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Bloise et al.: Gonadal Dysgenesis (Turner's Syndrome) With Male Phenotype and XO Chromosomal Constitution
1286
Books received
('arly embryonic tissue to a particular noxious agent. The roles of matl'rnal age, of the placenta, and of the "whole" cnvironmcnt of the mother, her nutrition and metabolism, not men'ly the changes in the uterus during pregnancy, were discussed as possible factors in the etiology of congenital anomalies.
Am.
J.
June, 1961 Obst. & Gynec.
Thc only slightly disappointing feature of this excellcnt volume is thc paucity of material dealing with the effects of radiation on embryonal development; but it may be true, as pointed out by Hamilton in the summation, that this subject is far too big to be covered adeCjuately in a symposium of this type.
Books received for review Atlas of Obstetric Technic. By J. Robert Willson. First edition. 304 pages, 55 plates. St. Louis, Mo., 1961, The C. V. Mosby Company. $14.50. The Choice of a Medical Career (Essays on the Fields of Medicine). By Joseph Garland and Joseph Stokes. First edition. 231 pages. Philadelphia, 1961, J. B. Lippincott Company. $5. The Conduct of Sex. By Lawrence K. Frank. First edition. 192 pages. New York, 1961, William Morrow & Co. $4·. Current Therapy-1961. Edited by Howard F. Conn. 806 pages. Philadelphia, 1961, W. B. Saunders Company. $12.50. Die Kortikosteroid.Behandlung hamatologischer. By J. A. Horster. First edition, 108 pages, 6' tables. New York, 1961, Intercontinental Medical Book Corp. $3.50. Endocrine Dysfunction and Infertility. Edited by S. J. Fomon. 8G pages, 19 figures, 10 tables. Columbus, Ohio, 1961, Ross Laboratories (Ross Conference on Pediatric Research-Report of the 35th). Fetal Electrocardiography. By S. D. Larks. 109
pages, 70 figures. Springfield, Ill., 1961, Charles C Thomas, Publisher. $6.50. Haimopoiesis. By G. E. W. Wolstenholme and M. O·Connor. 490 pages, Boston, 1961, Little, Brown and Company. $11. Hospital Infection. By R. E. O. Williams, R. Blowers, L. P. Garrod, and R. A. Shooter. 307 pages, 12 figures. Chicago, 1960, Year Book Publishers, Inc. Multiple-Choice Examinations in Medicine. By J. P. Hubbard and W. V. Clemans. 18G pages. Philadelphia, 1961, Lea & Febiger. $3.75. l}ractique Obstetricale. By B. Jamain. Third edition. 277 pages. Paris, 1960, L'Expansiou. A Student's Guide to Obstetrics and Gynaec ol • ogy. By C. J. Dewhurst. 229 pages, 19 figures. Philadelphia, 1961, J. B. Lippincott Company. $4-. Systemic Lupus Erythematosus. By D. L. Larson. 212 pages, 2 illustrations, 15 tables. Boston. 1961, Little, Brown & Company. $7.50. You'll Live Through It. By Miriam Lincoln. 221 pages. New York, 1961, Harper & Brothers. $3.50.
Selected abstracts The Lancet
Nm'. 1'!, 1960. *B1oise, \V., deAssis, L. ~L, Bottma, c., and Ferrari, I.: Gonadal Dysgenesis (TurIlCf'S Syndrome) With Male Phenotype ami XO Chromosomal Constitution, p. 1059.
