Processes for Separation, edited by K.K. Sirkar and D.R. Lloyd, AIChE Symposium Series No. 261, Volume 84, American Institute of Chemical Engineers, New York, NY 10017, 1988, 177 pages, $20.00 ( AIChE members), $40.00 (non-members, U.S.A. ) This book is a collection of 16 papers that covers a wide range of separations. Twelve of the papers were presented at the Summer National Meeting of the American Institute of Chemical Engineers in Minneapolis, Minnesota, in 1987. The remaining four papers were invited contributions. This book contains two excellent articles dealing with developments in separation technology. First, H.P. Hsieh of Alcoa Laboratories ( Aluminium Company of America, Alcoa Center, Pennsylvania) presents an excellent review of inorganic membranes. He describes the various types of inorganic membranes being developed and commercialized, as well as the methods used to make them. Second, Robert W. Callahan of the Separations Products Division of Hoechst Celanese Corp. (Somerville, New Jersey) gives an excellent review of the uses of Celgard@ microporous membranes for a variety of separations. Callahan discusses gas-gas, liquid-gas, and liquid-liquid membrane contactors, as well as immobilized liquid membranes. Examples of separation applications are presented for each system. The remainder of the papers vary in quality. About one-third of the papers are commercials from various companies touting their products, and the technical content of the papers is low. The other papers cover a variety of subjects, ranging from thermal-phase-inversion membranes to membranes containing photoreactive groups. Although these papers were reviewed for technical content, the editors should have set higher standard for the papers they accepted. Several papers are difficult to read because they are poorly organized or poorly written. As a result, this book is not as valuable as it could have been. However, the book contains some valuable technical information. SCOTT B. McCRAY Bend Research Inc. Bend, Oregon, U.S.A.
Biological Approaches to the Controlled Delivery of Drugs, edited by R.L. Juliano, Annals of the New York Academy of Sciences, Vol. 507, Dec. 22,1987, x + 364 pages, $91.00. Biological Approaches to the Controlled Delivery of Drugs contains 38 papers
314
that were presented at a symposium sponsored by the New York Academy of Sciences in New York City on January 13-l&1987. The symposium featured several noted researchers from North America and Western Europe and represented a snapshot of activity in this relatively young but rapidly diversifying field. The published collection is a well-organized blend of cellular and molecular biology, drug-design strategies, pharmacology, and pharmaceutics. The first papers are discussions concerning the biological barriers to macromolecular transport and strategies designed to enhance the delivery of polypeptides. These are followed by the bulk of the papers, which present strategies for targeting drug delivery and increasing the selectivity of drugs. Strategies include the use of prodrugs, viral agents, immunotoxins, monoclonal antibodies, lipoproteins, liposomes, emulsions, microspheres, and a host of other agents and drug-conjugate systems. The volume contains a number of studies previously unreported in the literature; however, most of papers were written as commentaries or review articles. Consequently, the volume is an excellent resource, both for those who need to keep abreast of current trends and for those new to the field. Only one paper was devoted to analytical methodology for supporting the development of targeted drug delivery. The paper was limited in scope but contained a good review of derivatization methods for the analysis of peptides by HPLC. Since analytical methodology is a major bottleneck in the advancement of drug delivery, and especially protein delivery, it was disappointing that more attention was not devoted to this area. Also conspicuously absent were discussions on the use of biologically sensitive systems for “on demand” delivery of drugs. Otherwise the book is a comprehensive account of current biological approaches to the controlled delivery of drugs. MARTIN E. SCHIMPF Bend Research Inc. Bend, Oregon, U.S.A.
of Membrane
Science,
Elsevier Science Publishers
45 (1989) 313-314 B.V.. Amsterdam - Printed
313
in The Netherlands
Book Reviews New Membrane Materials and Processes for Separation, edited by K.K. Sirkar and D.R. Lloyd, AIChE Symposium Series No. 261, Volume 84, American Institute of Chemical Engineers, New York, NY 10017, 1988, 177 pages, $20.00 ( AIChE members), $40.00 (non-members, U.S.A. ) This book is a collection of 16 papers that covers a wide range of separations. Twelve of the papers were presented at the Summer National Meeting of the American Institute of Chemical Engineers in Minneapolis, Minnesota, in 1987. The remaining four papers were invited contributions. This book contains two excellent articles dealing with developments in separation technology. First, H.P. Hsieh of Alcoa Laboratories ( Aluminium Company of America, Alcoa Center, Pennsylvania) presents an excellent review of inorganic membranes. He describes the various types of inorganic membranes being developed and commercialized, as well as the methods used to make them. Second, Robert W. Callahan of the Separations Products Division of Hoechst Celanese Corp. (Somerville, New Jersey) gives an excellent review of the uses of Celgard@ microporous membranes for a variety of separations. Callahan discusses gas-gas, liquid-gas, and liquid-liquid membrane contactors, as well as immobilized liquid membranes. Examples of separation applications are presented for each system. The remainder of the papers vary in quality. About one-third of the papers are commercials from various companies touting their products, and the technical content of the papers is low. The other papers cover a variety of subjects, ranging from thermal-phase-inversion membranes to membranes containing photoreactive groups. Although these papers were reviewed for technical content, the editors should have set higher standard for the papers they accepted. Several papers are difficult to read because they are poorly organized or poorly written. As a result, this book is not as valuable as it could have been. However, the book contains some valuable technical information. SCOTT B. McCRAY Bend Research Inc. Bend, Oregon, U.S.A.
Biological Approaches to the Controlled Delivery of Drugs, edited by R.L. Juliano, Annals of the New York Academy of Sciences, Vol. 507, Dec. 22,1987, x + 364 pages, $91.00. Biological Approaches to the Controlled Delivery of Drugs contains 38 papers
314
that were presented at a symposium sponsored by the New York Academy of Sciences in New York City on January 13-l&1987. The symposium featured several noted researchers from North America and Western Europe and represented a snapshot of activity in this relatively young but rapidly diversifying field. The published collection is a well-organized blend of cellular and molecular biology, drug-design strategies, pharmacology, and pharmaceutics. The first papers are discussions concerning the biological barriers to macromolecular transport and strategies designed to enhance the delivery of polypeptides. These are followed by the bulk of the papers, which present strategies for targeting drug delivery and increasing the selectivity of drugs. Strategies include the use of prodrugs, viral agents, immunotoxins, monoclonal antibodies, lipoproteins, liposomes, emulsions, microspheres, and a host of other agents and drug-conjugate systems. The volume contains a number of studies previously unreported in the literature; however, most of papers were written as commentaries or review articles. Consequently, the volume is an excellent resource, both for those who need to keep abreast of current trends and for those new to the field. Only one paper was devoted to analytical methodology for supporting the development of targeted drug delivery. The paper was limited in scope but contained a good review of derivatization methods for the analysis of peptides by HPLC. Since analytical methodology is a major bottleneck in the advancement of drug delivery, and especially protein delivery, it was disappointing that more attention was not devoted to this area. Also conspicuously absent were discussions on the use of biologically sensitive systems for “on demand” delivery of drugs. Otherwise the book is a comprehensive account of current biological approaches to the controlled delivery of drugs. MARTIN E. SCHIMPF Bend Research Inc. Bend, Oregon, U.S.A.