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Body Composition and Bioelectrical Impedance Analysis; Prognostic Significance of Measurements in Patients with Locally Advanced or Metastatic Cancer
Annals of Oncology 25 (Supplement 4): iv517–iv541, 2014 doi:10.1093/annonc/mdu356.47
supportive care 1526P
C. Bilir1, H. Engin2 1 Medical Oncology, Recep Tayyip Erdogan University School of Medicine, Rize, TURKEY 2 Internal Medicine, Medical Oncology, Bulent Ecevit University School of Medicine, Zonguldak, TURKEY
abstracts
Aim: There are many parameters in the Bio-impedance analysis (BIA) measurements such as total weight, body fat (BF%), fat free mass (FFM), muscle mass, metabolic age, basal metabolic rate, resistance and phase angle. But we do not know clearly which of the parameters is the most important or which one of them are associated with overall survival (OS).
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BODY COMPOSITION AND BIOELECTRICAL IMPEDANCE ANALYSIS; PROGNOSTIC SIGNIFICANCE OF MEASUREMENTS IN PATIENTS WITH LOCALLY ADVANCED OR METASTATIC CANCER
Methods: In total, 173 patients have included in the study who were all incurable. The nutritional status was assessed thgrough the use of the subjective global assessment (SGA). Bio- impedance analysis were measured by Tanita Inc., Tokyo, Japan, Model TBF 300 Results: In this investigation, 173 patients (33 healty control and 140 patients with diagnosed metastatic cancer) were studied, with a mean age 54 years in man and 51 years in women, in addition study population had more man compared to women. Patients with cancer had lower hemoglobulin and albumin levels compared to the controls (11.5 gr/v 13 gr/dL, P=0.04) and 3.75 gr/dL vs 4.2 gr/dL,P<0.001, respectiely). The median OS was 7 (3-4) months of the cancer group and women wre alive longer than men (22 vs 13 months, P<0.001). Multivarite analysis revealed that, BF% (HR,0.8, 95% I,0.74-0.87, r=35.8, P<0.001), TBW% (HR, 0.89, 95% CI, 0.82-0.97, r=7.8, P=0.035), BMI (HR, 0.83, 95%CI, 0.74-0.93, r=13.9, P=0.003) were found to be statically significantly associated with OS. Conclusions: Present study showed that, increased BMI, fat mass and total body water at the time of diagnosis cancer, are good prognostic factors in patients with metastatic disease. Gender did not have any impact on relation of BIA parameters with survival. Disclosure: All authors have declared no conflicts of interest.
© European Society for Medical Oncology 2014. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: [email protected].
supportive care 1526P
C. Bilir1, H. Engin2 1 Medical Oncology, Recep Tayyip Erdogan University School of Medicine, Rize, TURKEY 2 Internal Medicine, Medical Oncology, Bulent Ecevit University School of Medicine, Zonguldak, TURKEY
abstracts
Aim: There are many parameters in the Bio-impedance analysis (BIA) measurements such as total weight, body fat (BF%), fat free mass (FFM), muscle mass, metabolic age, basal metabolic rate, resistance and phase angle. But we do not know clearly which of the parameters is the most important or which one of them are associated with overall survival (OS).
Downloaded from https://academic.oup.com/annonc/article-abstract/25/suppl_4/iv533/2242214 by guest on 24 October 2019
BODY COMPOSITION AND BIOELECTRICAL IMPEDANCE ANALYSIS; PROGNOSTIC SIGNIFICANCE OF MEASUREMENTS IN PATIENTS WITH LOCALLY ADVANCED OR METASTATIC CANCER
Methods: In total, 173 patients have included in the study who were all incurable. The nutritional status was assessed thgrough the use of the subjective global assessment (SGA). Bio- impedance analysis were measured by Tanita Inc., Tokyo, Japan, Model TBF 300 Results: In this investigation, 173 patients (33 healty control and 140 patients with diagnosed metastatic cancer) were studied, with a mean age 54 years in man and 51 years in women, in addition study population had more man compared to women. Patients with cancer had lower hemoglobulin and albumin levels compared to the controls (11.5 gr/v 13 gr/dL, P=0.04) and 3.75 gr/dL vs 4.2 gr/dL,P<0.001, respectiely). The median OS was 7 (3-4) months of the cancer group and women wre alive longer than men (22 vs 13 months, P<0.001). Multivarite analysis revealed that, BF% (HR,0.8, 95% I,0.74-0.87, r=35.8, P<0.001), TBW% (HR, 0.89, 95% CI, 0.82-0.97, r=7.8, P=0.035), BMI (HR, 0.83, 95%CI, 0.74-0.93, r=13.9, P=0.003) were found to be statically significantly associated with OS. Conclusions: Present study showed that, increased BMI, fat mass and total body water at the time of diagnosis cancer, are good prognostic factors in patients with metastatic disease. Gender did not have any impact on relation of BIA parameters with survival. Disclosure: All authors have declared no conflicts of interest.
© European Society for Medical Oncology 2014. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: [email protected].