B10ise et al.: Gonodal Dysgenesis (Turner's Syndrome) With Male Phenotype and XO Chromosomal Constitution, p. 1059. :\ boy of 8 y<'ars had a bifid "scrotum" and? small urethral meatuscs. At operation a rU~J' Illcntary uterus and an undeveloped testiS, hut no O\'arian tissue were found. The nuclear
Volume 81 Number 6
sex (blood and oral smears and material from a skin biopsy) was male. Chromosomal counts (culture of bone marrow cells) showed that there were only 45 chromosollles present. Pairing of the chromosomes led to the belief that either the other X chromosome or the Y chronlOsorne was necessary. The conclusion was reached that XO chromosomal constitution is not incompatible with a male phenotype and the presence of an emhryonic testis. David M. Kydd
Obstetrics and Gynecology of the USSRt No . I , January-February, 1960. *La pin, L. N., IofIe-Golubchik, G. I., and Priev, I. G.: The Use of Microelements in FUllctional Uterine H emorrhages, p. 91. Lallin, IolTe-Golubchik, and Priev: The Usc of Microelements in Functional Uterine Hemorrhages, p. 91. Eight y-nine patipnts with menopausal hemorrhages and 20 patients with juvenile hemorrhages 'V<'n~ tr('at('d with solutions of slllfate salts of copper, cobalt, and manganese in a dosagl' of 5 to 6 mg. of ('aeh of these elements daily. In 77 patients of the first group the results were very satisfactory, in 6 the reslllts were doubtful, and in 6 no ('fIect was obtained. In the second grollp (the juvenile group) very good results were obtained in 17. In 2 patients the hl'morrhage recoIl1IlH'llced; however, repeated administration of the clem ents was effective. Research data pllblished by the Department of Chemistry of the l\f('dical School in Samarkand indicate that severe forms of anemia are connected with changes in the metabolism of copper, and t he intake of small amounts of copper or copper together with coba lt and manganese given to animals produced very satisfactory results.
Because of the satisfact ory results with the animal experimentations, the abo\'e elements w.ere administered to a group of patients as indtrat<'d ahove and n~s\llt.s were good. J(leob Solomc
tTl.. Book Revi.·w and Abstract Editor is plcasod In announce an exchange between the A~H:H.(CAN JOURNAL 0"OnSTETRICS ANn GYSF.COI .OGY and ()h J/t'tr ;u a,,,l GYIII' ,-olnl!)' nl.lh e USSR , D r. ~Iih:... lurr. Chid Editor. 1%1 is tI,e ~~II:ty-s('vcnth yeat' of bimnnlhl), publication of this journal. .lIlt"cut ly tile articles '><.lch have a concise English SUIIlInary. \Vc will publish a table o f contcoh and ~Il ahstract of One or two important articles.
Selected abstracts
1287
No.2, March-April, 1960, ,x'S himanovsky, R. N., and Werme1, E. M.: On the Treatment of Ovarian Cancer with NN'N"-Triethylene Thiophosphoramide ( thio-TEPA), p. 108. Shimanovsky and Wermel: Treatment of Ovarian Cancer With NN'N"-Triethylene Thiophosphoramide, p. 108. Thirty patients with ovarian carcinoma of tlw III a nd IV stages were treated with thioTEPA. In Stage III remission of up to 0111' year is achieved. In some cases the tumor and infiltrates diminish in size and become operahle. Dosages of 200 to 300 mg. per course are recommended to attain a long-term remission. The hest results were obtained by giving two consecutive courses of thio-TEPA with a I ~ to 2Y2 month interval, especially in instan ces where after the first course operation can be resorted to. In the treatment of the Grade IV cancer and Kruk cnberg's tumor, the rcsults were unsatisfactory, evidently because of insuffi cicnt doses of thio-TEPA. Thio-TEPA was also found efIective in cases of relapse following operation. The authors also sllggest that thio-TEPA for Stage I and II ovarian cancer, instituted immediately after a radical operation, would inJacob Solomr (Tease the rate of recovery . No.3, May-June, 1960. -lI'Vanina, L. V.: Pr('gnancy and Labor in \Vonwn Following Commissurotomy, p. 99. Vanina: Pregnancy and Labor in Women Following Commissurotomy, p. 99. Twenty gravidas wcre kept under observation followin g heart operations (1958-1959). Eight(','n of them underwent mitral commissurotomy ( in one recommissurotomy was performed), in 2 mitroaorta l cOlllmissurotomy was performed. Sixteen patients were operated on prior to pregnancy and 4- during gestation. The pregnancy was terminated with delivery in 14· women, in one with spontaneolls late abortion, in another with induccd ahortion; 4 wOlllcn were still pregnant at the time of the report. One patient di('d of cardiac insnfficiPllcy Oil the Im'lfth day aft('r c('sarean section. fn final evaluation, where the commissurotomy results afe considcrt'd cxccllent or good, the outcom.' of pn'gnancY and lahor is favorahle. In patients whC'l"e the results are f]uest ionahl<', pregnancy and labor are contraindicatcd. Ja cob Solome
Books received
('arly embryonic tissue to a particular noxious agent. The roles of matl'rnal age, of the placenta, and of the "whole" cnvironmcnt of the mother, her nutrition and metabolism, not men'ly the changes in the uterus during pregnancy, were discussed as possible factors in the etiology of congenital anomalies.
Am.
J.
June, 1961 Obst. & Gynec.
Thc only slightly disappointing feature of this excellcnt volume is thc paucity of material dealing with the effects of radiation on embryonal development; but it may be true, as pointed out by Hamilton in the summation, that this subject is far too big to be covered adeCjuately in a symposium of this type.
Books received for review Atlas of Obstetric Technic. By J. Robert Willson. First edition. 304 pages, 55 plates. St. Louis, Mo., 1961, The C. V. Mosby Company. $14.50. The Choice of a Medical Career (Essays on the Fields of Medicine). By Joseph Garland and Joseph Stokes. First edition. 231 pages. Philadelphia, 1961, J. B. Lippincott Company. $5. The Conduct of Sex. By Lawrence K. Frank. First edition. 192 pages. New York, 1961, William Morrow & Co. $4·. Current Therapy-1961. Edited by Howard F. Conn. 806 pages. Philadelphia, 1961, W. B. Saunders Company. $12.50. Die Kortikosteroid.Behandlung hamatologischer. By J. A. Horster. First edition, 108 pages, 6' tables. New York, 1961, Intercontinental Medical Book Corp. $3.50. Endocrine Dysfunction and Infertility. Edited by S. J. Fomon. 8G pages, 19 figures, 10 tables. Columbus, Ohio, 1961, Ross Laboratories (Ross Conference on Pediatric Research-Report of the 35th). Fetal Electrocardiography. By S. D. Larks. 109
pages, 70 figures. Springfield, Ill., 1961, Charles C Thomas, Publisher. $6.50. Haimopoiesis. By G. E. W. Wolstenholme and M. O·Connor. 490 pages, Boston, 1961, Little, Brown and Company. $11. Hospital Infection. By R. E. O. Williams, R. Blowers, L. P. Garrod, and R. A. Shooter. 307 pages, 12 figures. Chicago, 1960, Year Book Publishers, Inc. Multiple-Choice Examinations in Medicine. By J. P. Hubbard and W. V. Clemans. 18G pages. Philadelphia, 1961, Lea & Febiger. $3.75. l}ractique Obstetricale. By B. Jamain. Third edition. 277 pages. Paris, 1960, L'Expansiou. A Student's Guide to Obstetrics and Gynaec ol • ogy. By C. J. Dewhurst. 229 pages, 19 figures. Philadelphia, 1961, J. B. Lippincott Company. $4-. Systemic Lupus Erythematosus. By D. L. Larson. 212 pages, 2 illustrations, 15 tables. Boston. 1961, Little, Brown & Company. $7.50. You'll Live Through It. By Miriam Lincoln. 221 pages. New York, 1961, Harper & Brothers. $3.50.
Selected abstracts The Lancet
Nm'. 1'!, 1960. *B1oise, \V., deAssis, L. ~L, Bottma, c., and Ferrari, I.: Gonadal Dysgenesis (TurIlCf'S Syndrome) With Male Phenotype ami XO Chromosomal Constitution, p. 1059.
B10ise et al.: Gonodal Dysgenesis (Turner's Syndrome) With Male Phenotype and XO Chromosomal Constitution, p. 1059. :\ boy of 8 y<'ars had a bifid "scrotum" and? small urethral meatuscs. At operation a rU~J' Illcntary uterus and an undeveloped testiS, hut no O\'arian tissue were found. The nuclear
Volume 81 Number 6
sex (blood and oral smears and material from a skin biopsy) was male. Chromosomal counts (culture of bone marrow cells) showed that there were only 45 chromosollles present. Pairing of the chromosomes led to the belief that either the other X chromosome or the Y chronlOsorne was necessary. The conclusion was reached that XO chromosomal constitution is not incompatible with a male phenotype and the presence of an emhryonic testis. David M. Kydd
Obstetrics and Gynecology of the USSRt No . I , January-February, 1960. *La pin, L. N., IofIe-Golubchik, G. I., and Priev, I. G.: The Use of Microelements in FUllctional Uterine H emorrhages, p. 91. Lallin, IolTe-Golubchik, and Priev: The Usc of Microelements in Functional Uterine Hemorrhages, p. 91. Eight y-nine patipnts with menopausal hemorrhages and 20 patients with juvenile hemorrhages 'V<'n~ tr('at('d with solutions of slllfate salts of copper, cobalt, and manganese in a dosagl' of 5 to 6 mg. of ('aeh of these elements daily. In 77 patients of the first group the results were very satisfactory, in 6 the reslllts were doubtful, and in 6 no ('fIect was obtained. In the second grollp (the juvenile group) very good results were obtained in 17. In 2 patients the hl'morrhage recoIl1IlH'llced; however, repeated administration of the clem ents was effective. Research data pllblished by the Department of Chemistry of the l\f('dical School in Samarkand indicate that severe forms of anemia are connected with changes in the metabolism of copper, and t he intake of small amounts of copper or copper together with coba lt and manganese given to animals produced very satisfactory results.
Because of the satisfact ory results with the animal experimentations, the abo\'e elements w.ere administered to a group of patients as indtrat<'d ahove and n~s\llt.s were good. J(leob Solomc
tTl.. Book Revi.·w and Abstract Editor is plcasod In announce an exchange between the A~H:H.(CAN JOURNAL 0"OnSTETRICS ANn GYSF.COI .OGY and ()h J/t'tr ;u a,,,l GYIII' ,-olnl!)' nl.lh e USSR , D r. ~Iih:... lurr. Chid Editor. 1%1 is tI,e ~~II:ty-s('vcnth yeat' of bimnnlhl), publication of this journal. .lIlt"cut ly tile articles '><.lch have a concise English SUIIlInary. \Vc will publish a table o f contcoh and ~Il ahstract of One or two important articles.
Selected abstracts
1287
No.2, March-April, 1960, ,x'S himanovsky, R. N., and Werme1, E. M.: On the Treatment of Ovarian Cancer with NN'N"-Triethylene Thiophosphoramide ( thio-TEPA), p. 108. Shimanovsky and Wermel: Treatment of Ovarian Cancer With NN'N"-Triethylene Thiophosphoramide, p. 108. Thirty patients with ovarian carcinoma of tlw III a nd IV stages were treated with thioTEPA. In Stage III remission of up to 0111' year is achieved. In some cases the tumor and infiltrates diminish in size and become operahle. Dosages of 200 to 300 mg. per course are recommended to attain a long-term remission. The hest results were obtained by giving two consecutive courses of thio-TEPA with a I ~ to 2Y2 month interval, especially in instan ces where after the first course operation can be resorted to. In the treatment of the Grade IV cancer and Kruk cnberg's tumor, the rcsults were unsatisfactory, evidently because of insuffi cicnt doses of thio-TEPA. Thio-TEPA was also found efIective in cases of relapse following operation. The authors also sllggest that thio-TEPA for Stage I and II ovarian cancer, instituted immediately after a radical operation, would inJacob Solomr (Tease the rate of recovery . No.3, May-June, 1960. -lI'Vanina, L. V.: Pr('gnancy and Labor in \Vonwn Following Commissurotomy, p. 99. Vanina: Pregnancy and Labor in Women Following Commissurotomy, p. 99. Twenty gravidas wcre kept under observation followin g heart operations (1958-1959). Eight(','n of them underwent mitral commissurotomy ( in one recommissurotomy was performed), in 2 mitroaorta l cOlllmissurotomy was performed. Sixteen patients were operated on prior to pregnancy and 4- during gestation. The pregnancy was terminated with delivery in 14· women, in one with spontaneolls late abortion, in another with induccd ahortion; 4 wOlllcn were still pregnant at the time of the report. One patient di('d of cardiac insnfficiPllcy Oil the Im'lfth day aft('r c('sarean section. fn final evaluation, where the commissurotomy results afe considcrt'd cxccllent or good, the outcom.' of pn'gnancY and lahor is favorahle. In patients whC'l"e the results are f]uest ionahl<', pregnancy and labor are contraindicatcd. Ja cob Solome